Article ; Online: Outcomes of an extended-infusion piperacillin-tazobactam protocol implementation in a community teaching hospital adult intensive care unit.
2016 Volume 73, Issue 11 Suppl 3, Page(s) S100–5
Abstract: Objective: The purpose of this study is to evaluate the outcome differences between patients receiving piperacillin-tazobactam pre- and post-implementation of an extended infusion dosing protocol in a community teaching hospital adult intensive care ... ...
| Abstract | Objective: The purpose of this study is to evaluate the outcome differences between patients receiving piperacillin-tazobactam pre- and post-implementation of an extended infusion dosing protocol in a community teaching hospital adult intensive care unit. Methods: On December 19th, 2011, extended infusion dosing of piperacillin-tazobactam was implemented at St. John's Hospital's intensive and cardiac care units (ICU/CCU) following IRB-approval. This is a historical case-control cohort study involving review of electronic medical charts of patients who received traditional or extended infusion therapy. Data was collected for patients that received piperacillin-tazobactam in the ICU/CCU from December 19th, 2010 through March 19th, 2011 for traditional infusion and from December 19th, 2011 through March 19th, 2012 for extended infusion. Primary endpoints were ICU/CCU mortality at discharge and length of stay. Results: The study included 113 patients with 52 in the traditional-infusion group and 61 extended-infusion group. There was no statistically significant difference in the primary end-point of ICU/CCU mortality between the two groups (14.8% vs. 21.1%; p = 0.374). In the extended infusion group, there was a shorter length of ICU and CCU stay (8.32 vs. 12.06 days; p = 0.025) and shorter length of hospital stay (11.32 vs. 19.7 days; p = 0.006). The extended-infusion group showed a decrease in cost of therapy that was statistically significant ($120.21 vs. $155.17; p = 0.035). Adverse drug effects did not differ between the two study groups. Conclusion: This study showed that treatment with extended-infusion piperacillin-tazobactam therapy improved patient outcomes while maintaining patient safety and decreasing costs. |
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| MeSH term(s) | Adult ; Aged ; Aged, 80 and over ; Case-Control Studies ; Cohort Studies ; Delayed-Action Preparations/administration & dosage ; Female ; Hospitals, Community/methods ; Hospitals, Teaching/methods ; Humans ; Intensive Care Units ; Male ; Middle Aged ; Penicillanic Acid/administration & dosage ; Penicillanic Acid/analogs & derivatives ; Piperacillin/administration & dosage ; Piperacillin, Tazobactam Drug Combination ; Pseudomonas Infections/diagnosis ; Pseudomonas Infections/drug therapy ; Treatment Outcome |
| Chemical Substances | Delayed-Action Preparations ; Piperacillin, Tazobactam Drug Combination (157044-21-8) ; Penicillanic Acid (87-53-6) ; Piperacillin (X00B0D5O0E) |
| Language | English |
| Publishing date | 2016-05-17 |
| Publishing country | England |
| Document type | Journal Article |
| ZDB-ID | 1224627-x |
| ISSN | 1535-2900 ; 1079-2082 |
| ISSN (online) | 1535-2900 |
| ISSN | 1079-2082 |
| DOI | 10.2146/sp150041 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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