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  1. Article ; Online: Impact of Preoperative Patient Education on Postoperative Recovery in Abdominal Surgery: A Systematic Review.

    Brodersen, Freya / Wagner, Jonas / Uzunoglu, Faik Güntac / Petersen-Ewert, Corinna

    World journal of surgery

    2023  Volume 47, Issue 4, Page(s) 937–947

    Abstract: Background: Patient education is recommended as an essential component of Enhanced Recovery after Surgery (ERAS) protocols. However, there are many uncertainties regarding content and methodological criteria, which may have a significant impact on the ... ...

    Abstract Background: Patient education is recommended as an essential component of Enhanced Recovery after Surgery (ERAS) protocols. However, there are many uncertainties regarding content and methodological criteria, which may have a significant impact on the effectiveness of the intervention. The aim of this review is to assess the effect of preoperative patient education on postoperative recovery in abdominal surgery and to examine different patient education strategies for their effectiveness.
    Methods: We performed a systematic review according to the PRISMA guidelines. PubMed, CINAHL, and Cochrane were searched from 2011 to 2022. All studies investigating the effect of preoperative patient education on postoperative recovery in abdominal surgery were included. A critical quality assessment of all included studies was performed.
    Results: We identified 826 potentially suitable articles via a database search and included 12 studies in this review. The majority of the included studies reported a reduction in the length of hospital stay (LOS) and even a reduction in postoperative complications and adverse events. Patients with preoperative education seemed to have lower psychological stress and experience less anxiety. However, the contents, delivery, and general conditions were implemented differently, making comparison difficult. Moreover, the majority of the included studies were weak in quality.
    Conclusion: With this review, we report potential effects, current implementations, and frameworks of patient education. However, the results must be interpreted with caution and are not directly transferable to clinical practice. Further studies in this field are necessary to make concrete recommendations for clinical practice.
    MeSH term(s) Humans ; Patient Education as Topic ; Postoperative Complications/prevention & control ; Length of Stay ; Preoperative Care/methods ; Anxiety/prevention & control
    Language English
    Publishing date 2023-01-15
    Publishing country United States
    Document type Systematic Review ; Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 224043-9
    ISSN 1432-2323 ; 0364-2313
    ISSN (online) 1432-2323
    ISSN 0364-2313
    DOI 10.1007/s00268-022-06884-4
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    Zs.A 1336: Show issues Location:
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  2. Article: Simultaneous Distal Pancreatic Resection and Hyperthermic Intraperitoneal Chemotherapy (HIPEC) for Peritoneal Carcinomatosis in Adenocarcinoma of the Pancreas - A Case Report.

    Bardenhagen, Jan / Goetz, Mara / Izbicki, Jakob / Uzunoglu, Faik Güntac

    Chirurgia (Bucharest, Romania : 1990)

    2022  Volume 117, Issue 4, Page(s) 486–492

    Abstract: Pancreatic cancer remains one of the biggest challenges in oncology, as most patients are diagnosed in a stage of regional lymphatic or systemic spread of the disease. 10% of the patients present with peritoneal carcinomatosis upon diagnosis. In the past ...

    Abstract Pancreatic cancer remains one of the biggest challenges in oncology, as most patients are diagnosed in a stage of regional lymphatic or systemic spread of the disease. 10% of the patients present with peritoneal carcinomatosis upon diagnosis. In the past decades, cytoreductive surgery (CRS) combined with hyperthermic intraoperative intraperitoneal chemotherapy (HIPEC) has been developed and presents a new, individualized treatment option for patients with peritoneal disseminated cancer. This case report presents the case of a 39-year-old male with the initial diagnosis of a carcinoma of the pancreatic tail with localized peritoneal carcinomatosis. As an individualized approach, neoadjuvant chemotherapy was recommended with an option for a second exploration. Re-Staging revealed a reduction in tumor size. Cytoreductive surgery (CRS) including a distal splenopancreatectomy was performed and followed by HIPEC. Postoperatively, the patient developed a clinically relevant pancreatic fistula, however recovered and was able to receive adjuvant chemotherapy. Taken together, in pancreatic cancer with localized peritoneal carcinomatosis CRS and HIPEC are a valid option in highly selective cases with potential extended overall survival and an acceptable quality of life.
    MeSH term(s) Adenocarcinoma ; Adult ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Chemotherapy, Cancer, Regional Perfusion ; Combined Modality Therapy ; Humans ; Hyperthermia, Induced ; Hyperthermic Intraperitoneal Chemotherapy ; Male ; Pancreas ; Pancreatic Neoplasms/drug therapy ; Peritoneal Neoplasms/drug therapy ; Quality of Life ; Survival Rate ; Treatment Outcome ; Pancreatic Neoplasms
    Language English
    Publishing date 2022-09-01
    Publishing country Romania
    Document type Case Reports ; Journal Article
    ZDB-ID 419244-8
    ISSN 1842-368X ; 1221-9118 ; 0009-4730 ; 0377-5003
    ISSN (online) 1842-368X
    ISSN 1221-9118 ; 0009-4730 ; 0377-5003
    DOI 10.21614/chirurgia.2630
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Effects of Exercise Training on Patient-Specific Outcomes in Pancreatic Cancer Patients: A Scoping Review.

    Rosebrock, Kim / Sinn, Marianne / Uzunoglu, Faik G / Bokemeyer, Carsten / Jensen, Wiebke / Salchow, Jannike

    Cancers

    2023  Volume 15, Issue 24

    Abstract: Background: International guidelines have already highlighted the beneficial effects of exercise in common cancer entities. However, specific recommendations for pancreatic cancer are still missing. This scoping review aimed to evaluate the impact of ... ...

    Abstract Background: International guidelines have already highlighted the beneficial effects of exercise in common cancer entities. However, specific recommendations for pancreatic cancer are still missing. This scoping review aimed to evaluate the impact of exercise training on patient-specific outcomes in pancreatic cancer patients.
    Methods: A literature search was undertaken using PubMed, Web of Science, and Cochrane Library. We included randomized controlled trials (RCTs) published before August 2023 with structured exercise interventions during or after pancreatic cancer treatment.
    Results: Seven articles that prescribed home-based or supervised exercise with aerobic or resistance training or both were reviewed. The results indicate that exercise is feasible and safe in pancreatic cancer patients. Furthermore, exercise was associated with improved quality of life, cancer-related fatigue, and muscle strength. Concerning other outcomes, heterogeneous results were reported. We identified a lack of evidence, particularly for patients with advanced pancreatic cancer.
    Conclusion: Exercise interventions in pancreatic cancer patients are feasible and can lead to improved quality of life, cancer-related fatigue, and muscle strength. However, further studies with larger sample sizes are needed to clarify the potential of exercise in pancreatic cancer, in particular for advanced stages.
    Language English
    Publishing date 2023-12-18
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers15245899
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  4. Article: Tumor-Stroma Interaction in PDAC as a New Approach for Liquid Biopsy and its Potential Clinical Implications.

    Götze, Julian / Nitschke, Christine / Uzunoglu, Faik G / Pantel, Klaus / Sinn, Marianne / Wikman, Harriet

    Frontiers in cell and developmental biology

    2022  Volume 10, Page(s) 918795

    Abstract: The extremely poor prognosis for patients with pancreatic ductal adenocarcinoma (PDAC) has remained unchanged for decades. As a hallmark of PDAC histology, the distinct desmoplastic response in the tumor microenvironment is considered a key factor ... ...

    Abstract The extremely poor prognosis for patients with pancreatic ductal adenocarcinoma (PDAC) has remained unchanged for decades. As a hallmark of PDAC histology, the distinct desmoplastic response in the tumor microenvironment is considered a key factor exerting pro- and antitumor effects. Increasing emphasis has been placed on cancer-associated fibroblasts (CAFs), whose heterogeneity and functional diversity is reflected in the numerous subtypes. The myofibroblastic CAFs (myCAFs), inflammatory CAFs (iCAFs) and antigen presenting CAFs (apCAFs) are functionally divergent CAF subtypes with tumor promoting as well as repressing effects. Precise knowledge of the underlying interactions is the basis for a variety of treatment approaches, which are subsumed under the term antistromal therapy. Clinical implementation is still pending due to the lack of benefit-as well as paradoxical preclinical findings. While the prominent significance of CAFs in the immediate environment of the tumor is becoming clear, less is known about the circulating (c)CAFs. cCAFs are of particular interest as they seem not only to be potential new liquid biopsy biomarkers but also to support the survival of circulating tumor cells (CTC) in the bloodstream. In PDAC, CTCs correlate with an unfavorable outcome and can also be employed to monitor treatment response, but the current clinical relevance is limited. In this review, we discuss CTCs, cCAFs, secretomes that include EVs or fragments of collagen turnover as liquid biopsy biomarkers, and clinical approaches to target tumor stroma in PDAC.
    Language English
    Publishing date 2022-05-26
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2737824-X
    ISSN 2296-634X
    ISSN 2296-634X
    DOI 10.3389/fcell.2022.918795
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  5. Article ; Online: Centralization of Pancreatic Surgery in Europe.

    Polonski, Adam / Izbicki, Jakob R / Uzunoglu, Faik G

    Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract

    2019  Volume 23, Issue 10, Page(s) 2081–2092

    Abstract: Background: The objective of this article is a review and an analysis of the current state of centralization of pancreatic surgery in Europe. Numerous recent publications demonstrate higher postoperative in-hospital mortality rates in low-volume clinics ...

    Abstract Background: The objective of this article is a review and an analysis of the current state of centralization of pancreatic surgery in Europe. Numerous recent publications demonstrate higher postoperative in-hospital mortality rates in low-volume clinics after pancreatic resection than previously assumed due to their not publishing significantly worse outcomes when compared to high-volume centres. Although the benefits of centralization of pancreatic surgery in high-volume centres have been demonstrated in many studies, numerous countries have so far failed to establish centralization in their respective health care systems.
    Methods: A systematic literature search of the Medline database for studies concerning centralization of pancreatic surgery in Europe was conducted. The studies were reviewed independently for previously defined inclusion and exclusion criteria. We included 14 studies with a total of 117,634 patients. All data were extracted from or provided by health insurance company or governmental registry databases.
    Results: Thirteen out of the 14 studies demonstrate an improvement in their respective outcome related to volume. Twelve studies showed a significantly lower postoperative mortality rate in the highest annual volume group in comparison to overall postoperative mortality rate in the whole patient cohort.
    Conclusion: As the available data indicate, most European countries have so far failed to establish centralization of pancreatic surgery to high-volume centres due to numerous reasons. Considering a plateau in survival rates of patients undergoing treatment for pancreatic cancer in Europe during the last 15 years, this review enforces the worldwide plea for centralization to lower post-operative mortality after pancreatic surgery.
    MeSH term(s) Delivery of Health Care/organization & administration ; Europe ; Hospital Mortality ; Hospitals, High-Volume/statistics & numerical data ; Hospitals, Low-Volume/statistics & numerical data ; Humans ; Pancreatectomy/mortality ; Pancreatic Neoplasms/surgery ; Survival Rate
    Language English
    Publishing date 2019-04-29
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2012365-6
    ISSN 1873-4626 ; 1934-3213 ; 1091-255X
    ISSN (online) 1873-4626 ; 1934-3213
    ISSN 1091-255X
    DOI 10.1007/s11605-019-04215-y
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    Zs.A 5207: Show issues Location:
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    Zs.MO 354: Show issues

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  6. Article ; Online: Robotische Pankreatoduodenektomie: Variationen der Pankreasanastomose in modifizierter Blumgart-Technik.

    Seeger, Philipp / Distler, Marius / Thomaschewski, Michael / Zimmermann, Markus / Heumann, Asmus / Uzunoglu, Faik Güntac / Grützmann, Robert / Weber, Georg F / Brunner, Maximilian / Kersting, Stephan / Hackert, Thilo / Keck, Tobias / Nickel, Felix

    Zentralblatt fur Chirurgie

    2024  

    Title translation Robotic Pancreatoduodenectomy: Variations of Modified Blumgarts Pancreatojejunostomy.
    Language German
    Publishing date 2024-01-09
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 200935-3
    ISSN 1438-9592 ; 0044-409X
    ISSN (online) 1438-9592
    ISSN 0044-409X
    DOI 10.1055/a-2194-0785
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.MO 95: Show issues

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  7. Article: The Author Reply.

    Reeh, Matthias / Uzunoglu, Faik G

    Hepatobiliary & pancreatic diseases international : HBPD INT

    2016  Volume 15, Issue 1, Page(s) 109–110

    MeSH term(s) Female ; Humans ; Male ; Pancreatic Diseases/surgery ; Risk Assessment/methods
    Language English
    Publishing date 2016-02
    Publishing country Singapore
    Document type Comment ; Journal Article
    ZDB-ID 2241386-8
    ISSN 1499-3872
    ISSN 1499-3872
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  8. Article ; Online: Letter to Editor Reply to: "Centralization of Pancreatic Surgery in Europe: an Update".

    Uzunoglu, Faik G / Heumann, Asmus / Polonski, Adam / Izbicki, Jakob R

    Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract

    2019  Volume 23, Issue 11, Page(s) 2324–2325

    MeSH term(s) Digestive System Surgical Procedures ; Europe
    Language English
    Publishing date 2019-09-11
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 2012365-6
    ISSN 1873-4626 ; 1934-3213 ; 1091-255X
    ISSN (online) 1873-4626 ; 1934-3213
    ISSN 1091-255X
    DOI 10.1007/s11605-019-04387-7
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  9. Article ; Online: Perioperative management of pancreatic exocrine insufficiency-evidence-based proposal for a paradigm shift in pancreatic surgery.

    Stern, Louisa / Schuette, Miriam / Goetz, Mara R / Nitschke, Christine / Bardenhagen, Jan / Scognamiglio, Pasquale / Stüben, Björn-Ole / Calavrezos, Lenika / Amin, Tania / Heumann, Asmus / Lohse, Ansgar W / de Heer, Geraldine / Izbicki, Jakob R / Uzunoglu, Faik G

    HPB : the official journal of the International Hepato Pancreato Biliary Association

    2023  Volume 26, Issue 1, Page(s) 117–124

    Abstract: Background: Despite exocrine pancreatic insufficiency (EPI) being a significant consequence of pancreatic surgery, there is still no consensus on its perioperative management. This study aimed to evaluate unselective pancreatic enzyme replacement ... ...

    Abstract Background: Despite exocrine pancreatic insufficiency (EPI) being a significant consequence of pancreatic surgery, there is still no consensus on its perioperative management. This study aimed to evaluate unselective pancreatic enzyme replacement therapy (PERT).
    Methods: A prospective, observational study of patients undergoing partial pancreatectomy was conducted. EPI status was assessed pre- and postoperatively, based on three fecal-elastase measurements each. Characteristic symptoms were evaluated by questionnaire. In 85 post-surgical patients, the subjective burden of PERT was measured.
    Results: 101 patients were followed prospectively. Preoperative EPI screening was available for 83 patients, of which 48% were diagnosed with preexisting EPI. Of those patients with regular exocrine function, 54% developed EPI de novo; this rate being higher following pancreatic head resections (72%) compared to left-sided pancreatectomies (LP) (20%) (p = 0.016). Overall postoperative EPI prevalence was significantly greater following pancreatic head resections (86%) than LP (33%) (p < 0.001). Only young and female patients described a significant burden related to PERT.
    Conclusion: For all patients undergoing pancreatic head resection PERT should be considered beginning prior to surgery, due to the subgroup's high EPI rate and the comparatively low burden of PERT. Patients with LP are at lower risk and should be pre- and postoperatively screened and supplemented accordingly.
    MeSH term(s) Humans ; Female ; Prospective Studies ; Exocrine Pancreatic Insufficiency/diagnosis ; Exocrine Pancreatic Insufficiency/etiology ; Exocrine Pancreatic Insufficiency/drug therapy ; Pancreas ; Digestive System Surgical Procedures ; Pancreatectomy/adverse effects ; Enzyme Replacement Therapy/adverse effects
    Language English
    Publishing date 2023-09-09
    Publishing country England
    Document type Observational Study ; Journal Article
    ZDB-ID 2131251-5
    ISSN 1477-2574 ; 1365-182X
    ISSN (online) 1477-2574
    ISSN 1365-182X
    DOI 10.1016/j.hpb.2023.09.003
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  10. Article: Mindestmengen und Zertifizierungen der onkologischen Viszeralchirurgie in Deutschland – Fluch oder Segen?

    Kemper, Marius / Polonski, Adam / Uzunoglu, Faik G. / Melling, Nathaniel / Reeh, Matthias / Izbicki, Jakob R. / Graß, Julia-Kristin

    Allgemein- und Viszeralchirurgie up2date

    2023  Volume 17, Issue 01, Page(s) 89–100

    Keywords Zentrenbildung ; Zertifizierung ; Mindestmenge ; Qualitätsmanagement ; Viszeralchirurgie ; Weiterbildung
    Language German
    Publishing date 2023-02-01
    Publisher Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 2317051-7
    ISSN 1611-6461 ; 1611-6437
    ISSN (online) 1611-6461
    ISSN 1611-6437
    DOI 10.1055/a-1885-5039
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