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  1. AU="Uruchurtu, Ashley S S"
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  1. Article ; Online: Early mucosal events promote distinct mucosal and systemic antibody responses to live attenuated influenza vaccine.

    Thwaites, Ryan S / Uruchurtu, Ashley S S / Negri, Victor Augusti / Cole, Megan E / Singh, Nehmat / Poshai, Nelisa / Jackson, David / Hoschler, Katja / Baker, Tina / Scott, Ian C / Ros, Xavier Romero / Cohen, Emma Suzanne / Zambon, Maria / Pollock, Katrina M / Hansel, Trevor T / Openshaw, Peter J M

    Nature communications

    2023  Volume 14, Issue 1, Page(s) 8053

    Abstract: Compared to intramuscular vaccines, nasally administered vaccines have the advantage of inducing local mucosal immune responses that may block infection and interrupt transmission of respiratory pathogens. Live attenuated influenza vaccine (LAIV) is ... ...

    Abstract Compared to intramuscular vaccines, nasally administered vaccines have the advantage of inducing local mucosal immune responses that may block infection and interrupt transmission of respiratory pathogens. Live attenuated influenza vaccine (LAIV) is effective in preventing influenza in children, but a correlate of protection for LAIV remains unclear. Studying young adult volunteers, we observe that LAIV induces distinct, compartmentalized, antibody responses in the mucosa and blood. Seeking immunologic correlates of these distinct antibody responses we find associations with mucosal IL-33 release in the first 8 hours post-inoculation and divergent CD8
    MeSH term(s) Child ; Young Adult ; Humans ; Influenza Vaccines ; Antibody Formation ; Antibodies, Viral ; Influenza, Human ; Mucous Membrane ; Vaccines, Attenuated ; Immunity, Mucosal
    Chemical Substances Influenza Vaccines ; Antibodies, Viral ; Vaccines, Attenuated
    Language English
    Publishing date 2023-12-05
    Publishing country England
    Document type Journal Article
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-023-43842-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Delayed mucosal anti-viral responses despite robust peripheral inflammation in fatal COVID-19.

    Sidhu, Jasmin K / Siggins, Matthew K / Liew, Felicity / Russell, Clark D / Uruchurtu, Ashley S S / Davis, Christopher / Turtle, Lance / Moore, Shona C / Hardwick, Hayley E / Oosthuyzen, Wilna / Thomson, Emma C / Semple, Malcolm G / Baillie, J Kenneth / Openshaw, Peter J M / Thwaites, Ryan S

    The Journal of infectious diseases

    2023  

    Abstract: Background: While inflammatory and immune responses to SARS-CoV-2 infection in peripheral blood are extensively described, responses at the upper respiratory mucosal site of initial infection are relatively poorly defined. We sought to identify mucosal ... ...

    Abstract Background: While inflammatory and immune responses to SARS-CoV-2 infection in peripheral blood are extensively described, responses at the upper respiratory mucosal site of initial infection are relatively poorly defined. We sought to identify mucosal cytokine/chemokine signatures that distinguished COVID-19 severity categories, and relate these to disease progression and peripheral inflammation.
    Methods: We measured 35 cytokines and chemokines in nasal samples from 274 patients hospitalised with COVID-19. Analysis considered the timing of sampling during disease, as either the early (0-5 days post-symptom onset) or late (6-20 days post-symptom onset).
    Results: Patients that survived severe COVID-19 showed IFN-dominated mucosal immune responses (IFN-γ, CXCL10 and CXCL13) early in infection. These early mucosal responses were absent in patients that would progress to fatal disease despite equivalent SARS-CoV-2 viral load. Mucosal inflammation in later disease was dominated by IL-2, IL-10, IFN-γ, and IL-12p70, which scaled with severity but did not differentiate patients who would survive or succumb to disease. Cytokines and chemokines in the mucosa showed distinctions from responses evident in the peripheral blood, particularly during fatal disease.
    Conclusions: Defective early mucosal anti-viral responses anticipate fatal COVID-19 but are not associated with viral load. Early mucosal immune responses may define the trajectory of severe COVID-19.
    Language English
    Publishing date 2023-12-22
    Publishing country United States
    Document type Journal Article
    ZDB-ID 3019-3
    ISSN 1537-6613 ; 0022-1899
    ISSN (online) 1537-6613
    ISSN 0022-1899
    DOI 10.1093/infdis/jiad590
    Database MEDical Literature Analysis and Retrieval System OnLINE

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