LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Your last searches

  1. AU="Vaisman, Adva"
  2. AU="Rádiková, Žofia"
  3. AU=Poulin Stphane P.

Search results

Result 1 - 2 of total 2

Search options

  1. Article ; Online: Mortality prediction upon hospital admission - the value of clinical assessment: A retrospective, matched cohort study.

    Glick, Noam / Vaisman, Adva / Negru, Liat / Segal, Gad / Itelman, Eduard

    Medicine

    2022  Volume 101, Issue 39, Page(s) e30917

    Abstract: Accurate prediction of mortality upon hospital admission is of great value, both for the sake of patients and appropriate resources' allocation. A myriad of assessment tools exists for this purpose. The evidence relating to the comparative value of ... ...

    Abstract Accurate prediction of mortality upon hospital admission is of great value, both for the sake of patients and appropriate resources' allocation. A myriad of assessment tools exists for this purpose. The evidence relating to the comparative value of clinical assessment versus established indexes are scarce. We analyzed the accuracy of a senior physician's clinical assessment in a retrospective cohort of patients in a crude, general patients' population and later on a propensity matched patients' population. In one department of internal medicine in a tertiary hospital, of 9891 admitted patients, 973 (10%) were categorized as prone to death in a 6-months' duration by a senior physician. The risk of death was significantly higher for these patients [73.1% vs 14.1% mortality within 180 days; hazard ratio (HR) = 7.58; confidence intervals (CI) 7.02-8.19, P < .001]. After accounting for multiple, other patients' variables associated with increased risk of mortality, the correlation remained significant (HR = 3.25; CI 2.85-3.71, P < .001). We further performed a propensity matching analysis (a subgroup of 710 patients, subdivided to two groups with 355 patients each): survival rates were as low as 45% for patients categorized as prone to death compared to 78% in patients who weren't categorized as such (P < .001). Reliance on clinical evaluation, done by an experienced senior physician, is an appropriate tool for mortality prediction upon hospital admission, achieving high accuracy rates.
    MeSH term(s) Cohort Studies ; Hospital Mortality ; Hospitalization ; Hospitals ; Humans ; Proportional Hazards Models ; Retrospective Studies
    Language English
    Publishing date 2022-09-30
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80184-7
    ISSN 1536-5964 ; 0025-7974
    ISSN (online) 1536-5964
    ISSN 0025-7974
    DOI 10.1097/MD.0000000000030917
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  2. Article ; Online: Hospitalized patients with positive antiphospholipid antibodies who have low complement levels are at increased risk for death-a retrospective cohort study.

    Itelman, Edward / Perelman, Maxim / Bivar, Natali / Kent, Daniella / Vaisman, Adva / Segal, Gad / Negru, Liat / Dagan, Amir

    Lupus

    2023  Volume 32, Issue 5, Page(s) 668–674

    Abstract: Purpose: To investigate whether low complement levels can predict worse outcomes in patients hospitalized with positive anti-phospholipid antibodies.: Methods: This was a retrospective cohort study. We obtained demographics, laboratory, and ... ...

    Abstract Purpose: To investigate whether low complement levels can predict worse outcomes in patients hospitalized with positive anti-phospholipid antibodies.
    Methods: This was a retrospective cohort study. We obtained demographics, laboratory, and prognostic data of all consecutive patients hospitalized between 2007 and 2021, for whatever reason, with at least one positively abnormal anti-phospholipid antibody, who were also tested for complement levels (C3 or C4). We then compared the rates of long-term mortality, 1-year mortality, deep vein thrombosis, and pulmonary emboli between groups of low complement and normal complement levels. Multivariate analysis was used to control for levels of clinical and laboratory confounders.
    Results: We identified 32,286 patients tested for anti-phospholipid antibodies. Of those patients, 6800 tested positive for at least one anti-phospholipid antibody and had a documented complement level. Significant higher mortality rates were found in the low complement group, with an odds ratio for mortality (OR 1.93 CI 1.63-2.27
    Conclusions: Our study results indicate that low complement is associated with significantly higher mortality rates in admitted patients with elevated levels of anti-phospholipid antibodies. This finding correlates with recent literature suggesting a vital role for complement activation in anti-phospholipid syndrome.
    MeSH term(s) Humans ; Retrospective Studies ; Lupus Erythematosus, Systemic/complications ; Antibodies, Antiphospholipid ; Antiphospholipid Syndrome/complications ; Complement System Proteins ; Venous Thrombosis/etiology
    Chemical Substances Antibodies, Antiphospholipid ; Complement System Proteins (9007-36-7)
    Language English
    Publishing date 2023-03-23
    Publishing country England
    Document type Journal Article
    ZDB-ID 1154407-7
    ISSN 1477-0962 ; 0961-2033
    ISSN (online) 1477-0962
    ISSN 0961-2033
    DOI 10.1177/09612033231164091
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

To top