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  1. AU="Vahabirad, Mohammad"
  2. AU=Hamam Dana
  3. AU="Textor, Johannes"
  4. AU="Rao, Nanquan"
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  6. AU="Kulshreshtha, Ritu"
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  12. AU="He, Lingyuan"
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  14. AU="Wright, Joseph L"
  15. AU="Sun, Xuegang"
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  1. Article ; Online: Anticancer Action of Silver Nanoparticles in SKBR3 Breast Cancer Cells through Promotion of Oxidative Stress and Apoptosis.

    Vahabirad, Mohammad / Daei, Sajedeh / Abbasalipourkabir, Roghayeh / Ziamajidi, Nasrin

    BioMed research international

    2024  Volume 2024, Page(s) 7145339

    Abstract: Silver nanoparticles (AgNPs) are known as one of the highly utilized NPs owing to their unique characteristics in the field of cancer research. The goal of this research was to explore the oxidative stress, apoptosis, and angiogenesis in SKBR3 breast ... ...

    Abstract Silver nanoparticles (AgNPs) are known as one of the highly utilized NPs owing to their unique characteristics in the field of cancer research. The goal of this research was to explore the oxidative stress, apoptosis, and angiogenesis in SKBR3 breast cancer cells after exposure to AgNPs. The survival rate of SKBR3 cancer cells and MCF-10A normal breast cells was assessed under the effects of different concentrations (0, 32, 64, 128, and 250
    MeSH term(s) Humans ; Female ; Vascular Endothelial Growth Factor A/metabolism ; Proto-Oncogene Proteins c-akt/metabolism ; Silver/pharmacology ; Antioxidants/pharmacology ; Antioxidants/metabolism ; bcl-2-Associated X Protein/metabolism ; Metal Nanoparticles ; Breast Neoplasms/drug therapy ; Phosphatidylinositol 3-Kinases/metabolism ; Apoptosis ; Oxidative Stress ; Reactive Oxygen Species/metabolism
    Chemical Substances Vascular Endothelial Growth Factor A ; Proto-Oncogene Proteins c-akt (EC 2.7.11.1) ; Silver (3M4G523W1G) ; Antioxidants ; bcl-2-Associated X Protein ; Phosphatidylinositol 3-Kinases (EC 2.7.1.-) ; Reactive Oxygen Species
    Language English
    Publishing date 2024-02-19
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2698540-8
    ISSN 2314-6141 ; 2314-6133
    ISSN (online) 2314-6141
    ISSN 2314-6133
    DOI 10.1155/2024/7145339
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Mechanistic Insight into Age-Related Macular Degeneration (AMD): Anatomy, Epidemiology, Genetics, Pathogenesis, Prevention, Implications, and Treatment Strategies to Pace AMD Management.

    Amini, Mohammad Amin / Karbasi, Ashkan / Vahabirad, Mohammad / Khanaghaei, Masoud / Alizamir, Aida

    Chonnam medical journal

    2023  Volume 59, Issue 3, Page(s) 143–159

    Abstract: One of the most complicated eye disorders is age-related macular degeneration (AMD) which is the leading cause of irremediable blindness all over the world in the elderly. AMD is classified as early stage to late stage (advanced AMD), in which this stage ...

    Abstract One of the most complicated eye disorders is age-related macular degeneration (AMD) which is the leading cause of irremediable blindness all over the world in the elderly. AMD is classified as early stage to late stage (advanced AMD), in which this stage is divided into the exudative or neovascular form (wet AMD) and the nonexudative or atrophic form (dry AMD). Clinically, AMD primarily influences the central area of retina known as the macula. Importantly, the wet form is generally associated with more severe vision loss. AMD has a systemic component, where many factors, like aging, genetic, environment, autoimmune and non-autoimmune disorders are associated with this disease. Additionally, healthy lifestyles, regular exercise, maintaining a normal lipid profile and weight are crucial to decreasing the risk of AMD. Furthermore, therapeutic strategies for limiting AMD should encompass a variety of factors to avoid and improve drug interventions, and also need to take into account personalized genetic information. In conclusion, with the development of technology and research progress, visual impairment and legal blindness from AMD have been substantially reduced in incidence. This review article is focused on identifying and developing the knowledge about the association between genetics, and etiology with AMD. We hope that this review will encourage researchers and lecturers, open new discussions, and contribute to a better understanding of AMD that improves patients' visual acuity, and upgrades the quality of life of AMD patients.
    Language English
    Publishing date 2023-09-25
    Publishing country Korea (South)
    Document type Journal Article ; Review
    ZDB-ID 2536217-3
    ISSN 2233-7393 ; 2233-7385 ; 0377-9564
    ISSN (online) 2233-7393
    ISSN 2233-7385 ; 0377-9564
    DOI 10.4068/cmj.2023.59.3.143
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Silver Nanoparticles Exert Apoptotic Activity in Bladder Cancer 5637 Cells Through Alteration of Bax/Bcl-2 Genes Expression.

    Daei, Sajedeh / Ziamajidi, Nasrin / Abbasalipourkabir, Roghayeh / Aminzadeh, Zeynab / Vahabirad, Mohammad

    Chonnam medical journal

    2022  Volume 58, Issue 3, Page(s) 102–109

    Abstract: Bladder cancer is defined as a urinary tract malignancy that threatens men's and women's health. Due to the side effects of common chemotherapies, novel therapeutic strategies are necessary to overcome the issues concerning bladder cancer treatments. ... ...

    Abstract Bladder cancer is defined as a urinary tract malignancy that threatens men's and women's health. Due to the side effects of common chemotherapies, novel therapeutic strategies are necessary to overcome the issues concerning bladder cancer treatments. Nanotechnology has been suggested as a means to develop the next-generation objectives of cancer diagnosis and treatment among various novel therapies. Owing to the special characteristics that they can offer, silver nanoparticles (AgNPs) were investigated in this study to evaluate their apoptotic impact on bladder cancer 5637 cells. In this study, an MTT assay was conducted and appropriate concentrations of AgNPs were selected. Moreover, reactive oxygen species (ROS) production and apoptosis levels were determined using fluorimetric and Annexin/PI flow cytometry assays, respectively. Moreover, the activity of caspase 3,7, mRNA expression of Bax (Bcl-2-associated X) and Bcl-2 (B-cell lymphoma 2) were assessed based on colorimetric and qRT-PCR methods, respectively. The results indicated that AgNPs can significantly reduce the viability of 5637 cells in a dose-dependent mode as well as having the ability to elevate ROS production. Flow cytometry data showed that AgNPs lead to a remarkable increase in the apoptosis rate as compared with the control. Consistent with this, the induction of apoptosis was revealed by the overexpression of Bax, accompanied by a reduction in Bcl-2 expression compared to the control. Furthermore, AgNPs remarkably stimulated caspase 3,7 activation. In summary, AgNPs can mediate apoptosis in 5637 cells via excessive ROS formation, up-regulating Bax/Bcl-2 expression, and caspase 3,7 activation.
    Language English
    Publishing date 2022-09-23
    Publishing country Korea (South)
    Document type Journal Article
    ZDB-ID 2536217-3
    ISSN 2233-7393 ; 2233-7385 ; 0377-9564
    ISSN (online) 2233-7393
    ISSN 2233-7385 ; 0377-9564
    DOI 10.4068/cmj.2022.58.3.102
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Anti-cancer Activity of New Phosphoramide-functionalized Graphene Oxides: An Experimental and Theoretical Evaluation.

    Gholivand, Khodayar / Faraghi, Mohammad / Pooyan, Mahsa / Babaee, Leila Sarmadi / Malekshah, Rahime Eshaghi / Pirastehfar, Foroogh / Vahabirad, Mohammad

    Current medicinal chemistry

    2022  Volume 30, Issue 30, Page(s) 3486–3503

    Abstract: Background: Graphene oxide (GO)-based systems are among the drug delivery systems and have drawn a lot of interest in the field of medicine.: Methods: In this work, two novel phosphoramides with the formulas of (NHCHCH: Results: The results showed ...

    Abstract Background: Graphene oxide (GO)-based systems are among the drug delivery systems and have drawn a lot of interest in the field of medicine.
    Methods: In this work, two novel phosphoramides with the formulas of (NHCHCH
    Results: The results showed that GO-L1 and GO-L2 had a more inhibitory effect against cancer cells than that of L1 and L2, and GO-L2 showed the highest cytotoxicity with an IC
    Conclusion: Anticancer activity of phosphoramide compounds was increased after attachment on the GO surface, and the docking studies' results were in good accordance with the experimental cytotoxicity results.
    MeSH term(s) Humans ; Graphite/chemistry ; Phosphoramides ; Oxides/pharmacology ; Oxides/chemistry ; Spectroscopy, Fourier Transform Infrared
    Chemical Substances graphene oxide ; Graphite (7782-42-5) ; phosphoramide (13597-72-3) ; Phosphoramides ; Oxides
    Language English
    Publishing date 2022-11-01
    Publishing country United Arab Emirates
    Document type Journal Article
    ZDB-ID 1319315-6
    ISSN 1875-533X ; 0929-8673
    ISSN (online) 1875-533X
    ISSN 0929-8673
    DOI 10.2174/0929867330666221027152716
    Database MEDical Literature Analysis and Retrieval System OnLINE

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