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  1. Article ; Online: C-reactive protein as a candidate biomarker in fibrotic interstitial lung disease.

    Cottin, Vincent / Valenzuela, Claudia

    Respirology (Carlton, Vic.)

    2024  Volume 29, Issue 3, Page(s) 195–198

    MeSH term(s) Humans ; C-Reactive Protein ; Lung Diseases, Interstitial/diagnosis ; Lung Diseases, Interstitial/pathology ; Idiopathic Pulmonary Fibrosis/diagnosis ; Idiopathic Pulmonary Fibrosis/pathology ; Fibrosis ; Biomarkers ; Lung/pathology
    Chemical Substances C-Reactive Protein (9007-41-4) ; Biomarkers
    Language English
    Publishing date 2024-01-31
    Publishing country Australia
    Document type Editorial
    ZDB-ID 1435849-9
    ISSN 1440-1843 ; 1323-7799
    ISSN (online) 1440-1843
    ISSN 1323-7799
    DOI 10.1111/resp.14666
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 4957: Show issues Location:
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  2. Article: Maternal Characteristics and Infant Outcomes of Women Born in and Outside the United States:United States, 2020.

    Driscoll, Anne K / Valenzuela, Claudia P

    Vital & health statistics. Series 3, Analytical and epidemiological studies

    2022  , Issue 48, Page(s) 1–66

    Abstract: This report describes and compares maternalcharacteristics and infant outcomes by maternal place of birth (that is, whether the mother was born in the United States or in regions, subregions, and selected countries outside the United States) among births ...

    Abstract This report describes and compares maternalcharacteristics and infant outcomes by maternal place of birth (that is, whether the mother was born in the United States or in regions, subregions, and selected countries outside the United States) among births occurring in 2020.
    MeSH term(s) Female ; Humans ; Infant ; Infant, Low Birth Weight ; Infant, Newborn ; Infant, Premature ; Population Surveillance ; Pregnancy ; Pregnancy Outcome/epidemiology ; Pregnancy, Multiple ; Premature Birth ; Reproductive Techniques, Assisted ; United States/epidemiology
    Language English
    Publishing date 2022-07-07
    Publishing country United States
    Document type Journal Article
    ISSN 0886-4691
    ISSN 0886-4691
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  3. Article ; Online: Progressive pulmonary fibrosis: all roads lead to Rome (but not all at the same speed).

    Cottin, Vincent / Valenzuela, Claudia

    The European respiratory journal

    2022  Volume 60, Issue 4

    MeSH term(s) Humans ; Lung Diseases, Interstitial ; Prevalence ; Pulmonary Fibrosis ; Registries ; Rome
    Language English
    Publishing date 2022-10-06
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 639359-7
    ISSN 1399-3003 ; 0903-1936
    ISSN (online) 1399-3003
    ISSN 0903-1936
    DOI 10.1183/13993003.01449-2022
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  4. Article ; Online: Epidemiology and real-life experience in progressive pulmonary fibrosis.

    Valenzuela, Claudia / Cottin, Vincent

    Current opinion in pulmonary medicine

    2022  Volume 28, Issue 5, Page(s) 407–413

    Abstract: Purpose of review: Idiopathic pulmonary fibrosis (IPF), characterized by relentless disease progression from the time of diagnosis, is part of a larger group of chronic fibrosing interstitial lung diseases (ILDs). A proportion of patients with non-IPF ... ...

    Abstract Purpose of review: Idiopathic pulmonary fibrosis (IPF), characterized by relentless disease progression from the time of diagnosis, is part of a larger group of chronic fibrosing interstitial lung diseases (ILDs). A proportion of patients with non-IPF ILDs may develop, despite conventional treatment, a progressive pulmonary fibrosis (PPF), also referred to as ILD with a progressive fibrosing phenotype (PF-ILD). These patients experience worsening of respiratory symptoms, decline in lung function, and early mortality. The goal of this review is to describe the epidemiology and recent real-life cohorts of PF-ILD, with implications for management.
    Recent findings: The relatively new concept of PF-ILD has aroused active clinical research over the past years. To understand risk factors for progression and the real burden of the disease is crucial to improve management. In the last 2 years, different cohort studies have addressed these questions. They showed that almost one-third of the non-IPF fibrotic ILD patients develop PF-ILD or PPF.
    Summary: Emerging data show similarities in prognosis between patients with IPF or with non-IPF PF-ILD patients. Early detection and appropriate treatment of this group of patients is a priority. Further research is needed to identify risk factors of progression, to clarify the assessment of progression in clinical practice, for a better management of patients with PF-ILD in a real-world setting.
    MeSH term(s) Disease Progression ; Fibrosis ; Humans ; Idiopathic Pulmonary Fibrosis/drug therapy ; Lung Diseases, Interstitial/diagnosis ; Risk Factors
    Language English
    Publishing date 2022-08-01
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1285505-4
    ISSN 1531-6971 ; 1070-5287 ; 1078-1641
    ISSN (online) 1531-6971
    ISSN 1070-5287 ; 1078-1641
    DOI 10.1097/MCP.0000000000000908
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  5. Article ; Online: A Study on the Psychological Profile and Coping With the Disease in Patients With Lymphangioleiomyomatosis.

    Rudilla, David / Molina, María / Valenzuela, Claudia / Casanova, Álvaro / Ancochea, Julio

    Open respiratory archives

    2024  Volume 6, Issue 3, Page(s) 100327

    Abstract: Introduction: Lymphangioleiomyomatosis (LAM) is a rare disease that affects women almost exclusively. We aimed to determine the psychological profile in patients with LAM, and their potential association with sociodemographic and clinical features, and ... ...

    Abstract Introduction: Lymphangioleiomyomatosis (LAM) is a rare disease that affects women almost exclusively. We aimed to determine the psychological profile in patients with LAM, and their potential association with sociodemographic and clinical features, and to know their role in coping with the disease.
    Material and methods: Cross-sectional and descriptive study in collaboration with the Spanish Association of LAM (AELAM). The variables measured were: socio-demographic, psychological (anxiety, depression, demoralization, spirituality, resilience, social support), clinical (treatment) and health-related quality of life.
    Results: We studied 87 LAM patients, with a mean (SD) age of 47.7 (7.7) years, and time since diagnose was 10.1 (5.4) years. 75.9% of patients were receiving sirolimus or everolimus, and oxygen therapy was required in 34.5% of patients. Anxiety was found in 46% of patients, depression in 55%, while only 2% presented demoralization and 14% deficit in spirituality. Social support and resilience were adequate. The "non-severe" group (without oxygen therapy) presented worse results in anxiety. A structural equation model to explore association between variables, showed very adequate fit indices:
    Conclusions: This study performed on a large series of women with LAM describes their psychological profile, in addition to showing how they cope with the disease. We have found that other psychological constructs, such as perceived social support and resilience, are protective factors. Early psychological evaluation and intervention is necessary to reduce comorbidities and prevent mental health problems in women with LAM.
    Language English
    Publishing date 2024-04-23
    Publishing country Spain
    Document type Journal Article
    ISSN 2659-6636
    ISSN (online) 2659-6636
    DOI 10.1016/j.opresp.2024.100327
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  6. Article ; Online: Perinatal Mortality in the United States, 2020-2021.

    Valenzuela, Claudia P / Gregory, Elizabeth C W / Martin, Joyce A

    NCHS data brief

    2023  , Issue 489, Page(s) 1–8

    Abstract: Perinatal mortality(late fetal deaths at 28 completed weeks of gestation or more and early neonatal deaths younger than age 7 days) can be an indicator of the quality of health care before, during, and after delivery, and of the health status of the ... ...

    Abstract Perinatal mortality(late fetal deaths at 28 completed weeks of gestation or more and early neonatal deaths younger than age 7 days) can be an indicator of the quality of health care before, during, and after delivery, and of the health status of the nation (1,2). The U.S. perinatal mortality rate declined 30% from 1990 through 2011, was stable from 2011 through 2016, and declined 4% from 2017 through 2019 (1,3-5). This report describes changes in perinatal mortality, as well as its components, late fetal and early neonatal mortality, from 2020 to 2021, during the COVID-19 pandemic. Also shown are perinatal mortality rates by mother's age, the three largest race and Hispanic-origin groups, and state for 2021 compared with 2020.
    MeSH term(s) Child ; Female ; Humans ; Infant, Newborn ; Pregnancy ; Infant Mortality ; Pandemics ; Perinatal Death ; Perinatal Mortality ; Stillbirth/epidemiology ; United States/epidemiology
    Language English
    Publishing date 2023-12-12
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2506576-2
    ISSN 1941-4927 ; 1941-4935
    ISSN (online) 1941-4927
    ISSN 1941-4935
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  7. Article ; Online: Palliative care in COPD and ILD: a call for action.

    Wijsenbeek, Marlies / Valenzuela, Claudia / Holland, Anne

    The European respiratory journal

    2023  Volume 62, Issue 2

    MeSH term(s) Humans ; Palliative Care ; Lung Diseases, Interstitial ; Pulmonary Disease, Chronic Obstructive/complications ; Pulmonary Disease, Chronic Obstructive/therapy
    Language English
    Publishing date 2023-08-17
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 639359-7
    ISSN 1399-3003 ; 0903-1936
    ISSN (online) 1399-3003
    ISSN 0903-1936
    DOI 10.1183/13993003.01076-2023
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    Zs.MO 292: Show issues

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  8. Article ; Online: Inhaled treprostinil for interstitial lung disease-associated pulmonary hypertension: a silver lining on a very dark cloud.

    Cottin, Vincent / Valenzuela, Claudia / Humbert, Marc

    The European respiratory journal

    2023  Volume 61, Issue 6

    MeSH term(s) Humans ; Hypertension, Pulmonary/complications ; Hypertension, Pulmonary/drug therapy ; Lung Diseases, Interstitial/complications ; Lung Diseases, Interstitial/drug therapy
    Chemical Substances treprostinil (RUM6K67ESG)
    Language English
    Publishing date 2023-06-29
    Publishing country England
    Document type Editorial
    ZDB-ID 639359-7
    ISSN 1399-3003 ; 0903-1936
    ISSN (online) 1399-3003
    ISSN 0903-1936
    DOI 10.1183/13993003.00944-2023
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  9. Article ; Online: Interstitial lung disease-associated pulmonary hypertension - what the future holds.

    Cottin, Vincent / Diesler, Rémi / Turquier, Ségolène / Valenzuela, Claudia

    Current opinion in pulmonary medicine

    2023  Volume 29, Issue 5, Page(s) 406–415

    Abstract: Purpose of review: Pulmonary hypertension associated with interstitial lung disease (ILD-PH) is associated with significant alteration of quality of life, exercise capacity, and survival. Over the past 2 years, there were changes in the guideline ... ...

    Abstract Purpose of review: Pulmonary hypertension associated with interstitial lung disease (ILD-PH) is associated with significant alteration of quality of life, exercise capacity, and survival. Over the past 2 years, there were changes in the guideline definition and classification of ILD-PH, and positive randomized controlled trials were published.
    Recent findings: Pulmonary hypertension associated with chronic lung disease is now hemodynamically defined as a mean pulmonary artery pressure more than 20 mmHg, with pulmonary artery wedge pressure 15 mmHg or less, and pulmonary vascular resistance (PVR) at least 2 Wood units. Severe ILD-PH is defined by PVR more than 5 Wood units. In the INCREASE trial, patients receiving inhaled treprostinil had favorable significant changes in 6-min walk distance, NT-proBNP level, clinical worsening events, and forced vital capacity, which were maintained in the open label extension study. Promising results were obtained in a placebo-controlled pilot trial using escalated doses of inhaled nitric oxide. According to European guidelines, patients with ILD-PH should be referred to pulmonary hypertension centers, where inhaled treprostinil may be considered; phosphodiesterase type-5 inhibitors may also be considered in patients with severe ILD-PH.
    Summary: Recent changes in the definitions and a new therapeutic option have an impact on the diagnosis and management of ILD-PH.
    MeSH term(s) Humans ; Hypertension, Pulmonary/diagnosis ; Hypertension, Pulmonary/drug therapy ; Hypertension, Pulmonary/etiology ; Pulmonary Artery ; Quality of Life ; Lung Diseases, Interstitial/complications ; Lung Diseases, Interstitial/drug therapy ; Vascular Resistance
    Language English
    Publishing date 2023-07-07
    Publishing country United States
    Document type Review ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1285505-4
    ISSN 1531-6971 ; 1070-5287 ; 1078-1641
    ISSN (online) 1531-6971
    ISSN 1070-5287 ; 1078-1641
    DOI 10.1097/MCP.0000000000000992
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  10. Article ; Online: Fetal Mortality: United States, 2021.

    Gregory, Elizabeth C W / Valenzuela, Claudia P / Hoyert, Donna L

    National vital statistics reports : from the Centers for Disease Control and Prevention, National Center for Health Statistics, National Vital Statistics System

    2023  Volume 72, Issue 8, Page(s) 1–21

    Abstract: Objectives-This report presents 2021 fetal mortality data by maternal race and Hispanic origin, age, tobacco use during pregnancy, and state of residence, as well as by plurality, sex, gestational age, birthweight, and selected causes of death. Trends in ...

    Abstract Objectives-This report presents 2021 fetal mortality data by maternal race and Hispanic origin, age, tobacco use during pregnancy, and state of residence, as well as by plurality, sex, gestational age, birthweight, and selected causes of death. Trends in fetal mortality are also examined. Methods-Descriptive tabulations of data are presented and interpreted for all fetal deaths reported for the United States for 2021 with a stated or presumed period of gestation of 20 weeks or more. Cause-of-fetal-death data are restricted to residents of the 41 states and the District of Columbia, where cause of death was based on the 2003 fetal death report revision and less than 50% of deaths were attributed to Fetal death of unspecified cause (P95). Results-A total of 21,105 fetal deaths at 20 weeks of gestation or more were reported in the United States in 2021. The 2021 U.S. fetal mortality rate was 5.73 fetal deaths at 20 weeks of gestation or more per 1,000 live births and fetal deaths, which was essentially unchanged from the rate of 5.74 in 2020. The fetal mortality rate in 2021 for deaths occurring at 20-27 weeks of gestation was 2.95, essentially unchanged from 2020 (2.97). For deaths occurring at 28 weeks of gestation or more, the rate in 2021 (2.80) was not significantly different from 2020 (2.78). In 2021, the fetal mortality rate ranged from 3.94 for non-Hispanic, single-race Asian women to 9.89 for non-Hispanic, single-race Black women. Fetal mortality rates were highest for females under age 15 and aged 40 and over, for women who smoked during pregnancy, and for women with multiple gestation pregnancies. Five selected causes accounted for 89.9% of fetal deaths in the 41-state and District of Columbia reporting area.
    MeSH term(s) Adolescent ; Adult ; Female ; Humans ; Middle Aged ; Pregnancy ; District of Columbia/epidemiology ; Ethnicity ; Fetal Death ; Fetal Mortality ; Hispanic or Latino ; United States/epidemiology ; Age Factors ; Asian ; Black or African American
    Language English
    Publishing date 2023-07-27
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2192291-3
    ISSN 1551-8930 ; 1551-8922
    ISSN (online) 1551-8930
    ISSN 1551-8922
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