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  1. Article: Editorial: Kappa opioid receptors revealed: Disentangling the pharmacology to open up new therapeutic strategies.

    Walwyn, Wendy Margaret / Valenza, Marta

    Frontiers in pharmacology

    2022  Volume 13, Page(s) 973780

    Language English
    Publishing date 2022-08-12
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2022.973780
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: How useful are biomarkers for the diagnosis of Alzheimer's disease and especially for its therapy?

    Valenza, Marta / Scuderi, Caterina

    Neural regeneration research

    2022  Volume 17, Issue 10, Page(s) 2205–2207

    Language English
    Publishing date 2022-03-10
    Publishing country India
    Document type Journal Article
    ZDB-ID 2388460-5
    ISSN 1876-7958 ; 1673-5374
    ISSN (online) 1876-7958
    ISSN 1673-5374
    DOI 10.4103/1673-5374.335791
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  3. Article ; Online: The translational potential of cholesterol-based therapies for neurological disease.

    Valenza, Marta / Birolini, Giulia / Cattaneo, Elena

    Nature reviews. Neurology

    2023  Volume 19, Issue 10, Page(s) 583–598

    Abstract: Cholesterol is an important metabolite and membrane component and is enriched in the brain owing to its role in neuronal maturation and function. In the adult brain, cholesterol is produced locally, predominantly by astrocytes. When cholesterol has been ... ...

    Abstract Cholesterol is an important metabolite and membrane component and is enriched in the brain owing to its role in neuronal maturation and function. In the adult brain, cholesterol is produced locally, predominantly by astrocytes. When cholesterol has been used, recycled and catabolized, the derivatives are excreted across the blood-brain barrier. Abnormalities in any of these steps can lead to neurological dysfunction. Here, we examine how precise interactions between cholesterol production and its use and catabolism in neurons ensures cholesterol homeostasis to support brain function. As an example of a neurological disease associated with cholesterol dyshomeostasis, we summarize evidence from animal models of Huntington disease (HD), which demonstrate a marked reduction in cholesterol biosynthesis with clinically relevant consequences for synaptic activity and cognition. In addition, we examine the relationship between cholesterol loss in the brain and cognitive decline in ageing. We then present emerging therapeutic strategies to restore cholesterol homeostasis, focusing on evidence from HD mouse models.
    MeSH term(s) Animals ; Mice ; Cholesterol/metabolism ; Brain ; Neurons/physiology ; Huntington Disease/therapy ; Huntington Disease/metabolism ; Blood-Brain Barrier/metabolism ; Disease Models, Animal
    Chemical Substances Cholesterol (97C5T2UQ7J)
    Language English
    Publishing date 2023-08-29
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2491514-2
    ISSN 1759-4766 ; 1759-4758
    ISSN (online) 1759-4766
    ISSN 1759-4758
    DOI 10.1038/s41582-023-00864-5
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6257: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)
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  4. Article ; Online: Palmitoylethanolamide and White Matter Lesions: Evidence for Therapeutic Implications.

    Valenza, Marta / Facchinetti, Roberta / Steardo, Luca / Scuderi, Caterina

    Biomolecules

    2022  Volume 12, Issue 9

    Abstract: Palmitoylethanolamide (PEA), the naturally occurring amide of ethanolamine and palmitic acid, is an endogenous lipid compound endowed with a plethora of pharmacological functions, including analgesic, neuroprotective, immune-modulating, and anti- ... ...

    Abstract Palmitoylethanolamide (PEA), the naturally occurring amide of ethanolamine and palmitic acid, is an endogenous lipid compound endowed with a plethora of pharmacological functions, including analgesic, neuroprotective, immune-modulating, and anti-inflammatory effects. Although the properties of PEA were first characterized nearly 65 years ago, the identity of the receptor mediating these actions has long remained elusive, causing a period of research stasis. In the last two decades, a renewal of interest in PEA occurred, and a series of interesting studies have demonstrated the pharmacological properties of PEA and clarified its mechanisms of action. Recent findings showed the ability of formulations containing PEA in promoting oligodendrocyte differentiation, which represents the first step for the proper formation of myelin. This evidence opens new and promising research opportunities. White matter defects have been detected in a vast and heterogeneous group of diseases, including age-related neurodegenerative disorders. Here, we summarize the history and pharmacology of PEA and discuss its therapeutic potential in restoring white matter defects.
    MeSH term(s) Amides ; Analgesics ; Anti-Inflammatory Agents/pharmacology ; Ethanolamines/pharmacology ; Palmitic Acid ; Palmitic Acids/pharmacology ; Palmitic Acids/therapeutic use ; White Matter
    Chemical Substances Amides ; Analgesics ; Anti-Inflammatory Agents ; Ethanolamines ; Palmitic Acids ; Palmitic Acid (2V16EO95H1) ; palmidrol (6R8T1UDM3V)
    Language English
    Publishing date 2022-08-27
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2701262-1
    ISSN 2218-273X ; 2218-273X
    ISSN (online) 2218-273X
    ISSN 2218-273X
    DOI 10.3390/biom12091191
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  5. Article: The Impact of Complex PTSD on Suicide Risk in Patients with Bipolar Disorder: A Cross-Sectional Study.

    Iazzolino, Anna Maria / Valenza, Marta / D'Angelo, Martina / Longobardi, Grazia / Stefano, Valeria Di / Visalli, Giulia / Steardo, Luca / Scuderi, Caterina

    Journal of clinical medicine

    2024  Volume 13, Issue 3

    Abstract: Background: Patients with bipolar disorder (BD) are more likely than the general population to experience traumatic events, particularly during childhood, and these may predict and be a risk factor for the development of complex PTSD (cPTSD). The ... ...

    Abstract Background: Patients with bipolar disorder (BD) are more likely than the general population to experience traumatic events, particularly during childhood, and these may predict and be a risk factor for the development of complex PTSD (cPTSD). The presence of multiple traumas plays a relevant role from a psychopathological point of view, but little is known about the effect this may have on suicide attempts in patients with BD.
    Methods: A cross-sectional study was conducted comparing socio-demographic and clinical characteristics, recruiting 344 patients diagnosed with BD I and II, screened for the presence (or absence) of cPTSD using the International Trauma Questionnaire (ITQ). Suicide attempts were assessed directly during the clinical interview and from the patient's medical record.
    Results: The results emerging from the study indicate that cPTSD can be considered a risk factor for suicide attempts in patients with BD. Furthermore, evidence is provided to support the idea that cPTSD is highly prevalent in patients with BD and is related to a higher psychopathological burden.
    Conclusions: The results recommend an urgent and comprehensive assessment of suicidal risk in patients with comorbidity of both bipolar disorder and cPTSD. There is a crucial demand for early intervention initiatives and proactive prevention strategies to address the intricate intersection of these mental health challenges.
    Language English
    Publishing date 2024-01-24
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm13030673
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  6. Article: How effective are mood stabilizers in treating bipolar patients comorbid with cPTSD? Results from an observational study.

    Iazzolino, Anna Maria / Valenza, Marta / D'Angelo, Martina / Longobardi, Grazia / Di Stefano, Valeria / Luca, Steardo / Scuderi, Caterina / Steardo, Luca

    International journal of bipolar disorders

    2024  Volume 12, Issue 1, Page(s) 9

    Abstract: Background: Multiple traumatic experiences, particularly in childhood, may predict and be a risk factor for the development of complex post-traumatic stress disorder (cPTSD). Unfortunately, individuals with bipolar disorder (BP) are more likely to have ... ...

    Abstract Background: Multiple traumatic experiences, particularly in childhood, may predict and be a risk factor for the development of complex post-traumatic stress disorder (cPTSD). Unfortunately, individuals with bipolar disorder (BP) are more likely to have suffered traumatic events than the general population. Consequently, cPTSD could be comorbid with BD, and this may negatively affect psychopathological manifestations. To date, no one has explored whether such comorbidity also affects the response to treatment with mood stabilizers in BD patients.
    Results: Here, a cross-sectional study was carried out by comparing the response to treatment, measured by the Alda scale, in a cohort of 344 patients diagnosed with BD type I and II, screened for the presence (or absence) of cPTSD using the International Trauma Questionnaire. The main result that emerged from the present study is the poorer response to mood stabilizers in BD patients with comorbid cPTSD compared with BD patients without cPTSD.
    Conclusions: The results collected suggest the need for an add-on therapy focused on trauma in BD patients. This could represent an area of future interest in clinical research, capable of leading to more precise and quicker diagnoses as well as suggesting better tailored and more effective treatments.
    Language English
    Publishing date 2024-03-26
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2732954-9
    ISSN 2194-7511
    ISSN 2194-7511
    DOI 10.1186/s40345-024-00330-1
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  7. Article: Altered Waste Disposal System in Aging and Alzheimer's Disease: Focus on Astrocytic Aquaporin-4.

    Valenza, Marta / Facchinetti, Roberta / Steardo, Luca / Scuderi, Caterina

    Frontiers in pharmacology

    2020  Volume 10, Page(s) 1656

    Abstract: Among the diverse cell types included in the general population named glia, astrocytes emerge as being the focus of a growing body of research aimed at characterizing their heterogeneous and complex functions. Alterations of both their morphology and ... ...

    Abstract Among the diverse cell types included in the general population named glia, astrocytes emerge as being the focus of a growing body of research aimed at characterizing their heterogeneous and complex functions. Alterations of both their morphology and activities have been linked to a variety of neurological diseases. One crucial physiological need satisfied by astrocytes is the cleansing of the cerebral tissue from waste molecules. Several data demonstrate that aquaporin-4 (AQP-4), a protein expressed by astrocytes, is crucially important for facilitating the removal of waste products from the brain. Aquaporins are water channels found in all district of the human organism and the most abundant isoform in the brain is AQP-4. This protein is involved in a myriad of astrocytic activities, including calcium signal transduction, potassium buffering, synaptic plasticity, astrocyte migration, glial scar formation and neuroinflammation. The highest density of AQP-4 is found at the astrocytic domains closest to blood vessels, the endfeet that envelop brain vessels, with low to zero expression in other astrocytic membrane regions. Increased AQP-4 expression and loss of polarization have recently been documented in altered physiological conditions. Here we review the latest findings related to aging and Alzheimer's disease (AD) on this topic, as well as the available knowledge on pharmacological tools to target AQP-4.
    Language English
    Publishing date 2020-01-29
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2019.01656
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Systemic Inflammation and Astrocyte Reactivity in the Neuropsychiatric Sequelae of COVID-19: Focus on Autism Spectrum Disorders.

    Valenza, Marta / Steardo, Luca / Verkhratsky, Alexei / Scuderi, Caterina

    Frontiers in cellular neuroscience

    2021  Volume 15, Page(s) 748136

    Language English
    Publishing date 2021-11-29
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2452963-1
    ISSN 1662-5102
    ISSN 1662-5102
    DOI 10.3389/fncel.2021.748136
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  9. Article ; Online: Alternative Targets to Fight Alzheimer's Disease: Focus on Astrocytes.

    Valenza, Marta / Facchinetti, Roberta / Menegoni, Giorgia / Steardo, Luca / Scuderi, Caterina

    Biomolecules

    2021  Volume 11, Issue 4

    Abstract: The available treatments for patients affected by Alzheimer's disease (AD) are not curative. Numerous clinical trials have failed during the past decades. Therefore, scientists need to explore new avenues to tackle this disease. In the present review, we ...

    Abstract The available treatments for patients affected by Alzheimer's disease (AD) are not curative. Numerous clinical trials have failed during the past decades. Therefore, scientists need to explore new avenues to tackle this disease. In the present review, we briefly summarize the pathological mechanisms of AD known so far, based on which different therapeutic tools have been designed. Then, we focus on a specific approach that is targeting astrocytes. Indeed, these non-neuronal brain cells respond to any insult, injury, or disease of the brain, including AD. The study of astrocytes is complicated by the fact that they exert a plethora of homeostatic functions, and their disease-induced changes could be context-, time-, and disease specific. However, this complex but fervent area of research has produced a large amount of data targeting different astrocytic functions using pharmacological approaches. Here, we review the most recent literature findings that have been published in the last five years to stimulate new hypotheses and ideas to work on, highlighting the peculiar ability of palmitoylethanolamide to modulate astrocytes according to their morpho-functional state, which ultimately suggests a possible potential disease-modifying therapeutic approach for AD.
    Language English
    Publishing date 2021-04-19
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2701262-1
    ISSN 2218-273X ; 2218-273X
    ISSN (online) 2218-273X
    ISSN 2218-273X
    DOI 10.3390/biom11040600
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  10. Article ; Online: Corrigendum to "Quantitative comparison of the protein corona of nanoparticles with different matrices" [Int J Pharm X 2022 Oct 21;4: 100136].

    Ottonelli, Ilaria / Duskey, Jason Thomas / Genovese, Filippo / Pederzoli, Francesca / Caraffi, Riccardo / Valenza, Marta / Tosi, Giovanni / Vandelli, Maria Angela / Ruozi, Barbara

    International journal of pharmaceutics: X

    2023  Volume 5, Page(s) 100182

    Abstract: This corrects the article DOI: 10.1016/j.ijpx.2022.100136.]. ...

    Abstract [This corrects the article DOI: 10.1016/j.ijpx.2022.100136.].
    Language English
    Publishing date 2023-05-06
    Publishing country Netherlands
    Document type Published Erratum
    ISSN 2590-1567
    ISSN (online) 2590-1567
    DOI 10.1016/j.ijpx.2023.100182
    Database MEDical Literature Analysis and Retrieval System OnLINE

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