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  1. Article ; Online: Liver Transplantation in Patients With Niemann-Pick Disease--Single-Center Experience.

    Coelho, G R / Praciano, A M / Rodrigues, J P C / Viana, C F G / Brandão, K P / Valenca, J T / Garcia, J H P

    Transplantation proceedings

    2015  Volume 47, Issue 10, Page(s) 2929–2931

    Abstract: Niemann-Pick disease (NPD) is a rare syndrome caused by abnormal intracellular sphingomyelin lipid storage in cells known as "Pick cells." NPD can start in childhood or develop insidiously, with a predilection for reticuloendothelial cells and the ... ...

    Abstract Niemann-Pick disease (NPD) is a rare syndrome caused by abnormal intracellular sphingomyelin lipid storage in cells known as "Pick cells." NPD can start in childhood or develop insidiously, with a predilection for reticuloendothelial cells and the nervous system. NPD is a heterogeneous clinical, and biomolecular disorder which has 6 variants. There is no curable treatment for NPD. Generally, the treatment for all types of Niemann-Pick disease is to support. Type B NPD (NPD-B) is mostly characterized by hepatosplenomegaly, which can evolve to hepatic cirrhosis. In patients who progress to liver failure, liver transplantation may be improve liver function. The Transplant Service of Hospital Universitário Walter Cantídio performed its first liver transplants in patients with NPD-B with good results, demonstrating the efficacy of this procedure in selected cases.
    MeSH term(s) Adult ; Female ; Hepatomegaly/etiology ; Hepatomegaly/surgery ; Humans ; Liver Failure/etiology ; Liver Failure/surgery ; Liver Transplantation ; Male ; Niemann-Pick Disease, Type B/complications ; Niemann-Pick Disease, Type B/surgery ; Splenomegaly/etiology ; Splenomegaly/surgery ; Treatment Outcome
    Language English
    Publishing date 2015-12
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 82046-5
    ISSN 1873-2623 ; 0041-1345
    ISSN (online) 1873-2623
    ISSN 0041-1345
    DOI 10.1016/j.transproceed.2015.10.051
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 835: Show issues Location:
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  2. Article ; Online: A Brazilian regional basic diet-induced chronic malnutrition drives liver inflammation with higher ApoA-I activity in C57BL6J mice.

    Santos, M J S / Canuto, K M / de Aquino, C C / Martins, C S / Brito, G A C / Pessoa, T M R P / Bertolini, L R / de Sá Carneiro, I / Pinto, D V / Nascimento, J C R / da Silva, B B / Valença, J T / Guedes, M I F / Owen, J S / Oriá, R B

    Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas

    2020  Volume 53, Issue 6, Page(s) e9031

    Abstract: Malnutrition is still considered endemic in many developing countries. Malnutrition-enteric infections may cause lasting deleterious effects on lipid metabolism, especially in children living in poor settings. The regional basic diet (RBD), produced to ... ...

    Abstract Malnutrition is still considered endemic in many developing countries. Malnutrition-enteric infections may cause lasting deleterious effects on lipid metabolism, especially in children living in poor settings. The regional basic diet (RBD), produced to mimic the Brazilian northeastern dietary characteristics (rich in carbohydrate and low in protein) has been used in experimental malnutrition models, but few studies have explored the effect of chronic RBD on liver function, a central organ involved in cholesterol metabolism. This study aimed to investigate whether RBD leads to liver inflammatory changes and altered reverse cholesterol metabolism in C57BL6/J mice compared to the control group, receiving a standard chow diet. To evaluate liver inflammation, ionized calcium-binding adapter protein-1 (IBA-1) positive cell counting, interleukin (IL)-1β immunohistochemistry, and tumor necrosis factor (TNF)-α and IL-10 transcription levels were analyzed. In addition, we assessed reverse cholesterol transport by measuring liver apolipoprotein (Apo)E, ApoA-I, and lecithin-cholesterol acyltransferase (LCAT) by RT-PCR. Furthermore, serum alanine aminotransferase (ALT) was measured to assess liver function. RBD markedly impaired body weight gain compared with the control group (P<0.05). Higher hepatic TNF-α (P<0.0001) and IL-10 (P=0.001) mRNA levels were found in RBD-challenged mice, although without detectable non-alcoholic fatty liver disease. Marked IBA-1 immunolabeling and increased number of positive-IBA-1 cells were found in the undernourished group. No statistical difference in serum ALT was found. There was also a significant increase in ApoA mRNA expression in the undernourished group, but not ApoE and LCAT, compared with the control. Altogether our findings suggested that chronic RBD-induced malnutrition leads to liver inflammation with increased ApoA-I activity.
    MeSH term(s) Animals ; Apolipoprotein A-I/blood ; Apolipoprotein A-I/metabolism ; Brazil ; Chronic Disease ; Diet/adverse effects ; Humans ; Inflammation/blood ; Inflammation/metabolism ; Inflammation/pathology ; Liver/metabolism ; Male ; Malnutrition/blood ; Malnutrition/metabolism ; Malnutrition/pathology ; Mice ; Mice, Inbred C57BL
    Chemical Substances Apolipoprotein A-I
    Language English
    Publishing date 2020-05-08
    Publishing country Brazil
    Document type Journal Article
    ZDB-ID 786234-9
    ISSN 1414-431X ; 0100-879X
    ISSN (online) 1414-431X
    ISSN 0100-879X
    DOI 10.1590/1414-431x20209031
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.B 1359: Show issues Location:
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  3. Article: AgNOR pattern and PCNA analysis in fine needle biopsies of liver cell carcinoma.

    Valenca, J T / Escanhoel, C A / Metze, K

    Neoplasma

    2001  Volume 48, Issue 5, Page(s) 370–373

    Abstract: The aim of this study was to evaluate the prognostic and diagnostic value of AgNOR and PCNA staining mainly in fine needle biopsies of 34 liver cell carcinomas using an image analyzing system. The AgNOR number per nucleus and the relative AgNOR area, but ...

    Abstract The aim of this study was to evaluate the prognostic and diagnostic value of AgNOR and PCNA staining mainly in fine needle biopsies of 34 liver cell carcinomas using an image analyzing system. The AgNOR number per nucleus and the relative AgNOR area, but not the PCNA index, showed a significant correlation with the histological tumor grade according to the classical and the modified Edmondson-Steiner's classification. Regarding univariate survival, only the grade of the classical Edmondson-Steiner's classification was of prognostic significance. The parameters sex, age, maximum tumor diameter, mean AgNOR number, total nuclear area and relative AgNOR area, nuclear area, PCNA index or the grade of the modified Edmondson-Steiner's classification did not reach statistical significance regarding survival. By a factor analysis, two factors could be created, which could explain together 72% of the variance of all parameters included in the study. In a linear discriminant analysis, the AgNOR variables could separate between normal liver cells and cells from high grade or low grade carcinomas in 83.7% of the cases. Therefore, we think that the AgNOR technique can be usefully applied in needle biopsies of liver carcinomas for the differential diagnosis and tumor grading.
    MeSH term(s) Adolescent ; Adult ; Aged ; Aged, 80 and over ; Carcinoma, Hepatocellular/diagnosis ; Carcinoma, Hepatocellular/metabolism ; Carcinoma, Hepatocellular/pathology ; Female ; Humans ; Image Processing, Computer-Assisted ; Liver/metabolism ; Liver Neoplasms/diagnosis ; Liver Neoplasms/metabolism ; Liver Neoplasms/pathology ; Male ; Middle Aged ; Nucleolus Organizer Region/metabolism ; Prognosis ; Proliferating Cell Nuclear Antigen/biosynthesis ; Silver Staining/methods
    Chemical Substances Proliferating Cell Nuclear Antigen
    Language English
    Publishing date 2001
    Publishing country Slovakia
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 415445-9
    ISSN 0028-2685
    ISSN 0028-2685
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 28: Show issues Location:
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  4. Article ; Online: Successful organ transplantation from donors poisoned with a carbamate insecticide.

    Garcia, J H / Coelho, G R / Marques, G A / Gadelha, J B / Vasconcelos, J B / Valença, J T / Esmeraldo, R M / Meija, J A / Leite, C A / Almeida, E R

    American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons

    2010  Volume 10, Issue 6, Page(s) 1490–1492

    Abstract: Currently, liver transplantation is the only option for patients with end-stage liver disease. In Brazil, the mortality rate on the waiting list is about 25%. Multiple strategies to expand the donor pool are being pursed, however, grafts from poisoned ... ...

    Abstract Currently, liver transplantation is the only option for patients with end-stage liver disease. In Brazil, the mortality rate on the waiting list is about 25%. Multiple strategies to expand the donor pool are being pursed, however, grafts from poisoned donors are rarely used. This report documents successful liver, kidney and heart transplantations from four female donors who suffered brain death by hypoxia despite cardiopulmonary resuscitation following Aldicarb exposure ([2-methyl-2-(methylthio)propionaldehyde O-(methylcarbamoyl)-oxime]). The success rate of 12 grafts from four donors poisoned by Aldicarb was 91% 6 months after transplantation. Poisoned patients are another pool of organ donors who at present are probably underused by transplantation services. More studies are necessary to confirm the safety for the recipients.
    MeSH term(s) Adolescent ; Adult ; Carbamates/poisoning ; Child ; Female ; Follow-Up Studies ; Heart Transplantation/methods ; Humans ; Insecticides/poisoning ; Kidney Transplantation/methods ; Liver Transplantation/methods ; Liver Transplantation/mortality ; Time Factors ; Tissue Donors/supply & distribution ; Tissue and Organ Procurement/methods ; Treatment Outcome ; Waiting Lists ; Young Adult
    Chemical Substances Carbamates ; Insecticides
    Language English
    Publishing date 2010-07-12
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 2060594-8
    ISSN 1600-6143 ; 1600-6135
    ISSN (online) 1600-6143
    ISSN 1600-6135
    DOI 10.1111/j.1600-6143.2010.03132.x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5542: Show issues Location:
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  5. Article: Gallium-67 imaging in a patient with paracoccidioidomycosis: a case report.

    Teixeira, A B / Etchebehere, E C / Lima, M C / Santos, A O / Pires, B C / Valença, J T / Ramos, C D / Camargo, E E

    Revista do Instituto de Medicina Tropical de Sao Paulo

    1999  Volume 42, Issue 3, Page(s) 167–170

    Abstract: A 26 year-old female was admitted with abdominal pain, fever and weight loss. The clinical and laboratory investigations led to the diagnosis of paracoccidioidomycosis. Gallium-67 whole body images correlated well with the clinical course of the disease ... ...

    Abstract A 26 year-old female was admitted with abdominal pain, fever and weight loss. The clinical and laboratory investigations led to the diagnosis of paracoccidioidomycosis. Gallium-67 whole body images correlated well with the clinical course of the disease and with the patient's prognosis.
    MeSH term(s) Adult ; Female ; Follow-Up Studies ; Gallium Radioisotopes ; Humans ; Paracoccidioidomycosis/diagnostic imaging ; Paracoccidioidomycosis/drug therapy ; Radionuclide Imaging
    Chemical Substances Gallium Radioisotopes
    Language English
    Publishing date 1999-04-19
    Publishing country Brazil
    Document type Case Reports ; Journal Article
    ZDB-ID 128928-7
    ISSN 1678-9946 ; 0036-4665
    ISSN (online) 1678-9946
    ISSN 0036-4665
    DOI 10.1590/s0036-46652000000300011
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 292: Show issues Location:
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  6. Article: Tumor grade heterogeneity in urothelial bladder carcinoma--proposal of a system using combined numbers.

    Billis, A / Carvalho, R B / Mattos, A C / Negretti, F / Nogueira, C R / Oliveira, M C / Valença, J T / Adam, R L / Cotta, A C / Nunes, M S / Dinamarco, P V

    Scandinavian journal of urology and nephrology

    2001  Volume 35, Issue 4, Page(s) 275–279

    Abstract: Objective: There is no consensus for grading when more than one grade is present in bladder carcinoma. We propose a grading system that considers the primary (most common) and secondary (second most common) grade of bladder cancer. Grade was correlated ... ...

    Abstract Objective: There is no consensus for grading when more than one grade is present in bladder carcinoma. We propose a grading system that considers the primary (most common) and secondary (second most common) grade of bladder cancer. Grade was correlated with stage of the tumors.
    Material and methods: We studied 293 bladder transurethral resections or radical cystectomies. Grade was considered as 1, 2 or 3 according to the 1999 World Health Organization system. The number was repeated when only one grade was seen. A final score was obtained which ranged from 2 to 6. All cases were also graded according to the highest grade area even if it was focal.
    Results: According to the highest grade area, the distribution was 80 (74.07%), 27 (25.00%) and 1 (0.92%) for grade 1; 31 (24.03%), 69 (53.48%) and 29 (22.48%) for grade 2; and 0 (0%), 17 (30.35%) and 39 (69.64%) for grade 3, corresponding to the stages Ta, T1 and T2-T3, respectively. Using the system of combined numbers, grade 2 was stratified into subgroups 1 + 2 and 2 + 2 which are statistically different (p < 0.05) when considering stage. In grade 3, there was also a trend for statistical difference (p = 0.066) between grades 2 + 3 and 3 + 3.
    Conclusions: The grading system of combined numbers, stratifies grade 2 into subgroups 1 + 2 and 2 + 2, and grade 3 into subgroups 2 + 3 and 3 + 3 which are statistically different when considering stage. This grading system of combined numbers takes into consideration tumor heterogeneity and may be of value in prospective studies for analysis of prognosis and therapeutic response.
    MeSH term(s) Carcinoma, Transitional Cell/classification ; Carcinoma, Transitional Cell/pathology ; Humans ; Neoplasm Staging ; Urinary Bladder Neoplasms/classification ; Urinary Bladder Neoplasms/pathology
    Language English
    Publishing date 2001-06-19
    Publishing country England
    Document type Journal Article
    ZDB-ID 80198-7
    ISSN 1651-2065 ; 0036-5599
    ISSN (online) 1651-2065
    ISSN 0036-5599
    DOI 10.1080/003655901750425837
    Database MEDical Literature Analysis and Retrieval System OnLINE

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