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  1. Article ; Online: Lactobacillus

    Pararajasingam, Abirami / Uwagwu, Juliet

    BMJ case reports

    2017  Volume 2017

    Abstract: We present a 65-year-old diabetic patient with a complex liver abscess and bacteraemia ... ...

    Abstract We present a 65-year-old diabetic patient with a complex liver abscess and bacteraemia from
    MeSH term(s) Aged ; Anti-Bacterial Agents/therapeutic use ; Colony Count, Microbial ; Drainage ; Female ; Fluconazole/therapeutic use ; Humans ; Immunocompromised Host/immunology ; Lactobacillus/classification ; Lactobacillus/immunology ; Lactobacillus/isolation & purification ; Lactobacillus/pathogenicity ; Lethargy ; Linezolid/therapeutic use ; Liver Abscess/etiology ; Liver Abscess/microbiology ; Metronidazole/therapeutic use ; Microbial Sensitivity Tests ; Pleural Effusion/microbiology ; Probiotics/adverse effects ; Sepsis/etiology ; Sepsis/microbiology ; Treatment Outcome ; Venous Thrombosis/microbiology
    Chemical Substances Anti-Bacterial Agents ; Metronidazole (140QMO216E) ; Fluconazole (8VZV102JFY) ; Linezolid (ISQ9I6J12J)
    Language English
    Publishing date 2017-09-13
    Publishing country England
    Document type Case Reports ; Journal Article
    ISSN 1757-790X
    ISSN (online) 1757-790X
    DOI 10.1136/bcr-2016-218423
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Impact of penicillin allergy records on antimicrobial prescribing in hospitalised patients.

    Anton-Vazquez, Vanesa / Ferretti, Francesca / Kaya, Deniz / Mishra, Shashwat / Kerneis, Sven / Eden, Charlotte / Doan, Hong / Leung, Hiu Fung / Baltazar, Jeanelli / Starkey, Sarah / Uwagwu, Juliet / Dall'Antonia, Martino / Cepeda, Jorge

    Clinical medicine (London, England)

    2024  Volume 24, Issue 2, Page(s) 100024

    Abstract: Background: The overdiagnosis of penicillin allergy and misclassification of non-truly allergic reactions is a growing public health problem, associated with the overuse of broad-spectrum and restricted antimicrobials. We aimed to evaluate the impact of ...

    Abstract Background: The overdiagnosis of penicillin allergy and misclassification of non-truly allergic reactions is a growing public health problem, associated with the overuse of broad-spectrum and restricted antimicrobials. We aimed to evaluate the impact of penicillin allergy status on antimicrobial prescribing.
    Methods: A retrospective study of inpatients with a documented penicillin allergy receiving antimicrobials was conducted from 1 April to 1 July 2021. Antimicrobial prescribing and clinical characteristics were compared between patients with an active penicillin allergy label and those whose label was removed following antimicrobial stewardship team review. Antimicrobials were classified in two categories: i) 'Access' (recommended), ii) 'Watch and Reserve' (restricted) according to WHO AWaRe classification, a tool to guide appropriate antibiotic use.
    Results: 437 patients with a documented penicillin allergy receiving antimicrobials were included. 353 patients with an active penicillin allergy label, more frequently received antimicrobials from the 'Watch and Reserve list' (283;80% vs 30;37%; p<0.001). In contrast, 84 patients who were de-labelled received more often antimicrobials from the 'Access list' (53;63% vs 64;18%; p<0.001).
    Conclusions: Penicillin allergy reviews and de-labelling strategies may reduce the use of restricted antimicrobials under the 'Watch and Reserve list'. This practice should be encouraged and reinforced in all hospitals.
    Language English
    Publishing date 2024-02-20
    Publishing country England
    Document type Journal Article
    ZDB-ID 2048646-7
    ISSN 1473-4893 ; 1470-2118
    ISSN (online) 1473-4893
    ISSN 1470-2118
    DOI 10.1016/j.clinme.2024.100024
    Database MEDical Literature Analysis and Retrieval System OnLINE

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