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  1. Article: The bidirectional relationship between endometriosis and microbiome.

    Uzuner, Cansu / Mak, Jason / El-Assaad, Fatima / Condous, George

    Frontiers in endocrinology

    2023  Volume 14, Page(s) 1110824

    Abstract: Endometriosis has been described by many different theories of pathogenesis over the years. It is now also appreciated to be a state of chronic inflammation, and the role of immune dysfunction in its development has been proven. There is increasing ... ...

    Abstract Endometriosis has been described by many different theories of pathogenesis over the years. It is now also appreciated to be a state of chronic inflammation, and the role of immune dysfunction in its development has been proven. There is increasing evidence to support the role of the microbiome in the formation and progression of endometriosis
    MeSH term(s) Endometriosis/genetics ; Endometriosis/pathology ; Gastrointestinal Microbiome ; Inflammation/complications ; Microbiota ; Humans ; Female ; Epigenomics
    Language English
    Publishing date 2023-03-07
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2592084-4
    ISSN 1664-2392
    ISSN 1664-2392
    DOI 10.3389/fendo.2023.1110824
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Effectiveness of ultrasound for endometriosis diagnosis.

    Chen-Dixon, Katie / Uzuner, Cansu / Mak, Jason / Condous, George

    Current opinion in obstetrics & gynecology

    2022  Volume 34, Issue 5, Page(s) 324–331

    Abstract: Purpose of review: Endometriosis is a chronic benign gynaecological condition characterized by pelvic pain, subfertility and delay in diagnosis. There is an emerging philosophical shift from gold standard histopathological diagnosis through laparoscopy ... ...

    Abstract Purpose of review: Endometriosis is a chronic benign gynaecological condition characterized by pelvic pain, subfertility and delay in diagnosis. There is an emerging philosophical shift from gold standard histopathological diagnosis through laparoscopy to establishing diagnosis through noninvasive imaging.
    Recent findings: The ENZIAN classification system was updated in 2021 to be suitable for both diagnostic imaging and laparoscopy. The accuracy of transvaginal ultrasound (TVUS) in diagnosing endometriosis varies depending on location of the lesion. A recent international pilot study found that when ultrasound is performed in accordance with the IDEA consensus, a higher detection of deep endometriosis is seen, with an overall sensitivity of 88% and specificity of 79% compared with direct surgical visualization.
    Summary: Although ultrasound can detect adenomyosis, deep endometriosis and endometriomas, it is not possible to reliably detect superficial endometriosis. In the instance of a negative ultrasound with persistence of symptoms despite medical therapy, laparoscopy should be considered for diagnosis and treatment.
    MeSH term(s) Endometriosis ; Female ; Humans ; Pelvis ; Pilot Projects ; Sensitivity and Specificity ; Ultrasonography
    Language English
    Publishing date 2022-08-19
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1049382-7
    ISSN 1473-656X ; 1040-872X
    ISSN (online) 1473-656X
    ISSN 1040-872X
    DOI 10.1097/GCO.0000000000000812
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: An Ultrasound-based Prediction Model to Predict Ureterolysis during Laparoscopic Endometriosis Surgery.

    Zanardi, José Vitor C / Rocha, Rodrigo M / Leonardi, Mathew / Wood, Demi L / Lu, Chuan / Uzuner, Cansu / Mak, Jason / Condous, George

    Journal of minimally invasive gynecology

    2022  Volume 29, Issue 10, Page(s) 1170–1177

    Abstract: Study objective: To develop a model, including clinical features and ultrasound findings, to predict the need for ureterolysis (i.e., dissection of the ureter) during laparoscopy for endometriosis.: Design: A retrospective observational study of ... ...

    Abstract Study objective: To develop a model, including clinical features and ultrasound findings, to predict the need for ureterolysis (i.e., dissection of the ureter) during laparoscopy for endometriosis.
    Design: A retrospective observational study of patients who had undergone transvaginal ultrasound (TVS) according to the International Deep Endometriosis Analysis consensus and subsequent laparoscopy ± excision of endometriosis between January 2017 and February 2021 was conducted.
    Setting: Sydney Medical School Nepean, University of Sydney, Nepean Hospital, and Blue Mountains Hospital, New South Wales, Australia.
    Patients/participant: 177 patients.
    Intervention: The demographic, clinical, TVS, and intraoperative data were extracted through electronic clinical records.
    Measurements and main results: Multicategorical decision-tree and baseline models were built to choose the variables most correlated to the outcome under study. Receiver operating characteristic analysis was performed on the binary classification. Based on our results, we selected the variables performing with significant statistical differences (p <.05). During the study period, 177 consecutive patients were recruited and divided into 2 subgroups, ureterolysis (51.4%) and nonureterolysis (48.6%). Ureterolysis was noted in 87.5% of patients in which the left ovary was immobile (p <.001) and in 82.5% in which the right ovary was fixed (p <.001). For patients with right uterosacral ligament (USL) deep endometriosis (DE), ureterolysis was performed in 96.2% patients (p <.001) and 64.6% (p = .043) for left USL DE. Among patients with bowel DE, the proportion of patients undergoing ureterolysis was 95.5% (p <.001). The prognostic variables used in the final model to predict ureterolysis included dyschezia, absence of ovarian mobility, presence of right or left USL DE, and presence of bowel DE on TVS. According to the developed model, the baseline risk for performing ureterolysis is 20% in our sample. The overall model performance demonstrated an area under the receiver operating characteristic curve 0.82.
    Conclusion: Our study demonstrates that it is possible to predict the need for ureterolysis with clinical and sonographic data. Furthermore, patients presenting with a combination of the variables of our model (dyschezia, ovarian immobility, USL, and bowel DE lesions) have a high risk of ureterolysis. In contrast, patients without these features have a low risk (approximately 20%) of needing ureterolysis.
    MeSH term(s) Constipation/surgery ; Endometriosis/diagnostic imaging ; Endometriosis/pathology ; Endometriosis/surgery ; Female ; Humans ; Laparoscopy/adverse effects ; Sensitivity and Specificity ; Ultrasonography/methods ; Ureter/diagnostic imaging ; Ureter/pathology ; Ureter/surgery
    Language English
    Publishing date 2022-07-09
    Publishing country United States
    Document type Journal Article ; Observational Study
    ZDB-ID 2186934-0
    ISSN 1553-4669 ; 1553-4650
    ISSN (online) 1553-4669
    ISSN 1553-4650
    DOI 10.1016/j.jmig.2022.07.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  4. Article ; Online: Aplasia cutis congenita with foetus papyraceus: Case report and review of the literature.

    Uzuner, Cansu / Seeho, Sean Kin Ming / Smith, Christopher John

    Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology

    2017  Volume 37, Issue 6, Page(s) 811–812

    MeSH term(s) Adult ; Anti-Infective Agents, Local/administration & dosage ; Ectodermal Dysplasia/diagnosis ; Ectodermal Dysplasia/therapy ; Female ; Fetal Death ; Humans ; Infant, Newborn ; Male ; Occlusive Dressings ; Pregnancy ; Pregnancy, Twin ; Re-Epithelialization/drug effects ; Silver Nitrate/administration & dosage ; Treatment Outcome
    Chemical Substances Anti-Infective Agents, Local ; Silver Nitrate (95IT3W8JZE)
    Language English
    Publishing date 2017-03-20
    Publishing country England
    Document type Case Reports ; Journal Article
    ZDB-ID 604639-3
    ISSN 1364-6893 ; 0144-3615
    ISSN (online) 1364-6893
    ISSN 0144-3615
    DOI 10.1080/01443615.2017.1286305
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.B 2461: Show issues Location:
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  5. Article ; Online: External Validation of the "2021 AAGL Endometriosis Classification": A Retrospective Cohort Study.

    Mak, Jason / Eathorne, Allie / Leonardi, Mathew / Espada, Mercedes / Reid, Shannon / Zanardi, Jose Vitor / Uzuner, Cansu / Rocha, Rodrigo / Armour, Mike / Condous, George

    Journal of minimally invasive gynecology

    2023  Volume 30, Issue 5, Page(s) 374–381

    Abstract: Study objective: Externally validate the American Association of Gynecologic Laparoscopists (AAGL) staging system against surgical complexity and compare diagnostic accuracy with revised American Society for Reproductive Medicine (rASRM) stage, as was ... ...

    Abstract Study objective: Externally validate the American Association of Gynecologic Laparoscopists (AAGL) staging system against surgical complexity and compare diagnostic accuracy with revised American Society for Reproductive Medicine (rASRM) stage, as was done in original publication.
    Design: Retrospective, diagnostic accuracy study.
    Setting: Multicenter (Sydney, Australia).
    Patients: A total of 317 patients (January 2016-October 2021) were used in the final analysis.
    Interventions: A database of patients with coded surgical data was analyzed.
    Measurements and main results: Three independent observers assigned an AAGL surgical stage (1-4) as the index test and surgical complexity level (A-D) as the reference standard. Results from the most accurate of the 3 observers were used in the final analysis. The weighted kappa score for the overall performance of AAGL stage and rASRM to predict AAGL level was 0.48 and 0.48, respectively (no difference). This represents weaker agreement with AAGL level than was observed in the reference paper, which reported a weighted kappa of 0.62. Diagnostic accuracy (sensitivity, specificity, positive predictive value, and negative predictive value) for stage 1 to predict level A was 98.5%, 64.3%, 66.3%, and 98.3%; stage 2 to predict level B 31.2%, 90.5%, 27.0%, and 92.1 %; stage 3 to predict level C 12.3%, 94.1%, 59.3%, and 60.7%; stage 4 to predict level D 95.65%, 88.10%, 38.60%, and 99.62%. Area under the receiver operating characteristic curve for A vs B/C/D (cut point 9) was 0.87, A/B vs C/D (cut point 16) was 0.78, and A/B/C vs D (cut point 22) was 0.94.
    Conclusion: There was weak to moderate agreement between AAGL stage and AAGL surgical complexity level. Across all key indicators, the AAGL system did not perform as well in this external validation, nor did it outperform rASRM as it did in the reference paper. Results suggest the system is not generalizable.
    MeSH term(s) Humans ; Female ; United States ; Endometriosis/diagnosis ; Endometriosis/surgery ; Retrospective Studies ; Laparoscopy ; ROC Curve ; Australia
    Language English
    Publishing date 2023-01-05
    Publishing country United States
    Document type Multicenter Study ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2186934-0
    ISSN 1553-4669 ; 1553-4650
    ISSN (online) 1553-4669
    ISSN 1553-4650
    DOI 10.1016/j.jmig.2022.12.012
    Database MEDical Literature Analysis and Retrieval System OnLINE

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