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Artikel ; Online: Uncaria tomentosa.

Della Valle, Valentina

Giornale italiano di dermatologia e venereologia : organo ufficiale, Societa italiana di dermatologia e sifilografia

2017 Band 152, Heft 6, Seite(n) 651–657

Abstract: Uncaria tomentosa (U. tomentosa) or uña de gato, a species of vine of Rubiaceae family, was used from centuries in various medical conditions. Although there are no randomized controlled trials or published human outcome studies, some conditions ... ...

Abstract	Uncaria tomentosa (U. tomentosa) or uña de gato, a species of vine of Rubiaceae family, was used from centuries in various medical conditions. Although there are no randomized controlled trials or published human outcome studies, some conditions reportedly improved by U. tomentosa include osteoarthritis, rheumatoid arthritis, prostatitis, viral illnesses and cancer (acting as a non-specific immunomodulantign agent) and it may also have potential as an immunomodulating adaptogen in cellular aging. The understanding of some specific mechanisms of molecular action leads to the demonstration of various anti-inflammatory, immunostimulating and protective effects. These results bring the strong hypothesis that U. tomentosa could be effective in the topical treatment of dermatological manifestation, namely rosacea.
Sprache	Englisch
Erscheinungsdatum	2017-12
Erscheinungsland	Italy
Dokumenttyp	Journal Article
ZDB-ID	604114-0
ISSN	1827-1820 ; 0026-4741 ; 0392-0488
ISSN (online)	1827-1820
ISSN	0026-4741 ; 0392-0488
DOI	10.23736/S0392-0488.17.05712-1
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel: Efficacy and Safety of Intralesional Methotrexate in the Treatment of a Large Keratoacanthoma of the Dorsal Hand in a 99-Year-Old Woman.

Della Valle, Valentina / Milani, Massimo

Case reports in dermatology

2018 Band 10, Heft 3, Seite(n) 247–250

Abstract: Several case reports and retrospective studies have demonstrated that intralesional methotrexate (MTX) could be a very effective and safe alternative treatment of keratoacanthoma (KA). Here, we report a rapid clinical efficacy of two intralesional MTX ... ...

Abstract	Several case reports and retrospective studies have demonstrated that intralesional methotrexate (MTX) could be a very effective and safe alternative treatment of keratoacanthoma (KA). Here, we report a rapid clinical efficacy of two intralesional MTX injections (total dose 40 mg) that were performed 1 week apart in the treatment of a large KA lesion of the dorsal hand in a 99-year-old woman. The lesion, with a 3-cm major axis diameter and a thickness of 2 cm with a central ulceration had rapidly appeared on the right dorsal hand. A 3-mm punch biopsy confirmed the diagnosis of a well-differentiated KA-type spinous cellular carcinoma. Due to the presence of comorbidities (arterial hypertension and atrial fibrillation) and chronic treatment with antihypertensive and oral anticoagulant drugs, treatment with intralesional MTX was proposed to the patient. Two intralesional MTX injections of 20 mg each were performed 1 week apart. A very fast resolution of the lesion was observed after the first injection. A week after the second injection a full resolution of the skin lesion was observed, with a nearly complete resolution of the central ulceration. The treatment was very well tolerated. No local or systemic side effects were observed. This case report confirms that intralesional MTX could be considered an effective and safe treatment of KA also in very old subjects.
Sprache	Englisch
Erscheinungsdatum	2018-11-14
Erscheinungsland	Switzerland
Dokumenttyp	Case Reports
ZDB-ID	2505300-0
ISSN	1662-6567
ISSN	1662-6567
DOI	10.1159/000494322
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Preputial biopsy: A new single-operator, minimally invasive, bloodless, easy-to-do surgical technique.

Ghislanzoni, Massimo / Della Valle, Valentina / Bragazzi, Nicola L / Damiani, Giovanni

Dermatologic therapy

2020 Band 33, Heft 2, Seite(n) e13231

Mesh-Begriff(e)	Biopsy ; Foreskin ; Humans ; Male
Sprache	Englisch
Erscheinungsdatum	2020-02-04
Erscheinungsland	United States
Dokumenttyp	Letter
ZDB-ID	1354801-3
ISSN	1529-8019 ; 1396-0296
ISSN (online)	1529-8019
ISSN	1396-0296
DOI	10.1111/dth.13231
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel: Role of Artificial Intelligence (AI) in Surgery: Introduction, General Principles, and Potential Applications.

Mangano, Alberto / Valle, Valentina / Dreifuss, Nicolas H / Aguiluz, Gabriela / Masrur, Mario A

Surgical technology international

2021 Band 38, Seite(n) 17–21

Abstract: AI (Artificial intelligence) is an interdisciplinary field aimed at the development of algorithms to endow machines with the capability of executing cognitive tasks. The number of publications regarding AI and surgery has increased dramatically over the ... ...

Abstract	AI (Artificial intelligence) is an interdisciplinary field aimed at the development of algorithms to endow machines with the capability of executing cognitive tasks. The number of publications regarding AI and surgery has increased dramatically over the last two decades. This phenomenon can partly be explained by the exponential growth in computing power available to the largest AI training runs. AI can be classified into different sub-domains with extensive potential clinical applications in the surgical setting. AI will increasingly become a major component of clinical practice in surgery. The aim of the present Narrative Review is to give a general introduction and summarized overview of AI, as well as to present additional remarks on potential surgical applications and future perspectives in surgery.
Mesh-Begriff(e)	Algorithms ; Artificial Intelligence ; Forecasting ; Humans
Sprache	Englisch
Erscheinungsdatum	2021-05-02
Erscheinungsland	United States
Dokumenttyp	Journal Article ; Review
ZDB-ID	1225512-9
ISSN	1090-3941
ISSN	1090-3941
DOI	10.52198/21.STI.38.SO1369
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Robotic liver surgery: literature review and future perspectives.

Mangano, Alberto / Valle, Valentina / Masrur, Mario A / Bustos, Roberto E / Gruessner, Stephan / Giulianotti, Pier C

Minerva surgery

2021 Band 76, Heft 2, Seite(n) 105–115

Abstract: Introduction: Minimally invasive liver resections (MILR) have been gaining popularity over the last decades. MILR provides superior peri-operative outcome. Despite these advantages, the penetrance of MILR in the clinical setting has been limited, and it ...

Abstract	Introduction: Minimally invasive liver resections (MILR) have been gaining popularity over the last decades. MILR provides superior peri-operative outcome. Despite these advantages, the penetrance of MILR in the clinical setting has been limited, and it was slowed down, among other factors, also by the laparoscopic technological limitations. Evidence acquisition: A literature review has been carried out (Pubmed, Embase and Scopus platforms) focusing on the role of robotic surgery in MILR. Evidence synthesis: The literature review results are presented and our additional remarks on the topic are discussed. Conclusions: Robotic MILR has been helping to expand the penetrance of MIS in liver surgery by making possible increasingly more challenging procedures. Minor resections still represent most of the robotic liver surgery data currently available. Robotic liver surgery is safe and effective, and it shows perioperative outcomes comparable with laparoscopic and open surgery. The oncological efficacy, within the limitations of the current level of evidence (mostly retrospective studies and literature heterogeneity), seems to show promising result. High quality prospective randomized studies, the use of prospective registry data, and multi-institutional efforts are needed.
Mesh-Begriff(e)	Hepatectomy ; Laparoscopy ; Liver ; Retrospective Studies ; Robotic Surgical Procedures/adverse effects
Sprache	Englisch
Erscheinungsdatum	2021-04-24
Erscheinungsland	Italy
Dokumenttyp	Journal Article
ZDB-ID	3067899-7
ISSN	2724-5438
ISSN (online)	2724-5438
DOI	10.23736/S2724-5691.21.08495-9
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel: Efficacy and Safety of Intralesional Methotrexate in the Treatment of a Large Keratoacanthoma of the Dorsal Hand in a 99-Year-Old Woman

Della Valle, Valentina / Milani, Massimo

Case Reports in Dermatology

2018 Band 10, Heft 3, Seite(n) 247–250

Körperschaft	Outpatient Dermatology Service, Milan, Italy Medical Department, Cantabria Labs Difa Cooper, Caronno Pertusella, Italy
Abstract	Several case reports and retrospective studies have demonstrated that intralesional methotrexate (MTX) could be a very effective and safe alternative treatment of keratoacanthoma (KA). Here, we report a rapid clinical efficacy of two intralesional MTX injections (total dose 40 mg) that were performed 1 week apart in the treatment of a large KA lesion of the dorsal hand in a 99-year-old woman. The lesion, with a 3-cm major axis diameter and a thickness of 2 cm with a central ulceration had rapidly appeared on the right dorsal hand. A 3-mm punch biopsy confirmed the diagnosis of a well-differentiated KA-type spinous cellular carcinoma. Due to the presence of comorbidities (arterial hypertension and atrial fibrillation) and chronic treatment with antihypertensive and oral anticoagulant drugs, treatment with intralesional MTX was proposed to the patient. Two intralesional MTX injections of 20 mg each were performed 1 week apart. A very fast resolution of the lesion was observed after the first injection. A week after the second injection a full resolution of the skin lesion was observed, with a nearly complete resolution of the central ulceration. The treatment was very well tolerated. No local or systemic side effects were observed. This case report confirms that intralesional MTX could be considered an effective and safe treatment of KA also in very old subjects.
Schlagwörter	Keratoacanthoma ; Intralesional methotrexate ; Squamous cell carcinoma
Sprache	Englisch
Erscheinungsdatum	2018-11-14
Verlag	S. Karger AG
Erscheinungsort	Basel, Switzerland
Dokumenttyp	Artikel
Anmerkung	Single Case ; This article is licensed under the Creative Commons Attribution-NonCommercial 4.0 International License (CC BY-NC).
ZDB-ID	2505300-0
ISSN	1662-6567 ; 1662-6567
ISSN (online)	1662-6567
ISSN	1662-6567
DOI	10.1159/000494322
Datenquelle	Karger Verlag

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Artikel: Robotic approach to treat Median Arcuate Ligament syndrome: a case report.

Bustos, Roberto / Papamichail, Michail / Mangano, Alberto / Valle, Valentina / Giulianotti, Pier Cristoforo

Journal of surgical case reports

2020 Band 2020, Heft 5, Seite(n) rjaa088

Abstract: The Median Arcuate Ligament (MAL) syndrome is the symptomatic compression of the celiac trunk by the MAL and other ganglionic periaortic tissue. Despite its rarity, this condition is significant from a clinical, diagnostic and management standpoint and ... ...

Abstract	The Median Arcuate Ligament (MAL) syndrome is the symptomatic compression of the celiac trunk by the MAL and other ganglionic periaortic tissue. Despite its rarity, this condition is significant from a clinical, diagnostic and management standpoint and it is usually a diagnosis of exclusion. A 61-year-old female with history of intermittent postprandial epigastric pain was diagnosed with MAL syndrome during CT scan imaging (no other causes of pain were identified). Patient successfully underwent robotic MAL release with symptoms improvement after surgery. The robotic approach is feasible and may allow a very precise and delicate dissection with release of the MAL.
Schlagwörter	covid19
Sprache	Englisch
Erscheinungsdatum	2020-05-18
Erscheinungsland	England
Dokumenttyp	Case Reports
ISSN	2042-8812
ISSN	2042-8812
DOI	10.1093/jscr/rjaa088
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel: Role of Indocyanine Green (ICG)-Enhanced Fluorescence in Primary and Revisional Bariatric Surgery: Narrative Overview of Selected Literature and Intraoperative Surgical Videos.

Mangano, Alberto / Valle, Valentina / Dreifuss, Nicolas H / Schlottmann, Francisco / Cubisino, Antonio / Baz, Carolina / Masrur, Mario A

Surgical technology international

2021 Band 40, Seite(n) 79–84

Abstract: Laparoscopic sleeve gastrectomy is one of the most common bariatric surgical procedures. Despite being easier to perform than other bariatric procedures, it is not free of complications. Leaks are some of the most severe events, and are observed in ... ...

Abstract	Laparoscopic sleeve gastrectomy is one of the most common bariatric surgical procedures. Despite being easier to perform than other bariatric procedures, it is not free of complications. Leaks are some of the most severe events, and are observed in around 0.5-6% of cases. Use of the near-infrared indocyanine green (ICG) perfusion test during sleeve gastrectomy seems to be promising. However, its application in sleeve gastrectomy is still in fieri. Similarly, ICG is not commonly used in Roux-en-Y gastric bypass. This report presents the main evidence from selected literature regarding the use of ICG during sleeve gastrectomy and Roux-en-Y gastric bypass, along with our remarks. It also provides intraoperative video clips and photographs showing the use of ICG in this surgical field.
Mesh-Begriff(e)	Bariatric Surgery/adverse effects ; Fluorescence ; Gastrectomy/adverse effects ; Gastrectomy/methods ; Gastric Bypass/methods ; Humans ; Indocyanine Green ; Laparoscopy/methods ; Obesity, Morbid/surgery ; Reoperation ; Retrospective Studies
Chemische Substanzen	Indocyanine Green (IX6J1063HV)
Sprache	Englisch
Erscheinungsdatum	2021-12-23
Erscheinungsland	United States
Dokumenttyp	Journal Article
ZDB-ID	1225512-9
ISSN	1090-3941
ISSN	1090-3941
DOI	10.52198/22.STI.40.GS1517
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel: Robot-assisted enucleation of gigantic liver hemangiomas: Case series of 3 patients.

Giulianotti, Pier Cristoforo / Bustos, Roberto / Valle, Valentina / Aguiluz, Gabriela / Pavelko, Yevhen / Fernandes, Eduardo

International journal of surgery case reports

2019 Band 60, Seite(n) 244–248

Abstract: Introduction: Liver hemangiomas are benign liver lesions that require surgical excision when large and symptomatic. Often, these tumors are removed through large anatomical resections which sacrifice more liver parenchyma than needed. Tumor enucleation, ...

Abstract	Introduction: Liver hemangiomas are benign liver lesions that require surgical excision when large and symptomatic. Often, these tumors are removed through large anatomical resections which sacrifice more liver parenchyma than needed. Tumor enucleation, which takes advantage of a digitoclasia-like technique along the plane between the tumor pseudo-capsule and liver parenchyma, poses challenges when performed laparoscopically. We propose a parenchymal sparing, minimally invasive, robotic-assisted technique to remove liver hemangiomas. Presentation of cases: Three male patients with symptomatic hemangiomas were treated in our center between 2015 and 2018. The lesions were located in segment II, III and segment IV-V respectively. Robotic-assisted hemangioma enucleation was accomplished successfully in all three patients. The procedures were performed with a parenchyma-sparing intent and a formal segmentectomy was not required. There were no conversions to open surgery. Discussion: The robotic platform provides a powerful tool in the enucleation of liver hemangiomas. The enhanced vision and the superior suturing ability allow to develop safely the plane between the tumor pseudo-capsule and the liver parenchyma, with outstanding selective control of all the vascular supply and drainage encountered during the dissection. Furthermore, precision of the hilar dissection allows selective lobar or sectorial arterial control which helps minimize intraoperative bleeding. Conclusion: In our experience, robot-assisted enucleation of liver hemangiomas offers low morbidity, fast recovery, excellent cosmetic results, and it could become a therapeutic option when the location of the hemangioma allows this approach.
Schlagwörter	covid19
Sprache	Englisch
Erscheinungsdatum	2019-06-21
Erscheinungsland	Netherlands
Dokumenttyp	Journal Article
ISSN	2210-2612
ISSN	2210-2612
DOI	10.1016/j.ijscr.2019.06.033
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Surgical opioid-avoidance protocol: a postoperative pharmacological multimodal analgesic intervention in diverse patient populations.

Votta-Velis, Gina / Daviglus, Martha L / Borgeat, Alain / Beckmann, Katharina / Ta, Andrew Q / Parker, John L / Kravets, Sasha / Garcia, Olga L / Pirzada, Amber / Gastala, Nicole / Valle, Valentina / Benken, Jamie J / Campara, Maya / Aguiluz, Gabriela / Memtsoudis, Stavros G / Giulianotti, Pier C / Benedetti, Enrico

Regional anesthesia and pain medicine

2023 Band 48, Heft 12, Seite(n) 594–600

Abstract: Introduction: This study evaluated the effect of a surgical opioid-avoidance protocol (SOAP) on postoperative pain scores. The primary goal was to demonstrate that the SOAP was as effective as the pre-existing non-SOAP (without opioid restriction) ... ...

Abstract	Introduction: This study evaluated the effect of a surgical opioid-avoidance protocol (SOAP) on postoperative pain scores. The primary goal was to demonstrate that the SOAP was as effective as the pre-existing non-SOAP (without opioid restriction) protocol by measuring postoperative pain in a diverse, opioid-naive patient population undergoing inpatient surgery across multiple surgical services. Methods: This prospective cohort study was divided into SOAP and non-SOAP groups based on surgery date. The non-SOAP group had no opioid restrictions (n=382), while the SOAP group (n=449) used a rigorous, opioid-avoidance order set with patient and staff education regarding multimodal analgesia. A non-inferiority analysis assessed the SOAP impact on postoperative pain scores. Results: Postoperative pain scores in the SOAP group compared with the non-SOAP group were non-inferior (95% CI: -0.58, 0.10; non-inferiority margin=-1). The SOAP group consumed fewer postoperative opioids (median=0.67 (IQR=15) vs 8.17 morphine milliequivalents (MMEs) (IQR=40.33); p<0.01) and had fewer discharge prescription opioids (median=0 (IQR=60) vs 86.4 MMEs (IQR=140.4); p<0.01). Discussion: The SOAP was as effective as the non-SOAP group in postoperative pain scores across a diverse patient population and associated with lower postoperative opioid consumption and discharge prescription opioids.
Mesh-Begriff(e)	Humans ; Analgesics, Opioid ; Prospective Studies ; Analgesics ; Pain Management/methods ; Pain, Postoperative/diagnosis ; Pain, Postoperative/etiology ; Pain, Postoperative/prevention & control ; Morphine
Chemische Substanzen	Analgesics, Opioid ; Analgesics ; Morphine (76I7G6D29C)
Sprache	Englisch
Erscheinungsdatum	2023-04-06
Erscheinungsland	England
Dokumenttyp	Journal Article
ZDB-ID	1425299-5
ISSN	1532-8651 ; 1098-7339 ; 0146-521X
ISSN (online)	1532-8651
ISSN	1098-7339 ; 0146-521X
DOI	10.1136/rapm-2022-103864
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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