Article: Modafinil in the treatment of excessive daytime sleepiness.
Cleveland Clinic journal of medicine
2007 Volume 74, Issue 8, Page(s) 561–6, 568–71
Abstract: Modafinil (Provigil) is approved for treating excessive daytime sleepiness associated with narcolepsy, for shift-work sleep disorder, and as an adjunctive treatment in patients with obstructive sleep apnea syndrome who have residual daytime sleepiness ... ...
| Abstract | Modafinil (Provigil) is approved for treating excessive daytime sleepiness associated with narcolepsy, for shift-work sleep disorder, and as an adjunctive treatment in patients with obstructive sleep apnea syndrome who have residual daytime sleepiness despite optimal treatment with continuous positive airway pressure. Although modafinil improves measures of sleepiness, it does not generally normalize them, and it may be less effective than other stimulants for some narcoleptic patients. We need head-to-head comparisons of modafinil with traditional stimulants in humans to better define its role. We review the current approved and off-label uses of this drug and the evidence behind them. |
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| MeSH term(s) | Attention Deficit Disorder with Hyperactivity/drug therapy ; Benzhydryl Compounds/adverse effects ; Benzhydryl Compounds/pharmacology ; Benzhydryl Compounds/therapeutic use ; Central Nervous System Stimulants/adverse effects ; Central Nervous System Stimulants/pharmacology ; Central Nervous System Stimulants/therapeutic use ; Continuous Positive Airway Pressure ; Disorders of Excessive Somnolence ; Drug Interactions ; Humans ; Modafinil ; Multiple Sclerosis/drug therapy ; Narcolepsy/drug therapy ; Parkinson Disease/drug therapy ; Sleep Apnea, Obstructive/drug therapy | |||||
| Chemical Substances | Benzhydryl Compounds ; Central Nervous System Stimulants ; Modafinil (R3UK8X3U3D) | |||||
| Language | English | |||||
| Publishing date | 2007-08-10 | |||||
| Publishing country | United States | |||||
| Document type | Journal Article ; Review | |||||
| ZDB-ID | 639116-3 | |||||
| ISSN | 0891-1150 | |||||
| ISSN | 0891-1150 | |||||
| DOI | 10.3949/ccjm.74.8.561 | |||||
| Shelf mark |
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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