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  1. Article: Control of translation and mRNA degradation by miRNAs and siRNAs.

    Valencia-Sanchez, Marco Antonio / Liu, Jidong / Hannon, Gregory J / Parker, Roy

    Genes & development

    2006  Volume 20, Issue 5, Page(s) 515–524

    Abstract: The control of translation and mRNA degradation is an important part of the regulation of gene expression. It is now clear that small RNA molecules are common and effective modulators of gene expression in many eukaryotic cells. These small RNAs that ... ...

    Abstract The control of translation and mRNA degradation is an important part of the regulation of gene expression. It is now clear that small RNA molecules are common and effective modulators of gene expression in many eukaryotic cells. These small RNAs that control gene expression can be either endogenous or exogenous micro RNAs (miRNAs) and short interfering RNAs (siRNAs) and can affect mRNA degradation and translation, as well as chromatin structure, thereby having impacts on transcription rates. In this review, we discuss possible mechanisms by which miRNAs control translation and mRNA degradation. An emerging theme is that miRNAs, and siRNAs to some extent, target mRNAs to the general eukaryotic machinery for mRNA degradation and translation control.
    MeSH term(s) Animals ; Eukaryotic Cells/metabolism ; Gene Expression ; MicroRNAs/genetics ; MicroRNAs/metabolism ; Protein Biosynthesis ; RNA Processing, Post-Transcriptional ; RNA, Messenger/metabolism ; RNA, Small Interfering/genetics ; RNA, Small Interfering/metabolism ; Transcription, Genetic
    Chemical Substances MicroRNAs ; RNA, Messenger ; RNA, Small Interfering
    Language English
    Publishing date 2006-03-01
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 806684-x
    ISSN 1549-5477 ; 0890-9369
    ISSN (online) 1549-5477
    ISSN 0890-9369
    DOI 10.1101/gad.1399806
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2292: Show issues Location:
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  2. Article: MicroRNA-dependent localization of targeted mRNAs to mammalian P-bodies.

    Liu, Jidong / Valencia-Sanchez, Marco Antonio / Hannon, Gregory J / Parker, Roy

    Nature cell biology

    2005  Volume 7, Issue 7, Page(s) 719–723

    Abstract: Small RNAs, including small interfering RNAs (siRNAs) and microRNAs (miRNAs) can silence target genes through several different effector mechanisms. Whereas siRNA-directed mRNA cleavage is increasingly understood, the mechanisms by which miRNAs repress ... ...

    Abstract Small RNAs, including small interfering RNAs (siRNAs) and microRNAs (miRNAs) can silence target genes through several different effector mechanisms. Whereas siRNA-directed mRNA cleavage is increasingly understood, the mechanisms by which miRNAs repress protein synthesis are obscure. Recent studies have revealed the existence of specific cytoplasmic foci, referred to herein as processing bodies (P-bodies), which contain untranslated mRNAs and can serve as sites of mRNA degradation. Here we demonstrate that Argonaute proteins--the signature components of the RNA interference (RNAi) effector complex, RISC--localize to mammalian P-bodies. Moreover, reporter mRNAs that are targeted for translational repression by endogenous or exogenous miRNAs become concentrated in P-bodies in a miRNA-dependent manner. These results provide a link between miRNA function and mammalian P-bodies and suggest that translation repression by RISC delivers mRNAs to P-bodies, either as a cause or as a consequence of inhibiting protein synthesis.
    MeSH term(s) 3' Untranslated Regions/genetics ; 3' Untranslated Regions/metabolism ; Argonaute Proteins ; Caenorhabditis elegans Proteins/genetics ; Cell Line ; Cell Line, Tumor ; Cytoplasmic Structures/metabolism ; Endoribonucleases/metabolism ; Eukaryotic Initiation Factor-2 ; Gene Expression Regulation ; HeLa Cells ; Humans ; Immunoprecipitation ; MicroRNAs/genetics ; MicroRNAs/metabolism ; Microscopy, Fluorescence ; Mutation/physiology ; Peptide Initiation Factors/genetics ; Peptide Initiation Factors/metabolism ; Protein Binding ; RNA Transport ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; RNA, Small Interfering/genetics ; RNA, Small Interfering/metabolism ; RNA-Induced Silencing Complex/metabolism ; Receptors, CXCR4/genetics ; Trans-Activators/metabolism ; Transfection
    Chemical Substances 3' Untranslated Regions ; AGO2 protein, human ; Argonaute Proteins ; Caenorhabditis elegans Proteins ; Eukaryotic Initiation Factor-2 ; MicroRNAs ; Peptide Initiation Factors ; RNA, Messenger ; RNA, Small Interfering ; RNA-Induced Silencing Complex ; Receptors, CXCR4 ; Trans-Activators ; let-7 microRNA, C elegans ; Endoribonucleases (EC 3.1.-) ; DCP1A protein, human (EC 3.1.27.-) ; DCP2 protein, human (EC 3.1.27.-)
    Language English
    Publishing date 2005-06-05
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, P.H.S.
    ZDB-ID 1474722-4
    ISSN 1476-4679 ; 1465-7392
    ISSN (online) 1476-4679
    ISSN 1465-7392
    DOI 10.1038/ncb1274
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 12: Show issues

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