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  1. Article ; Online: PM/Scl-Overlap-Syndrom bei einem 14-jährigen Mädchen nach SARS-CoV-2-Infektion.

    Dadak, Lisbeth / Heil, Peter Maximilian / Geleff, Silvana / Prosch, Helmut / Idzko, Marco / Hojreh, Azadeh / Szepfalusi, Zsolt / Valent, Isabella / Emminger, Wolfgang

    Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG

    2023  Volume 21, Issue 6, Page(s) 661–663

    Language German
    Publishing date 2023-07-10
    Publishing country Germany
    Document type Letter
    ZDB-ID 2093479-8
    ISSN 1610-0387 ; 1610-0379
    ISSN (online) 1610-0387
    ISSN 1610-0379
    DOI 10.1111/ddg.15044_g
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6148: Show issues Location:
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  2. Article ; Online: PM/Scl overlap syndrome in a 14-year-old girl manifesting after a SARS-CoV-2 infection.

    Dadak, Lisbeth / Heil, Peter Maximilian / Geleff, Silvana / Prosch, Helmut / Idzko, Marco / Hojreh, Azadeh / Szepfalusi, Zsolt / Valent, Isabella / Emminger, Wolfgang

    Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG

    2023  Volume 21, Issue 6, Page(s) 661–663

    MeSH term(s) Female ; Humans ; Adolescent ; COVID-19/complications ; COVID-19/diagnosis ; SARS-CoV-2 ; Autoimmune Diseases ; Autoantibodies ; Connective Tissue Diseases ; Scleroderma, Systemic
    Chemical Substances Autoantibodies
    Language English
    Publishing date 2023-06-01
    Publishing country Germany
    Document type Case Reports ; Letter
    ZDB-ID 2093479-8
    ISSN 1610-0387 ; 1610-0379
    ISSN (online) 1610-0387
    ISSN 1610-0379
    DOI 10.1111/ddg.15044
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6148: Show issues Location:
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  3. Article ; Online: Parents' understanding of medication at discharge and potential harm in children with medical complexity.

    Selzer, Axana / Eibensteiner, Fabian / Kaltenegger, Lukas / Hana, Michelle / Laml-Wallner, Gerda / Geist, Matthias Benjamin / Mandler, Christopher / Valent, Isabella / Arbeiter, Klaus / Mueller-Sacherer, Thomas / Herle, Marion / Aufricht, Christoph / Boehm, Michael

    Archives of disease in childhood

    2024  Volume 109, Issue 3, Page(s) 215–221

    Abstract: Objective: Children with medical complexity (CMC) are among the most vulnerable patient groups. This study aimed to evaluate their prevalence and risk factors for medication misunderstanding and potential harm (PH) at discharge.: Design and setting: ... ...

    Abstract Objective: Children with medical complexity (CMC) are among the most vulnerable patient groups. This study aimed to evaluate their prevalence and risk factors for medication misunderstanding and potential harm (PH) at discharge.
    Design and setting: Cross-sectional study at a tertiary care centre.
    Study population: CMC admitted at Medical University of Vienna between May 2018 and January 2019.
    Intervention: CMC and caregivers underwent a structured interview at discharge; medication understanding and PH for adverse events were assessed by a hybrid approach.
    Main outcome measures: Medication misunderstanding rate; PH.
    Results: For 106 included children (median age 9.6 years), a median number of 5.0 (IQR 3.0-8.0) different medications were prescribed. 83 CMC (78.3%) demonstrated at least one misunderstanding, in 33 CMC (31.1%), potential harm was detected, 5 of them severe. Misunderstandings were associated with more medications (r=0.24, p=0.013), new prescriptions (r=0.23, p=0.019), quality of medication-related communication (r=-0.21, p=0.032), low level of education (p=0.013), low language skills (p=0.002) and migratory background (p=0.001). Relative risk of PH was 2.27 times increased (95% CI 1.23 to 4.22) with new medications, 2.14 times increased (95% CI 1.10 to 4.17) with migratory background.
    Conclusion: Despite continuous care at a tertiary care centre and high level of subjective satisfaction, high prevalence of medication misunderstanding with relevant risk for PH was discovered in CMC and their caregivers. This demonstrates the need of interventions to improve patient safety, with stratification of medication-related communication for high-risk groups and a restructured discharge process focusing on detection of misunderstandings ('unknown unknowns').
    MeSH term(s) Child ; Humans ; Patient Discharge ; Cross-Sectional Studies ; Parents ; Hospitalization ; Caregivers
    Language English
    Publishing date 2024-02-19
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 524-1
    ISSN 1468-2044 ; 0003-9888 ; 1359-2998
    ISSN (online) 1468-2044
    ISSN 0003-9888 ; 1359-2998
    DOI 10.1136/archdischild-2022-325119
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.MA 3: Show issues

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  4. Article: Targeted Training for Subspecialist Care in Children With Medical Complexity.

    Eibensteiner, Fabian / Ritschl, Valentin / Valent, Isabella / Schaup, Rebecca Michaela / Hellmann, Axana / Kaltenegger, Lukas / Daniel-Fischer, Lisa / Oviedo Flores, Krystell / Brandstaetter, Stefan / Stamm, Tanja / Schaden, Eva / Aufricht, Christoph / Boehm, Michael

    Frontiers in pediatrics

    2022  Volume 10, Page(s) 851033

    Abstract: Background: Children with medical complexity (CMC) are prone to medical errors and longer hospital stays, while residents do not feel prepared to provide adequate medical care for this vulnerable population. No educational guidance for the training of ... ...

    Abstract Background: Children with medical complexity (CMC) are prone to medical errors and longer hospital stays, while residents do not feel prepared to provide adequate medical care for this vulnerable population. No educational guidance for the training of future pediatric tertiary care specialists outside their field of expertise involving the multidisciplinary care of CMC exists. We investigated pediatric residents past educational needs and challenges to identify key learning content for future training involving care for CMC.
    Methods: This was a prospective mixed-methods study at a single pediatric tertiary care center. Qualitative semi-structured interviews with residents were conducted, submitted to thematic content analysis, linked to the American Board of Pediatrics (ABP) general pediatrics content outline, and analyzed with importance performance analysis (IPA). Quantitative validation was focused on key themes of pediatric nephrology within the scope of an online survey among pediatric residents and specialists.
    Results: A total of 16 interviews, median duration 69 min [interquartile range IQR 35], were conducted. The 280 listed themes of the ABP general pediatrics content outline were reduced to 165 themes, with 86% (theoretical) knowledge, 12% practical skills, and 2% soft skills. IPA identified 23 knowledge themes to be of high importance where improvement is necessary and deemed fruitful. Quantitative validation among 84 residents and specialists (response rate 55%) of key themes in nephrology yielded high agreement among specialists in pediatric nephrology but low interrater agreement among trainees and "trained" non-nephrologists. The occurrence of themes in the qualitative interviews and their calculated importance in the quantitative survey were highly correlated (tau = 0.57,
    Conclusion: Regarding patient safety, this study revealed the heterogeneous aspects and the importance of training future pediatric tertiary care specialists outside their field of expertise involving the multidisciplinary care of CMC. Our results may lay the groundwork for future detailed analysis and development of training boot camps that might be able to aid the improvement of patient safety by decreasing preventable harm by medical errors, especially for vulnerable patient groups, such as CMC in tertiary care pediatrics.
    Language English
    Publishing date 2022-05-16
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2711999-3
    ISSN 2296-2360
    ISSN 2296-2360
    DOI 10.3389/fped.2022.851033
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Circulating microRNAs 34a, 122, and 192 are linked to obesity-associated inflammation and metabolic disease in pediatric patients.

    Lischka, Julia / Schanzer, Andrea / Hojreh, Azadeh / Ba-Ssalamah, Ahmed / de Gier, Charlotte / Valent, Isabella / Item, Chike Bellarmine / Greber-Platzer, Susanne / Zeyda, Maximilian

    International journal of obesity (2005)

    2021  Volume 45, Issue 8, Page(s) 1763–1772

    Abstract: Background: Obesity-associated chronic low-grade inflammation leads to dysregulation of central lipid and glucose metabolism pathways leading to metabolic disorders. MicroRNAs (miRNAs) are known to control regulators of metabolic homeostasis. We aimed ... ...

    Abstract Background: Obesity-associated chronic low-grade inflammation leads to dysregulation of central lipid and glucose metabolism pathways leading to metabolic disorders. MicroRNAs (miRNAs) are known to control regulators of metabolic homeostasis. We aimed to assess the relationship of circulating miRNAs with inflammatory modulators and metabolic disorders in pediatric obesity.
    Methods: From a pediatric cohort with severe obesity (n = 109), clinically thoroughly characterized including diverse routine blood parameters, oral glucose tolerance test, and liver MRI, a panel of 16 circulating miRNAs was quantified using qRT-PCR. Additionally, markers of inflammation TNFα, IL1 receptor antagonist, procalcitonin, CRP, and IL-6 were measured.
    Results: Markers of obesity-associated inflammation, TNFα, IL-1Ra, and procalcitonin, all significantly correlated with concentrations of miRNAs 122 and 192. Concentrations of these miRNAs negatively correlated with serum adiponectin and were among those strongly linked to parameters of dyslipidemia and liver function. Moreover, miRNA122 concentrations correlated with HOMA-IR. Several miRNA levels including miRNAs 34a, 93, 122, and 192 were statistically significantly differing between individuals with prediabetes, impaired glucose tolerance, metabolic syndrome, or nonalcoholic fatty liver disease compared to the respective controls. Additionally, miRNA 192 was significantly elevated in metabolically unhealthy obesity.
    Conclusions: A miRNA pattern associated with obesity-associated inflammation and comorbidities may be used to distinguish metabolically healthy from unhealthy pediatric patients with obesity. Moreover, these changes in epigenetic regulation could potentially be involved in the etiology of obesity-linked metabolic disease in children and adolescents.
    MeSH term(s) Adolescent ; Child ; Female ; Humans ; Inflammation ; Male ; Metabolic Syndrome/epidemiology ; Metabolic Syndrome/metabolism ; MicroRNAs/blood ; Pediatric Obesity/epidemiology ; Pediatric Obesity/metabolism
    Chemical Substances MIRN122 microRNA, human ; MIRN192 microRNA, human ; MIRN34 microRNA, human ; MicroRNAs
    Language English
    Publishing date 2021-05-13
    Publishing country England
    Document type Journal Article
    ZDB-ID 752409-2
    ISSN 1476-5497 ; 0307-0565
    ISSN (online) 1476-5497
    ISSN 0307-0565
    DOI 10.1038/s41366-021-00842-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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