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Article: A Preliminary Study of the Role of Endothelial-Mesenchymal Transitory Factor SOX 2 and CD147 in the Microvascularization of Oral Squamous Cell Carcinoma.

Zisis, Vasileios / Anastasiadou, Pinelopi A / Poulopoulos, Athanasios / Vahtsevanos, Konstantinos / Paraskevopoulos, Konstantinos / Andreadis, Dimitrios

Cureus

2024 Volume 16, Issue 1, Page(s) e52265

Abstract: Introduction: The aim of this study was to detect the possible endothelial expression of embryonic-type cancer stem cells (CSC) marker SOX2 and the stemness-type CSC marker CD147 in oral potential malignant disorders (OPMDs), oral leukoplakia (OL) in ... ...

Abstract	Introduction: The aim of this study was to detect the possible endothelial expression of embryonic-type cancer stem cells (CSC) marker SOX2 and the stemness-type CSC marker CD147 in oral potential malignant disorders (OPMDs), oral leukoplakia (OL) in particular, and oral squamous cell carcinoma (OSCC). Methods: This study focuses on the immunohistochemical pattern of expression of CSC protein-biomarkers SOX2 and CD147 in paraffin-embedded samples of 21 OSCCs of different grades of differentiation and 30 cases of OLs with different grades of dysplasia, compared to normal oral mucosa. Results: The protein biomarker SOX2 was expressed in the endothelial cells, but without establishing any statistically significant correlation among OSCC, OL, and normal tissue specimens. However, SOX endothelial staining was noticed in 7/30 (23.3%) cases of OL (one non-dysplastic, one mildly dysplastic, one moderately dysplastic, and four severely dysplastic cases) and 5/21 (23.8%) cases of OSCC (two well-differentiated, one moderately differentiated, and two poorly differentiated cases). Although CD147 is expressed in normal oral epithelium, OL, and OSCC neoplastic cells, its vascular-endothelial expression was noticed in only 2/5 (40%) cases of normal oral epithelium, 1/30 (3.3%) cases of OL (one severely dysplastic case), and 4/21 (19%) cases of OSCC (two well-differentiated, one moderately differentiated, and one poorly differentiated case). Therefore, no statistically significant correlation among OSCC, OL, and normal tissue specimens was established. Conclusion: The endothelial presence of SOX2 both in oral potentially malignant and malignant lesions suggests that SOX2 may be implicated in the microvascularization process and associated with the degree of dysplasia in OL. The expression of CD147 may be attributed both to local inflammation and tumorigenesis. The implementation of CD147 in larger groups of tissue samples will shed some light on its role in cancer and inflammation. The evidence so far supports the need for more studies, which may support the clinical significance of these novel cancer stem cell biomarkers.
Language	English
Publishing date	2024-01-14
Publishing country	United States
Document type	Journal Article
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.52265
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Article: Intraductal papilloma of the sublingual gland imitating a ranula.

Tatsis, Dimitris / Kechagias, Nikolaos / Tsekos, Antonios / Petrakis, Georgios / Vahtsevanos, Konstantinos

Journal of the Korean Association of Oral and Maxillofacial Surgeons

2022 Volume 48, Issue 1, Page(s) 59–62

Abstract: Ductal papillomas are rare benign lesions of the salivary glands with two distinctive types, intraductal and inverted. The rarest anatomical location where intraductal papillomas occur is the major salivary glands. In the present study, we report an ... ...

Abstract	Ductal papillomas are rare benign lesions of the salivary glands with two distinctive types, intraductal and inverted. The rarest anatomical location where intraductal papillomas occur is the major salivary glands. In the present study, we report an intraductal papilloma of the left sublingual gland with the relevant clinical, imaging, and histopathological findings and postoperative follow-up. To our knowledge, this is the fourth case of an intraductal papilloma of a sublingual gland to be reported in the international literature. We present this rare case because of its clinical and radiological imitation of a ranula.
Language	English
Publishing date	2022-02-28
Publishing country	Korea (South)
Document type	Case Reports
ZDB-ID	2763851-0
ISSN	2234-5930 ; 2234-7550
ISSN (online)	2234-5930
ISSN	2234-7550
DOI	10.5125/jkaoms.2022.48.1.59
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Article: Graft-Versus-Host Disease: Can Biomarkers Assist in Differential Diagnosis, Prognosis, and Therapeutic Strategy?

Alexoudi, Vaia-Aikaterini / Gavriilaki, Eleni / Cheva, Angeliki / Sakellari, Ioanna / Papadopoulou, Stavroula / Paraskevopoulos, Konstantinos / Vahtsevanos, Konstantinos

Pharmaceuticals (Basel, Switzerland)

2024 Volume 17, Issue 3

Abstract: A crucial complication after allogeneic hematopoietic cell transplantation (alloHCT), namely, acute graft-versus-host disease (aGVHD), occurs in about 50% of transplant recipients, leading to high morbidity and mortality. Thus far, the diagnosis of GVHD ... ...

Abstract	A crucial complication after allogeneic hematopoietic cell transplantation (alloHCT), namely, acute graft-versus-host disease (aGVHD), occurs in about 50% of transplant recipients, leading to high morbidity and mortality. Thus far, the diagnosis of GVHD has been mainly established through clinical features and histologic or laboratory evidence of periductal lymphocyte infiltration, fibroplasia, and mixed lymphocytic and plasmocytic inflammation. Intensive research is focused on identifying biomarkers for the early diagnosis, prediction of disease, response to treatment, prognosis, and risk stratification of patients. The serum biomolecules that have been investigated are reported and summarized. Moreover, oral tissue involvement in GVHD is described, and other biomarkers that have been proposed, such as saliva, are analyzed. Future research is highlighted as a necessity in order for these biomarkers to be validated and quantified for use in clinical practice.
Language	English
Publishing date	2024-02-26
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2193542-7
ISSN	1424-8247
ISSN	1424-8247
DOI	10.3390/ph17030298
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Article: Metastatic myxoid liposarcoma to the tongue: a unique intraoral metastasis.

Tatsis, Dimitris / Deligiannidis, Dimitris / Papaemmanouil, Styliani / Vahtsevanos, Konstantinos

Contemporary oncology (Poznan, Poland)

2020 Volume 24, Issue 3, Page(s) 203–205

Abstract: The first case of a myxoid liposarcoma metastatic to the tongue of a 78-year-old male patient with primary scrotal liposarcoma for the past seven years is reported. The patient presented with a firm exophytic mass of the left dorsal surface of the tongue, ...

Abstract	The first case of a myxoid liposarcoma metastatic to the tongue of a 78-year-old male patient with primary scrotal liposarcoma for the past seven years is reported. The patient presented with a firm exophytic mass of the left dorsal surface of the tongue, sized 4 to 4.5 cm, with oedema and bleeding. Myxoid liposarcoma is a malignancy with relatively good prognosis and low metastatic rate but high local recurrence. This is the second case report recorded of a metastatic liposarcoma to the oral cavity. Clinical and imaging considerations, as well pathological details concerning the myxoid liposarcoma, are described.
Language	English
Publishing date	2020-07-22
Publishing country	Poland
Document type	Case Reports
ISSN	1428-2526
ISSN	1428-2526
DOI	10.5114/wo.2020.97483
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Article: Quality of Life in Patients With Tongue Cancer After Surgical Treatment: A 12-Month Prospective Study.

Palitzika, Dimitra / Tilaveridis, Ioannis / Lavdaniti, Maria / Vahtsevanos, Konstantinos / Kosintzi, Angeliki / Antoniades, Konstantinos

Cureus

2022 Volume 14, Issue 2, Page(s) e22511

Abstract: Aim of the study The project assessed the quality of life in post-operative patients with tongue cancer at three-month intervals in the first year after the operation. Material and methods A longitudinal prospective cohort study was conducted in the oral ...

Abstract	Aim of the study The project assessed the quality of life in post-operative patients with tongue cancer at three-month intervals in the first year after the operation. Material and methods A longitudinal prospective cohort study was conducted in the oral and maxillofacial department of a large public general hospital in northern Greece. Fifty-six patients out of a total of 156 with oral cancer were chosen for the study, who completed distinct quality-of-life surveys (EORTC QLQ-C30, and QLQ Head & Neck Module FACT-G). Results Tumor size correlated negatively with various EORTC QLQ-C30 scores, such as role functioning (p = 0.004) and cognitive functioning (p = 0.007), in the third evaluation. Tumor size correlated positively with subscale problems such as social eating (p = 0.001) and weight loss (p = 0.004) in the QLQ Head & Neck Module. The role functioning subscale (p = 0.003), the pain subscale (p = 0.001), and the speech issues QLQ Head & Neck module subscale (p = 0.003) adversely correlated with cancer stage. Patients who received flap reconstruction significantly differed from those who did not, on the EORTC QLQ-C30 cognitive functioning (U = 139.0, p = 0.006), dyspnea (U = 391.5, p = 0.006), and diarrhea (U = 425.0, p = 0.007) subscales during the third evaluation. Differences were also found in the QLQ-H&N35 subscale of sticky saliva (U = 391.0, p = 0.006). Patients with flap reconstruction did not significantly differ from those with immediate closure after one year. Differences concerned the EORTC QLQ-C30 subscales of cognitive functioning, dyspnea, and diarrhea, and the QLQ Head & Neck Module subscale of sticky saliva on the third assessment. No statistically significant correlations were observed between tumor size and cancer stage in the fourth assessment, but the grade of cancer positively correlated with the EORTC QLQ-C30 subscale of constipation (p = 0.000). Conclusions Our study suggests that quality of life is impaired in patients with tongue cancer who have undergone surgical interventions, particularly within the first month post-operation. However, quality of life is fully restored one year after the surgical excision. Future studies should explore early interventions to help healthcare providers better treat this unique group of patients.
Language	English
Publishing date	2022-02-23
Publishing country	United States
Document type	Journal Article
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.22511
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Article: Preliminary Study of the Cancer Stem Cells' Biomarker CD147 in Leukoplakia: Dysplasia and Squamous Cell Carcinoma of Oral Epithelial Origin.

Zisis, Vasileios / Andreadis, Dimitrios / Anastasiadou, Pinelopi / Vahtsevanos, Konstantinos / Akrivou, Meni / Vizirianakis, Ioannis S / Poulopoulos, Athanasios

Cureus

2023 Volume 15, Issue 5, Page(s) e38807

Abstract: Objectives Cancer stem cells (CSCs) are responsible for initiating the process of carcinogenesis de novo, as well as through the transformation of oral potential malignant disorders (OPMDs) to oral squamous cell carcinoma (OSCC). The aim of our study was ...

Abstract	Objectives Cancer stem cells (CSCs) are responsible for initiating the process of carcinogenesis de novo, as well as through the transformation of oral potential malignant disorders (OPMDs) to oral squamous cell carcinoma (OSCC). The aim of our study was to detect the expression of stemness-type CSC marker CD147 in oral leukoplakias (OLs), the most common OPMD, and OSCCs as well. Materials and methods This study focuses on the semiquantitative immunohistochemical pattern of the expression of the CSC protein biomarker CD147 in paraffin-embedded samples of 20 OSCCs of different grades of differentiation and 30 cases of OLs without or with different grades of dysplasia, compared to the normal oral epithelium in terms of cells' stain positivity. Statistical analysis was performed through Statistical Package for Social Sciences (SPSS) version 25.0 (IBM SPSS Statistics, Armonk, NY) with Pearson chi-square test, and the significance level was set at 0.05 (p=0.05). In addition, the study clarified the expression of the respective gene of
Language	English
Publishing date	2023-05-09
Publishing country	United States
Document type	Journal Article
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.38807
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Article ; Online: Sialadenitis as a complication of radioiodine therapy in patients with thyroid cancer: where do we stand?

Adramerinas, Marios / Andreadis, Dimitrios / Vahtsevanos, Konstantinos / Poulopoulos, Athanasios / Pazaitou-Panayiotou, Kalliopi

Hormones (Athens, Greece)

2021 Volume 20, Issue 4, Page(s) 669–678

Abstract: Purpose: This study aims to elaborate on the current knowledge concerning the mechanism, frequency, clinical manifestations, diagnostic procedures, prevention, and management of radioactive iodine (RAI)-induced sialadenitis in patients receiving ... ...

Abstract	Purpose: This study aims to elaborate on the current knowledge concerning the mechanism, frequency, clinical manifestations, diagnostic procedures, prevention, and management of radioactive iodine (RAI)-induced sialadenitis in patients receiving treatment for differentiated thyroid cancer (DTC). Methods: A review of the literature was carried out through the " www.ncbi.nlm.nih.gov/pubmed " database focusing on the results of the past decade. Results: The high concentration of RAI in the salivary glands results in high beta radiation exposure of the striated duct cells and stem cells. This exposure leads to acute and/or chronic sialadenitis with obstructive symptoms and progressive loss of salivary gland function and xerostomia, with severe impact on patients' quality of life. No standard diagnostic method has been established. As far as prevention is concerned, many approaches have been proposed, such as sialogogues, local massage, vitamin E, and amifostine administration. Although there is no unanimity as to their effectiveness, the use of sialogogues is recommended. Treatment includes conservative drug therapy and sialendoscopy when necessary. Conclusion: RAI-induced sialadenitis has a major impact on patients' quality of life. Due to the good prognosis of DTC, the reduction of sialadenitis and its prognosis, prevention, and treatment constitute a priority for the overall treatment of these patients. Further studies that will establish a coherent treatment protocol for this condition are necessary.
MeSH term(s)	Humans ; Iodine Radioisotopes/adverse effects ; Quality of Life ; Radiotherapy/adverse effects ; Salivary Glands ; Sialadenitis/etiology ; Thyroid Neoplasms/radiotherapy
Chemical Substances	Iodine Radioisotopes
Language	English
Publishing date	2021-06-18
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2075912-5
ISSN	2520-8721 ; 1109-3099
ISSN (online)	2520-8721
ISSN	1109-3099
DOI	10.1007/s42000-021-00304-3
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Article ; Online: A safe modality.

Kyrgidis, A / Vahtsevanos, K

British dental journal

2009 Volume 206, Issue 11, Page(s) 561; author reply 562

MeSH term(s)	Bone Density Conservation Agents/adverse effects ; Diphosphonates/adverse effects ; Humans ; Jaw Diseases/prevention & control ; Osteonecrosis/prevention & control ; Periodontal Diseases/complications ; Risk Factors ; Smoking/adverse effects ; Tooth Extraction/adverse effects
Chemical Substances	Bone Density Conservation Agents ; Diphosphonates
Language	English
Publishing date	2009-06-13
Publishing country	England
Document type	Comment ; Letter
ZDB-ID	218090-x
ISSN	1476-5373 ; 0007-0610
ISSN (online)	1476-5373
ISSN	0007-0610
DOI	10.1038/sj.bdj.2009.481
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Article ; Online: Prevention of Frey's Syndrome with the Use of Porcine Dermal Collagen Graft: Retrospective Analysis of 76 "Formal" Parotidectomies for Benign Pathologies.

Vahtsevanos, Kostas / Chatziavramidis, Angelos / Papadiochos, Ioannis Yiannis / Koloutsos, Georgios / Stefanidis, Anastasios / Kitikidou, Kyriaki / Ntomouchtsis, Aris / Patrikidou, Anna

The Annals of otology, rhinology, and laryngology

2021 Volume 130, Issue 9, Page(s) 1036–1043

Abstract: Background: Frey's syndrome is a well-known complication of parotid surgery; its prevention may be achieved by the use of an interpositional barrier between the overlying flaps and the exposed parenchymal bed of parotid gland. The aim of this study was ... ...

Abstract	Background: Frey's syndrome is a well-known complication of parotid surgery; its prevention may be achieved by the use of an interpositional barrier between the overlying flaps and the exposed parenchymal bed of parotid gland. The aim of this study was to retrospectively evaluate clinical outcomes with and without the interpositional placement of a porcine dermal collagen graft (PDCG) for prevention of syndrome occurrence. Methods: We conducted a 20-year retrospective study including the patients who had undergone "formal" (superficial, total, or subtotal) parotidectomies for benign pathologies. The inclusion criteria also involved patients that were (i) regularly monitored about clinical symptoms related to syndrome, and (ii) examined with Minor starch-iodine test. The severity of the diagnosed syndrome was retrospectively evaluated according to the grading score system of Luna-Ortiz. To assess group differences in terms of the extent of dissection in operating sites, we estimated the tumor and histological specimen volumes using the available dimensions. Results: We included Conclusion: Porcine dermal collagen is a safe, practical, and useful means for parotid reconstruction, since it seems to contribute in prevention of Frey's syndrome when increased amount of glandular tissue has to be removed. Additional randomized controlled studies with bigger samples are required to better assess the PDCG use in parotid surgery.
MeSH term(s)	Adenolymphoma/surgery ; Adenoma/surgery ; Adenoma, Pleomorphic ; Adolescent ; Adult ; Aged ; Aged, 80 and over ; Chronic Disease ; Collagen/therapeutic use ; Female ; Humans ; Male ; Middle Aged ; Otorhinolaryngologic Surgical Procedures/methods ; Parotid Diseases/surgery ; Parotid Neoplasms/surgery ; Parotitis/surgery ; Postoperative Complications/prevention & control ; Retrospective Studies ; Sialadenitis/surgery ; Sweating, Gustatory/prevention & control ; Teratoma/surgery ; Young Adult
Chemical Substances	Permacol ; Collagen (9007-34-5)
Language	English
Publishing date	2021-02-06
Publishing country	United States
Document type	Journal Article
ZDB-ID	120642-4
ISSN	1943-572X ; 0003-4894
ISSN (online)	1943-572X
ISSN	0003-4894
DOI	10.1177/0003489421990185
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Article ; Online: Primary mucosal melanoma of the oral cavity: current therapy and future directions.

Chatzistefanou, Ioannis / Kolokythas, Antonia / Vahtsevanos, Konstantinos / Antoniades, Konstantinos

Oral surgery, oral medicine, oral pathology and oral radiology

2016 Volume 122, Issue 1, Page(s) 17–27

Abstract: Background: Primary mucosal melanoma of the oral cavity is a highly aggressive malignancy of melanocytic origin. The aim of this study is to report a case series of oral mucosal melanomas (OMMs) and provide a review of the literature with regard to ... ...

Abstract	Background: Primary mucosal melanoma of the oral cavity is a highly aggressive malignancy of melanocytic origin. The aim of this study is to report a case series of oral mucosal melanomas (OMMs) and provide a review of the literature with regard to treatment guidelines for and prognosis of this pathologic entity. Study design: We report three cases of OMMs treated in our institutions and the results of a literature review, in which the words "oral" and "mucosal melanoma" were used as the main keywords. Results: Surgical resection of the primary tumor with wide resection margins appears to be the recommended primary treatment modality with the aim to achieve tumor-free margins. Elective neck dissection and adjuvant radiotherapy have been advocated for locoregional control. Chemotherapy has not been shown to improve survival and is mainly used for palliative purposes. Immunotherapy and biochemotherapy seem to significantly improve survival and could open new therapeutic horizons. Conclusions: The prognosis of OMMs remains poor despite treatment. Early diagnosis and aggressive surgical resection followed by adjuvant therapies could be the key to improving survival. Multicenter randomized clinical trials, which may be difficult to conduct because of the rarity to the lesion, would aid in the development of new strategies.
MeSH term(s)	Aged ; Combined Modality Therapy ; Diagnosis, Differential ; Fatal Outcome ; Female ; Humans ; Male ; Melanoma/diagnosis ; Melanoma/pathology ; Melanoma/therapy ; Middle Aged ; Mouth Mucosa/pathology ; Mouth Neoplasms/diagnosis ; Mouth Neoplasms/pathology ; Mouth Neoplasms/therapy ; Prognosis
Language	English
Publishing date	2016-07
Publishing country	United States
Document type	Case Reports ; Journal Article ; Review
ZDB-ID	2650843-6
ISSN	2212-4411 ; 2212-4403
ISSN (online)	2212-4411
ISSN	2212-4403
DOI	10.1016/j.oooo.2016.01.005
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