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  1. Article ; Online: Stereotactic body radiation therapy for prostate cancer after surgical treatment of prostatic obstruction

    Constance Huck / Vérane Achard / Priyamvada Maitre / Vedang Murthy / Thomas Zilli

    Clinical and Translational Radiation Oncology, Vol 45, Iss , Pp 100709- (2024)

    Impact on urinary morbidity and mitigation strategies

    1481  

    Abstract: In the past decade, stereotactic body radiation therapy (SBRT) has emerged as a valid treatment option for patients with localized prostate cancer. Despite the promising results of ultra-hypofractionation in terms of tolerance and disease control, the ... ...

    Abstract In the past decade, stereotactic body radiation therapy (SBRT) has emerged as a valid treatment option for patients with localized prostate cancer. Despite the promising results of ultra-hypofractionation in terms of tolerance and disease control, the toxicity profile of SBRT for prostate cancer patients with a history of surgical treatment of benign prostate hyperplasia is still underreported. Here we present an overview of the available data on urinary morbidity for prostate cancer patients treated with SBRT after prior surgical treatments for benign prostate hyperplasia. Technical improvements useful to minimize toxicity and possible treatments for radiation-induced urethritis are discussed.
    Keywords Prostate cancer ; Radiotherapy ; Stereotactic body radiation therapy ; Transurethral resection ; Adenomectomy ; Toxicity ; Medical physics. Medical radiology. Nuclear medicine ; R895-920 ; Neoplasms. Tumors. Oncology. Including cancer and carcinogens ; RC254-282
    Language English
    Publishing date 2024-03-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Urinary toxicity after salvage re-irradiation for prostate cancer local failure after definitive radiotherapy

    Giovanna Dipasquale / Thomas Zilli / Claudio Fiorino / Vérane Achard / Michel Rouzaud / Raymond Miralbell

    Journal of Contemporary Brachytherapy, Vol 14, Iss 3, Pp 222-

    a clinical and dosimetric prognostic factors analysis

    2022  Volume 226

    Keywords prostate cancer ; prognostic factors ; re-irradiation ; urinary toxicity ; Medicine ; R
    Language English
    Publishing date 2022-06-01T00:00:00Z
    Publisher Termedia Publishing House
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  3. Article ; Online: Elective Nodal Irradiation for Oligorecurrent Nodal Prostate Cancer

    Orane Lorton, MS Dipl Ing / Vérane Achard, MD, PhD / Nikolaos Koutsouvelis, MS / Maud Jaccard, MS, PhD / Frederik Vanhoutte, MS, PhD / Giovanna Dipasquale, MS / Piet Ost, MD, PhD / Thomas Zilli, MD

    Advances in Radiation Oncology, Vol 8, Iss 6, Pp 101290- (2023)

    Interobserver Variability in the PEACE V-STORM Randomized Phase 3 Trial

    2023  

    Abstract: Purpose: Consistency in delineation of pelvic lymph node regions for prostate cancer elective nodal radiation therapy is still challenging despite current guidelines. The aim of this study was to evaluate the interobserver variability in elective lymph ... ...

    Abstract Purpose: Consistency in delineation of pelvic lymph node regions for prostate cancer elective nodal radiation therapy is still challenging despite current guidelines. The aim of this study was to evaluate the interobserver variability in elective lymph node delineation in the PEACE V - STORM randomized phase 2 trial for oligorecurrent nodal prostate cancer. Methods and Materials: Twenty-three centers were asked to delineate the elective pelvic nodal clinical target volume (CTV) of a postoperative oligorecurrent nodal prostate cancer benchmark case using a modified Radiation Therapy Oncology Group (RTOG) 2009 template (upper limit at the L4/L5 interspace). Overall, intersection and overflow volumes, Dice coefficient, Hausdorff distance, and count maps merged with computed tomography images were analyzed. Results: The mean volume including the 23 nodal CTVs was 430.4 ± 64.1 cm3, larger than the modified RTOG 2009 CTV reference volume (386.1 cm3). The intersection common volume between the modified reference RTOG 2009 and the 23 nodal CTVs was estimated at 83.9%, whereas the overflow volume was 23.4%, mainly located at the level of the presacral and the upper limit of the L4/L5 interspace. The mean Dice coefficient was 0.79 ± 0.02, whereas the mean Hausdorff distance was 27 ± 4.4 mm. Conclusions: In salvage radiation therapy treatment of oligorecurrent nodal prostate cancer, variations in elective lymph node volume delineation were mainly observed in the presacral and common iliac areas. Routine implementation and diffusion of available contouring guidelines together with a constant evaluation and evidence-based updating are expected to further decrease the existing variability in pelvic node contouring.
    Keywords Medical physics. Medical radiology. Nuclear medicine ; R895-920 ; Neoplasms. Tumors. Oncology. Including cancer and carcinogens ; RC254-282
    Language English
    Publishing date 2023-11-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

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