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  1. Article ; Online: Prevalence and management of severe asthma in the Nordic countries

    Susanne Hansen / Anna von Bülow / Patrik Sandin / Olivia Ernstsson / Christer Janson / Lauri Lehtimäki / Hannu Kankaanranta / Charlotte Ulrik / Bernt Bøgvald Aarli / Hanna Fues Wahl / Kirk Geale / Sheila Tuyet Tang / Maija Wolf / Tom Larsen / Alan Altraja / Helena Backman / Maritta Kilpeläinen / Arja Viinanen / Dora Ludviksdottir /
    Paula Kauppi / Asger Sverrild / Sverre Lehmann / Vibeke Backer / Valentyna Yasinska / Tina Skjold / Jussi Karjalainen / Apostolos Bossios / Celeste Porsbjerg

    ERJ Open Research, Vol 9, Iss

    findings from the NORDSTAR cohort

    2023  Volume 2

    Abstract: Background Real-life evidence on prevalence and management of severe asthma is limited. Nationwide population registries across the Nordic countries provide unique opportunities to describe prevalence and management patterns of severe asthma at ... ...

    Abstract Background Real-life evidence on prevalence and management of severe asthma is limited. Nationwide population registries across the Nordic countries provide unique opportunities to describe prevalence and management patterns of severe asthma at population level. In nationwide register data from Sweden, Norway and Finland, we examined the prevalence of severe asthma and the proportion of severe asthma patients being managed in specialist care. Methods This is a cross-sectional study based on the Nordic Dataset for Asthma Research (NORDSTAR) research collaboration platform. We identified patients with severe asthma in adults (aged ≥18 years) and in children (aged 6–17 years) in 2018 according to the European Respiratory Society/American Thoracic Society definition. Patients managed in specialist care were those with an asthma-related specialist outpatient contact (only available in Sweden and Finland). Results Overall, we identified 598 242 patients with current asthma in Sweden, Norway and Finland in 2018. Among those, the prevalence of severe asthma was 3.5%, 5.4% and 5.2% in adults and 0.4%, 1.0%, and 0.3% in children in Sweden, Norway and Finland, respectively. In Sweden and Finland, 37% and 40% of adult patients with severe asthma and two or more exacerbations, respectively, were managed in specialist care; in children the numbers were 56% and 41%, respectively. Conclusion In three Nordic countries, population-based nationwide data demonstrated similar prevalence of severe asthma. In children, severe asthma was a rare condition. Notably, a large proportion of patients with severe asthma were not managed by a respiratory specialist, suggesting the need for increased recognition of severe asthma in primary care.
    Keywords Medicine ; R
    Subject code 610
    Language English
    Publishing date 2023-04-01T00:00:00Z
    Publisher European Respiratory Society
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Low levels of endogenous anabolic androgenic steroids in females with severe asthma taking corticosteroids

    Valentyna Yasinska / Cristina Gómez / Johan Kolmert / Magnus Ericsson / Anton Pohanka / Anna James / Lars I. Andersson / Maria Sparreman-Mikus / Ana R. Sousa / John H. Riley / Stewart Bates / Per S. Bakke / Nazanin Zounemat Kermani / Massimo Caruso / Pascal Chanez / Stephen J. Fowler / Thomas Geiser / Peter H. Howarth / Ildikó Horváth /
    Norbert Krug / Paolo Montuschi / Marek Sanak / Annelie Behndig / Dominick E. Shaw / Richard G. Knowles / Barbro Dahlén / Anke-Hilse Maitland-van der Zee / Peter J. Sterk / Ratko Djukanovic / Ian M. Adcock / Kian Fan Chung / Craig E. Wheelock / Sven-Erik Dahlén / Eva Wikström Jonsson / H. Ahmed

    ERJ Open Research, Vol 9, Iss

    2023  Volume 5

    Abstract: Rationale Patients with severe asthma are dependent upon treatment with high doses of inhaled corticosteroids (ICS) and often also oral corticosteroids (OCS). The extent of endogenous androgenic anabolic steroid (EAAS) suppression in asthma has not ... ...

    Abstract Rationale Patients with severe asthma are dependent upon treatment with high doses of inhaled corticosteroids (ICS) and often also oral corticosteroids (OCS). The extent of endogenous androgenic anabolic steroid (EAAS) suppression in asthma has not previously been described in detail. The objective of the present study was to measure urinary concentrations of EAAS in relation to exogenous corticosteroid exposure. Methods Urine collected at baseline in the U-BIOPRED (Unbiased Biomarkers for the Prediction of Respiratory Disease outcomes) study of severe adult asthmatics (SA, n=408) was analysed by quantitative mass spectrometry. Data were compared to that of mild-to-moderate asthmatics (MMA, n=70) and healthy subjects (HC, n=98) from the same study. Measurements and main results The concentrations of urinary endogenous steroid metabolites were substantially lower in SA than in MMA or HC. These differences were more pronounced in SA patients with detectable urinary OCS metabolites. Their dehydroepiandrosterone sulfate (DHEA-S) concentrations were <5% of those in HC, and cortisol concentrations were below the detection limit in 75% of females and 82% of males. The concentrations of EAAS in OCS-positive patients, as well as patients on high-dose ICS only, were more suppressed in females than males (p<0.05). Low levels of DHEA were associated with features of more severe disease and were more prevalent in females (p<0.05). The association between low EAAS and corticosteroid treatment was replicated in 289 of the SA patients at follow-up after 12–18 months. Conclusion The pronounced suppression of endogenous anabolic androgens in females might contribute to sex differences regarding the prevalence of severe asthma.
    Keywords Medicine ; R
    Subject code 610
    Language English
    Publishing date 2023-10-01T00:00:00Z
    Publisher European Respiratory Society
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  3. Article ; Online: The effect of the COVID-19 pandemic on severe asthma care in Europe

    Katrien Eger / Dora Paroczai / Alison Bacon / Florence Schleich / Svetlana Sergejeva / Arnaud Bourdin / Isabelle Vachier / Eleftherios Zervas / Konstantinos Katsoulis / Dimosthenis Papapetrou / Konstantinos Kostikas / Zsuzsanna Csoma / Enrico Heffler / Giorgio Walter Canonica / Ineta Grisle / Kristina Bieksiene / Jolita Palacionyte / Anneke ten Brinke / Simone Hashimoto /
    Frank W.J.M. Smeenk / Gert-Jan Braunstahl / Simone van der Sar / Florin Mihălţan / Natalia Nenasheva / Marina Peredelskaya / Biljana Zvezdin / Ivan Čekerevac / Sanja Hromiš / Vojislav Ćupurdija / Zorica Lazic / Branislava Milenkovic / Sanja Dimic-Janjic / Valentyna Yasinska / Barbro Dahlén / Apostolos Bossios / Nikolaos Lazarinis / David Aronsson / Arne Egesten / Abul Kashem Mohammad Munir / Lars Ahlbeck / Christer Janson / Sabina Škrgat / Natalija Edelbaher / Joerg Leuppi / Fabienne Jaun / Jochen Rüdiger / Nikolay Pavlov / Pietro Gianella / Reta Fischer / Florian Charbonnier / Rekha Chaudhuri / Steven James Smith / Simon Doe / Michelle Fawdon / Matthew Masoli / Liam Heaney / Hans Michael Haitchi / Ramesh Kurukulaaratchy / Olivia Fulton / Betty Frankemölle / Toni Gibson / Karen Needham / Peter Howarth / Ratko Djukanovic / Elisabeth Bel / Michael Hyland

    ERJ Open Research, Vol 8, Iss

    will care change for good?

    2022  Volume 2

    Abstract: Background The coronavirus disease 2019 (COVID-19) pandemic has put pressure on healthcare services, forcing the reorganisation of traditional care pathways. We investigated how physicians taking care of severe asthma patients in Europe reorganised care, ...

    Abstract Background The coronavirus disease 2019 (COVID-19) pandemic has put pressure on healthcare services, forcing the reorganisation of traditional care pathways. We investigated how physicians taking care of severe asthma patients in Europe reorganised care, and how these changes affected patient satisfaction, asthma control and future care. Methods In this European-wide cross-sectional study, patient surveys were sent to patients with a physician-diagnosis of severe asthma, and physician surveys to severe asthma specialists between November 2020 and May 2021. Results 1101 patients and 268 physicians from 16 European countries contributed to the study. Common physician-reported changes in severe asthma care included use of video/phone consultations (46%), reduced availability of physicians (43%) and change to home-administered biologics (38%). Change to phone/video consultations was reported in 45% of patients, of whom 79% were satisfied or very satisfied with this change. Of 709 patients on biologics, 24% experienced changes in biologic care, of whom 92% were changed to home-administered biologics and of these 62% were satisfied or very satisfied with this change. Only 2% reported worsening asthma symptoms associated with changes in biologic care. Many physicians expect continued implementation of video/phone consultations (41%) and home administration of biologics (52%). Conclusions Change to video/phone consultations and home administration of biologics was common in severe asthma care during the COVID-19 pandemic and was associated with high satisfaction levels in most but not all cases. Many physicians expect these changes to continue in future severe asthma care, though satisfaction levels may change after the pandemic.
    Keywords Medicine ; R
    Subject code 360
    Language English
    Publishing date 2022-05-01T00:00:00Z
    Publisher European Respiratory Society
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

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