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  1. Book ; Online: Cytokine-Ion Channel Interactions in Pulmonary Inflammation

    Vadász, István / Vadász, István / Lucas, Rudolf

    2019  

    Keywords Medicine ; Immunology ; Pulmonary Edema ; Acute Lung Injury ; Pro-inflammatory cytokines ; TNF ; Heart Failure ; ENaC ; Na+-K+-ATPase ; TRPV4 ; TRPC6 ; NKCC1
    Size 1 electronic resource (198 pages)
    Publisher Frontiers Media SA
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT021229841
    ISBN 9782889457038 ; 2889457036
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article ; Online: Alveolar-capillary endocytosis and trafficking in acute lung injury and acute respiratory distress syndrome.

    Kryvenko, Vitalii / Vadász, István

    Frontiers in immunology

    2024  Volume 15, Page(s) 1360370

    Abstract: Acute respiratory distress syndrome (ARDS) is associated with high morbidity and mortality but lacks specific therapeutic options. Diverse endocytic processes play a key role in all phases of acute lung injury (ALI), including the initial insult, ... ...

    Abstract Acute respiratory distress syndrome (ARDS) is associated with high morbidity and mortality but lacks specific therapeutic options. Diverse endocytic processes play a key role in all phases of acute lung injury (ALI), including the initial insult, development of respiratory failure due to alveolar flooding, as a consequence of altered alveolar-capillary barrier function, as well as in the resolution or deleterious remodeling after injury. In particular, clathrin-, caveolae-, endophilin- and glycosylphosphatidyl inositol-anchored protein-mediated endocytosis, as well as, macropinocytosis and phagocytosis have been implicated in the setting of acute lung damage. This manuscript reviews our current understanding of these endocytic pathways and subsequent intracellular trafficking in various phases of ALI, and also aims to identify potential therapeutic targets for patients with ARDS.
    MeSH term(s) Humans ; Respiratory Distress Syndrome/therapy ; Endocytosis ; Acute Lung Injury/therapy ; Pinocytosis ; Phagocytosis
    Language English
    Publishing date 2024-03-12
    Publishing country Switzerland
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2024.1360370
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Modeling the Human Alveolar Epithelium: Promises and Challenges.

    Kryvenko, Vitalii / Vadász, István

    American journal of respiratory cell and molecular biology

    2024  Volume 70, Issue 5, Page(s) 329–330

    MeSH term(s) Humans ; Models, Biological ; Alveolar Epithelial Cells/metabolism ; Pulmonary Alveoli/metabolism ; Pulmonary Alveoli/pathology ; Animals
    Language English
    Publishing date 2024-02-14
    Publishing country United States
    Document type Editorial ; Research Support, N.I.H., Extramural ; Comment
    ZDB-ID 1025960-0
    ISSN 1535-4989 ; 1044-1549
    ISSN (online) 1535-4989
    ISSN 1044-1549
    DOI 10.1165/rcmb.2023-0471ED
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Keratinocyte growth factor in acute respiratory distress syndrome.

    Vadász, István

    The Lancet. Respiratory medicine

    2017  Volume 5, Issue 6, Page(s) 459–460

    Language English
    Publishing date 2017-06
    Publishing country England
    Document type Journal Article
    ZDB-ID 2686754-0
    ISSN 2213-2619 ; 2213-2600
    ISSN (online) 2213-2619
    ISSN 2213-2600
    DOI 10.1016/S2213-2600(17)30172-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Mechanisms of Hypercapnia-Induced Endoplasmic Reticulum Dysfunction.

    Kryvenko, Vitalii / Vadász, István

    Frontiers in physiology

    2021  Volume 12, Page(s) 735580

    Abstract: Protein transcription, translation, and folding occur continuously in every living cell and are essential for physiological functions. About one-third of all proteins of the cellular proteome interacts with the endoplasmic reticulum (ER). The ER is a ... ...

    Abstract Protein transcription, translation, and folding occur continuously in every living cell and are essential for physiological functions. About one-third of all proteins of the cellular proteome interacts with the endoplasmic reticulum (ER). The ER is a large, dynamic cellular organelle that orchestrates synthesis, folding, and structural maturation of proteins, regulation of lipid metabolism and additionally functions as a calcium store. Recent evidence suggests that both acute and chronic hypercapnia (elevated levels of CO
    Language English
    Publishing date 2021-11-19
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2564217-0
    ISSN 1664-042X
    ISSN 1664-042X
    DOI 10.3389/fphys.2021.735580
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Novel transfection methods in primary lung cell cultures.

    Kryvenko, Vitalii / Vadász, István

    American journal of physiology. Lung cellular and molecular physiology

    2021  Volume 321, Issue 4, Page(s) L734–L735

    MeSH term(s) Cell Culture Techniques ; Lung ; Transfection
    Language English
    Publishing date 2021-09-22
    Publishing country United States
    Document type Editorial ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 1013184-x
    ISSN 1522-1504 ; 1040-0605
    ISSN (online) 1522-1504
    ISSN 1040-0605
    DOI 10.1152/ajplung.00371.2021
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Molecular mechanisms of Na,K-ATPase dysregulation driving alveolar epithelial barrier failure in severe COVID-19.

    Kryvenko, Vitalii / Vadász, István

    American journal of physiology. Lung cellular and molecular physiology

    2021  Volume 320, Issue 6, Page(s) L1186–L1193

    Abstract: A significant number of patients with coronavirus disease 2019 (COVID-19) develop acute respiratory distress syndrome (ARDS) that is associated with a poor outcome. The molecular mechanisms driving failure of the alveolar barrier upon severe acute ... ...

    Abstract A significant number of patients with coronavirus disease 2019 (COVID-19) develop acute respiratory distress syndrome (ARDS) that is associated with a poor outcome. The molecular mechanisms driving failure of the alveolar barrier upon severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection remain incompletely understood. The Na,K-ATPase is an adhesion molecule and a plasma membrane transporter that is critically required for proper alveolar epithelial function by both promoting barrier integrity and resolution of excess alveolar fluid, thus enabling appropriate gas exchange. However, numerous SARS-CoV-2-mediated and COVID-19-related signals directly or indirectly impair the function of the Na,K-ATPase, thereby potentially contributing to disease progression. In this Perspective, we highlight some of the putative mechanisms of SARS-CoV-2-driven dysfunction of the Na,K-ATPase, focusing on expression, maturation, and trafficking of the transporter. A therapeutic mean to selectively inhibit the maladaptive signals that impair the Na,K-ATPase upon SARS-CoV-2 infection might be effective in reestablishing the alveolar epithelial barrier and promoting alveolar fluid clearance and thus advantageous in patients with COVID-19-associated ARDS.
    MeSH term(s) Biological Transport/physiology ; COVID-19/pathology ; Humans ; Pulmonary Alveoli/pathology ; Pulmonary Edema/pathology ; SARS-CoV-2 ; Severe Acute Respiratory Syndrome/pathology ; Sodium-Potassium-Exchanging ATPase/metabolism ; Tight Junctions/pathology
    Chemical Substances Sodium-Potassium-Exchanging ATPase (EC 7.2.2.13)
    Language English
    Publishing date 2021-03-09
    Publishing country United States
    Document type Editorial ; Research Support, Non-U.S. Gov't
    ZDB-ID 1013184-x
    ISSN 1522-1504 ; 1040-0605
    ISSN (online) 1522-1504
    ISSN 1040-0605
    DOI 10.1152/ajplung.00056.2021
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Editorial: Elevated Carbon Dioxide Sensing and Physiologic Effects.

    Cummins, Eoin P / Bharat, Ankit / Sznajder, Jacob I / Vadász, István

    Frontiers in physiology

    2022  Volume 13, Page(s) 894222

    Language English
    Publishing date 2022-04-27
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2564217-0
    ISSN 1664-042X
    ISSN 1664-042X
    DOI 10.3389/fphys.2022.894222
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Antianabolic Effects of Hypercapnia: No Country for Strong Men.

    Kryvenko, Vitalii / Vadász, István

    American journal of respiratory cell and molecular biology

    2019  Volume 62, Issue 1, Page(s) 8–9

    MeSH term(s) AMP-Activated Protein Kinases ; Carbon Dioxide ; Humans ; Hypercapnia ; Male ; Muscle, Skeletal ; Protein Biosynthesis
    Chemical Substances Carbon Dioxide (142M471B3J) ; AMP-Activated Protein Kinases (EC 2.7.11.31)
    Language English
    Publishing date 2019-07-10
    Publishing country United States
    Document type Editorial ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 1025960-0
    ISSN 1535-4989 ; 1044-1549
    ISSN (online) 1535-4989
    ISSN 1044-1549
    DOI 10.1165/rcmb.2019-0225ED
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: The role of CD36 in endothelial albumin transcytosis.

    Kryvenko, Vitalii / Vadász, István

    American journal of physiology. Lung cellular and molecular physiology

    2019  Volume 316, Issue 5, Page(s) L738–L739

    MeSH term(s) Albumins ; Endothelial Cells ; Fatty Acids ; Transcytosis
    Chemical Substances Albumins ; Fatty Acids
    Language English
    Publishing date 2019-03-06
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 1013184-x
    ISSN 1522-1504 ; 1040-0605
    ISSN (online) 1522-1504
    ISSN 1040-0605
    DOI 10.1152/ajplung.00104.2019
    Database MEDical Literature Analysis and Retrieval System OnLINE

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