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  1. Article ; Online: Treatment of fibromyalgia among patients with mastalgia and fibromyalgia improved mastalgia.

    Yılmaz, Tonguç Utku / Inanır, Murat / Çınar, Saffet / Güler, Sertaç Ata / Utkan, Nihat Zafer

    Agri : Agri (Algoloji) Dernegi'nin Yayin organidir = The journal of the Turkish Society of Algology

    2024  Volume 36, Issue 2, Page(s) 113–119

    Abstract: Objectives: The aim of this study is to examine the effect of fibromyalgia (FM) treatment on mastalgia by performing fibromyalgia screening in patients who applied for mastalgia and whose underlying cause could not be found.: Methods: Patients who ... ...

    Title translation Mastaljisi olan fibromiyalji ve mastalji hastalarında tedavi ile mastalji düzeliyor.
    Abstract Objectives: The aim of this study is to examine the effect of fibromyalgia (FM) treatment on mastalgia by performing fibromyalgia screening in patients who applied for mastalgia and whose underlying cause could not be found.
    Methods: Patients who applied to Kocaeli University General Surgery Outpatient Clinic between November 2017 and November 2020 with breast pain were included (n=120). Patients without cancer, systemic disease, previous breast surgery, and breast mass larger than 3 cm (n=30) were referred to the Physical Therapy and Rehabilitation Outpatient Clinic. A total of 13 patients (43%) were diagnosed with FMS. Twelve of them were given selective serotonin-noradrenaline reuptake inhibitor (duloxetine) treatment for 3 months. Turkish version of the Short Form - 36 (SF-36) quality of life scores, Visual Analog Scale (VAS), Cardiff breast pain score before and after treatment were compared. The remaining 17 patients were followed as only mastalgia.
    Results: Patients with fibromyalgia and mastalgia had similar demographic results. At the end of the 3rd month, the complaints of breast pain completely regressed in all of the patients. Statistically significant changes were detected in VAS score, the number of trigger points, and SF-36 quality of life scores, Cardiff breast pain score after duloxetine treatment.
    Conclusion: In the presence of unexplained mastalgia, fibromyalgia should be kept in mind. Duloxetine treatment improved the breast pain and quality of life in patients with mastalgia and fibromyalgia.
    MeSH term(s) Humans ; Fibromyalgia/complications ; Mastodynia ; Duloxetine Hydrochloride ; Quality of Life ; Norepinephrine
    Chemical Substances Duloxetine Hydrochloride (9044SC542W) ; Norepinephrine (X4W3ENH1CV)
    Language English
    Publishing date 2024-04-01
    Publishing country Turkey
    Document type Journal Article
    ZDB-ID 1283669-2
    ISSN 2458-9446 ; 1300-0012
    ISSN (online) 2458-9446
    ISSN 1300-0012
    DOI 10.14744/agri.2022.58219
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  2. Article ; Online: Emergent approach to small bowel tumors: diagnosis and treatment.

    Sahin, Enes / Şahin, Kazım / Köken, Haşim / Güler, Sertaç Ata / Şimşek, Turgay / Utkan, Nihat Zafer / Şahin, Mustafa

    Ulusal travma ve acil cerrahi dergisi = Turkish journal of trauma & emergency surgery : TJTES

    2024  Volume 30, Issue 3, Page(s) 155–159

    Abstract: Background: This study presents the diagnosis and treatment of rare small bowel tumors through clinical cases.: Methods: Patients treated between 2000 and 2023 were included in the study. The clinical records of the patients were analyzed ... ...

    Title translation İnce bağırsak tümörlerine acil yaklaşım: Teşhis ve tedavi.
    Abstract Background: This study presents the diagnosis and treatment of rare small bowel tumors through clinical cases.
    Methods: Patients treated between 2000 and 2023 were included in the study. The clinical records of the patients were analyzed retrospectively.
    Results: A total of 34 patients were included in the study. Of these patients, 26 (75.5%) were male and eight (23.5%) were female. The mean age of the patients was 62.1 years. The most common symptoms and signs were abdominal pain (76.4%), bloating (38.2%), and nausea and vomiting (17.6%). Diagnostic methods included computed tomography (CT) (82.3%), upper gastrointestinal double balloon enteroscopy (35.2%), and capsule endoscopy (5.8%). Diagnoses included adenocarcinoma in 13 cases, gastrointestinal stromal tumors (GISTs) in 12 cases, and neuroendocrine tumors (NETs) in two cases.
    Conclusion: Small bowel tumors frequently present with abdominal pain, bloating, and nausea and vomiting. CT and endoscopic procedures are the primary diagnostic tools. Small bowel cancers are often diagnosed late due to subtle clinical findings and the limitations of endoscopic imaging. Targeted screening strategies may be beneficial for certain at-risk and symptomatic patient groups. Early surgical intervention offers significant advantages for diagnosed patients.
    MeSH term(s) Humans ; Male ; Female ; Middle Aged ; Retrospective Studies ; Intestinal Neoplasms/diagnosis ; Intestinal Neoplasms/surgery ; Capsule Endoscopy ; Abdominal Pain/etiology ; Vomiting ; Nausea
    Language English
    Publishing date 2024-03-20
    Publishing country Turkey
    Document type Journal Article
    ZDB-ID 2253739-9
    ISSN 1307-7945 ; 1306-696X
    ISSN (online) 1307-7945
    ISSN 1306-696X
    DOI 10.14744/tjtes.2024.33680
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  3. Article ; Online: Clinicopathological evaluation of idiopathic granulomatous mastitis patients: A retrospective analysis from a tertiary care hospital in Turkey.

    Yaprak Bayrak, Busra / Cam, Isa / Eruyar, Ahmet Tugrul / Utkan, Nihat Zafer

    Annals of diagnostic pathology

    2021  Volume 55, Page(s) 151812

    Abstract: Idiopathic granulomatous mastitis (IGM) is a chronic inflammatory disease of the breast with unknown etiology that is characterized by granuloma formation. We analyzed the clinical, radiological, and therapeutic approaches; the recurrence rate of the ... ...

    Abstract Idiopathic granulomatous mastitis (IGM) is a chronic inflammatory disease of the breast with unknown etiology that is characterized by granuloma formation. We analyzed the clinical, radiological, and therapeutic approaches; the recurrence rate of the disease; and the pathological findings diagnosed with mastitis in a retrospective study. We evaluated a total of 77 patients subjected to core needle or excisional biopsy with preliminary diagnosis of mastitis between January 2017-December 2019 who diagnosed with IGM, nonspecific mastitis/abscess, or periductal mastitis/plasma cell mastitis as a result of their pathological assessment. The mean age was 39.24 ± 10.6. Though 65 patients were diagnosed with IGM (84.4%), other diagnoses were reported as nonspecific mastitis/abscess (n = 9), periductal mastitis (n = 2) and plasma cell mastitis (n = 1). Recurrence occurred in 30 (39%) patients during follow-up. In patients without IGM, the number of 5-year postpartum mastitis diagnoses was significantly higher (p = 0.0008) while number of 2-year postpartum mastitis diagnoses was lower (p = 0.255) compared to those in IGM patients. The rates of axillary lymphadenopathy, bacterial culture, parity, and menopausal status were not different in patients without IGM. Linear correlation analysis did not reveal a significant relationship between radiological preliminary diagnosis and pathological diagnosis with BI-RADS classification. A detailed assessment, accompanied with clinical, radiological, and pathological findings, should be performed to achieve an accurate diagnosis and effective patient management in IGM. Furthermore, IGM should always be considered in the differential diagnosis of mastitis among breast masses.
    MeSH term(s) Adult ; Biopsy, Large-Core Needle ; Breast/pathology ; Breast Neoplasms/diagnosis ; Breast Neoplasms/pathology ; Diagnosis, Differential ; Female ; Granulomatous Mastitis/diagnosis ; Granulomatous Mastitis/pathology ; Humans ; Mammography ; Mastitis/diagnosis ; Mastitis/pathology ; Middle Aged ; Pregnancy ; Recurrence ; Retrospective Studies ; Tertiary Care Centers ; Turkey
    Language English
    Publishing date 2021-09-04
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1440011-x
    ISSN 1532-8198 ; 1092-9134
    ISSN (online) 1532-8198
    ISSN 1092-9134
    DOI 10.1016/j.anndiagpath.2021.151812
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  4. Article ; Online: Intraductal botulinum toxin injection suppressed the inflammation in experimental acute pancreatitis.

    Yılmaz, Tonguç Utku / Eraldemir, Fatma Ceyla / Gürel, Bora / Yavuz, Ömer / Acar, Esra / İşken, Tonguç / Yılmaz, Hasan / Utkan, Nihat Zafer

    Ulusal travma ve acil cerrahi dergisi = Turkish journal of trauma & emergency surgery : TJTES

    2023  Volume 28, Issue 12, Page(s) 1659–1666

    Abstract: Background: Acute pancreatitis (AP) is inflammation of pancreas in which pancreas enzymatic activity is increased. Parasym-pathetic innervation of pancreas plays an important role in several functions of pancreas. Botulinum toxin (BTx) might be a tool ... ...

    Title translation Deneysel akut pankreatit modelinde intraduktal botulinum toksin uygulaması enflamasyonu baskıladı.
    Abstract Background: Acute pancreatitis (AP) is inflammation of pancreas in which pancreas enzymatic activity is increased. Parasym-pathetic innervation of pancreas plays an important role in several functions of pancreas. Botulinum toxin (BTx) might be a tool to suppress the pancreas activity in AP.
    Methods: In the preliminary experimental study, BTx (15U/kg) was administered directly and intraductal ways. After 10 days, blood amylase, lipase, trypsinogen, insulin, and glucagon levels were compared and no significant difference was seen between groups. Intraductal BTx administration is preferred for experimental AP model in rats; control, AP, intraductal BTx, and AP with Intraductal BTx (AP+BTx). AP was created by intraperitoneal injection of cerulean 20 µg/kg/injection (5 times). After 24 h, serum amylase, lipase, IL-6, IL-1β, TNF-α, and IL-10 were measured and pancreas tissue was evaluated for inflammation and necrosis.
    Results: Mean serum amylase, lipase IL-6, IL-1β, and TNF-α levels of the AP group were significantly higher compared to the other groups (p<0.05). However, there was no significant difference between the amylase and lipase levels of control, BTx, and AP+BTx groups. Serum insulin and glucagon levels in AP group were significantly higher than control and BTx groups (p<0.05). However, there is no significant difference between the insulin and glucagon levels of AP and AP+BTx groups. in pathological evaluation. In AP+ BTx group, there is less amount of centrilobular necrosis and there is mild inflammation and hyperplasia of pancreatic duct epithelium.
    Conclusion: Administration of intraductal BTx suppressed the AP without making significant suppression in endogenous activity of pancreas.
    MeSH term(s) Animals ; Rats ; Pancreatitis/drug therapy ; Tumor Necrosis Factor-alpha ; Acute Disease ; Glucagon ; Interleukin-6 ; Inflammation/drug therapy ; Amylases ; Necrosis ; Lipase ; Botulinum Toxins ; Insulins
    Chemical Substances Tumor Necrosis Factor-alpha ; Glucagon (9007-92-5) ; Interleukin-6 ; Amylases (EC 3.2.1.-) ; Lipase (EC 3.1.1.3) ; Botulinum Toxins (EC 3.4.24.69) ; Insulins
    Language English
    Publishing date 2023-06-01
    Publishing country Turkey
    Document type Journal Article
    ZDB-ID 2253739-9
    ISSN 1307-7945 ; 1306-696X
    ISSN (online) 1307-7945
    ISSN 1306-696X
    DOI 10.14744/tjtes.2021.90140
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  5. Article: Breast Recurrence of Acute Myeloid Leukemia After Bone Marrow Transplantation: A Case Report About Myeloid Sarcoma of the Breast.

    Varol, Ecenur / Kiraz, Umay / Güler, Sertaç Ata / Vural, Çiğdem / Gülbaş, Zafer / Utkan, Nihat Zafer

    European journal of breast health

    2021  Volume 17, Issue 3, Page(s) 292–295

    Abstract: Myeloid sarcoma of the breast is a rare malignancy, can be seen after bone marrow transplantation. Although there are no specific features for this malignancy which is difficult to diagnose, some common features draw attention in the published case ... ...

    Abstract Myeloid sarcoma of the breast is a rare malignancy, can be seen after bone marrow transplantation. Although there are no specific features for this malignancy which is difficult to diagnose, some common features draw attention in the published case reports. Since there is no consensus on the treatment of myeloid sarcoma of the breast, we aimed to explain our own diagnosis and treatment methods in this case report.
    Language English
    Publishing date 2021-06-24
    Publishing country Turkey
    Document type Case Reports
    ISSN 2587-0831
    ISSN 2587-0831
    DOI 10.4274/ejbh.galenos.2021.6386
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  6. Article ; Online: Local Steroid Treatment: An Effective Procedure for Idiopathic Granulomatous Mastitis, Including Complicated Cases.

    Ertürk, Taha Furkan / Çakır, Özgür / Yaprak Bayrak, Büşra / Güneş, Abdullah / Aydemir, Selahattin / Utkan, Nihat Zafer

    Journal of investigative surgery : the official journal of the Academy of Surgical Research

    2021  Volume 35, Issue 4, Page(s) 745–751

    Abstract: Purpose: To evaluate the effectiveness of treatment with topical and intralesional steroids for idiopathic granulomatous mastitis (IGM) and to compare with surgical methods.: Methods: Data were retrospectively collected from records. Intralesional ... ...

    Abstract Purpose: To evaluate the effectiveness of treatment with topical and intralesional steroids for idiopathic granulomatous mastitis (IGM) and to compare with surgical methods.
    Methods: Data were retrospectively collected from records. Intralesional steroid injection and topical steroid administration, hereafter referred to as local steroid treatment (LST) were applied in Group 1. Surgery (local excision, wide excision, and mastectomy) was performed in Group 2. In Group 1, changes in lesion sizes were recorded and factors complicating treatment were identified. The Numeric Pain Rating Scale was used to determine subjective pain. LST and surgery were compared with regard to: pain before and after the treatment; complication rate; recurrence rate; and treatment cost.
    Results: There were 38 and 48 patients in Group 1 and Group 2, respectively. In the LST group, 72 lesions were present and 70 of 72 (97%) responded completely to treatment. Pretreatment median maximum diameter was 23.50 (15.25-35.25) mm, which regressed to 16 (12-25) mm after the first session. While the pretreatment pain scores of Group 1 and Group 2 were similar (p = 0.756), there was a significant difference in the post-treatment pain scores (p < 0.001). No recurrence occurred in any patients in Group 1, while recurrence developed in 15 (31.2%) patients in Group 2 (p < 0.001).
    Conclusion: LST is a treatment for IGM that is cheap, with high efficiency, negligible recurrence, and has good esthetic outcome. Our results suggest that LST should be the first-line treatment option for all IGM patients, including complicated cases.
    MeSH term(s) Breast Neoplasms/surgery ; Female ; Granulomatous Mastitis/drug therapy ; Granulomatous Mastitis/surgery ; Humans ; Mastectomy ; Retrospective Studies ; Steroids ; Treatment Outcome
    Chemical Substances Steroids
    Language English
    Publishing date 2021-06-21
    Publishing country United States
    Document type Journal Article
    ZDB-ID 639444-9
    ISSN 1521-0553 ; 0894-1939
    ISSN (online) 1521-0553
    ISSN 0894-1939
    DOI 10.1080/08941939.2021.1933272
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  7. Article ; Online: Decreased serum levels of glycerol-3- phosphate dehydrogenase 1 and monoacylglycerol lipase act as diagnostic biomarkers for breast cancer.

    Karaosmanoglu Yoneten, Kubra / Kasap, Murat / Arga, Kazim Yalcin / Akpinar, Gurler / Utkan, Nihat Zafer

    Cancer biomarkers : section A of Disease markers

    2021  Volume 34, Issue 1, Page(s) 67–76

    Abstract: Background: Breast cancer (BC) is one of the most life-threatening cancer types among women. Despite major developments in medical sciences and technologies, the incidence and mortality rates of BC cases are still increasing. One of the reasons for this ...

    Abstract Background: Breast cancer (BC) is one of the most life-threatening cancer types among women. Despite major developments in medical sciences and technologies, the incidence and mortality rates of BC cases are still increasing. One of the reasons for this increase is the absence of an easy to perform early-diagnostic tool. Although there are defined BC biomarkers routinely used for diagnostic and prognostic purposes, none of these biomarkers is useful for early diagnosis. Therefore, early diagnosis of BC remains an important challenge and there is a great need for the early-diagnostic biomarker(s).
    Objective: In this study, we aimed to evaluate the diagnostic and prognostic values of glycerol-3-phosphate dehydrogenase (GPD1) and monoacylglycerol lipase (MAGL) proteins as non-invasive serum biomarkers.
    Methods: GPD1 and MAGL serum levels were determined by ELISA for BC patients (n= 100) from five different subtypes, and healthy controls (n= 20), and a comparative analysis was performed to determine statistically significant expression differences among the groups.
    Results: The results provided evidence that GPD1 acted as a diagnostic biomarker in distinguishing triple-negative breast cancer (TNBC) patients from other subtypes, and MAGL acted as a diagnostic biomarker in distinguishing healthy individuals from BC patients.
    Conclusion: GPD1 and MAGL might be proposed as non-invasive diagnostic biomarkers for BC with high sensitivity and specificity.
    MeSH term(s) Biomarkers, Tumor ; Breast Neoplasms/diagnosis ; Female ; Glycerol ; Humans ; Male ; Monoacylglycerol Lipases/metabolism ; Oxidoreductases ; Phosphates ; Triple Negative Breast Neoplasms/diagnosis
    Chemical Substances Biomarkers, Tumor ; Phosphates ; Oxidoreductases (EC 1.-) ; Monoacylglycerol Lipases (EC 3.1.1.23) ; Glycerol (PDC6A3C0OX)
    Language English
    Publishing date 2021-10-14
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2203517-5
    ISSN 1875-8592 ; 1574-0153 ; 1875-8592
    ISSN (online) 1875-8592 ; 1574-0153
    ISSN 1875-8592
    DOI 10.3233/CBM-203093
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  8. Article ; Online: Intravoxel incoherent motion magnetic resonance imaging for breast cancer: A comparison with molecular subtypes and histological grades.

    Uslu, Hande / Önal, Tugay / Tosun, Mesude / Arslan, Arzu S / Ciftci, Ercument / Utkan, Nihat Zafer

    Magnetic resonance imaging

    2021  Volume 78, Page(s) 35–41

    Abstract: Purpose: The purpose of this paper is to investigate whether the IVIM parameters (D, D *, f) helps to determine the molecular subtypes and histological grades of breast cancer.: Methods: Fifty-one patients with breast cancer were included in the ... ...

    Abstract Purpose: The purpose of this paper is to investigate whether the IVIM parameters (D, D *, f) helps to determine the molecular subtypes and histological grades of breast cancer.
    Methods: Fifty-one patients with breast cancer were included in the study. All subjects were examined by 3 T Magnetic Resonance Imaging (MRI). Diffusion-weighted imaging (DWI) was undertaken with 16 b-values. IVIM parameters [D (true diffusion coefficient), D* (pseudo-diffusion coefficient), f (perfusion fraction)] were calculated. Histopathological reports were reviewed to histological grade, histological type, and immunohistochemistry. IVIM parameters of tumors with different histological grades and molecular subtypes were compared.
    Results: D* and f were significantly different between molecular subtypes (p = 0.019, p = 0.03 respectively). D* and f were higher in the HER-2 group and lower in Triple negative (-) group (D*:36.8 × 10
    Conclusion: D* and f values measured with IVIM imaging were useful for assessing breast cancer molecular subtyping. IVIM imaging may be an alternative to breast biopsy for sub-typing of breast cancer with further research.
    MeSH term(s) Adult ; Aged ; Biopsy ; Breast Neoplasms/diagnostic imaging ; Breast Neoplasms/pathology ; Female ; Humans ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Movement ; Neoplasm Grading
    Language English
    Publishing date 2021-02-06
    Publishing country Netherlands
    Document type Comparative Study ; Journal Article
    ZDB-ID 604885-7
    ISSN 1873-5894 ; 0730-725X
    ISSN (online) 1873-5894
    ISSN 0730-725X
    DOI 10.1016/j.mri.2021.02.005
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  9. Article: The Effect of Residual Gastric Volume on Body Mass Index, Excess Weight Loss Rate and Metabolic Response after Sleeve Gastrectomy.

    Şahin, Kazım / Güler, Sertaç Ata / Şimşek, Turgay / Şahin, Enes / Varol, Ecenur / Çakır, Özgür / Utkan, Nihat Zafer / Cantürk, Nuh Zafer

    Chirurgia (Bucharest, Romania : 1990)

    2022  Volume 118, Issue 4, Page(s) 380–390

    Abstract: Background/aim: To investigate the metabolic response and body mass index reduction according to the remaining stomach volume between 6-12 months after the operation in patients who underwent sleeve gastrectomy surgery for obesity and to determine the ... ...

    Abstract Background/aim: To investigate the metabolic response and body mass index reduction according to the remaining stomach volume between 6-12 months after the operation in patients who underwent sleeve gastrectomy surgery for obesity and to determine the relationship between the remaining stomach volume and metabolic improvement.
    Conclusion: The smaller the residual gastric volume after laparoscopic sleeve gastrectomy, the higher the %EWL and the greater the decrease in HbA1c. This study show that laparoscopic sleeve gastrectomy is an effective surgical procedure in patients with Type 2 diabetes mellitus.
    MeSH term(s) Humans ; Adult ; Middle Aged ; Body Mass Index ; Diabetes Mellitus, Type 2 ; Glycated Hemoglobin ; Residual Volume ; Treatment Outcome ; Stomach ; Gastrectomy ; Albumins
    Chemical Substances Glycated Hemoglobin ; Albumins
    Language English
    Publishing date 2022-05-20
    Publishing country Romania
    Document type Journal Article
    ZDB-ID 419244-8
    ISSN 1842-368X ; 1221-9118 ; 0009-4730 ; 0377-5003
    ISSN (online) 1842-368X
    ISSN 1221-9118 ; 0009-4730 ; 0377-5003
    DOI 10.21614/chirurgia.2023.v.118.i.4.p.380
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  10. Article ; Online: Serum cholecystokinin levels can be a predictive factor for difficult cholecystectomy: Decreased cholecystokinin receptor levels.

    Yılmaz, Tonguç Utku / Eraldemir, Fatma Ceyla / Vural, Çiğdem / Çınar, Saffet / Acar, Esra / Caglayangil, Serdar / Yaprak Bayrak, Büşra / Utkan, Nihat Zafer

    Ulusal travma ve acil cerrahi dergisi = Turkish journal of trauma & emergency surgery : TJTES

    2022  Volume 28, Issue 7, Page(s) 947–953

    Abstract: Background: Laparoscopic cholecystectomy (LC) is being performed frequently in general surgery practice. Estimation of difficult cholecystectomy is very important to take precautions against complications. Cholecystokinin (CCK) is an important enzyme ... ...

    Title translation Serum kolesistokinin düzeyi, zor kolesistektomi için belirleyici faktör olabilir: Azalmış kolesistokinin reseptör düzeyleri.
    Abstract Background: Laparoscopic cholecystectomy (LC) is being performed frequently in general surgery practice. Estimation of difficult cholecystectomy is very important to take precautions against complications. Cholecystokinin (CCK) is an important enzyme for gall-bladder motility. CCK receptor is the target for CCK. Fibrosis and emptying problems of gallbladder are related with difficult cholecys-tectomies. We aimed to evaluate the association between plasma CCK and difficult cholecystectomy and try to explain the mechanism.
    Methods: Prospective cross-sectional study was conducted on a group of patients with cholelithiasis Patients who underwent elective cholecystectomy were classified into easy, difficult and very difficult preoperatively using LC difficulty scores. Pre-operative gallbladder empting ratios were measured by ultrasonography. Serum C-reactive protein, and postprandial serum CCK and pancreas polypeptide levels were measured before the operation. Operation data including operation times, adhesion scores, and complications were collected. Tissue CCK receptor levels and tissue fibrosis scores were obtained.
    Results: Easy, difficult, and very difficult LC (DLC) groups were consisted of 34, 28, and 8 patients, respectively. Gallbladder emp-tying was 60% in easy LC group, but 15% in very DLC group. Plasma CCK levels in easy group (37.4 pg/ml) were significantly lower than plasma CCK levels of difficult (58.6 pg/ml), and very difficult groups (66.23 pg/ml). Tissue CCK receptor levels of easy, difficult, and very difficult were 372.4, 178.3, and 144.1 ng/100 mg, respectively. Adhesion scores and fibrosis scores of very difficult group were significantly higher than other groups. Operation times were significantly longer in very difficult group. There were two conversions to open in very DLC group (25%).
    Conclusion: CCK is a reliable parameter for determining the difficulty of LC. Decreased CCK receptor levels with fibrosis of gallbladder are the probably responsible mechanism.
    MeSH term(s) Cholecystectomy ; Cholecystokinin ; Cross-Sectional Studies ; Humans ; Prospective Studies ; Receptors, Cholecystokinin
    Chemical Substances Receptors, Cholecystokinin ; Cholecystokinin (9011-97-6)
    Language English
    Publishing date 2022-06-27
    Publishing country Turkey
    Document type Journal Article
    ZDB-ID 2253739-9
    ISSN 1307-7945 ; 1306-696X
    ISSN (online) 1307-7945
    ISSN 1306-696X
    DOI 10.14744/tjtes.2022.96572
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