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Article ; Online: Maternal plasma markers in intrauterine growth restriction and small for gestational age complicated pregnancy: the role of sFlt-1/PlGF.

Libretti, Alessandro / Valsecchi, Luca / Zerbini, Gianpaolo / Remorgida, Valentino / Candiani, Massimo

2023 Volume 75, Issue 6, Page(s) 588–589

MeSH term(s)	Pregnancy ; Infant, Newborn ; Female ; Humans ; Fetal Growth Retardation/diagnosis ; Gestational Age ; Placenta Growth Factor ; Infant, Small for Gestational Age ; Vascular Endothelial Growth Factor Receptor-1
Chemical Substances	Placenta Growth Factor (144589-93-5) ; Vascular Endothelial Growth Factor Receptor-1 (EC 2.7.10.1)
Language	English
Publishing date	2023-08-04
Publishing country	Italy
Document type	Journal Article ; Comment
ZDB-ID	3062815-5
ISSN	2724-6450
ISSN (online)	2724-6450
DOI	10.23736/S2724-606X.23.05384-8
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Article ; Online: Effects of flexible sacrum position at birth on maternal and neonatal outcomes: A retrospective cohort study.

Caglioni, Martina / Cantatore, Francesco / Valsecchi, Luca / Miglioli, Cesare / Dumont, Roxane / Rinaldi, Stefania / Candiani, Massimo / Salvatore, Stefano

International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics

2023 Volume 163, Issue 3, Page(s) 911–919

Abstract: Objective: To examine the differences in both maternal and neonatal outcomes between flexible and non-flexible sacrum positions at birth.: Methods: A descriptive, cross-sectional, retrospective study was carried out on a sample of low-risk pregnant ... ...

Abstract	Objective: To examine the differences in both maternal and neonatal outcomes between flexible and non-flexible sacrum positions at birth. Methods: A descriptive, cross-sectional, retrospective study was carried out on a sample of low-risk pregnant women. Univariate and multivariate logistic regressions and multivariate linear regressions were conducted to estimate the association between our discrete or continuous variables of interest. Maternal outcomes were perineal tear, maternal blood loss, second stage length; neonatal outcomes were Apgar scores and neonatal asphyxia. Results were adjusted for maternal age, neonatal birth weight, and epidural analgesia. Results: We considered for final analysis 2198 women. In primiparous women, women giving birth in the all-fours position were significantly more likely to have an intact perineum (P = 0.011) and a shorter length of the second stage of labor (P = 0.022). Maternal age (P = 0.005) and neonatal weight (P = 0.013) significantly increased perineal tearing; maternal age (P = 0.004) and neonatal birth weight (P < 0.001) were significantly associated with a higher amount of blood loss. Maternal age (P = 0.002) and neonatal weight (P < 0.001) significantly increased the length of the second stage of labor. For multiparous women, the side-lying position was significantly correlated with an intact perineum (P = 0.031); maternal age and intact perineum were statistically inversely associated. Epidural analgesia significantly increased the length of the second stage of labor in both nulliparous (P < 0.001) and pluriparous women (P < 0.001). No significant differences were found in neonatal outcomes. Conclusion: Women with a low-risk labor should be free to choose their birth position as flexible sacrum positions are shown to increase maternal well-being and do not affect neonatal health.
MeSH term(s)	Infant, Newborn ; Pregnancy ; Female ; Humans ; Retrospective Studies ; Sacrum ; Birth Weight ; Cross-Sectional Studies ; Labor, Obstetric
Language	English
Publishing date	2023-06-04
Publishing country	United States
Document type	Journal Article
ZDB-ID	80149-5
ISSN	1879-3479 ; 0020-7292
ISSN (online)	1879-3479
ISSN	0020-7292
DOI	10.1002/ijgo.14897
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Zs.A 355: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: High dose antithrombin supplementation in early preeclampsia: A randomized, double blind, placebo-controlled study.

D'Angelo, Armando / Valsecchi, Luca

Thrombosis research

2016 Volume 140, Page(s) 7–13

Abstract: Introduction: Antithrombin levels are often reduced in preeclampsia and infusion of antithrombin concentrates has been reported to prolong gestation in severe preeclampsia. We aimed to evaluate efficacy and safety of high-dose antithrombin (ATIII) ... ...

Abstract	Introduction: Antithrombin levels are often reduced in preeclampsia and infusion of antithrombin concentrates has been reported to prolong gestation in severe preeclampsia. We aimed to evaluate efficacy and safety of high-dose antithrombin (ATIII) supplementation in patients with single pregnancies and preeclampsia occurring before 30 weeks of gestation. Materials and methods: In November 2004 a double-blind, placebo-controlled trial (code KB033) was started in 13 Italian centers. The planned sample size was of 240 patients (intention-to-treat, ITT population) to detect a 30% relative risk reduction of the primary endpoint, composite perinatal morbidity. Eligible patients were randomized to high dose AT (3000 IU/daily, ATIII Kedrion S.p.A., Italy), or placebo (1% glycine) for 7 days or less until delivery, whichever came first. The per-protocol (PP) population was restricted to patients receiving at least two days of treatment. Results: The study was terminated by the sponsor in October 2007 after the enrolment of 38 evaluable patients - 20 randomized to high dose AT and 18 to placebo, 27 treated for 2 days or more - out of 164 screened patients. Enrolment failures were mainly represented by requirement for immediate delivery and consent refusal (91 patients). The primary endpoint occurred in 15 of 38 patients (39.5%), with a relative risk in the AT arm of 0.85 (95% CI 0.42-1.75) and 0.79 (95% CI 0.30-2.11) in the ITT and PP populations, respectively. Living neonates in the two arms had similar weight at birth, Apgar scores, and duration of hospitalization in neonatal ICU. In mothers, AT supplementation was associated with reduced blood loss at delivery and with surrogate laboratory markers (LDH, d-dimer). Conclusions: The results of this markedly underpowered trial, albeit suggestive of a potential maternal benefit, cannot support high-dose AT supplementation to improve fetal/neonatal outcomes in early preeclampsia.
MeSH term(s)	Adult ; Antithrombin III/administration & dosage ; Antithrombin III/therapeutic use ; Antithrombins/administration & dosage ; Antithrombins/therapeutic use ; Double-Blind Method ; Female ; Fibrin Fibrinogen Degradation Products/analysis ; Humans ; Infant, Newborn ; Placebo Effect ; Pre-Eclampsia/blood ; Pre-Eclampsia/drug therapy ; Pregnancy ; Treatment Outcome
Chemical Substances	Antithrombins ; Fibrin Fibrinogen Degradation Products ; fibrin fragment D ; Antithrombin III (9000-94-6)
Language	English
Publishing date	2016-04
Publishing country	United States
Document type	Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
ZDB-ID	121852-9
ISSN	1879-2472 ; 0049-3848
ISSN (online)	1879-2472
ISSN	0049-3848
DOI	10.1016/j.thromres.2016.01.024
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Article: Early increase in circulating carbonic anhydrase IX: A potential new predictive biomarker of preeclampsia.

Galbiati, Silvia / Gabellini, Daniela / Ambrosi, Alessandro / Soriani, Nadia / Pasi, Federica / Locatelli, Massimo / Lucianò, Roberta / Candiani, Massimo / Valsecchi, Luca / Zerbini, Gianpaolo / Smid, Maddalena

Frontiers in molecular biosciences

2023 Volume 10, Page(s) 1075604

Abstract: Preeclampsia (PE) is a severe complication of pregnancy. The identification of a reliable predictive biomarker could help in setting up a specific preventive strategy. To this aim, we studied carbonic anhydrase IX (CAIX) as a marker of hypoxia (a pathway ...

Abstract	Preeclampsia (PE) is a severe complication of pregnancy. The identification of a reliable predictive biomarker could help in setting up a specific preventive strategy. To this aim, we studied carbonic anhydrase IX (CAIX) as a marker of hypoxia (a pathway involved in PE pathogenesis) and compared the diagnostic accuracy of CAIX to that of the validated biomarker sFlt1/PlGF ratio. Fifteen women with overt PE and 38 women at a risk of developing PE, sampled at different time intervals during gestation (a total of 82 plasma samples collected), were enrolled and underwent the CAIX measurement. CAIX levels significantly increased (
Language	English
Publishing date	2023-01-19
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2814330-9
ISSN	2296-889X
ISSN	2296-889X
DOI	10.3389/fmolb.2023.1075604
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Article ; Online: Weekly Paclitaxel for Pregnancy Associated Breast Cancer.

Girardelli, Serena / Bonomo, Barbara / Papale, Margherita / di Loreto, Eugenia / Grossi, Elena / Scarfone, Giovanna / Rabaiotti, Emanuela / Valsecchi, Luca / Mangili, Giorgia / Candiani, Massimo / Peccatori, Fedro

Clinical breast cancer

2023 Volume 24, Issue 3, Page(s) 199–203

Abstract: Background: Pregnancy associated breast cancer is the most common cancer diagnosed during pregnancy. When chemotherapy is indicated, although it is more common to use anthracycline-based chemotherapy as a first treatment, we suggest weekly paclitaxel as ...

Abstract	Background: Pregnancy associated breast cancer is the most common cancer diagnosed during pregnancy. When chemotherapy is indicated, although it is more common to use anthracycline-based chemotherapy as a first treatment, we suggest weekly paclitaxel as a valid alternative both in the adjuvant and neoadjuvant setting, as this allows for weekly assessment of maternal-fetal well-being and a quicker maternal and fetal bone marrow recovery in cases of unexpected preterm delivery. Patients and methods: We present a case series of pregnant breast cancer patients treated with weekly paclitaxel between 2016 and 2022. Patient demographics and tumor characteristics, data on management, delivery, and maternal-neonatal outcomes were extrapolated from institutional electronic databases. Results: Eighteen patients underwent weekly paclitaxel for breast cancer during pregnancy (PrBC); 17 were primary diagnoses and 1 was a recurrence. None of the patients had severe adverse reactions to CT. Two cases of preterm prelabour rupture of membranes were reported while in 1 case treatment was stopped due to threatened preterm birth. Two babies were born large for gestational age, 2 were small for gestational age and 2 babies were growth restricted at birth. At a mean follow up of 42.9 months, 1 patient died, 1 patient was diagnosed with disease recurrence and another patient was diagnosed with disease progression. Conclusion: Weekly paclitaxel can be safely administered during pregnancy and should be included in the current therapeutic options for PrBC.
MeSH term(s)	Female ; Humans ; Infant, Newborn ; Pregnancy ; Antibiotics, Antineoplastic/adverse effects ; Breast Neoplasms/pathology ; Neoplasm Recurrence, Local/drug therapy ; Neoplasm Recurrence, Local/chemically induced ; Paclitaxel ; Premature Birth/chemically induced ; Premature Birth/drug therapy
Chemical Substances	Antibiotics, Antineoplastic ; Paclitaxel (P88XT4IS4D)
Language	English
Publishing date	2023-12-13
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	2106734-X
ISSN	1938-0666 ; 1526-8209
ISSN (online)	1938-0666
ISSN	1526-8209
DOI	10.1016/j.clbc.2023.11.007
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Zs.A 5800: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 498: Show issues

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Article ; Online: A narrative review of pregnancy after malignancies in young women that don't originate in the female genital organs or in the breast.

Girardelli, Serena / Mangili, Giorgia / Cosio, Stefania / Rabaiotti, Emanuela / Fanucchi, Antonio / Valsecchi, Luca / Candiani, Massimo / Gadducci, Angiolo

Critical reviews in oncology/hematology

2021 Volume 159, Page(s) 103240

Abstract: While cancer during pregnancy and its treatment has grown to be a popular topic in recent years, little is known on how to advise patients looking to conceive or conceiving after cancer treatment. The aim of this paper is to review the available ... ...

Abstract	While cancer during pregnancy and its treatment has grown to be a popular topic in recent years, little is known on how to advise patients looking to conceive or conceiving after cancer treatment. The aim of this paper is to review the available literature on the impact of pregnancy on survivors of the most common childhood cancers, brain cancer, haematological malignancies, thyroid cancer, melanomas and sarcomas. Its main objective is to be a source of information for clinicians looking to counsel patients in these delicate moments exploiting all the available literature, albeit scarce. Given the available literature, we conclude that the presence of a multidisciplinary team is of great importance in supporting the patient and her loved ones when facing pregnancy with a previous cancer diagnosis.
MeSH term(s)	Breast Neoplasms/diagnosis ; Breast Neoplasms/epidemiology ; Breast Neoplasms/therapy ; Child ; Female ; Fertilization ; Genitalia, Female ; Humans ; Pregnancy ; Survivors
Language	English
Publishing date	2021-01-20
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	605680-5
ISSN	1879-0461 ; 0737-9587 ; 1040-8428
ISSN (online)	1879-0461
ISSN	0737-9587 ; 1040-8428
DOI	10.1016/j.critrevonc.2021.103240
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Article ; Online: Meningiomas in Gynecology and Reproduction: an Updated Overview for Clinical Practice.

Girardelli, Serena / Albano, Luigi / Mangili, Giorgia / Valsecchi, Luca / Rabaiotti, Emanuela / Cavoretto, Paolo Ivo / Mortini, Pietro / Candiani, Massimo

Reproductive sciences (Thousand Oaks, Calif.)

2021 Volume 29, Issue 9, Page(s) 2452–2464

Abstract: There is various evidence to suggest a relationship between female hormones and meningiomas; as clinicians, we often come to face challenging situations involving female patients diagnosed with meningiomas during the post-pubertal phases of their life. ... ...

Abstract	There is various evidence to suggest a relationship between female hormones and meningiomas; as clinicians, we often come to face challenging situations involving female patients diagnosed with meningiomas during the post-pubertal phases of their life. We aimed to review the specific circumstances (pregnancy, postpartum, hormonal contraception and hormone replacement therapy, gender-affirming hormonal treatment) clinicians might come to face during their daily clinical practice, given the absence of available guidelines. We therefore conducted a narrative review on articles found in PubMed and Embase databases using appropriate keywords. Ninety-six relevant articles were included. The available evidence on managing meningiomas in post-pubertal women often implies personal strategies, highlighting the lack of a unified approach. The knowledge of the biological links between female hormones and meningiomas is fundamental to correctly counsel patients in various life phases. Prospective randomized studies are required to improve available guidelines on how to best manage meningiomas in female post-pubertal patients.
MeSH term(s)	Female ; Gynecology ; Hormones ; Humans ; Meningeal Neoplasms/therapy ; Meningioma/therapy ; Pregnancy ; Prospective Studies ; Reproduction
Chemical Substances	Hormones
Language	English
Publishing date	2021-05-10
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2276411-2
ISSN	1933-7205 ; 1933-7191
ISSN (online)	1933-7205
ISSN	1933-7191
DOI	10.1007/s43032-021-00606-2
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Article ; Online: Carboplatin Use in Pregnancy for Stage IB3 Cervical Cancer: Case Report and Review of the Literature.

Rabaiotti, Emanuela / Girardelli, Serena / Valsecchi, Luca / Bergamini, Alice / Petrone, Micaela / Mangili, Giorgia / Candiani, Massimo

Journal of adolescent and young adult oncology

2019 Volume 9, Issue 3, Page(s) 445–448

Abstract: Locally advanced stage cervical cancer diagnosed during pregnancy is a clinical challenge and requires skill in balancing maternal management, fetal care, and oncological treatment. Cisplatin has been routinely used as a first line agent for neoadjuvant ... ...

Abstract	Locally advanced stage cervical cancer diagnosed during pregnancy is a clinical challenge and requires skill in balancing maternal management, fetal care, and oncological treatment. Cisplatin has been routinely used as a first line agent for neoadjuvant chemotherapy in this situation, even though it has also recently been associated with fetal hearing loss. We report a case of stage IB3 cervical cancer diagnosed at 17 gestational weeks successfully treated with neoadjuvant chemotherapy using carboplatin and paclitaxel during pregnancy. Carboplatin is a valid alternative to cisplatin for advanced stage cervical carcinoma in a pregnant patient, in particular in view of the neonatal complications (primarily ototoxicity) that are associated with
MeSH term(s)	Adult ; Antineoplastic Agents/pharmacology ; Antineoplastic Agents/therapeutic use ; Carboplatin/pharmacology ; Carboplatin/therapeutic use ; Female ; Humans ; Neoplasm Staging ; Uterine Cervical Neoplasms/drug therapy
Chemical Substances	Antineoplastic Agents ; Carboplatin (BG3F62OND5)
Language	English
Publishing date	2019-12-02
Publishing country	United States
Document type	Case Reports ; Journal Article ; Review
ZDB-ID	2607978-1
ISSN	2156-535X ; 2156-5333
ISSN (online)	2156-535X
ISSN	2156-5333
DOI	10.1089/jayao.2019.0118
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Article ; Online: Weekly Paclitaxel Administered During a Twin Pregnancy for Recurrent Breast Cancer: Case Report and Review of the Literature.

Girardelli, Serena / Rabaiotti, Emanuela / Mauro, Fabio / Gentilini, Oreste / Zucchinelli, Patrizia / Cioffi, Raffaella / Valsecchi, Luca / Mangili, Giorgia / Peccatori, Fedro A / Candiani, Massimo

Journal of adolescent and young adult oncology

2022 Volume 11, Issue 6, Page(s) 632–636

Abstract: Although cancer treatment during single pregnancy has been standardized, how to manage cancer diagnosed during a multiple gestation is still unclear. Chemotherapy during pregnancy has shown to be safe, however, there are reports of increased risks of ... ...

Abstract	Although cancer treatment during single pregnancy has been standardized, how to manage cancer diagnosed during a multiple gestation is still unclear. Chemotherapy during pregnancy has shown to be safe, however, there are reports of increased risks of fetal complications such as intrauterine growth restriction and preterm birth. Also, how to best adjust this to the pharmacokinetic characteristics of a twin gestation has yet to be fully investigated. We report the case of an IVF twin pregnancy with a diagnosis of breast cancer recurrence shortly after conception, and how the pregnancy was managed to obtain optimal obstetric, maternal/oncological, and fetal outcomes.
MeSH term(s)	Infant, Newborn ; Humans ; Female ; Pregnancy, Twin ; Paclitaxel/pharmacology ; Paclitaxel/therapeutic use ; Breast Neoplasms/drug therapy ; Premature Birth
Chemical Substances	Paclitaxel (P88XT4IS4D)
Language	English
Publishing date	2022-02-18
Publishing country	United States
Document type	Review ; Case Reports ; Journal Article
ZDB-ID	2607978-1
ISSN	2156-535X ; 2156-5333
ISSN (online)	2156-535X
ISSN	2156-5333
DOI	10.1089/jayao.2021.0181
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Article: Maternal Arsenic Exposure and Gestational Diabetes: A Systematic Review and Meta-Analysis

Salmeri, Noemi / Villanacci, Roberta / Ottolina, Jessica / Bartiromo, Ludovica / Cavoretto, Paolo / Dolci, Carolina / Lembo, Rosalba / Schimberni, Matteo / Valsecchi, Luca / Viganò, Paola / Candiani, Massimo

Nutrients. 2020 Oct. 11, v. 12, no. 10

2020

Abstract: Gestational diabetes mellitus (GDM) is a metabolic complication associated with adverse outcomes for mother and fetus. Arsenic (As) exposure has been suggested as a possible risk factor for its development. The aim of this meta-analysis was to provide a ... ...

Abstract	Gestational diabetes mellitus (GDM) is a metabolic complication associated with adverse outcomes for mother and fetus. Arsenic (As) exposure has been suggested as a possible risk factor for its development. The aim of this meta-analysis was to provide a comprehensive overview of published evidence on the association between As and GDM. The systematic search from PubMed, MEDLINE, and Scopus was limited to full-length manuscripts published in peer-reviewed journals up to April 2020, identifying fifty articles. Ten studies met the inclusion criteria, nine for quantitative synthesis with a total of n = 1984 GDM cases. The overall pooled risk was 1.56 (95% Confidence Interval - CI = 1.23, 1.99) with moderate heterogeneity (χ² = 21.95; I²% = 64). Several differences among the included studies that may account for heterogeneity were investigated. Stratification for exposure indicator confirmed a positive association for studies assessing urine As. A slightly higher risk was detected pooling studies based in Asia rather than in North America. Stratification for GDM diagnostic criteria showed higher risks when diagnosis was made according to the Canadian Diabetes Association (CDA-SOGC) or World Health Organization (WHO) criteria, whereas a lower risk was observed when adopting the American Diabetes Association (ADA) criteria. These results provide additional evidence for a possible association between As exposure and GDM, although the data need to be interpreted with caution due to heterogeneity.
Keywords	World Health Organization ; arsenic ; confidence interval ; fetus ; gestational diabetes ; journals ; meta-analysis ; nutrients ; risk factors ; synthesis ; systematic review ; urine ; Asia ; North America
Language	English
Dates of publication	2020-1011
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article
Note	NAL-light
ZDB-ID	2518386-2
ISSN	2072-6643
ISSN	2072-6643
DOI	10.3390/nu12103094
Database	NAL-Catalogue (AGRICOLA)

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