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Article ; Online: Correction: Hypoxia induced hERG trafficking defect linked to cell cycle arrest in SH-SY5Y cells.

Vaddi, Damodara Reddy / Piao, Lin / Khan, Shakil A / Wang, Ning / Prabhakar, Nanduri R / Nanduri, Jayasri

2024 Volume 19, Issue 1, Page(s) e0297301

Abstract: This corrects the article DOI: 10.1371/journal.pone.0215905.]. ...

Abstract	[This corrects the article DOI: 10.1371/journal.pone.0215905.].
Language	English
Publishing date	2024-01-11
Publishing country	United States
Document type	Published Erratum
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0297301
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Article: Protective effect of Terminalia arjuna against alcohol induced oxidative damage of rat erythrocyte membranes.

Hebbani, Ananda Vardhan / Vaddi, Damodara Reddy / Dd, Padma Priya / NCh, Varadacharyulu

Journal of Ayurveda and integrative medicine

2021 Volume 12, Issue 2, Page(s) 330–339

Abstract: Background: Alcohol is a widely abused drug with many health implications, mainly caused by the oxidative and nitrosative stress on different body parts. Ayurvedic herbalism authenticates the multiple therapeutic applications of Terminalia arjuna bark ... ...

Abstract	Background: Alcohol is a widely abused drug with many health implications, mainly caused by the oxidative and nitrosative stress on different body parts. Ayurvedic herbalism authenticates the multiple therapeutic applications of Terminalia arjuna bark due to its rich phytochemical repertoire. Objective: To observe the extent of oxidative damage caused to erythrocytes by alcohol and assess the protective ability of T. arjuna bark powder aqueous extract (AETA) against the damage. Materials and methods: Wister albino rats were categorized into four groups of eight rats per group; first group (control) was fed with glucose, second group was given alcohol at a dose of 20% v/v; 5g alcohol/kg b. wt/day, third group was co-administered with AETA (0.5 g/kg b. wt/day) and alcohol and the fourth group was kept on bark extract alone. Blood samples were collected and evaluated for different biochemical parameters after the completion of the treatment period. Results: Alcohol significantly increased the erythrocyte membrane protein carbonyl and malondialdehyde (MDA) contents, along with a concomitant decrease in the membrane antioxidant status, when compared to the control group. Chromatographic analysis of the alcohol-treated rat erythrocyte membranes revealed altered membrane individual phospholipid contents and fluidity properties. Alcohol-induced morphological changes in the erythrocytes and its effect on decreasing the resistance of hypotonic shock induced by NaCl are evident from the hemolysis curves. However, AETA administration to alcoholic rats beneficially modulated the membrane properties anvd protected erythrocytes from damage. Conclusion: Results suggest that AETA protects erythrocytes from alcohol-induced oxidative stress, biophysical, and biochemical changes very effectively.
Language	English
Publishing date	2021-03-14
Publishing country	United States
Document type	Journal Article
ISSN	0975-9476
ISSN	0975-9476
DOI	10.1016/j.jaim.2021.02.001
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Article: Protective effect of Terminalia arjuna against alcohol induced oxidative damage of rat erythrocyte membranes

Hebbani, Ananda Vardhan / Vaddi, Damodara Reddy / DD, Padma Priya / NCh, Varadacharyulu

Journal of Ayurveda and integrative medicine. 2021 Feb. 11,

2021

Abstract: Alcohol is a widely abused drug with many health implications, mainly caused by the oxidative and nitrosative stress on different body parts. Ayurvedic herbalism authenticates the multiple therapeutic applications of Terminalia arjuna bark due to its ... ...

Abstract	Alcohol is a widely abused drug with many health implications, mainly caused by the oxidative and nitrosative stress on different body parts. Ayurvedic herbalism authenticates the multiple therapeutic applications of Terminalia arjuna bark due to its rich phytochemical repertoire.To observe the extent of oxidative damage caused to erythrocytes by alcohol and assess the protective ability of T. arjuna bark powder aqueous extract (AETA) against the damage.Wister albino rats were categorized into four groups of eight rats per group; first group (control) was fed with glucose, second group was given alcohol at a dose of 20% v/v; 5g alcohol/kg b. wt/day, third group was co-administered with AETA (0.5 g/kg b. wt/day) and alcohol and the fourth group was kept on bark extract alone. Blood samples were collected and evaluated for different biochemical parameters after the completion of the treatment period.Alcohol significantly increased the erythrocyte membrane protein carbonyl and malondialdehyde (MDA) contents, along with a concomitant decrease in the membrane antioxidant status, when compared to the control group. Chromatographic analysis of the alcohol-treated rat erythrocyte membranes revealed altered membrane individual phospholipid contents and fluidity properties. Alcohol-induced morphological changes in the erythrocytes and its effect on decreasing the resistance of hypotonic shock induced by NaCl are evident from the hemolysis curves. However, AETA administration to alcoholic rats beneficially modulated the membrane properties anvd protected erythrocytes from damage.Results suggest that AETA protects erythrocytes from alcohol-induced oxidative stress, biophysical, and biochemical changes very effectively.
Keywords	Ayurvedic medicine ; Terminalia arjuna ; albino ; alcohols ; antioxidants ; bark ; bark extracts ; chromatography ; erythrocyte membrane ; erythrocytes ; glucose ; hemolysis ; illicit drugs ; malondialdehyde ; membrane proteins ; oxidative stress ; phospholipids ; phytochemicals ; protective effect ; rats ; therapeutics
Language	English
Dates of publication	2021-0211
Publishing place	Elsevier B.V.
Document type	Article
Note	NAL-light ; Pre-press version
ISSN	0975-9476
DOI	10.1016/j.jaim.2021.02.001
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Hypoxia induced hERG trafficking defect linked to cell cycle arrest in SH-SY5Y cells.

Vaddi, Damodara Reddy / Piao, Lin / Khan, Shakil A / Wang, Ning / Prabhakar, Nanduri R / Nanduri, Jayasri

PloS one

2019 Volume 14, Issue 4, Page(s) e0215905

Abstract: The alpha subunit of the voltage gated human ether-a-go-go-related (hERG) potassium channel regulates cell excitability in a broad range of cell lines. HERG channels are also expressed in a variety of cancer cells and control cell proliferation and ... ...

Abstract	The alpha subunit of the voltage gated human ether-a-go-go-related (hERG) potassium channel regulates cell excitability in a broad range of cell lines. HERG channels are also expressed in a variety of cancer cells and control cell proliferation and apoptosis. Hypoxia, a common feature of tumors, alters gating properties of hERG currents in SH-SY5Y neuroblastoma cells. In the present study, we examined the molecular mechanisms and physiological significance underlying hypoxia-altered hERG currents in SH-SY5Y neuroblastoma cells. Hypoxia reduced the surface expression of 150kDa form and increased 125kDa form of hERG protein expression in the endoplasmic reticulum (ER). The changes in protein expression were associated with ~50% decrease in hERG potassium conductance. ER retention of hERG 125kDa form by CH was due to defective trafficking and was rescued by exposing cells to hypoxia at low temperatures or treatment with E-4031, a hERG channel blocker. Prolonged association of hERG with molecular chaperone Hsp90 resulting in complex oligomeric insoluble aggregates contributed to ER accumulation and trafficking defect. Hypoxia increased reactive oxygen species (ROS) levels and manganese (111) tetrakis (1methyl-4-pyridyl) porphyrin pentachloride, a membrane-permeable antioxidant prevented hypoxia-induced degradation of 150kDa and accumulation of 125kDa forms. Impaired trafficking of hERG by hypoxia was associated with reduced cell proliferation and this effect was prevented by antioxidant treatment. These results demonstrate that hypoxia through increased oxidative stress impairs hERG trafficking, leading to decreased K+ currents resulting in cell cycle arrest in SH-SY5Y cells.
MeSH term(s)	Cell Cycle Checkpoints ; Cell Hypoxia ; Cell Line, Tumor ; Cell Proliferation ; Endoplasmic Reticulum/metabolism ; Ether-A-Go-Go Potassium Channels/metabolism ; HEK293 Cells ; HSP90 Heat-Shock Proteins/metabolism ; Humans ; Protein Transport ; Reactive Oxygen Species/metabolism
Chemical Substances	Ether-A-Go-Go Potassium Channels ; HSP90 Heat-Shock Proteins ; Reactive Oxygen Species
Language	English
Publishing date	2019-04-24
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0215905
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Article ; Online: Protective Effect of aqueous bark extract of Terminalia Arjuna against Alcohol-Induced Hepato and Nephrotoxicity in Rats

Ananda Vardhan Hebbani / vaddi Damodara Reddy / N Ch Varadacharyulu

International Journal of Phytomedicine, Vol 7, Iss 2, Pp 142-

2015 Volume 153

Abstract: Present study is an attempt to forward a locally available aqueous bark powder extract of Terminalia arjuna (AETA) as potential therapeutic agent against alcohol-induced oxidative/nitrosative stress mediated hepato and nephrotoxicity in rats. Alcohol ... ...

Abstract	Present study is an attempt to forward a locally available aqueous bark powder extract of Terminalia arjuna (AETA) as potential therapeutic agent against alcohol-induced oxidative/nitrosative stress mediated hepato and nephrotoxicity in rats. Alcohol administration significantly raised the plasma concentrations of nitrogenous compounds and increased activities of alcoholic marker enzymes, gamma glutamyl transferase (γGT), plasma transaminases (AST and ALT), alkaline phosphatase (ALP) and lactate dehydrogenase (LDH). Besides, we found abnormalities in the levels of plasma lipids, lipoproteins in alcohol administered rats along with increased lipid peroxidation and nitric oxide (NOx) levels. Moreover, significantly decreased hepatic and kidney antioxidant enzymes, superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx) and the content of reduced glutathione (GSH) in alcohol administered rats were noticed. Administration of AETA to alcoholic rats significantly brought these alterations in plasma to normal and also significantly reduced the levels of lipid peroxidation and restored the enzymic and nonenzymatic antioxidants in liver. These findings were further confirmed by hepatic and kidney histopathological studies. Co-administration of alcohol along with AETA offers protective effect against alcohol-induced stress and these protective effects are due to its multiple actions of its bioactive compounds.
Keywords	Alcohol ; Hepatotoxicity ; Nephrotoxicity ; Oxidative stress ; Terminalia Arjuna ; Medicine (General) ; R5-920 ; Medicine ; R
Language	English
Publishing date	2015-08-01T00:00:00Z
Publisher	Advanced Research Journals
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Therapeutic Potential of Pterocarpus santalinus L.: An Update.

Bulle, Saradamma / Reddyvari, Hymavathi / Nallanchakravarthula, Varadacharyulu / Vaddi, Damodara Reddy

Pharmacognosy reviews

2016 Volume 10, Issue 19, Page(s) 43–49

Abstract: Recently there has been increasing interest in plants and plant-derived compounds as raw food and medicinal agents. In Ayurveda, an Indian system of traditional medicine, a wide spectrum of medicinal properties of Pterocarpus santalinus is described. ... ...

Abstract	Recently there has been increasing interest in plants and plant-derived compounds as raw food and medicinal agents. In Ayurveda, an Indian system of traditional medicine, a wide spectrum of medicinal properties of Pterocarpus santalinus is described. Many important bioactive phytocompounds have been extracted and identified from the heartwood of P. santalinus. Bioactive compounds typically occur in small amounts and have more subtle effects than nutrients. These bioactive compounds influence cellular activities that modify the risk of disease rather than prevent deficiency diseases. A wide array of biological activities and potential health benefits of P. santalinus have been reported, including antioxidative, antidiabetic, antimicrobial, anticancer, and anti-inflammatory properties, and protective effects on the liver, gastric mucosa, and nervous system. All these protective effects were attributed to bioactive compounds present in P. santalinus. The major bioactive compounds present in the heartwood of P. santalinus are santalin A and B, savinin, calocedrin, pterolinus K and L, and pterostilbenes. The bioactive compounds have potentially important health benefits: These compounds can act as antioxidants, enzyme inhibitors and inducers, inhibitors of receptor activities, and inducers and inhibitors of gene expression, among other actions. The present review aims to understand the pharmacological effects of P. santalinus on health and disease with "up-to-date" discussion.
Language	English
Publishing date	2016-02-10
Publishing country	India
Document type	Journal Article ; Review
ZDB-ID	2566714-2
ISSN	0976-2787 ; 0973-7847
ISSN (online)	0976-2787
ISSN	0973-7847
DOI	10.4103/0973-7847.176575
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Article ; Online: Modification of erythrocyte membrane proteins, enzymes and transport mechanisms in chronic alcoholics: an in vivo and in vitro study.

Maturu, Paramahamsa / Vaddi, Damodara Reddy / Pannuru, Padmavathi / Nallanchakravarthula, Varadacharyulu

Alcohol and alcoholism (Oxford, Oxfordshire)

2013 Volume 48, Issue 6, Page(s) 679–686

Abstract: Aim: The aim of the study was to elucidate the molecular mechanisms underlying the alcohol perturbation leading to deleterious effects on erythrocyte membrane transport in chronic alcoholics.: Methods: Membrane bound enzyme activities such as Na(+), ... ...

Abstract	Aim: The aim of the study was to elucidate the molecular mechanisms underlying the alcohol perturbation leading to deleterious effects on erythrocyte membrane transport in chronic alcoholics. Methods: Membrane bound enzyme activities such as Na(+), K(+)-ATPase, Ca(2+),Mg(2+)-ATPase and acetylcholine esterase and membrane transport analysis by in vitro and erythrocyte membrane profile analysis in controls and chronic alcoholic red cells were analyzed. Results: It was observed that decreased Na(+), K(+)-ATPase enzyme activity and increased activities of Ca(2+),Mg(2+)-ATPase and acetylcholine esterase in chronic alcoholics compared to controls. The in vitro studies of erythrocytes suggested that there is an increased uptake of glucose through chronic alcoholic red cells. However, glucose utilization by chronic alcoholic red cells was decreased. An increased sensitivity of ouabain for its binding site on Na(+), K(+)-ATPase in chronic alcoholic erythrocyte membrane was evident from this study. Though there appears to be an increased Na(+) influx in chronic alcoholic cells, the status of Na(+) transport is not altered much. However, ouabain caused slight disturbances in the transport of sodium, similar disturbances in the potassium transport resulting in much accumulation of potassium in red cells. Conclusions: It was concluded that chronic alcohol consumption modified certain membrane bound proteins, enzymes and transport mechanisms in chronic alcoholics.
MeSH term(s)	Acetylcholinesterase/blood ; Adenosine Triphosphatases/metabolism ; Adult ; Alcoholics ; Alcoholism/blood ; Alcoholism/enzymology ; Blood Glucose/analysis ; Blood Glucose/metabolism ; Blood Proteins/analysis ; Blood Proteins/metabolism ; Carrier Proteins/analysis ; Carrier Proteins/metabolism ; Electrophoresis, Polyacrylamide Gel ; Enzyme Inhibitors/pharmacology ; Erythrocyte Membrane/chemistry ; Erythrocyte Membrane/drug effects ; Erythrocyte Membrane/enzymology ; Humans ; Male ; Membrane Proteins/analysis ; Middle Aged ; Ouabain/pharmacology ; Potassium/blood ; Silver Staining ; Sodium/blood
Chemical Substances	Blood Glucose ; Blood Proteins ; Carrier Proteins ; Enzyme Inhibitors ; Membrane Proteins ; Ouabain (5ACL011P69) ; Sodium (9NEZ333N27) ; Acetylcholinesterase (EC 3.1.1.7) ; Adenosine Triphosphatases (EC 3.6.1.-) ; Potassium (RWP5GA015D)
Language	English
Publishing date	2013-11
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	604956-4
ISSN	1464-3502 ; 0309-1635 ; 0735-0414
ISSN (online)	1464-3502
ISSN	0309-1635 ; 0735-0414
DOI	10.1093/alcalc/agt071
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Article ; Online: Increased erythrocyte antioxidant status protects against smoking induced hemolysis in moderate smokers.

Pannuru, Padmavathi / Vaddi, Damodara Reddy / Kindinti, Rameswara Reddy / Varadacharyulu, Nallanchakravarthula

Human & experimental toxicology

2011 Volume 30, Issue 10, Page(s) 1475–1481

Abstract: Cigarette smoking is common in societies worldwide and has been identified as injurious to human health. Human red blood cells are important targets for electrophilic and oxidant foreign compounds. In the present study, the possible role of antioxidant ... ...

Abstract	Cigarette smoking is common in societies worldwide and has been identified as injurious to human health. Human red blood cells are important targets for electrophilic and oxidant foreign compounds. In the present study, the possible role of antioxidant status on smoking-induced erythrocyte hemolysis of smokers was studied. Erythrocyte superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx) activities, reduced glutathione (GSH) level, erythrocyte membrane lipid peroxidation, total cholesterol and phospholipids were determined. Further, nitrite/nitrate levels (NO(2)/NO(3)) in both plasma and erythrocyte lysate were measured. Results showed increased plasma and erythrocyte membrane lipid peroxidation and nitrite/nitrate levels in smokers. The activities of SOD, CAT and GPx were also increased with reduced glutathione (GSH) level in smokers. No significant change was observed in smokers red cell hemolysis and cholesterol/phospholipid (C/P) ratio compared to controls. Erythrocyte membrane lipid peroxidation was positively correlated with SOD (r = 0.482, p < 0.01) and GPx (r = 0.368, p < 0.018) in smokers. Increased levels of nitrite/nitrate and antioxidant status of erythrocytes might be playing a crucial role in protecting red cell from free radical damage induced by cigarette smoke.
MeSH term(s)	Adult ; Alanine Transaminase/blood ; Antioxidants/analysis ; Aspartate Aminotransferases/blood ; Cell Membrane/metabolism ; Cholesterol, HDL/blood ; Cholesterol, LDL/blood ; Erythrocytes/metabolism ; Glutathione/blood ; Hemolysis ; Humans ; Lipid Peroxidation ; Male ; Nitric Oxide/blood ; Osmotic Fragility ; Oxidoreductases/blood ; Smoking/adverse effects ; Smoking/blood
Chemical Substances	Antioxidants ; Cholesterol, HDL ; Cholesterol, LDL ; Nitric Oxide (31C4KY9ESH) ; Oxidoreductases (EC 1.-) ; Aspartate Aminotransferases (EC 2.6.1.1) ; Alanine Transaminase (EC 2.6.1.2) ; Glutathione (GAN16C9B8O)
Language	English
Publishing date	2011-10
Publishing country	England
Document type	Journal Article
ZDB-ID	1027454-6
ISSN	1477-0903 ; 0144-5952 ; 0960-3271
ISSN (online)	1477-0903
ISSN	0144-5952 ; 0960-3271
DOI	10.1177/0960327110396527
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Article ; Online: Xanthine oxidase mediates hypoxia-inducible factor-2α degradation by intermittent hypoxia.

Nanduri, Jayasri / Vaddi, Damodara Reddy / Khan, Shakil A / Wang, Ning / Makerenko, Vladislav / Prabhakar, Nanduri R

PloS one

2013 Volume 8, Issue 10, Page(s) e75838

Abstract: Sleep-disordered breathing with recurrent apnea produces chronic intermittent hypoxia (IH). We previously reported that IH leads to down-regulation of HIF-2α protein via a calpain-dependent signaling pathway resulting in oxidative stress. In the present ... ...

Abstract	Sleep-disordered breathing with recurrent apnea produces chronic intermittent hypoxia (IH). We previously reported that IH leads to down-regulation of HIF-2α protein via a calpain-dependent signaling pathway resulting in oxidative stress. In the present study, we delineated the signaling pathways associated with calpain-dependent HIF-2α degradation in cell cultures and rats subjected to chronic IH. Reactive oxygen species (ROS) scavengers prevented HIF-2α degradation by IH and ROS mimetic decreased HIF-2α protein levels in rat pheochromocytoma PC12 cell cultures, suggesting that ROS mediate IH-induced HIF-2α degradation. IH activated xanthine oxidase (XO) by increased proteolytic conversion of xanthine dehydrogenase to XO. ROS generated by XO activated calpains, which contributed to HIF-2α degradation by IH. Calpain-induced HIF-2α degradation involves C-terminus but not the N-terminus of the HIF-2α protein. Pharmacological blockade as well as genetic knock down of XO prevented IH induced calpain activation and HIF-2α degradation in PC12 cells. Systemic administration of allopurinol to rats prevented IH-induced hypertension, oxidative stress and XO activation in adrenal medulla. These results demonstrate that ROS generated by XO activation mediates IH-induced HIF-2α degradation via activation of calpains.
MeSH term(s)	Animals ; Basic Helix-Loop-Helix Transcription Factors/metabolism ; Cell Hypoxia/physiology ; Immunoblotting ; Male ; PC12 Cells ; Rats ; Rats, Sprague-Dawley ; Reactive Oxygen Species/metabolism ; Xanthine Oxidase/metabolism
Chemical Substances	Basic Helix-Loop-Helix Transcription Factors ; Reactive Oxygen Species ; endothelial PAS domain-containing protein 1 (1B37H0967P) ; Xanthine Oxidase (EC 1.17.3.2)
Language	English
Publishing date	2013-10-04
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ISSN	1932-6203
ISSN (online)	1932-6203
DOI	10.1371/journal.pone.0075838
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Article ; Online: Alterations in erythrocyte membrane fluidity and Na+/K+ -ATPase activity in chronic alcoholics.

Maturu, Paramahamsa / Vaddi, Damodara Reddy / Pannuru, Padmavathi / Nallanchakravarthula, Varadacharyulu

Molecular and cellular biochemistry

2010 Volume 339, Issue 1-2, Page(s) 35–42

Abstract: Ethanol disorders biological membranes causing perturbations in the bilayer and also by altering the physicochemical properties of membrane lipids. But, chronic alcohol consumption also increases nitric oxide (NO) production. There was no systemic study ... ...

Abstract	Ethanol disorders biological membranes causing perturbations in the bilayer and also by altering the physicochemical properties of membrane lipids. But, chronic alcohol consumption also increases nitric oxide (NO) production. There was no systemic study was done related to alcohol-induced production of NO and consequent formation of peroxynitrite mediated changes in biophysical and biochemical properties, structure, composition, integrity and function of erythrocyte membranes in chronic alcoholics. Hence, keeping all these conditions in mind the present study was undertaken to investigate the role of over produced nitric oxide on red cell membrane physicochemical properties in chronic alcoholics. Human male volunteers aged 44 +/- 6 years with similar dietary habits were divided into two groups, namely nonalcoholic controls and chronic alcoholics (~125 g of alcohol at least five times per week for the past 10-12 years). Elevated nitrite and nitrate levels in plasma and lysate, changes in erythrocyte membrane individual phospholipid composition, increased lipid peroxidation, protein carbonyls, cholesterol and phospholipids ratio (C/P ratio) and anisotropic value (gamma) with decreased sulfhydryl groups and Na(+)/K(+)-ATPase activity in alcoholics was evident from this study. RBC lysate NO was positively correlated with C/P ratio (r = 0.547) and anisotropic (gamma) value (r = 0.428), Na(+)/K(+)-ATPase activity was negatively correlated with RBC lysate NO (r = -0.372) and anisotropic (gamma) value (r = -0.624) in alcoholics. Alcohol-induced overproduction of nitric oxide reacts with superoxide radicals to produce peroxynitrite, which appears to be responsible for changes in erythrocyte membrane lipids and the activity of Na(+)/K(+)-ATPase.
MeSH term(s)	Adult ; Alcoholics ; Chronic Disease ; Erythrocyte Membrane/drug effects ; Erythrocyte Membrane/physiology ; Ethanol/adverse effects ; Humans ; Male ; Membrane Fluidity/drug effects ; Membrane Fluidity/physiology ; Nitrates/metabolism ; Nitric Oxide/metabolism ; Nitrites/metabolism ; Sodium-Potassium-Exchanging ATPase/metabolism
Chemical Substances	Nitrates ; Nitrites ; Nitric Oxide (31C4KY9ESH) ; Ethanol (3K9958V90M) ; Sodium-Potassium-Exchanging ATPase (EC 7.2.2.13)
Language	English
Publishing date	2010-01-03
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	184833-1
ISSN	1573-4919 ; 0300-8177
ISSN (online)	1573-4919
ISSN	0300-8177
DOI	10.1007/s11010-009-0367-z
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