Article ; Online: Epidemiology of Tracheostomized Adult Patients Admitted to Specialized Weaning Centers After Acute COVID-19.
2024 Volume 69, Issue 2, Page(s) 202–209
Abstract: Background: Epidemiological data on patients with COVID-19 referred to specialized weaning centers (SWCs) are sparse, particularly in low- and middle-income countries. Our aim was to describe clinical features, epidemiology, and outcomes of subjects ... ...
| Abstract | Background: Epidemiological data on patients with COVID-19 referred to specialized weaning centers (SWCs) are sparse, particularly in low- and middle-income countries. Our aim was to describe clinical features, epidemiology, and outcomes of subjects admitted to SWCs in Argentina. Methods: We conducted a prospective, multi-center, observational study between July 2020-December 2021 in 12 SWCs. We collected demographic characteristics, laboratory results, pulmonary function, and dependence on mechanical ventilation at admission, decannulation, weaning from mechanical ventilation, and status at discharge. A multiple logistic model was built to predict home discharge. Results: We enrolled 568 tracheostomized adult subjects after the acute COVID-19 phase who were transferred to SWCs. Age was 62 [52-71], males 70%, Charlson comorbidity index was 2 [0-3], and length of stay in ICU was 42 [32-56] d. Of the 315 ventilator-dependent subjects, 72.4% were weaned, 427 (75.2%) were decannulated, and 366 subjects (64.5%) were discharged home. The mortality rate was 6.0%. In multivariate analysis, age (odds ratio 0.30 [95% CI 0.16-0.56], Conclusions: Most subjects with COVID-19 transferred to SWCs were weaned, achieved decannulation, and were discharged to home. Age, high-comorbidity burden, prolonged mechanical ventilation in ICU, renal failure at admission, and expiratory muscle weakness were inversely associated with home discharge. |
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| MeSH term(s) | Humans ; Male ; COVID-19/epidemiology ; Muscle Weakness ; Prospective Studies ; Renal Insufficiency ; Respiration, Artificial ; Ventilator Weaning ; Female ; Middle Aged ; Aged | |||||
| Language | English | |||||
| Publishing date | 2024-01-24 | |||||
| Publishing country | United States | |||||
| Document type | Journal Article ; Multicenter Study ; Observational Study | |||||
| ZDB-ID | 603252-7 | |||||
| ISSN | 1943-3654 ; 0098-9142 ; 0020-1324 | |||||
| ISSN (online) | 1943-3654 | |||||
| ISSN | 0098-9142 ; 0020-1324 | |||||
| DOI | 10.4187/respcare.11113 | |||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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