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  1. Book ; Thesis: Die Bedeutung von gastrointestinalen und metabolischen Erkrankungen für die Komposition und Stabilität der Darmmikrobiota

    Frost, Fabian Burkhard / Völker, Uwe / Bruns, Tony / Müller, Dominik N.

    2021  

    Institution Universität Greifswald
    Author's details vorgelegt von Dr. med. Fabian Burkhard Frost ; 1. Gutachter: Prof. Dr. rer. nat. Uwe Völker, Greifswald, 2. Gutachter: Prof. Dr. med. habil. Tony Bruns, Aachen, 3. Gutachter: Prof. Dr. rer. nat. Dominik N. Müller, Berlin
    Language German ; English
    Size 26 Seiten, 54 ungezählte Seiten, Illustrationen (farbig), Diagramme (farbig)
    Publishing place Greifswald
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Habilitationsschrift, Universitätsmedizin der Universität Greifswald, 2021
    Note Literaturverzeichnis: Seite 21-25. - Literaturangaben
    HBZ-ID HT021297083
    Database Catalogue ZB MED Medicine, Health

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  2. Book ; Thesis: Biotransformation und ihre Induzierbarkeit von Derivaten des 7-Benzyloxy-cumarin in der Rattenleber

    Völker, Uwe

    2001  

    Author's details von Uwe Völker
    Language German
    Size 96, XIII Bl., graph. Darst., 29 cm
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Jena, Univ., Diss., 2001
    HBZ-ID HT013323647
    Database Catalogue ZB MED Medicine, Health

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  3. Book ; Online: Schlußbericht "MetaXpress - Meta-analysis of gene expression"

    Völker, Uwe

    Laufzeit des Projektes: 01.01.2013 - 31.03.2014

    2014  

    Title variant MetaXpress
    Author's details Autor/Projektleiter: Uwe Völker
    Language German
    Size Online-Ressource (7 S., 268,12 KB)
    Publisher Technische Informationsbibliothek u. Universitätsbibliothek ; Interfakultäres Inst. für Genetik und Funktionelle Genomforschung, Abt. für Funktionelle Genomforschung, Univ.-Medizin
    Publishing place Hannover ; Greifswald
    Document type Book ; Online
    Note Förderkennzeichen BMBF 81X2400103 ; Unterschiede zwischen dem gedruckten Dokument und der elektronischen Ressource können nicht ausgeschlossen werden
    Database Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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  4. Book ; Thesis: Gewichts- und Größenvergleich von Plazenten und Feten bei intrauterinem Fruchttod

    Völker, Uwe

    1992  

    Author's details vorgelegt von Uwe Völker
    Size S. 8 - 16 : Ill., graph. Darst.
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Erlangen-Nürnberg, Univ., Diss., 1992
    Note Aus: Perinatalmedizin ; 4, 1992
    HBZ-ID HT004362186
    Database Catalogue ZB MED Medicine, Health

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  5. Article ; Online: Bottom-Up Community Proteome Analysis of Saliva Samples and Tongue Swabs by Data-Dependent Acquisition Nano LC-MS/MS Mass Spectrometry.

    Rabe, Alexander / Gesell Salazar, Manuela / Völker, Uwe

    Methods in molecular biology (Clifton, N.J.)

    2021  Volume 2327, Page(s) 221–238

    Abstract: Analysis using mass spectrometry enables the characterization of metaproteomes in their native environments and overcomes the limitation of proteomics of pure cultures. Metaproteomics is a promising approach to link functions of currently actively ... ...

    Abstract Analysis using mass spectrometry enables the characterization of metaproteomes in their native environments and overcomes the limitation of proteomics of pure cultures. Metaproteomics is a promising approach to link functions of currently actively expressed genes to the phylogenetic composition of the microbiome in their habitat. In this chapter, we describe the preparation of saliva samples and tongue swabs for nLC-MS/MS measurements and their bioinformatic analysis based on the Trans-Proteomic Pipeline and Prophane to study the oral microbiome .
    MeSH term(s) Phylogeny ; Proteome ; Proteomics ; Saliva ; Tandem Mass Spectrometry ; Tongue
    Chemical Substances Proteome
    Language English
    Publishing date 2021-08-19
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-0716-1518-8_13
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Inference of differential gene regulatory networks using boosted differential trees.

    Galindez, Gihanna / List, Markus / Baumbach, Jan / Völker, Uwe / Mäder, Ulrike / Blumenthal, David B / Kacprowski, Tim

    Bioinformatics advances

    2024  Volume 4, Issue 1, Page(s) vbae034

    Abstract: Summary: Diseases can be caused by molecular perturbations that induce specific changes in regulatory interactions and their coordinated expression, also referred to as network rewiring. However, the detection of complex changes in regulatory ... ...

    Abstract Summary: Diseases can be caused by molecular perturbations that induce specific changes in regulatory interactions and their coordinated expression, also referred to as network rewiring. However, the detection of complex changes in regulatory connections remains a challenging task and would benefit from the development of novel nonparametric approaches. We develop a new ensemble method called BoostDiff (boosted differential regression trees) to infer a differential network discriminating between two conditions. BoostDiff builds an adaptively boosted (AdaBoost) ensemble of differential trees with respect to a target condition. To build the differential trees, we propose differential variance improvement as a novel splitting criterion. Variable importance measures derived from the resulting models are used to reflect changes in gene expression predictability and to build the output differential networks. BoostDiff outperforms existing differential network methods on simulated data evaluated in four different complexity settings. We then demonstrate the power of our approach when applied to real transcriptomics data in COVID-19, Crohn's disease, breast cancer, prostate adenocarcinoma, and stress response in
    Availability and implementation: BoostDiff is available at https://github.com/scibiome/boostdiff_inference.
    Language English
    Publishing date 2024-02-29
    Publishing country England
    Document type Journal Article
    ISSN 2635-0041
    ISSN (online) 2635-0041
    DOI 10.1093/bioadv/vbae034
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Role of the Putative Histidine Kinase BP1092 in

    Debandi, Martina / Carrica, Mariela / Hentschker, Christian / Baroli, Carlos / Völker, Uwe / Rodriguez, Maria Eugenia / Surmann, Kristin / Lamberti, Yanina

    Journal of proteome research

    2024  

    Abstract: Bordetella ... ...

    Abstract Bordetella pertussis
    Language English
    Publishing date 2024-04-22
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2078618-9
    ISSN 1535-3907 ; 1535-3893
    ISSN (online) 1535-3907
    ISSN 1535-3893
    DOI 10.1021/acs.jproteome.3c00817
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Book ; Online ; Thesis: Metaproteomic characterization of the human oral microbiome in health and during different treatments

    Rabe, Alexander [Verfasser] / Völker, Uwe [Akademischer Betreuer] / Gesell Salazar, Manuela Akademischer Betreuer] / [Völker, Uwe [Gutachter] / van Dijl, Jan Maarten [Gutachter]

    2023  

    Author's details Alexander Rabe ; Gutachter: Uwe Völker, Jan Maarten van Dijl ; Uwe Völker, Manuela Gesell Salazar
    Keywords Biowissenschaften, Biologie ; Life Science, Biology
    Subject code sg570
    Language German
    Publisher Universität Greifswald
    Publishing place Greifswald
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

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  9. Book ; Online ; Thesis: Einfluss des Guanylatzyklasestimulators Riociguat auf die induzierte Herzinsuffizienz nach transverser Aortenkonstriktion (TAC) im Mausmodell

    Benkner, Alexander [Verfasser] / Völker, Uwe [Gutachter] / Brügmann, Tobias [Gutachter]

    2022  

    Author's details Alexander Benkner ; Gutachter: Uwe Völker, Tobias Brügmann
    Keywords Biowissenschaften, Biologie ; Life Science, Biology
    Subject code sg570
    Language German
    Publisher Universität Greifswald
    Publishing place Greifswald
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

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  10. Article ; Online: Fetal Zone Steroids Show Discrete Effects on Hyperoxia-Induced Attenuation of Migration in Cultured Oligodendrocyte Progenitor Cells.

    Sunny, Donna E / Krüger, Elisabeth L / Hammer, Elke / Völker, Uwe / Heckmann, Matthias

    Oxidative medicine and cellular longevity

    2022  Volume 2022, Page(s) 2606880

    Abstract: Cerebral oxygenation disturbances contribute to the pathogenesis of brain lesions in preterm infants with white matter damage. These children are at risk of developing long-term neurodevelopmental disabilities. Preterm birth is associated with sudden ... ...

    Abstract Cerebral oxygenation disturbances contribute to the pathogenesis of brain lesions in preterm infants with white matter damage. These children are at risk of developing long-term neurodevelopmental disabilities. Preterm birth is associated with sudden hormonal changes along with an untimely increase in oxygen tissue tension. There is a persistent high postnatal production of fetal zone steroids (FZS), which serve in the fetoplacental unit as precursors for placental estrogen synthesis during pregnancy. The role of FZS in events associated with oxygenation differences and their impact on the developing white matter is not well understood. Therefore, we investigated the effect of hyperoxia (80% O
    MeSH term(s) Animals ; Dehydroepiandrosterone/pharmacology ; Estradiol/pharmacology ; Female ; Humans ; Hyperoxia/metabolism ; Infant, Newborn ; Infant, Premature/metabolism ; Oligodendrocyte Precursor Cells/metabolism ; Placenta/metabolism ; Pregnancy ; Premature Birth ; Proteomics ; Rats ; Steroids/pharmacology
    Chemical Substances Steroids ; Dehydroepiandrosterone (459AG36T1B) ; Estradiol (4TI98Z838E)
    Language English
    Publishing date 2022-05-09
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2455981-7
    ISSN 1942-0994 ; 1942-0994
    ISSN (online) 1942-0994
    ISSN 1942-0994
    DOI 10.1155/2022/2606880
    Database MEDical Literature Analysis and Retrieval System OnLINE

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