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  1. Article ; Online: Severe Acute Cor Pulmonale in Patients with COVID-19 Acute Respiratory Distress Syndrome: Caution with Left Turn.

    Evrard, Bruno / Goudelin, Marine / Vaidie, Julien / Fedou, Anne-Laure / Vignon, Philippe

    American journal of respiratory and critical care medicine

    2022  Volume 205, Issue 8, Page(s) 961–964

    MeSH term(s) COVID-19/complications ; Heart Failure ; Humans ; Hypertension, Pulmonary ; Pulmonary Heart Disease/etiology ; Respiratory Distress Syndrome/etiology ; Respiratory Distress Syndrome/therapy
    Language English
    Publishing date 2022-02-23
    Publishing country United States
    Document type Letter
    ZDB-ID 1180953-x
    ISSN 1535-4970 ; 0003-0805 ; 1073-449X
    ISSN (online) 1535-4970
    ISSN 0003-0805 ; 1073-449X
    DOI 10.1164/rccm.202107-1568LE
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Uh II Zs.80: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Long-term immunosuppressive treatment is not associated with worse outcome in patients hospitalized in the intensive care unit for septic shock: the PACIFIC study.

    Vaidie, Julien / Peju, Edwige / Jandeaux, Louise-Marie / Lesouhaitier, Mathieu / Lacherade, Jean-Claude / Guillon, Antoine / Wittebole, Xavier / Asfar, Pierre / Evrard, Bruno / Daix, Thomas / Vignon, Philippe / François, Bruno

    Critical care (London, England)

    2023  Volume 27, Issue 1, Page(s) 340

    Abstract: Background: Except in a few retrospective studies mainly including patients under chemotherapy, information regarding the impact of immunosuppressive therapy on the prognosis of patients admitted to the intensive care unit (ICU) for septic shock is ... ...

    Abstract Background: Except in a few retrospective studies mainly including patients under chemotherapy, information regarding the impact of immunosuppressive therapy on the prognosis of patients admitted to the intensive care unit (ICU) for septic shock is scarce. Accordingly, the PACIFIC study aimed to asses if immunosuppressive therapy is associated with an increased mortality in patients admitted to the ICU for septic shock.
    Methods: This was a retrospective epidemiological multicentre study. Eight high enroller centres in septic shock randomised controlled trials (RCTs) participated in the study. Patients in the "exposed" group were selected from the screen failure logs of seven recent RCTs and excluded because of immunosuppressive treatment. The "non-exposed" patients were those included in the placebo arm of the same RCTs. A multivariate logistic regression model was used to estimate the risk of death.
    Results: Among the 433 patients enrolled, 103 were included in the "exposed" group and 330 in the "non-exposed" group. Reason for immunosuppressive therapy included organ transplantation (n = 45 [44%]) or systemic disease (n = 58 [56%]). ICU mortality rate was 24% in the "exposed" group and 25% in the "non-exposed" group (p = 0.9). Neither in univariate nor in multivariate analysis immunosuppressive therapy was associated with a higher ICU mortality (OR: 0.95; [95% CI 0.56-1.58]: p =  0.86 and 1.13 [95% CI 0.61-2.05]: p =  0.69, respectively) or 3-month mortality (OR: 1.13; [95% CI 0.69-1.82]: p =  0.62 and OR: 1.36 [95% CI 0.78-2.37]: p =  0.28, respectively).
    Conclusions: In this study, long-term immunosuppressive therapy excluding chemotherapy was not associated with significantly higher or lower ICU and 3-month mortality in patients admitted to the ICU for septic shock.
    MeSH term(s) Humans ; Shock, Septic/drug therapy ; Immunosuppressive Agents/therapeutic use ; Long-Term Care ; Immunosuppression Therapy ; Intensive Care Units
    Chemical Substances Immunosuppressive Agents
    Language English
    Publishing date 2023-09-02
    Publishing country England
    Document type Multicenter Study ; Journal Article
    ZDB-ID 2041406-7
    ISSN 1466-609X ; 1364-8535
    ISSN (online) 1466-609X
    ISSN 1364-8535
    DOI 10.1186/s13054-023-04626-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5517: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  3. Article ; Online: Population pharmacokinetics and Bayesian estimators for intravenous mycophenolate mofetil in haematopoietic stem cell transplant patients.

    Labriffe, Marc / Vaidie, Julien / Monchaud, Caroline / Debord, Jean / Turlure, Pascal / Girault, Stephane / Marquet, Pierre / Woillard, Jean-Baptiste

    British journal of clinical pharmacology

    2020  Volume 86, Issue 8, Page(s) 1550–1559

    Abstract: Aims: Intravenous mycophenolate mofetil (IV MMF), a prodrug of mycophenolic acid (MPA), is used during nonmyeloablative and reduced-intensity conditioning haematopoetic stem cell transplantation (HCT) to improve engraftment and reduce graft-versus-host ... ...

    Abstract Aims: Intravenous mycophenolate mofetil (IV MMF), a prodrug of mycophenolic acid (MPA), is used during nonmyeloablative and reduced-intensity conditioning haematopoetic stem cell transplantation (HCT) to improve engraftment and reduce graft-versus-host disease. The aims of this study were to develop population pharmacokinetic models and Bayesian estimators based on limited sampling strategies to allow for individual dose adjustment of intravenous mycophenolate mofetil administered by infusion in haematopoietic stem cell transplant patients.
    Methods: Sixty-three MPA concentration-time profiles (median [min-max] = 6 [4-7] samples) were collected from 34 HCT recipients transplanted for 14 (1-45) days and administered IV MMF every 8 hours, concomitantly with cyclosporine. The database was split into development (75%) and validation (25%) datasets. Pharmacokinetic models characterized by a single compartment with first-order elimination, combined with two gamma distributions to describe the transformation of MMF into mycophenolic acid, were developed using in parallel nonparametric (Pmetrics) and parametric (ITSIM) approaches. The performances of the models and the derived Bayesian estimators were evaluated in the validation set.
    Results: The best limited sampling strategy led to a bias (min, max), root mean square error between observed and modeled interdose areas under the curve in the validation dataset of -11.72% (-31.08%, 5.00%), 14.9% for ITSIM and -2.21% (-23.40%, 30.01%), 12.4% for Pmetrics with three samples collected at 0.33, 2 and 3 hours post dosing.
    Conclusion: Population pharmacokinetic models and Bayesian estimators for IV MMF in HCT have been developed and are now available online (https://pharmaco.chu-limoges.fr) for individual dose adjustment based on the interdose area under the curve.
    MeSH term(s) Area Under Curve ; Bayes Theorem ; Female ; Hematopoietic Stem Cell Transplantation ; Humans ; Immunosuppressive Agents ; Male ; Mycophenolic Acid
    Chemical Substances Immunosuppressive Agents ; Mycophenolic Acid (HU9DX48N0T)
    Language English
    Publishing date 2020-02-28
    Publishing country England
    Document type Journal Article
    ZDB-ID 188974-6
    ISSN 1365-2125 ; 0306-5251 ; 0264-3774
    ISSN (online) 1365-2125
    ISSN 0306-5251 ; 0264-3774
    DOI 10.1111/bcp.14261
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1118: Show issues Location:
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  4. Article ; Online: Characteristics and outcome of adults with severe autoimmune hemolytic anemia admitted to the intensive care unit: Results from a large French observational study.

    Pouchelon, Clara / Lafont, Charlotte / Lafarge, Antoine / Comont, Thibault / Riviere, Etienne / Boutboul, David / Fieschi, Claire / Dossier, Antoine / Audia, Sylvain / Vaidie, Julien / Ruivard, Marc / Gobert, Delphine / Bonnard, Guillaume / Graveleau, Julie / Mahevas, Matthieu / Godeau, Bertrand / Michel, Marc

    American journal of hematology

    2022  Volume 97, Issue 10, Page(s) E371–E373

    MeSH term(s) Adult ; Anemia, Hemolytic ; Anemia, Hemolytic, Autoimmune/therapy ; Hospitalization ; Humans ; Intensive Care Units
    Language English
    Publishing date 2022-08-02
    Publishing country United States
    Document type Letter ; Observational Study
    ZDB-ID 196767-8
    ISSN 1096-8652 ; 0361-8609
    ISSN (online) 1096-8652
    ISSN 0361-8609
    DOI 10.1002/ajh.26665
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1251: Show issues Location:
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  5. Article ; Online: Flow cytometry detection of CD138 expression continuum between monotypic B and plasma cells is associated with both high IgM peak levels and MYD88 mutation and contributes to diagnosis of Waldenström macroglobulinemia.

    Gayet, Mylene / Leymarie, Vincent / Derouault, Paco / Guérin, Estelle / Vaidié, Julien / Pascal, Virginie / Boulin, Mélanie / Dmytruk, Nataliya / Chauzeix, Jasmine / Trimoreau, Franck / Gachard, Nathalie / Feuillard, Jean / Rizzo, David

    Cytometry. Part B, Clinical cytometry

    2021  Volume 102, Issue 1, Page(s) 62–69

    Abstract: Background: Differential diagnosis of Waldenström macroglobulinemia (WM) with other indolent B-cell malignancies is still a challenge. Here, we propose an original and simple analysis of routine flow cytometry (FCM) unraveling the characteristic ongoing ...

    Abstract Background: Differential diagnosis of Waldenström macroglobulinemia (WM) with other indolent B-cell malignancies is still a challenge. Here, we propose an original and simple analysis of routine flow cytometry (FCM) unraveling the characteristic ongoing plasma cell (PC) differentiation of WM tumor B-cells.
    Methods: FCM analysis of both B-cells and PC was performed on a series of 77 patients with IgM peak. MYD88 and CXCR4 mutations were studied using an allele-specific PCR and by high throughput sequencing.
    Results: Twenty seven (35%), 46 (58%) and 4 (5%) patients were classified as WM, IgM monoclonal gammopathy of undetermined significance (MGUS) or other B-NHL respectively. MYD88 mutation was found in 25/27 WM (93%) and in 29/46 MGUS (63%). Using FCM, monotypic B-cells were found in 27/27 WM (100%) and 34/46 MGUS (74%). Monotypic CD138pos/CD38pos PCs were detected in 23/27 WM (85%) and 25/46 MGUS (54%). Highlighting the ongoing PC differentiation of WM tumor B-cells by FCM, we evidenced a CD138 expression continuum between monotypic B-cells and PCs. This pattern remained absent in control samples and was significantly associated with higher IgM peaks (p = 6.10
    Conclusions: FCM exploration of both B-cells and PC led to identify a CD138 expression continuum as an objective marker of ongoing PC differentiation of WM tumor cells and was strongly associated with increased IgM peak levels and MYD88 mutations. This approach could contribute to place FCM at the forefront of WM diagnosis.
    MeSH term(s) Flow Cytometry ; Humans ; Immunoglobulin M/genetics ; Mutation/genetics ; Myeloid Differentiation Factor 88/genetics ; Plasma Cells/pathology ; Syndecan-1/genetics ; Waldenstrom Macroglobulinemia/diagnosis ; Waldenstrom Macroglobulinemia/genetics
    Chemical Substances Immunoglobulin M ; MYD88 protein, human ; Myeloid Differentiation Factor 88 ; SDC1 protein, human ; Syndecan-1
    Language English
    Publishing date 2021-02-25
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2099657-3
    ISSN 1552-4957 ; 1552-4949 ; 0196-4763
    ISSN (online) 1552-4957
    ISSN 1552-4949 ; 0196-4763
    DOI 10.1002/cyto.b.21995
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1688: Show issues Location:
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