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  1. Article ; Online: Implementing a Personalized Antimicrobial Stewardship Program for Women with Gynecological Cancers and Healthcare-Associated Infections

    Simona Di Giambenedetto / Alberto Borghetti / Lorena Quagliozzi / Valeria Gallucci / Francesca Lombardi / Arturo Ciccullo / Anna Fagotti / Enrica Tamburrini / Giovanni Scambia

    Journal of Personalized Medicine, Vol 12, Iss 4, p

    2022  Volume 650

    Abstract: Healthcare-associated infections (HCAIs) represent a major cause of morbidity and mortality in gynecologic cancer patients, requiring personalized cures. A retrospective study on gynecologic patients with HCAIs, managed through an antimicrobial ... ...

    Abstract Healthcare-associated infections (HCAIs) represent a major cause of morbidity and mortality in gynecologic cancer patients, requiring personalized cures. A retrospective study on gynecologic patients with HCAIs, managed through an antimicrobial stewardship program, was performed, focusing on rates of clinical cure, breakthrough/relapse of infections, death, and time of hospital stay (THS). In total, 27 patients (median 60 years, mainly suffering from ovarian, cervical, and uterine cancer) were evaluated by a specialist in infectious diseases and were mainly diagnosed with complicated urinary tract (cUTIs, 12 cases, 44.4%) and bloodstream infections (BSIs, 9 cases, 33.3%). A total of 15 cases (11 cUTIs, 73.3%) were managed with no need for hospitalization and received a median of 11 days of outpatient parenteral antimicrobial therapy (OPAT). In the remaining 12 cases (BSIs in 8 cases, 66.7%), the median THS was 11 days, with 15 days median overall duration of antimicrobial therapy (median 5-day reduction in THS). The management of patients also included source control and wound care. All patients reached clinical cure, with no case of breakthrough infection, one case of relapse, and one death within 30 days (not attributable to the infection). HCAIs in patients with gynecologic tumors can be managed through a patient-centered, multidisciplinary antimicrobial stewardship program.
    Keywords gynecologic oncology ; personalized medicine ; healthcare-associated infections ; antimicrobial stewardship ; OPAT ; Medicine ; R
    Subject code 610
    Language English
    Publishing date 2022-04-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article: Climate–growth relationships of silver fir (Abies alba Mill.) in marginal populations of Central Italy

    Mazza, Gianluigi / Carlo Urbinati / Maria Chiara Manetti / Valeria Gallucci

    Dendrochronologia. 2014, v. 32

    2014  

    Abstract: This study is part of a LIFE+ project on marginal mountain ecosystem conservation. In five mixed European beech-silver fir forests of Central Italy (Tuscany and Marches), classified as priority habitats of the Natura 2000 Network, we analysed the ... ...

    Abstract This study is part of a LIFE+ project on marginal mountain ecosystem conservation. In five mixed European beech-silver fir forests of Central Italy (Tuscany and Marches), classified as priority habitats of the Natura 2000 Network, we analysed the climate–growth relationships of silver fir (Abies alba Mill.) along an altitudinal gradient. The aims of this study were: (i) to identify the main spatial patterns in the frequency domain of both silver fir growth and climate variables in five different sites and (ii) to detect the overall climate sensitivity of the target species through time.Multivariate analysis displayed groups of chronologies with similar growth patterns for each frequency band-pass, discriminating for altitude and geographical location. The spectral density of climate variables at seasonal scale displayed common spatial patterns during late-spring and summer months. In stands where fir grows in optimal conditions, the most significant growth responses to climate were the positive influence of late-spring and summer precipitations of the previous year and the negative effect of summer temperatures of both previous and current year, although decreasing during the last decades. On the other hand, the site at lowest altitude shows a low and not very consistent climate sensitivity as compared to the preferred altitudes. At the highest site (1375m asl) the positive effect of previous year spring–summer precipitation and summer temperature of both previous and current year disappears.Results suggest that in the studied areas a water-use increase in summer is a possible response of silver fir to the significant reduction of spring precipitation and general temperature increase throughout the 20th century.These findings provide additional information on silver fir responses to climate variability at different altitudes, useful for calibrating silvicultural treatments to apply for conservation of sensitive ecosystems and of tree species in mountain areas.
    Keywords Abies alba ; adverse effects ; altitude ; climatic factors ; ecosystems ; forests ; habitats ; spring ; summer ; temperature ; trees ; Italy
    Language English
    Size p. 181-190.
    Publishing place Elsevier GmbH
    Document type Article
    ZDB-ID 2088117-4
    ISSN 1612-0051 ; 1125-7865
    ISSN (online) 1612-0051
    ISSN 1125-7865
    DOI 10.1016/j.dendro.2014.04.004
    Database NAL-Catalogue (AGRICOLA)

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