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  1. Article ; Online: Nasal sprays for treating COVID-19: a scientific note.

    Chavda, Vivek P / Baviskar, Kajal P / Vaghela, Dixa A / Raut, Shilpa S / Bedse, Anjali P

    Pharmacological reports : PR

    2023  Volume 75, Issue 2, Page(s) 249–265

    Abstract: Clinical management of COVID-19 has been a daunting task. Due to the lack of specific treatment, vaccines have been regarded as the first line of defence. Innate responses and cell-mediated systemic immunity, including serum antibodies, have been the ... ...

    Abstract Clinical management of COVID-19 has been a daunting task. Due to the lack of specific treatment, vaccines have been regarded as the first line of defence. Innate responses and cell-mediated systemic immunity, including serum antibodies, have been the primary focus of practically all studies of the immune response to COVID-19. However, owing to the difficulties encountered by the conventional route, alternative routes for prophylaxis and therapy became the need of the hour. The first site invaded by SARS-CoV-2 is the upper respiratory tract. Nasal vaccines are already in different stages of development. Apart from prophylactic purposes, mucosal immunity can be exploited for therapeutic purposes too. The nasal route for drug delivery offers many advantages over the conventional route. Besides offering a needle-free delivery, they can be self-administered. They present less logistical burden as there is no need for refrigeration. The present article focuses on various aspects of nasal spray for eliminating COVID-19.
    MeSH term(s) Humans ; COVID-19 ; Nasal Sprays ; SARS-CoV-2 ; Administration, Intranasal ; Vaccines
    Chemical Substances Nasal Sprays ; Vaccines
    Language English
    Publishing date 2023-02-27
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2186248-5
    ISSN 2299-5684 ; 1734-1140
    ISSN (online) 2299-5684
    ISSN 1734-1140
    DOI 10.1007/s43440-023-00463-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 861: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Self-assembled peptide hydrogels for the treatment of diabetes and associated complications.

    Chavda, Vivek P / Teli, Divya / Balar, Pankti C / Davidson, Majid / Bojarska, Joanna / Vaghela, Dixa A / Apostolopoulos, Vasso

    Colloids and surfaces. B, Biointerfaces

    2024  Volume 235, Page(s) 113761

    Abstract: Diabetes is a widespread epidemic that includes a number of comorbid conditions that greatly increase the chance of acquiring other chronic illnesses. Every year, there are significantly more people with diabetes because of the rise in type-2 diabetes ... ...

    Abstract Diabetes is a widespread epidemic that includes a number of comorbid conditions that greatly increase the chance of acquiring other chronic illnesses. Every year, there are significantly more people with diabetes because of the rise in type-2 diabetes prevalence. The primary causes of illness and mortality worldwide are, among these, hyperglycemia and its comorbidities. There has been a lot of interest in the creation of peptide-based hydrogels as a potentially effective platform for the treatment of diabetes and its consequences. Here, we emphasize the use of self-assembled hydrogel formulations and their unique potential for the treatment/management of type-2 diabetes and its consequences. (i.e., wounds). Key aspects covered include the characteristics of self-assembled peptide hydrogels, methods for their preparation, and their pre-clinical and clinical applications in addressing metabolic disorders such as type-2 diabetes.
    MeSH term(s) Humans ; Wound Healing ; Hydrogels/therapeutic use ; Peptides/therapeutic use ; Diabetes Mellitus, Type 2/drug therapy ; Diabetes Mellitus/drug therapy
    Chemical Substances Hydrogels ; Peptides
    Language English
    Publishing date 2024-01-17
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1500523-9
    ISSN 1873-4367 ; 0927-7765
    ISSN (online) 1873-4367
    ISSN 0927-7765
    DOI 10.1016/j.colsurfb.2024.113761
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Nanoemulsions: summary of a decade of research and recent advances.

    Chavda, Vivek P / Balar, Pankti C / Bezbaruah, Rajashri / Vaghela, Dixa A / Rynjah, Damanbhalang / Bhattacharjee, Bedanta / Sugandhi, Vrashabh V / Paiva-Santos, Ana Cláudia

    Nanomedicine (London, England)

    2024  

    Abstract: Nanoemulsions consist of a combination of several components such as oil, water, emulsifiers, surfactants and cosurfactants. Various techniques for producing nanoemulsions include high-energy and low-energy approaches such as high-pressure homogenization, ...

    Abstract Nanoemulsions consist of a combination of several components such as oil, water, emulsifiers, surfactants and cosurfactants. Various techniques for producing nanoemulsions include high-energy and low-energy approaches such as high-pressure homogenization, microfluidization, jet disperser and phase inversion methods. The properties of a formulation can be influenced by elements such as the composition, concentration, size and charge of droplets, which in turn can affect the technique of manufacture. Characterization is conducted by the assessment of several factors such as physical properties, pH analysis, viscosity measurement and refractive index determination. This article offers a thorough examination of the latest developments in nanoemulsion technology, with a focus on their wide-ranging applications and promising future possibilities. It also discusses the administration of nanoemulsions through several methods.
    Language English
    Publishing date 2024-01-31
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2277839-1
    ISSN 1748-6963 ; 1743-5889
    ISSN (online) 1748-6963
    ISSN 1743-5889
    DOI 10.2217/nnm-2023-0199
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6617: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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