Article: Copper(I/II)-Promoted Diverse Imidazo[1,2-α]pyridine Synthesis on Solid-Phase Bound DNA Oligonucleotides for Encoded Library Design
Organic letters. 2021 June 28, v. 23, no. 14
2021
Abstract: DNA-encoded libraries designed around heterocyclic scaffolds have proven highly productive in target-based screening. Here, we show the synthesis of imidazopyridines on a controlled pore glass-coupled DNA oligonucleotide for solid phase-initiated encoded ...
| Abstract | DNA-encoded libraries designed around heterocyclic scaffolds have proven highly productive in target-based screening. Here, we show the synthesis of imidazopyridines on a controlled pore glass-coupled DNA oligonucleotide for solid phase-initiated encoded library synthesis. The target compounds were synthesized by a variant of the A3 coupling reaction from aminopyridines, alkynes, and aldehydes promoted by copper(I/II) and furnished diverse substituted scaffolds with functionalities for library design. Although proceeding under forcing conditions, it produced minimal DNA damage. |
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| Keywords | DNA ; DNA damage ; alkynes ; copper ; oligonucleotides ; pyridines |
| Language | English |
| Dates of publication | 2021-0628 |
| Size | p. 5480-5484. |
| Publishing place | American Chemical Society |
| Document type | Article |
| ISSN | 1523-7052 |
| DOI | 10.1021/acs.orglett.1c01834 |
| Database | NAL-Catalogue (AGRICOLA) |
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