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  1. Article: Predictors of Significant Liver Fibrosis in People with Chronic Hepatitis C Who Inject Drugs in the Czech Republic.

    Frankova, Sona / Uzlova, Nikola / Merta, Dusan / Pitova, Veronika / Sperl, Jan

    Life (Basel, Switzerland)

    2023  Volume 13, Issue 4

    Abstract: Background and objectives: HCV infection often remains untreated in people who inject drugs (PWID), albeit they may present with advanced liver fibrosis at a young age. We aimed to assess the rate of patients with significant fibrosis in PWID starting ... ...

    Abstract Background and objectives: HCV infection often remains untreated in people who inject drugs (PWID), albeit they may present with advanced liver fibrosis at a young age. We aimed to assess the rate of patients with significant fibrosis in PWID starting anti-HCV therapy and identify the factors associated with severe fibrosis.
    Methods: The cohort of 200 patients was divided into two groups: F0-F2 (N = 154, 77%), patients with liver stiffness measurement (LSM) < 10.0 kPa, and F3-F4 (N = 46, 23%), with LSM ≥ 10.0 kPa, indicating significant liver fibrosis.
    Results: In group F3-F4, there were significantly more males, and the patients were older, with a higher BMI. The number of long-term abstaining patients was significantly higher in group F3-F4 compared with group F0-F2, as well as the proportion of patients reporting harmful drinking. Obesity (OR 4.77), long-term abstinence from illicit drugs (OR 4.06), harmful drinking (OR 2.83), and older age (OR 1.17) were significant predictors of advanced fibrosis in PWID starting anti-HCV therapy.
    Conclusions: A quarter of PWID presented with significant liver fibrosis at treatment initiation. Obesity, long-term drug abstinence, harmful drinking, and older age contributed to significant liver fibrosis.
    Language English
    Publishing date 2023-04-02
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662250-6
    ISSN 2075-1729
    ISSN 2075-1729
    DOI 10.3390/life13040932
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Transient Elastography as the First-Line Assessment of Liver Fibrosis and Its Correlation with Serum Markers.

    Uzlova, Nikola / Mnozil Stridova, Katerina / Merta, Dusan / Rychlik, Ivan / Frankova, Sona

    Medicina (Kaunas, Lithuania)

    2023  Volume 59, Issue 4

    Abstract: Background and ... ...

    Abstract Background and objectives
    MeSH term(s) Male ; Female ; Humans ; Middle Aged ; Elasticity Imaging Techniques/adverse effects ; Elasticity Imaging Techniques/methods ; Biopsy/methods ; Liver Cirrhosis/diagnostic imaging ; Liver Cirrhosis/etiology ; Liver/pathology ; Biomarkers ; Fibrosis
    Chemical Substances Biomarkers
    Language English
    Publishing date 2023-04-12
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2188113-3
    ISSN 1648-9144 ; 1010-660X
    ISSN (online) 1648-9144
    ISSN 1010-660X
    DOI 10.3390/medicina59040752
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Can Renal Parameters Predict the Mortality of Hospitalized COVID-19 Patients?

    Zolotov, Eli / Sigal, Anat / Havrda, Martin / Jeřábková, Karolína / Krátká, Karolína / Uzlová, Nikola / Rychlík, Ivan

    Kidney & blood pressure research

    2022  Volume 47, Issue 5, Page(s) 309–319

    Abstract: Introduction: Our study aimed to analyze whether renal parameters can predict mortality from COVID-19 disease in hospitalized patients.: Methods: This retrospective cohort includes all adult patients with confirmed COVID-19 disease who were ... ...

    Abstract Introduction: Our study aimed to analyze whether renal parameters can predict mortality from COVID-19 disease in hospitalized patients.
    Methods: This retrospective cohort includes all adult patients with confirmed COVID-19 disease who were consecutively admitted to the tertiary hospital during the 4-month period (September 1 to December 31, 2020). We analyzed their basic laboratory values, urinalysis, comorbidities, length of hospitalization, and survival. The RIFLE and KDIGO criteria were used for AKI and CKD grading, respectively. To display renal function evolution and the severity of renal damage, we subdivided patients further into 6 groups as follows: group 1 (normal renal function), group 2 (CKD grades 2 + 3a), group 3 (AKI-DROP defined as whose s-Cr level dropped by >33.3% during the hospitalization), group 4 (CKD 3b), group 5 (CKD 4 + 5), and group 6 (AKI-RISE defined as whose s-Cr level was elevated by ≥50% within 7 days or by ≥26.5 μmol/L within 48 h during hospitalization). Then, we used eGFR on admission independently of renal damage to check whether it can predict mortality. Only 4 groups were used: group I - normal renal function (eGFR > 1.5 mL/s), group II - mild renal involvement (eGFR 0.75-1.5), group III - moderate (eGFR 0.5-0.75), and group IV - severe (GFR <0.5).
    Results: A total of 680 patients were included in our cohort; among them, 244 patients displayed normal renal function, 207 patients fulfilled AKI, and 229 patients suffered from CKD. In total, a significantly higher mortality rate was found in the AKI and the CKD groups versus normal renal function - 37.2% and 32.3% versus 9.4%, respectively (p < 0.001). In addition, the groups 1-6 divided by severity of renal damage reported mortality of 9.4%, 21.2%, 24.1%, 48.7%, 62.8%, and 55.1%, respectively (p < 0.001). The mean hospitalization duration of alive patients with normal renal findings was 9.5 days, while it was 12.1 days in patients with any renal damage (p < 0.001). When all patients were compared according to eGFR on admission, the mortality was as follows: group I (normal) 9.8%, group II (mild) 22.1%, group III (moderate) 40.9%, and group IV (severe) 50.5%, respectively (p < 0.001). It was a significantly better mortality predictor than CRP on admission (AUC 0.7053 vs. 0.6053).
    Conclusions: Mortality in patients with abnormal renal function was 3 times higher compared to patients with normal renal function. Also, patients with renal damage had a worse and longer hospitalization course. Lastly, eGFR on admission, independently of renal damage type, was an excellent tool for predicting mortality. Further, the change in s-Cr levels during hospitalization reflected the mortality prognosis.
    MeSH term(s) Acute Kidney Injury ; Adult ; COVID-19 ; Female ; Hospital Mortality ; Humans ; Kidney/physiology ; Male ; Renal Insufficiency, Chronic ; Retrospective Studies ; Risk Factors
    Language English
    Publishing date 2022-01-20
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1326018-2
    ISSN 1423-0143 ; 1420-4096
    ISSN (online) 1423-0143
    ISSN 1420-4096
    DOI 10.1159/000522100
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1458: Show issues Location:
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  4. Article: Importance of breath tests for the evaluation liver function in patients with chronic kidney disease.

    Mejzlíková, Nikola / Krátká, Karolína / Vejvodová, Miluše / Libicherová, Pavla / Uzlová, Nikola / Vránová, Jana / Rychlík, Ivan

    Vnitrni lekarstvi

    2020  Volume 66, Issue 3, Page(s) 50–52

    Abstract: Breath tests for the evaluation liver metabolic function are a non-invasive diagnostic method with high sensitivity and specificity. Up today, the issue of liver damage in patients with chronic kidney disease has not been investigated sufficiently, ... ...

    Title translation Význam dechových testů k hodnocení jaterních funkcí u pacientů s chronickým onemocněním ledvin.
    Abstract Breath tests for the evaluation liver metabolic function are a non-invasive diagnostic method with high sensitivity and specificity. Up today, the issue of liver damage in patients with chronic kidney disease has not been investigated sufficiently, although it might have significant clinical consequences. The following article describes the principles of breath tests, experiences with breath tests in patients with chronic kidney disease (CKD) and the results of our pilot study with methacetin breath tests in patients with CKD and in regular peritoneal dialysis treatment.
    MeSH term(s) Breath Tests ; Humans ; Liver/pathology ; Liver Cirrhosis ; Liver Function Tests ; Pilot Projects ; Renal Insufficiency, Chronic/diagnosis
    Language English
    Publishing date 2020-09-25
    Publishing country Czech Republic
    Document type Journal Article
    ZDB-ID 138213-5
    ISSN 1801-7592 ; 0042-773X
    ISSN (online) 1801-7592
    ISSN 0042-773X
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.B 327: Show issues Location:
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  5. Article: Transient elastography - role in the assessment of the liver disease development.

    Uzlová, Nikola / Mejzlíková, Nikola / Fraňková, Soňa / Libicherová, Pavla / Nosek, David / Rychlík, Ivan

    Vnitrni lekarstvi

    2019  Volume 64, Issue 10, Page(s) 916–922

    Abstract: Transient elastography, an examination based on the liver stiffness measurement, is a method validated for the non-invasive liver fibrosis staging. This method was recently successfully introduced into routine clinical practice. In accordance with the ... ...

    Title translation Tranzientní elastografie - přínos v hodnocení vývoje jaterního onemocnění.
    Abstract Transient elastography, an examination based on the liver stiffness measurement, is a method validated for the non-invasive liver fibrosis staging. This method was recently successfully introduced into routine clinical practice. In accordance with the global- wide screening of viral hepatitis (chronic viral hepatitis type B and type C) and with the increasing effectiveness of antiviral therapy, as well as with the increasing prevalence of non-alcoholic fatty liver disease (NAFLD), the part of population requiring the care of hepatologists is certain to increase. Now more than ever we need a non-invasive, fast, safe, inexpensive and reliable method for evaluating patients with chronic liver disease. A new area of ​​use of elastography appears to be used to measure the stiffness of the spleen as a prediction of the presence of esophageal varices or the stiffness (or rather fibrosis) of transplanted kidneys. The aim of this review is to provide a comprehensive view of transient elastography, its principles, advantages and pitfalls, including its use in everyday clinical practice. Key words: cirrhosis - fibrosis - renal allograft - transient elastography.
    MeSH term(s) Elasticity Imaging Techniques ; Humans ; Kidney Transplantation ; Liver ; Liver Cirrhosis/diagnostic imaging
    Language English
    Publishing date 2019-01-15
    Publishing country Czech Republic
    Document type Journal Article ; Review
    ZDB-ID 138213-5
    ISSN 1801-7592 ; 0042-773X
    ISSN (online) 1801-7592
    ISSN 0042-773X
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 327: Show issues Location:
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