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Article ; Online: The Challenge of Diagnosing COPD in Individuals Who Have Never Smoked.

Rodríguez-García, Carlota / Candal-Pedreira, Cristina / Pérez-Ríos, Mónica / Ruano-Ravina, Alberto / Valdés-Cuadrado, Luis

Chest

2023 Volume 164, Issue 4, Page(s) 835–836

MeSH term(s)	Humans ; Smoke ; Pulmonary Disease, Chronic Obstructive/diagnosis ; Pulmonary Disease, Chronic Obstructive/epidemiology ; Smoking/adverse effects ; Smoking/epidemiology ; Nicotiana ; Risk Factors
Chemical Substances	Smoke
Language	English
Publishing date	2023-09-30
Publishing country	United States
Document type	Editorial
ZDB-ID	1032552-9
ISSN	1931-3543 ; 0012-3692
ISSN (online)	1931-3543
ISSN	0012-3692
DOI	10.1016/j.chest.2023.05.011
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Article ; Online: Factors Related with Hospital Attendance and Mortality in Patients with COPD: A Case-Control Study in a Real-Life Setting.

López-Pardo, María Estrella / Candal-Pedreira, Cristina / Valdés-Cuadrado, Luis / Represas-Represas, Cristina / Ruano-Ravina, Alberto / Pérez-Ríos, Mónica

International journal of chronic obstructive pulmonary disease

2022 Volume 17, Page(s) 809–819

Abstract: Introduction: The rising trend in hospital admissions among patients with chronic obstructive pulmonary disease (COPD) is worrying, not only because of the increasing costs, but also because of the worsening quality of life. We aimed to identify the ... ...

Abstract	Introduction: The rising trend in hospital admissions among patients with chronic obstructive pulmonary disease (COPD) is worrying, not only because of the increasing costs, but also because of the worsening quality of life. We aimed to identify the predictive factors of hospital admission, re-admission and mortality of COPD patients through using information exclusively registered in electronic clinical records. Methods: We conducted a population-based case-control study. All data were sourced from the different information systems comprising the Galician Health Service electronic record database. We included in the study patients diagnosed with COPD (code R95 in the medical record), ≥35 years old and with at least one spirometry performed ≤3 years prior inclusion. We fitted three logistic regression models, each one to ascertain the factors that influence the probability of admission, re-admission, and mortality, and calculated odds ratios (OR) with their 95% confidence intervals (95% CI). Results: COPD patients were admitted due to respiratory causes a mean of 1.51 times across the period December 2016-December 2017, with 55% requiring re-admission in the next 90 days. The factor most closely associated with the re-admission profile was home oxygen therapy (OR 3.06 95% CI 2.42-3.87), followed by male gender (OR 2.01 95% CI 1.48-2.72), a CHA2D-VASc scale score >2 (OR 1.28 95% CI 1.16-1.42), and severity by clinical risk group stratification (OR 1.14 95% CI 1.04-1.26). Male sex (OR 1.47 CI 95% 1.04-2.09), having been readmitted ≥2 times (OR 1.34 CI 95% 1.11-1.61) and being ≥70 years old (OR 1.05 CI 95% 1.03-1.08) increase the probability of dying from COPD during the study period. Conclusion: These results confirm the complexity of management of COPD exacerbations, and indicate the need to establish strategies that would ensure continuity of care after hospital admission, with the aim of preventing re-admissions and death.
MeSH term(s)	Adult ; Aged ; Case-Control Studies ; Hospitalization ; Hospitals ; Humans ; Male ; Pulmonary Disease, Chronic Obstructive/drug therapy ; Pulmonary Disease, Chronic Obstructive/therapy ; Quality of Life
Language	English
Publishing date	2022-04-14
Publishing country	New Zealand
Document type	Journal Article
ZDB-ID	2212419-6
ISSN	1178-2005 ; 1176-9106
ISSN (online)	1178-2005
ISSN	1176-9106
DOI	10.2147/COPD.S355236
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Article ; Online: Factors Linked to Frequent Attendance in the Out-of-hospital Setting by Patients With Chronic Obstructive Pulmonary Disease.

López-Pardo, María Estrella / Candal-Pedreira, Cristina / Valdés-Cuadrado, Luis / Represas-Represas, Cristina / Ruano-Ravina, Alberto / Pérez-Ríos, Mónica

Archivos de bronconeumologia

2022 Volume 59, Issue 2, Page(s) 119–122

MeSH term(s)	Humans ; Pulmonary Disease, Chronic Obstructive/epidemiology ; Pulmonary Disease, Chronic Obstructive/therapy ; Hospitals
Language	Spanish
Publishing date	2022-08-13
Publishing country	Spain
Document type	Case Reports
ZDB-ID	733126-5
ISSN	1579-2129 ; 0300-2896
ISSN (online)	1579-2129
ISSN	0300-2896
DOI	10.1016/j.arbres.2022.08.001
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Article ; Online: Effect of an intensive tobacco cessation program on the smoker narrative: A content analysis and grounded theory.

Rábade-Castedo, Carlos / Zamarrón-Sanz, Carlos / Hermida-Ameijeiras, Álvaro / Abelleira-Paris, Romina / Casal-Mouriño, Ana / Ferreiro-Fernández, Lucia / Rodríguez-Núñez, Nuria / Ricoy-Gabaldón, Jorge / Toubes-Navarro, María Elena / Álvarez-Dobaño, José Manuel / Valdés-Cuadrado, Luis

Tobacco induced diseases

2024 Volume 22

Abstract: Introduction: The smoker's narrative during smoking quitting provides insight into aspects not fully explored in daily clinical practice. The aim of the study was to analyze the smoker narrative using two types of methodologies: content analysis and ... ...

Abstract	Introduction: The smoker's narrative during smoking quitting provides insight into aspects not fully explored in daily clinical practice. The aim of the study was to analyze the smoker narrative using two types of methodologies: content analysis and grounded theory, before and after smoking cessation intervention, provided to the smoker in a specialized Smoking Cessation Unit accredited by the Spanish Society of Pneumology and Thoracic Surgery. Methods: A prospective observational study of current smokers included in a tobacco cessation program between 2017 and 2020 was conducted at the Smoking Cessation Unit of Santiago de Compostela Health Area, Spain. Routine clinical variables and patient narrative data were collected. A descriptive analysis of the sample, the content of the textual corpus, and a grounded theory were performed in semi-structured interviews at baseline and at follow-up at 6 months. Results: A total of 116 patients were included (mean age 55.6 ± 10.6 years; 56.9% male; mean nicotine dependence score 5.7 ± 1.6). Quantitative analysis of the narrative shows that the most frequent phrases and words are associated with smoking, nicotine craving, and predisposition for smoking cessation. After the intervention, phrases related to the manifestation of abstinence, response to pharmacological treatment, and self-perception of smoking cessation were predominant. In the qualitative analysis, the most frequent categories in the smoker's textual corpus were dependence, motivation, and emotionality, which decreased after the intervention (11.4%, 21.4%, and 9.9%, respectively) accompanied by increased satisfaction (19.2%) and the manifestation of abstinence (21.5%). Conclusions: Motivation, nicotine dependence, and sensitivity to emotions are all closely intertwined in the current smoker narrative and can be modified as a consequence of treatment.
Language	English
Publishing date	2024-02-15
Publishing country	Greece
Document type	Journal Article
ZDB-ID	2194616-4
ISSN	1617-9625 ; 1617-9625
ISSN (online)	1617-9625
ISSN	1617-9625
DOI	10.18332/tid/183607
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Article ; Online: Clinical characteristics of chronic obstructive pulmonary disease in never-smokers: A systematic review.

Rodríguez García, Carlota / Ruano-Ravina, Alberto / Pérez Ríos, Mónica / Martín Gisbert, Lucía / Varela-Lema, Leonor / Candal-Pedreira, Cristina / Represas-Represas, Cristina / Rey-Brandariz, Julia / Valdés-Cuadrado, Luis / Agustí, Alvar

Respiratory medicine

2023 Volume 214, Page(s) 107284

Abstract: Introduction: Chronic Obstructive Pulmonary Disease (COPD) is the third cause of death worldwide. While tobacco smoking is a key risk factor, COPD also occurs in never-smokers (NS). However, available evidence on risk factors, clinical characteristics, ... ...

Abstract	Introduction: Chronic Obstructive Pulmonary Disease (COPD) is the third cause of death worldwide. While tobacco smoking is a key risk factor, COPD also occurs in never-smokers (NS). However, available evidence on risk factors, clinical characteristics, and natural history of the disease in NS is scarce. Here, we perform a systematic review of the literature to better describe the characteristics of COPD in NS. Methods: We searched different databases following the PRISMA guidelines with explicit inclusion and exclusion criteria. A purpose-designed quality scale was applied to the studies included in the analysis. It was not possible to pool the results due to the high heterogeneity of the studies included. Results: A total of 17 studies that met the selection criteria were included, albeit only 2 of them studied NS exclusively. The total number of participants in these studies were 57,146 subjects, 25,047 of whom were NS and 2,655 of the latter had NS-COPD. Compared to COPD in smokers, COPD in NS is more frequent in women and older ages, and is associated with a slightly higher prevalence of comorbidities. There are not enough studies to understand if COPD progression and clinical symptoms in NS are different to that of ever-smokers. Conclusions: There is a significant knowledge gap on COPD in NS. Given that COPD in NS account for about a third of all COPD patients in the world, particularly in low-middle income countries, and the decrease in tobacco consumption in high income countries, understanding COPD in NS constitutes a public-health priority.
MeSH term(s)	Humans ; Female ; Smokers ; Pulmonary Disease, Chronic Obstructive/epidemiology ; Risk Factors ; Tobacco Smoking ; Comorbidity
Language	English
Publishing date	2023-05-19
Publishing country	England
Document type	Systematic Review ; Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	1003348-8
ISSN	1532-3064 ; 0954-6111
ISSN (online)	1532-3064
ISSN	0954-6111
DOI	10.1016/j.rmed.2023.107284
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Article ; Online: Diagnosis and Treatment of Pleural Effusion. Recommendations of the Spanish Society of Pulmonology and Thoracic Surgery. Update 2022.

Botana Rial, Maribel / Pérez Pallarés, Javier / Cases Viedma, Enrique / López González, Francisco Julián / Porcel, José Manuel / Rodríguez, María / Romero Romero, Beatriz / Valdés Cuadrado, Luis / Villena Garrido, Victoria / Cordovilla Pérez, Rosa

Archivos de bronconeumologia

2022

Abstract: Pleural effusion (PE) is a common yet complex disease that requires specialized, multidisciplinary management. Recent advances, novel diagnostic techniques, and innovative patient-centered therapeutic proposals have prompted an update of the current ... ...

Abstract	Pleural effusion (PE) is a common yet complex disease that requires specialized, multidisciplinary management. Recent advances, novel diagnostic techniques, and innovative patient-centered therapeutic proposals have prompted an update of the current guidelines. This document provides recommendations and protocols based on a critical review of the literature on the epidemiology, etiology, diagnosis, prognosis, and new therapeutic options in PE, and addresses some cost-effectiveness issues related to the main types of PE.
Language	Spanish
Publishing date	2022-09-30
Publishing country	Spain
Document type	Practice Guideline
ZDB-ID	733126-5
ISSN	1579-2129 ; 0300-2896
ISSN (online)	1579-2129
ISSN	0300-2896
DOI	10.1016/j.arbres.2022.09.017
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Article: A pulmonary rehabilitation program reduces hospitalizations in chronic obstructive pulmonary disease patients: A cost-effectiveness study.

Toubes-Navarro, Maria Elena / Gude-Sampedro, Francisco / Álvarez-Dobaño, José Manuel / Reyes-Santias, Francisco / Rábade-Castedo, Carlos / Rodríguez-García, Carlota / Lado-Baleato, Óscar / Lago-Fidalgo, Raquel / Sánchez-Martínez, Noelia / Ricoy-Gabaldón, Jorge / Casal-Mouriño, Ana / Abelleira-Paris, Romina / Riveiro-Blanco, Vanessa / Zamarrón-Sanz, Carlos / Rodríguez-Núñez, Nuria / Lama-López, Adriana / Ferreiro-Fernández, Lucía / Valdés-Cuadrado, Luis

Annals of thoracic medicine

2023 Volume 18, Issue 4, Page(s) 190–198

Abstract: Background: Although pulmonary rehabilitation (PR) is recommended in patients with chronic obstructive pulmonary disease (COPD), there is a scarcity of data demonstrating the cost-effectiveness and effectiveness of PR in reducing exacerbations.: ... ...

Abstract	Background: Although pulmonary rehabilitation (PR) is recommended in patients with chronic obstructive pulmonary disease (COPD), there is a scarcity of data demonstrating the cost-effectiveness and effectiveness of PR in reducing exacerbations. Methods: A quasi-experimental study in 200 patients with COPD was conducted to determine the number of exacerbations 1 year before and after their participation in a PR program. Quality of life was measured using the COPD assessment test and EuroQol-5D. The costs of the program and exacerbations were assessed the year before and after participation in the PR program. The incremental cost-effectiveness ratio (ICER) was estimated in terms of quality-adjusted life years (QALYs). Results: The number of admissions, length of hospital stay, and admissions to the emergency department decreased after participation in the PR program by 48.2%, 46.6%, and 42.5%, respectively ( Conclusions: PR contributes to reducing the number of exacerbations in patients with COPD, thereby slowing clinical deterioration. In addition, it is cost-effective in terms of QALYs.
Language	English
Publishing date	2023-10-17
Publishing country	India
Document type	Journal Article
ZDB-ID	2241287-6
ISSN	1998-3557 ; 1817-1737
ISSN (online)	1998-3557
ISSN	1817-1737
DOI	10.4103/atm.atm_70_23
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Article ; Online: Residential radon and characteristics of chronic obstructive pulmonary disease.

Pando-Sandoval, Ana / Ruano-Ravina, Alberto / Torres-Durán, María / Dacal-Quintas, Raquel / Valdés-Cuadrado, Luis / Hernández-Hernández, Jesús R / Consuegra-Vanegas, Angélica / Candal-Pedreira, Cristina / Varela-Lema, Leonor / Fernández-Villar, Alberto / Pérez-Ríos, Mónica

Scientific reports

2022 Volume 12, Issue 1, Page(s) 1381

Abstract: It is not known whether residential radon exposure may be linked to the development of chronic obstructive pulmonary disease (COPD) and/or have an influence on the functional characteristics or exacerbations of COPD. The aim of this study was therefore ... ...

Abstract	It is not known whether residential radon exposure may be linked to the development of chronic obstructive pulmonary disease (COPD) and/or have an influence on the functional characteristics or exacerbations of COPD. The aim of this study was therefore to ascertain whether there might be an association between residential radon concentrations and certain characteristics of COPD. We analyzed COPD cases drawn from a case-control study conducted in an area of high radon exposure. Data were collected on spirometric pulmonary function variables, hospital admissions, and smoking. Radon measurements were taken using alpha-track-type CR-39 detectors individually placed in patients' homes. All statistical analyses were performed using the IBM SPSS v22 computer software program. The study included 189 COPD cases (79.4% men; median age 64 years). The median radon concentration was 157 Bq/m
MeSH term(s)	Aged ; Aged, 80 and over ; Air Pollution, Indoor/analysis ; Case-Control Studies ; Environmental Exposure/analysis ; Female ; Housing ; Housing Quality ; Humans ; Male ; Middle Aged ; Patient Admission ; Pulmonary Disease, Chronic Obstructive/diagnosis ; Pulmonary Disease, Chronic Obstructive/physiopathology ; Radon/analysis ; Respiratory Function Tests ; Risk Factors ; Smoking
Chemical Substances	Radon (Q74S4N8N1G)
Language	English
Publishing date	2022-01-26
Publishing country	England
Document type	Journal Article ; Multicenter Study ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-022-05421-6
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Article ; Online: Efectividad de los programas de cesación tabáquica en fumadores de tabaco de liar en Galicia.

Rábade Castedo, Carlos / Pou Álvarez, Cristina / Hermida Ameijeiras, Álvaro / Zamarrón Sanz, Carlos / Estany Gestal, Ana / Ferreiro Fernández, Lucia / Toubes Navarro, María Elena / Rodríguez Núñez, Nuria / Lama López, Adriana / Valdés Cuadrado, Luis

Revista espanola de salud publica

2021 Volume 95

Abstract: Objective: Currently in developed countries there is an increase in the consumption of roll your own tobacco, which is associated with a higher proportion of users of this form of tobacco who wish to make an attempt to quit. The objective of this study ... ...

Title translation	Effectiveness of smoking cessation programs of roll-your-own tobacco smokers in Galicia.
Abstract	Objective: Currently in developed countries there is an increase in the consumption of roll your own tobacco, which is associated with a higher proportion of users of this form of tobacco who wish to make an attempt to quit. The objective of this study was to analyze the effectiveness of tobacco cessation interventions based on the type of tobacco consumed. Methods: Longitudinal study of a cohort of 641 smokers recruited between 2015 and 2018 in a health area of Galicia included in smoking cessation programs, based on psychological counseling and pharmacological treatment. The characteristics and success of the intervention were evaluated in two groups: roll your own tobacco smokers (RYO) and manufactured tobacco smokers (MT). A logistic regression was performed to determine the probability of success in smoking cessation. The risk measure was the odds ratio (OR) with its 95% confidence interval. Results: RYO users started at a younger age and had a lower sociocultural stratum than MT users. Interventions to quit smoking in RYO users were associated with less abstinence at 4 weeks (52% MT vs 38% LT) (OR: 0.5; 95% CI 0.35-0.99; p=0.045;) and at 3 months (42% TM vs 30% TL) (OR:0.6; 95% CI 0.33-0.98; p=0.04). Conclusions: Smoking cessation programs are less effective in short-term RYO users. There are no differences in long-term abstinence between the two groups.
MeSH term(s)	Humans ; Longitudinal Studies ; Smokers ; Smoking Cessation ; Spain ; Tobacco Products
Language	Spanish
Publishing date	2021-11-02
Publishing country	Spain
Document type	Journal Article
ZDB-ID	1288657-9
ISSN	2173-9110 ; 0034-8899 ; 1135-5727
ISSN (online)	2173-9110
ISSN	0034-8899 ; 1135-5727
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Article: Pathophysiologic mechanisms of cardiovascular disease in obstructive sleep apnea syndrome.

Zamarrón, Carlos / Valdés Cuadrado, Luis / Alvarez-Sala, Rodolfo

Pulmonary medicine

2013 Volume 2013, Page(s) 521087

Abstract: Obstructive sleep apnea syndrome (OSAS) is a highly prevalent sleep disorder, characterized by repeated disruptions of breathing during sleep. This disease has many potential consequences including excessive daytime sleepiness, neurocognitive ... ...

Abstract	Obstructive sleep apnea syndrome (OSAS) is a highly prevalent sleep disorder, characterized by repeated disruptions of breathing during sleep. This disease has many potential consequences including excessive daytime sleepiness, neurocognitive deterioration, endocrinologic and metabolic effects, and decreased quality of life. Patients with OSAS experience repetitive episodes of hypoxia and reoxygenation during transient cessation of breathing that provoke systemic effects. Furthermore, there may be increased levels of biomarkers linked to endocrine-metabolic and cardiovascular alterations. Epidemiological studies have identified OSAS as an independent comorbid factor in cardiovascular and cerebrovascular diseases, and physiopathological links may exist with onset and progression of heart failure. In addition, OSAS is associated with other disorders and comorbidities which worsen cardiovascular consequences, such as obesity, diabetes, and metabolic syndrome. Metabolic syndrome is an emerging public health problem that represents a constellation of cardiovascular risk factors. Both OSAS and metabolic syndrome may exert negative synergistic effects on the cardiovascular system through multiple mechanisms (e.g., hypoxemia, sleep disruption, activation of the sympathetic nervous system, and inflammatory activation). It has been found that CPAP therapy for OSAS provides an objective improvement in symptoms and cardiac function, decreases cardiovascular risk, improves insulin sensitivity, and normalises biomarkers. OSAS contributes to the pathogenesis of cardiovascular disease independently and by interaction with comorbidities. The present review focuses on indirect and direct evidence regarding mechanisms implicated in cardiovascular disease among OSAS patients.
Language	English
Publishing date	2013-06-27
Publishing country	Egypt
Document type	Journal Article
ZDB-ID	2603580-7
ISSN	2090-1844 ; 2090-1836
ISSN (online)	2090-1844
ISSN	2090-1836
DOI	10.1155/2013/521087
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