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  1. AU="V. Balaji"
  2. AU="Hanache, Sarah"
  3. AU="Aziz Belkadi"
  4. AU="Weiying, Lu"
  5. AU="Hiroki Ishikawa"
  6. AU=Fischer Lorenz
  7. AU="Hooberman, B H"
  8. AU="Vaid, Nidhi"
  9. AU="Xiao Han"
  10. AU="Stuart G. Tangye"
  11. AU="Yao-Zhong Zhao"
  12. AU="Chern, Chang-Ming"
  13. AU="Floeter, Jens"
  14. AU="Wijnen, Petal"
  15. AU="Saravanamuthu, Pira"
  16. AU="Kalpana Deepa Priya Dorayappan"
  17. AU="Xiao, Hongkui"
  18. AU="Lali, Arvind M"
  19. AU="Kim, Hyojeong"
  20. AU="Nasseri, Saeed"
  21. AU="Kluge"
  22. AU="Bierbaumer, Lisa"
  23. AU="Rashid, Muhammad"
  24. AU="Huang, Chiun-Sheng"
  25. AU="Shevchuk, O O"
  26. AU="Mulvihill, Emily"
  27. AU="Gandhi, Adarsh"
  28. AU="Zhao, Chuanrui"
  29. AU="Shelley Wiart"
  30. AU="Lydia E. Wroblewski" AU="Lydia E. Wroblewski"
  31. AU="Paterson, Ross"
  32. AU="Alexander Marx"
  33. AU="Robinson, Jill"
  34. AU="Mitchell, Adam W M"
  35. AU="Ingham, Jesse R"

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  1. Artikel: Development of high entropy alloys (HEAs): Current trends.

    V, Balaji / M, Anthony Xavior

    Heliyon

    2024  Band 10, Heft 7, Seite(n) e26464

    Abstract: A novel concept of developing multi-principal elements, or compositional complex alloys is referred as high-entropy alloys (HEAs). This review addresses the role of entropy in alloying additions along with the effect of various elements listed in the ... ...

    Abstract A novel concept of developing multi-principal elements, or compositional complex alloys is referred as high-entropy alloys (HEAs). This review addresses the role of entropy in alloying additions along with the effect of various elements listed in the periodic table in forming the HEAs. Phase formation rules and the associated parameters along with their significance are discussed. The physical metallurgy technique is elaborated with reference to the high-entropy effect, severe lattice distortion effect, sluggish diffusion effect, and cocktail effects. Various types of HEAs such as light weight HEAs, nanoprecipitate HEAs, ultrafine-grained HEAs, dual-phase HEAS and TRIP/TWIN HEAs are discussed. Further, the effects of mechanical alloying in HEAs are presented. Finally, the microstructural effects and mechanical properties of HEAs are addressed with reference to the published literature.
    Sprache Englisch
    Erscheinungsdatum 2024-02-19
    Erscheinungsland England
    Dokumenttyp Journal Article ; Review
    ZDB-ID 2835763-2
    ISSN 2405-8440
    ISSN 2405-8440
    DOI 10.1016/j.heliyon.2024.e26464
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: Bridging observations, theory and numerical simulation of the ocean using machine learning

    Maike Sonnewald / Redouane Lguensat / Daniel C Jones / Peter D Dueben / Julien Brajard / V Balaji

    Environmental Research Letters, Vol 16, Iss 7, p

    2021  Band 073008

    Abstract: Progress within physical oceanography has been concurrent with the increasing sophistication of tools available for its study. The incorporation of machine learning (ML) techniques offers exciting possibilities for advancing the capacity and speed of ... ...

    Abstract Progress within physical oceanography has been concurrent with the increasing sophistication of tools available for its study. The incorporation of machine learning (ML) techniques offers exciting possibilities for advancing the capacity and speed of established methods and for making substantial and serendipitous discoveries. Beyond vast amounts of complex data ubiquitous in many modern scientific fields, the study of the ocean poses a combination of unique challenges that ML can help address. The observational data available is largely spatially sparse, limited to the surface, and with few time series spanning more than a handful of decades. Important timescales span seconds to millennia, with strong scale interactions and numerical modelling efforts complicated by details such as coastlines. This review covers the current scientific insight offered by applying ML and points to where there is imminent potential. We cover the main three branches of the field: observations, theory, and numerical modelling. Highlighting both challenges and opportunities, we discuss both the historical context and salient ML tools. We focus on the use of ML in situ sampling and satellite observations, and the extent to which ML applications can advance theoretical oceanographic exploration, as well as aid numerical simulations. Applications that are also covered include model error and bias correction and current and potential use within data assimilation. While not without risk, there is great interest in the potential benefits of oceanographic ML applications; this review caters to this interest within the research community.
    Schlagwörter ocean science ; physical oceanography ; observations ; theory ; modelling ; supervised machine learning ; Environmental technology. Sanitary engineering ; TD1-1066 ; Environmental sciences ; GE1-350 ; Science ; Q ; Physics ; QC1-999
    Thema/Rubrik (Code) 551
    Sprache Englisch
    Erscheinungsdatum 2021-01-01T00:00:00Z
    Verlag IOP Publishing
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  3. Artikel ; Online: Interplay of sequence, topology and termini charge in determining the stability of the aggregates of GNNQQNY mutants

    Alka Srivastava / Petety V Balaji

    PLoS ONE, Vol 9, Iss 5, p e

    a molecular dynamics study.

    2014  Band 96660

    Abstract: This study explores the stabilities of single sheet parallel systems of three sequence variants of 1GNNQQNY7, N2D, N2S and N6D, with variations in aggregate size (5-8) and termini charge (charged or neutral). The aggregates were simulated at 300 and 330 ... ...

    Abstract This study explores the stabilities of single sheet parallel systems of three sequence variants of 1GNNQQNY7, N2D, N2S and N6D, with variations in aggregate size (5-8) and termini charge (charged or neutral). The aggregates were simulated at 300 and 330 K. These mutations decrease amyloid formation in the yeast prion protein Sup35. The present study finds that these mutations cause instability even in the peptide context. The protonation status of termini is found to be a key determinant of stabilities; other determinants are sequence, position of mutation and aggregate size. All systems with charged termini are unstable, whereas both stable and unstable systems are found when the termini are neutral. When termini are charged, the largest stable aggregate for the N2S and N6D systems has 3 to 4 peptides whereas N2D mutation supports oligomers of larger size (5-and 6-mers) as well. Mutation at 2nd position (N2S and N2D) results in fewer H-bonds at the mutated as well as neighboring (Gly1/Gln4) positions. However, no such effect is found if mutation is at 6th position (N6D). The effect of Asn→Asp mutation depends on the position and termini charge: it is more destabilizing at the 2nd position than at the 6th in case of neutral termini, however, the opposite is true in case of charged termini. Appearance of twist in stable systems and in smaller aggregates formed in unstable systems suggests that twist is integral to amyloid arrangement. Disorder, dissociation or rearrangement of peptides, disintegration or collapse of aggregates and formation of amorphous aggregates observed in these simulations are likely to occur during the early stages of aggregation also. The smaller aggregates formed due to such events have a variety of arrangements of peptides. This suggests polymorphic nature of oligomers and presence of a heterogeneous mixture of oligomers during early stages of aggregation.
    Schlagwörter Medicine ; R ; Science ; Q
    Thema/Rubrik (Code) 612
    Sprache Englisch
    Erscheinungsdatum 2014-01-01T00:00:00Z
    Verlag Public Library of Science (PLoS)
    Dokumenttyp Artikel ; Online
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  4. Artikel ; Online: Rv3634c from Mycobacterium tuberculosis H37Rv encodes an enzyme with UDP-Gal/Glc and UDP-GalNAc 4-epimerase activities.

    Peehu Pardeshi / K Krishnamurthy Rao / Petety V Balaji

    PLoS ONE, Vol 12, Iss 4, p e

    2017  Band 0175193

    Abstract: A bioinformatics study revealed that Mycobacterium tuberculosis H37Rv (Mtb) contains sequence homologs of Campylobacter jejuni protein glycosylation enzymes. The ORF Rv3634c from Mtb was identified as a sequence homolog of C. jejuni UDP-Gal/GalNAc 4- ... ...

    Abstract A bioinformatics study revealed that Mycobacterium tuberculosis H37Rv (Mtb) contains sequence homologs of Campylobacter jejuni protein glycosylation enzymes. The ORF Rv3634c from Mtb was identified as a sequence homolog of C. jejuni UDP-Gal/GalNAc 4-epimerase. This study reports the cloning of Rv3634c and its expression as an N-terminal His-tagged protein. The recombinant protein was shown to have UDP-Gal/Glc 4-epimerase activity by GOD-POD assay and by reverse phase HPLC. This enzyme was shown to have UDP-GalNAc 4-epimerase activity also. Residues Ser121, Tyr146 and Lys150 were shown by site-directed mutagenesis to be important for enzyme activity. Mutation of Ser121 and Tyr146 to Ala and Phe, respectively, led to complete loss of activity whereas mutation of Lys150 to Arg led to partial loss of activity. There were no gross changes in the secondary structures of any of these three mutants. These results suggest that Ser121 and Tyr146 are essential for epimerase activity of Rv3634c. UDP-Gal/Glc 4-epimerases from other organisms also have a catalytic triad consisting of Ser, Tyr and Lys. The triad carries out proton transfer from nucleotide sugar to NAD+ and back, thus effecting the epimerization of the substrate. Addition of NAD+ to Lys150 significantly abrogates the loss of activity, suggesting that, as in other epimerases, NAD+ is associated with Rv3634c.
    Schlagwörter Medicine ; R ; Science ; Q
    Thema/Rubrik (Code) 572
    Sprache Englisch
    Verlag Public Library of Science (PLoS)
    Dokumenttyp Artikel ; Online
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  5. Artikel ; Online: Epidemiological characterisation of Streptococcus pneumoniae from India using multilocus sequence typing

    T Gopi / J Ranjith / S Anandan / V Balaji

    Indian Journal of Medical Microbiology, Vol 34, Iss 1, Pp 17-

    2016  Band 21

    Abstract: Objective: The aim of this study was to utilize the multilocus sequence typing (MLST) technique to characterise Streptococcus pneumoniae among clinical isolates in India. MLST was used to determine clonality, to establish genetic relatedness, to check ... ...

    Abstract Objective: The aim of this study was to utilize the multilocus sequence typing (MLST) technique to characterise Streptococcus pneumoniae among clinical isolates in India. MLST was used to determine clonality, to establish genetic relatedness, to check for correlation between serotypes and sequence types (STs) and its relevance associated with antibiotic resistance. Methods: Forty consecutive invasive S. pneumoniae isolates in children <5 years were characterised. Preliminary identification of serotype and antibiotic susceptible profile was followed with MLST technique to identify the STs of the isolates. STs were then analysed for clonality using an eBURST algorithm and genetic relatedness using Sequence Type Analysis and Recombinational Tests version 2 software. Results: The most common ST was ST63. Among the forty isolates, we identified nine novel STs, six of which had known alleles but in new combinations, three of which had new alleles in their sequence profile. The new STs assigned were 8501–8509. One clonal complex was found among the 40 strains characterised. The most common serotypes in this study were serotype 19F, 14 and 5. Non-susceptibility to penicillin and erythromycin was observed in 2.5% and 30% of the isolates, respectively. Conclusion: This study shows a significant number of novel STs among the 40 isolates characterised (9/40, 22.5%), however, internationally recognised strains were also circulating in India, indicating, there could be greater geographical variation in pneumococcal STs in India. Molecular epidemiology data is essential to understand the population dynamics of S. pneumoniae in India before the introduction of pneumococcal vaccines in NIP in India.
    Schlagwörter Clonal complex ; India ; multilocus sequence typing ; sequence types ; Streptococcus pneumoniae ; Science ; Q ; Microbiology ; QR1-502
    Erscheinungsdatum 2016-01-01T00:00:00Z
    Verlag Medknow Publications
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  6. Artikel ; Online: A perspective on testing for gestational diabetes mellitus

    Seshiah Veerasamy / Anil Kapur / V Balaji / Hema Divakar

    Indian Journal of Endocrinology and Metabolism, Vol 19, Iss 4, Pp 529-

    2015  Band 532

    Schlagwörter Diseases of the endocrine glands. Clinical endocrinology ; RC648-665 ; Specialties of internal medicine ; RC581-951 ; Internal medicine ; RC31-1245 ; Medicine ; R
    Sprache Englisch
    Erscheinungsdatum 2015-01-01T00:00:00Z
    Verlag Endocrine Society of India
    Dokumenttyp Artikel ; Online
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  7. Artikel ; Online: Bal Dattatraya Tilak Lecture1986

    C V Seshadri and V Balaji

    Proceedings of Indian National Science Academy, Vol 54, Iss 1A (2015)

    Equity is Good SciencePart I: Time, Calendar Time and Peasant Concepts of Time

    2015  

    Abstract: Bal Dattatraya Tilak Lecture1986: Equity is Good SciencePart I: Time, Calendar Time and Peasant Concepts of ... ...

    Abstract Bal Dattatraya Tilak Lecture1986: Equity is Good SciencePart I: Time, Calendar Time and Peasant Concepts of Time
    Schlagwörter Science ; Q
    Sprache Englisch
    Erscheinungsdatum 2015-02-01T00:00:00Z
    Verlag Indian National Science Academy
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  8. Artikel ; Online: Corynebacterium amycolatum

    Mallika Sengupta / P. Naina / V. Balaji / Shalini Anandan

    Journal of Clinical and Diagnostic Research, Vol 9, Iss 12, Pp DD01-DD

    An Unexpected Pathogen in the Ear

    2015  Band 03

    Abstract: Non-diphtheritic Corynebacteria are now being increasingly recognised as the causative agents of various infections. Among these organisms, Corynebacterium amycolatum is the most frequently isolated one. It has been isolated from urine, pus, catheter ... ...

    Abstract Non-diphtheritic Corynebacteria are now being increasingly recognised as the causative agents of various infections. Among these organisms, Corynebacterium amycolatum is the most frequently isolated one. It has been isolated from urine, pus, catheter tips, blood, prostatic secretion, cerebrospinal fluid and sputum. However, to the best of our knowledge, there are no reports on its role in ear infections. Here, we present 12 cases of ear infection with C.amycolatum. A high index of suspicion is necessary for identification of these gram positive bacilli as they resemble other Corynebacterium species on gram stain. They have metachromatic granules which can be demonstrated by Albert’s stain and form characteristic dry, flat colonies on blood agar. These organisms are frequently resistant to ceftriaxone and imipenem. In our study, among the 12 isolates, eight isolates were resistant to ceftriaxone and four to imipenem and two were intermediately susceptible to ceftriaxone although all the 12 strains were uniformly susceptible to vancomycin. All the isolates were negative for toxA and toxB genes by PCR. Genomic sequencing of two isolates confirmed them as C.amycolatum. C.amycolatum is a relatively rare cause of pyogenic ear infections. As it demonstrates more antibiotic resistance than other similar organisms, careful identification with antibiotic susceptibility testing is required in managing these infections.
    Schlagwörter diphtheroids ; ear infection ; resistance ; toxa and toxb genes ; Medicine ; R
    Thema/Rubrik (Code) 630
    Sprache Englisch
    Erscheinungsdatum 2015-12-01T00:00:00Z
    Verlag JCDR Research and Publications Private Limited
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  9. Artikel ; Online: Varying Overhead Ad Hoc on Demand Vector Routing in Highly Mobile Ad Hoc Network

    V. Balaji / V. Duraisamy

    Journal of Computer Science, Vol 7, Iss 5, Pp 678-

    2011  Band 682

    Abstract: Problem statement: An inherent feature of mobile ad hoc networks is the frequent change of network topology leading to stability and reliability problems of the network. Highly dynamic and dense network have to maintain acceptable level of service to ... ...

    Abstract Problem statement: An inherent feature of mobile ad hoc networks is the frequent change of network topology leading to stability and reliability problems of the network. Highly dynamic and dense network have to maintain acceptable level of service to data packets and limit the network control overheads. This capability is closely related as how quickly the network protocol control overhead is managed as a function of increased link changes. Dynamically limiting the routing control overheads based on the network topology improves the throughput of the network. Approach: In this study we propose Varying Overhead - Ad hoc on Demand Vector routing protocol (VO-AODV) for highly dynamic mobile Ad hoc network. The VO-AODV routing protocol proposed dynamically modifies the active route time based on the network topology. Results and Conclusion: Simulation results prove that the proposed model decreases the control overheads without decreasing the QOS of the network.
    Schlagwörter </keyword><keyword>Mobile Ad Hoc Network (MANET) ; Ad Hoc on Demand Distance Vector (AODV) ; Dynamic Source Routing (DSR) ; Distance Sequenced Distance Vector (DSDV) ; Optimized Link State Routing (OLSR) ; Fish Eye State Routing (FSR) ; Active Route Timeout (ART) ; route error ; associativity based routing ; Electronic computers. Computer science ; QA75.5-76.95 ; Instruments and machines ; QA71-90 ; Mathematics ; QA1-939 ; Science ; Q ; DOAJ:Computer Science ; DOAJ:Technology and Engineering
    Thema/Rubrik (Code) 000
    Sprache Englisch
    Erscheinungsdatum 2011-01-01T00:00:00Z
    Verlag Science Publications
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  10. Artikel ; Online: Extended spectrum β-lactamase producing Shigella flexneri serotype-2 causing bacteremia in a patient with uncontrolled diabetes mellitus

    Marilyn M Ninan / Tarun K George / V Balaji / I Ramya

    Indian Journal of Pathology and Microbiology, Vol 59, Iss 3, Pp 420-

    2016  Band 421

    Abstract: We report a case of Shigella flexneri serotype-2 causing bacteremia in an elderly gentleman with uncontrolled diabetes mellitus, who had no other apparent risk factors. Antibiotic susceptibility testing revealed that the organism was a multidrug ... ...

    Abstract We report a case of Shigella flexneri serotype-2 causing bacteremia in an elderly gentleman with uncontrolled diabetes mellitus, who had no other apparent risk factors. Antibiotic susceptibility testing revealed that the organism was a multidrug resistant extended spectrum beta-lactamase producing straian, which was confirmed by molecular characterization. This rare case alerts both the clinician and microbiologist to a previously unaddressed risk factor of Shigella spp. causing bacteremia, as well as emerging resistant strains that are on the rise in immunocompromised patients.
    Schlagwörter Bacteremia ; diabetes mellitus ; Shigella flexneri ; Pathology ; RB1-214 ; Medicine ; R ; Microbiology ; QR1-502 ; Science ; Q
    Sprache Englisch
    Erscheinungsdatum 2016-01-01T00:00:00Z
    Verlag Medknow Publications
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