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Article: Peritonealkarzinose beim Magenkarzinom. Rolle der Chirurgie und HIPEC. Peritoneal carcinomatosis and gastric cancer. Role of surgery and HIPEC

Brandt, A. / Uzunoglu, F. G. / Vashist, Y. K.

2016 Volume 22, Issue 6, Page(s) 413

Language	German
Document type	Article
ZDB-ID	1229978-9
ISSN	0947-8965
Database	Current Contents Medicine

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Article: Chirurgische Therapie des Magenkarzinoms. Onkologische Standards und technische Fortschritte. Surgical treatment of gastric cancer. Oncological standards and technical progress

Uzunoglu, F. G. / Wellner, U. / Izbicki, J. R. / Vashist, Y. K.

Der Onkologe

2016 Volume 22, Issue 6, Page(s) 384

Language	German
Document type	Article
ZDB-ID	1229978-9
ISSN	0947-8965
Database	Current Contents Medicine

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Article ; Online: Surgery of esophageal cancer.

Uzunoglu, F G / Reeh, M / Kutup, A / Izbicki, J R

Langenbeck's archives of surgery

2013 Volume 398, Issue 2, Page(s) 189–193

Abstract: Background: Surgery is the only option for curative treatment in patients with esophageal carcinoma. Despite the debates related to the peri-operative therapy regime, a generally accepted consensus on surgical approach is not reached yet. The debate ... ...

Abstract	Background: Surgery is the only option for curative treatment in patients with esophageal carcinoma. Despite the debates related to the peri-operative therapy regime, a generally accepted consensus on surgical approach is not reached yet. The debate focuses mainly on pros and cons between radical transthoracic resection and the (limited) transhiatal resection in the last decade. Methods: The PubMed database was searched for randomized trials, meta-analyses, and retrospective single-center studies. The search terms were "esophageal carcinoma," "esophageal junction carcinomas," "transhiatal," "transthoracic," "morbidity," "mortality," and "surgery." Results: The radical transthoracic approach should be the standard of care for esophageal carcinoma since it does not go along with an increased risk of postoperative morbidity or mortality but reveals an improved survival. Patient-related co-morbidities are the most influencing factors for the postoperative outcome. For type II esophageal junction carcinoma, treatment options from transhiatal extended gastrectomy to esophagectomy with hemigastrectomy or esophagogastrectomy with colonic interposition are existing. In type III esophagogastric junction carcinomas, the transhiatal extended gastrectomy is the standard of care, and the minimally invasive approach should be performed in specialized centers. Conclusion: Based on current available study results, this expert review provides a decision support for the best surgical strategy depending on tumor localization and patients' characteristics.
MeSH term(s)	Anastomosis, Surgical ; Esophageal Neoplasms/mortality ; Esophageal Neoplasms/pathology ; Esophageal Neoplasms/surgery ; Esophagectomy/methods ; Esophagectomy/mortality ; Esophagogastric Junction/pathology ; Esophagogastric Junction/surgery ; Humans ; Lymph Node Excision ; Lymphatic Metastasis/pathology ; Minimally Invasive Surgical Procedures
Language	English
Publishing date	2013-01-25
Publishing country	Germany
Document type	Journal Article ; Review
ZDB-ID	1423681-3
ISSN	1435-2451 ; 1435-2443
ISSN (online)	1435-2451
ISSN	1435-2443
DOI	10.1007/s00423-013-1052-y
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Article ; Online: Non-trauma Emergency Pancreatoduodenectomies: A Single-Center Retrospective Analysis.

Nentwich, Michael F / Reeh, M / Uzunoglu, F G / Bachmann, K / Bockhorn, M / Izbicki, J R / Vashist, Y K

World journal of surgery

2016 Volume 40, Issue 9, Page(s) 2261–2266

Abstract: Objective: To retrospectively assess the frequency and indications for emergency pancreatoduodenctomies in a tertiary referral center.: Methods: Pancreatoduodenectomies between January 2005 and January 2014 were retrospectively assessed for emergency ...

Abstract	Objective: To retrospectively assess the frequency and indications for emergency pancreatoduodenctomies in a tertiary referral center. Methods: Pancreatoduodenectomies between January 2005 and January 2014 were retrospectively assessed for emergency indications defined as surgery following unplanned hospital admission in less than 24 h. Data on indications and on the intraoperative as well as the post-operative course were collected. Results: Out of 583 pancreatoduodenectomies during the interval, a total of 10 (1.7 %) were performed as an emergency surgery. Indications included uncontrollable bleeding, duodenal and proximal jejunal perforations, and endoscopic retrograde cholangiopancreatography-related complications. Three of the 10 (30.0 %) patients died during the hospital course. In one patient, an intraoperative mass transfusion was necessary. No intraoperative death occurred. All but one patient were American Society of Anesthesiologists class three or higher. In two cases, the pancreatic remnant was left without anastomosis for second-stage pancreatojejunostomy. Median operation time was 326.5 min (SD 100.3 min). Hospital stay of the surviving patients was prolonged (median 43.0 days; SD 24.0 days). Conclusion: Emergency pancreatoduodenectomies are non-frequent, have a diverse range of indications and serve as an ultima ratio to cope with severe injuries and complications around the pancreatic head area.
MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; Cholangiopancreatography, Endoscopic Retrograde/adverse effects ; Duodenum/injuries ; Duodenum/surgery ; Emergencies ; Female ; Hemorrhage/surgery ; Humans ; Intestinal Perforation/surgery ; Jejunum/injuries ; Jejunum/surgery ; Length of Stay/statistics & numerical data ; Male ; Middle Aged ; Operative Time ; Pancreaticoduodenectomy/statistics & numerical data ; Retrospective Studies
Language	English
Publishing date	2016-06-14
Publishing country	United States
Document type	Journal Article
ZDB-ID	224043-9
ISSN	1432-2323 ; 0364-2313
ISSN (online)	1432-2323
ISSN	0364-2313
DOI	10.1007/s00268-016-3525-y
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Article: Multimodale Therapie des Ösophaguskarzinoms: Pro und Kontra

Hölscher, A. H. / Fetzner, U. K. / Uzunoğlu, F. G. / Izbicki, J. R.

Allgemein- und Viszeralchirurgie up2date

2014 Volume 8, Issue 03, Page(s) 199–214

Abstract: Dieser Beitrag wägt das Für und Wider der multimodalen Therapie des Ösophaguskarzinoms ab und stellt die Behandlungsoptionen der verschiedenen Vorgehensweisen dar. Anhand wissenschaftlicher Daten werden die ...

Abstract	Dieser Beitrag wägt das Für und Wider der multimodalen Therapie des Ösophaguskarzinoms ab und stellt die Behandlungsoptionen der verschiedenen Vorgehensweisen dar. Anhand wissenschaftlicher Daten werden die Argumente pro und kontra multimodale Therapie für Adeno- und Plattenepithelkarzinome des Ösophagus erörtert.
Language	German
Publishing date	2014-06-01
Publisher	Georg Thieme Verlag KG
Publishing place	Stuttgart ; New York
Document type	Article
ZDB-ID	2317051-7
ISSN	1611-6461 ; 1611-6437
ISSN (online)	1611-6461
ISSN	1611-6437
DOI	10.1055/s-0033-1357932
Database	Thieme publisher's database

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Article ; Online: Notfallsternotomie bei perkutaner zentralvenöser Punktion - ein Fallbericht.

Uzunoglu, F G / Koenig, A M / Bockhorn, M / Cataldegirmen, G / Izbicki, J / Benhidjeb, T

Zentralblatt fur Chirurgie

2012 Volume 137, Issue 3, Page(s) 262–263

Title translation	Emergency sternotomy during percutaneous central venous catheterisation - a case report.
MeSH term(s)	Aged ; Angiography ; Arteriovenous Shunt, Surgical ; Catheterization, Central Venous/adverse effects ; Diagnosis, Differential ; Emergencies ; Hemothorax/diagnostic imaging ; Hemothorax/etiology ; Hemothorax/surgery ; Humans ; Intraoperative Complications/diagnostic imaging ; Intraoperative Complications/etiology ; Intraoperative Complications/surgery ; Male ; Renal Dialysis ; Sternotomy ; Subclavian Vein/diagnostic imaging ; Subclavian Vein/injuries ; Subclavian Vein/surgery ; Thrombosis/diagnostic imaging ; Thrombosis/surgery
Language	German
Publishing date	2012-06
Publishing country	Germany
Document type	Case Reports ; Journal Article
ZDB-ID	200935-3
ISSN	1438-9592 ; 0044-409X
ISSN (online)	1438-9592
ISSN	0044-409X
DOI	10.1055/s-0030-1262756
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Article ; Online: A pleiotropy scan to discover new susceptibility loci for pancreatic ductal adenocarcinoma.

Giaccherini, M / Rende, M / Gentiluomo, M / Corradi, C / Archibugi, L / Ermini, S / Maiello, E / Morelli, L / van Eijck, C H J / Cavestro, G M / Schneider, M / Mickevicius, A / Adamonis, K / Basso, D / Hlavac, V / Gioffreda, D / Talar-Wojnarowska, R / Schöttker, B / Lovecek, M /

Vanella, G / Gazouli, M / Uno, M / Malecka-Wojciesko, E / Vodicka, P / Goetz, M / Bijlsma, M F / Petrone, M C / Bazzocchi, F / Kiudelis, M / Szentesi, A / Carrara, S / Nappo, G / Brenner, H / Milanetto, A C / Soucek, P / Katzke, V / Peduzzi, G / Rizzato, C / Pasquali, C / Chen, X / Capurso, G / Hackert, T / Bueno-de-Mesquita, B / Uzunoglu, F G G / Hegyi, P / Greenhalf, W / Theodoropoulos, G E E / Sperti, C / Perri, F / Oliverius, M / Mambrini, A / Tavano, F / Farinella, R / Arcidiacono, P G / Lucchesi, M / Bunduc, S / Kupcinskas, J / Di Franco, G / Stocker, S / Neoptolemos, J P / Bambi, F / Jamroziak, K / Testoni, S G G / Aoki, M N / Mohelnikova-Duchonova, B / Izbicki, J R / Pezzilli, R / Lawlor, R T / Kauffmann, E F / López de Maturana, E / Malats, N / Canzian, F / Campa, D

Mutagenesis

2024

Abstract: Pleiotropic variants (i.e., genetic polymorphisms influencing more than one phenotype) are often associated with cancer risk. A scan of pleiotropic variants was successfully conducted ten years ago in relation to pancreatic ductal adenocarcinoma ... ...

Abstract	Pleiotropic variants (i.e., genetic polymorphisms influencing more than one phenotype) are often associated with cancer risk. A scan of pleiotropic variants was successfully conducted ten years ago in relation to pancreatic ductal adenocarcinoma susceptibility. However, in the last decade, genetic association studies performed on several human traits have greatly increased the number of known pleiotropic variants. Based on the hypothesis that variants already associated with a least one trait have a higher probability of association with other traits, 61,052 variants reported to be associated by at least one genome wide association study (GWAS) with at least one human trait were tested in the present study consisting of two phases (discovery and validation), comprising a total of 16,055 pancreatic ductal adenocarcinoma (PDAC) cases and 212,149 controls. The meta-analysis of the two phases showed two loci (10q21.1-rs4948550 (P=6.52×10-5) and 7q36.3-rs288762 (P=3.03×10-5) potentially associated with PDAC risk. 10q21.1-rs4948550 shows a high degree of pleiotropy and it is also associated with colorectal cancer risk while 7q36.3-rs288762 is situated 28,558 base pairs upstream of the Sonic Hedgehog (SHH) gene, which is involved in the cell differentiation process and PDAC etiopathogenesis. In conclusion, none of the single nucleotide polymorphisms (SNPs) showed a formally statistically significant association after correction for multiple testing. However, given their pleiotropic nature and association with various human traits including colorectal cancer, the two SNPs showing the best associations with PDAC risk merit further investigation through fine mapping and ad hoc functional studies.
Language	English
Publishing date	2024-04-12
Publishing country	England
Document type	Journal Article
ZDB-ID	632903-2
ISSN	1464-3804 ; 0267-8357
ISSN (online)	1464-3804
ISSN	0267-8357
DOI	10.1093/mutage/geae012
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Article ; Online: Blood fibrinogen levels discriminate low- and high-risk intraductal papillary mucinous neoplasms (IPMNs).

Nentwich, M F / Menzel, K / Reeh, M / Uzunoglu, F G / Ghadban, T / Bachmann, K / Schrader, J / Bockhorn, M / Izbicki, J R / Perez, D

European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology

2017 Volume 43, Issue 4, Page(s) 758–762

Abstract: Backround: The risk assessment of intraductal papillary mucinous neoplasms (IPMN) to either guide patients to surgical resection or watchful waiting is still under debate. Additional markers to better separate low and high-risk lesions would improve ... ...

Abstract	Backround: The risk assessment of intraductal papillary mucinous neoplasms (IPMN) to either guide patients to surgical resection or watchful waiting is still under debate. Additional markers to better separate low and high-risk lesions would improve patient selection. Methods: Patients who underwent pancreatic resections for IPMNs between January 2008 and December 2012 with available blood samples were selected and retrospectively assessed. Data on cyst characteristics such as cyst size, duct relation and main-duct dilatation were collected and plasma fibrinogen levels were measured. Results: A total of 73 patients fulfilled the inclusion criteria by pancreatic resection for pathologically confirmed IPMN and available blood sample. Histologically, IPMNs were classified as low-grade and borderline in 52 (71.2%, group 1) and as high-grade and invasive in 21 (28.8%, group 2) of all cases. Fibrinogen levels showed significant differences between the two groups (group 1: mean 3.62 g/L (SD ± 1.14); group 2: mean 4.49 g/L (SD ± 1.57); p = 0.027). A ROC-curve analysis calculated cut-off value of 4.71 g/L separated groups 1 and 2 (p = 0.008). Fibrinogen levels remained as the only significant factor in multivariable analysis, cyst size and duct relation were not significant. Conclusion: Blood fibrinogen differed between low and high risk IPMNs and therefore, the use of fibrinogen as an additional discriminator in the pre-operative risk assessment of IPMNs should be further evaluated.
MeSH term(s)	Adenocarcinoma, Mucinous/blood ; Adenocarcinoma, Mucinous/pathology ; Adenocarcinoma, Mucinous/surgery ; Adult ; Aged ; Aged, 80 and over ; Carcinoma, Pancreatic Ductal/blood ; Carcinoma, Pancreatic Ductal/pathology ; Carcinoma, Pancreatic Ductal/surgery ; Carcinoma, Papillary/blood ; Carcinoma, Papillary/pathology ; Carcinoma, Papillary/surgery ; Female ; Fibrinogen/metabolism ; Humans ; Male ; Middle Aged ; Multivariate Analysis ; Neoplasm Grading ; Neoplasm Invasiveness ; Pancreatectomy ; Pancreatic Neoplasms/blood ; Pancreatic Neoplasms/pathology ; Pancreatic Neoplasms/surgery ; ROC Curve ; Retrospective Studies
Chemical Substances	Fibrinogen (9001-32-5)
Language	English
Publishing date	2017-01-16
Publishing country	England
Document type	Journal Article
ZDB-ID	632519-1
ISSN	1532-2157 ; 0748-7983
ISSN (online)	1532-2157
ISSN	0748-7983
DOI	10.1016/j.ejso.2016.12.013
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Zs.A 1149: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 549: Show issues

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Article ; Online: Evaluation of the MDACC clinical classification system for pancreatic cancer patients in an European multicenter cohort.

Uzunoglu, F G / Welte, M-N / Gavazzi, F / Maggino, L / Perinel, J / Salvia, R / Janot, M / Reeh, M / Perez, D / Montorsi, M / Zerbi, A / Adham, M / Uhl, W / Bassi, C / Izbicki, J R / Malleo, G / Bockhorn, M

European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology

2018 Volume 45, Issue 5, Page(s) 793–799

Abstract: Background: The MDACC group recommends to extend the current borderline classification for pancreatic cancer into three groups: type A patients with resectable/borderline tumor anatomy, type B with resectable/borderline resectable tumor anatomy and ... ...

Abstract	Background: The MDACC group recommends to extend the current borderline classification for pancreatic cancer into three groups: type A patients with resectable/borderline tumor anatomy, type B with resectable/borderline resectable tumor anatomy and clinical findings suspicious for extrapancreatic disease and type C with borderline resectable and marginal performance status/severe pre-existing comorbidity profile or age>80. This study intents to evaluate the proposed borderline classification system in a multicenter patient cohort without neoadjuvant treatment. Methods: Evaluation was based on a multicenter database of pancreatic cancer patients undergoing surgery from 2005 to 2016 (n = 1020). Complications were classified based on the Clavien-Dindo classification. χ Results: Most patients (55.1%) were assigned as type A patients, followed by type C (35.8%) and type B patients (9.1%). Neither the complication rate, nor the mortality rate revealed a correlation to any subgroup. Type B patients had a significant worse progression free (p < 0.001) and overall survival (p = 0.005). Type B classification was identified as an independent prognostic marker for progression free survival (p = 0.005, HR 1.47). Conclusion: The evaluation of the proposed classification in a cohort without neoadjuvant treatment did not justify an additional medical borderline subgroup. A new subgroup based on prognostic borderline patients might be the main target group for neoadjuvant protocols in future.
MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; Europe ; Female ; Humans ; Male ; Margins of Excision ; Middle Aged ; Neoadjuvant Therapy ; Neoplasm Staging ; Pancreatic Neoplasms/mortality ; Pancreatic Neoplasms/pathology ; Pancreatic Neoplasms/surgery ; Postoperative Complications ; Prognosis ; Retrospective Studies ; Survival Rate ; Treatment Outcome
Language	English
Publishing date	2018-12-19
Publishing country	England
Document type	Evaluation Studies ; Journal Article ; Multicenter Study
ZDB-ID	632519-1
ISSN	1532-2157 ; 0748-7983
ISSN (online)	1532-2157
ISSN	0748-7983
DOI	10.1016/j.ejso.2018.12.012
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Article ; Online: Diverse prognostic value of the GTn promoter polymorphism in squamous cell and adeno carcinoma of the oesophagus.

Ghadban, T / Miro, J T / Trump, F / Tsui, T Y / Uzunoglu, F G / Reeh, M / Gebauer, F / Bachmann, K / Wellner, U / Kalinin, V / Pantel, K / Izbicki, J R / Vashist, Y K

Clinical genetics

2016 Volume 90, Issue 4, Page(s) 343–350

Abstract: The basal transcription of heme oxygenase-1 (HO-1) regulation is dependent upon a GT repeat germ line polymorphism (GTn) in the promoter of the HO-1 gene. We determined the prognostic value of HO-1 promoter polymorphism on the natural postoperative ... ...

Abstract	The basal transcription of heme oxygenase-1 (HO-1) regulation is dependent upon a GT repeat germ line polymorphism (GTn) in the promoter of the HO-1 gene. We determined the prognostic value of HO-1 promoter polymorphism on the natural postoperative course of complete resected oesophageal cancer. Genomic DNA from 297 patients was amplified by polymerase chain reaction and sequenced. The results were correlated with clinicopathological parameters, disseminated tumour cells in bone marrow (DTC) and clinical outcome. Depending on short allele with <25 and long allele with ≥25, GTn repeats three genotypes (SS, SL and LL) were defined. A diverse role of GTn was evident in squamous cell carcinoma (SCC) and adenocarcinoma (AC). In SCC, the SS genotype presented less advanced tumours with lower rate DTC in bone marrow and relapse compared with L-allele carriers. In contrast, AC patients with the SS genotype displayed a complete opposing tumour characteristic. The disease-free (DFS) and overall survival (OS) in SCC patients was markedly reduced in LL genotypes (p < 0.001). In AC contrarily the SS genotype patients displayed the worst DFS and OS (p < 0.001). GTn is a strong prognostic factor with diverse prognostic value for recurrence and survival in AC and SCC.
MeSH term(s)	Adenocarcinoma/genetics ; Adenocarcinoma/pathology ; Adenocarcinoma/surgery ; Carcinoma, Squamous Cell/genetics ; Carcinoma, Squamous Cell/pathology ; Carcinoma, Squamous Cell/surgery ; DNA Mutational Analysis ; Disease-Free Survival ; Esophageal Neoplasms/genetics ; Esophageal Neoplasms/pathology ; Esophageal Neoplasms/surgery ; Female ; Heme Oxygenase-1/chemistry ; Heme Oxygenase-1/genetics ; Humans ; Male ; Middle Aged ; Polymorphism, Genetic ; Prognosis ; Promoter Regions, Genetic ; Recurrence ; Repetitive Sequences, Nucleic Acid ; Treatment Outcome
Chemical Substances	HMOX1 protein, human (EC 1.14.14.18) ; Heme Oxygenase-1 (EC 1.14.14.18)
Language	English
Publishing date	2016-05-06
Publishing country	Denmark
Document type	Journal Article
ZDB-ID	221209-2
ISSN	1399-0004 ; 0009-9163
ISSN (online)	1399-0004
ISSN	0009-9163
DOI	10.1111/cge.12765
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