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  1. Article: Highly Purified Conjugates of Natural Chlorin with Cobalt Bis(dicarbollide) Nanoclusters for PDT and BNCT Therapy of Cancer.

    Fedotova, Maria K / Usachev, Maksim N / Bogdanova, Ekaterina V / Diachkova, Ekaterina / Vasil'ev, Yuriy / Bregadze, Vladimir I / Mironov, Andrey F / Grin, Mikhail A

    Bioengineering (Basel, Switzerland)

    2021  Volume 9, Issue 1

    Abstract: To combine the neutron-capturing and photodynamic properties of boron nanoclusters and derivatives of natural chlorins, respectively, in one molecule, conjugate of chlorin e6 methyl ester with cyclen and dioxane and nitrile derivatives of cobalt bis( ... ...

    Abstract To combine the neutron-capturing and photodynamic properties of boron nanoclusters and derivatives of natural chlorins, respectively, in one molecule, conjugate of chlorin e6 methyl ester with cyclen and dioxane and nitrile derivatives of cobalt bis(dicarbollide) were synthesized. The conditions for the purification of compounds by HPLC were selected since the work with natural compounds is complicated by the production of closely related impurities.
    Language English
    Publishing date 2021-12-25
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2746191-9
    ISSN 2306-5354
    ISSN 2306-5354
    DOI 10.3390/bioengineering9010005
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: A Novel Photoswitchable Azobenzene-Containing Local Anesthetic Ethercaine with Light-Controlled Biological Activity In Vivo.

    Noev, Alexey / Kuznetsov, Nikita / Korenev, Georgiy / Morozova, Natalia / Vasil'ev, Yuriy / Suvorov, Nikita / Diachkova, Ekaterina / Usachev, Maksim / Pankratov, Andrei / Grin, Mikhail

    International journal of molecular sciences

    2022  Volume 23, Issue 10

    Abstract: Pain is a common symptom that impairs the quality of life for people around the world. Local anesthetics widely used for pain relief have a number of side effects, which makes the development of both new drugs and new ways to control their activity ... ...

    Abstract Pain is a common symptom that impairs the quality of life for people around the world. Local anesthetics widely used for pain relief have a number of side effects, which makes the development of both new drugs and new ways to control their activity particularly important. Photopharmacology makes it possible to reduce the side effects of an anesthetic and control its biological activity in the body. The purpose of this work was to create a new light-controlled local anesthetic and study its biological activity in animals. A compound with a simple scheme of synthesis was chosen to shift the UV-Vis absorption band towards the visible range of the spectrum and was synthesized for the first time. Some computer calculations were performed to make sure that the aforementioned changes would not lead to loss of biological activity. The micellar form of the new compound was prepared, and in vivo biological studies were carried out in rabbits. The existence of a local anesthetic effect, which disappeared almost completely on irradiation with light (λ = 395 nm), was shown using the surface anesthesia model. Moreover, the possibility of multiple reversible changes in the biological activity of ethercaine under the action of light was demonstrated. The latter compound manifests no local irritating effect, either. The data obtained indicate the prospects for the development of new compounds based on azobenzene for light-controlled local anesthesia.
    MeSH term(s) Anesthesia, Local ; Anesthetics, Local/pharmacology ; Animals ; Azo Compounds ; Humans ; Pain ; Quality of Life ; Rabbits
    Chemical Substances Anesthetics, Local ; Azo Compounds ; azobenzene (F0U1H6UG5C)
    Language English
    Publishing date 2022-05-11
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms23105352
    Database MEDical Literature Analysis and Retrieval System OnLINE

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