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Article ; Online: Optimizing Antibiotic Therapy for Intravenous Drug Users: A Narrative Review Unraveling Pharmacokinetics/Pharmacodynamics Challenges.

Colaneri, Marta / Genovese, Camilla / Valsecchi, Pietro / Calia, Matteo / Cattaneo, Dario / Gori, Andrea / Bruno, Raffaele / Seminari, Elena

European journal of drug metabolism and pharmacokinetics

2024 Volume 49, Issue 2, Page(s) 123–129

Abstract: Intravenous drug users (IVDUs) face heightened susceptibility to life-threatening gram-positive bacterial infections, particularly methicillin-resistant Staphylococcus aureus (MRSA). While the standard antibiotic dosing strategies for special patients, ... ...

Abstract	Intravenous drug users (IVDUs) face heightened susceptibility to life-threatening gram-positive bacterial infections, particularly methicillin-resistant Staphylococcus aureus (MRSA). While the standard antibiotic dosing strategies for special patients, such as obese or critically ill individuals, are known to be inadequate, raising concerns about treatment efficacy, a similar sort of understanding has not been assessed for IVDUs yet. With this in mind, this review examines the pharmacokinetic/pharmacodynamic characteristics of antibiotics commonly used against gram-positive bacteria in IVDUs. Focusing on daptomycin, vancomycin, teicoplanin, aminoglycosides, and the novel lipoglycopeptide dalbavancin, the study reveals significant pharmacokinetic variations in IVDUs, suggesting the need for personalized dosing. Concomitant opioid substitution therapy and other factors, such as malnutrition, contribute to altered pharmacokinetics/pharmacodynamics, emphasizing the importance of targeted therapeutic drug monitoring. Overall, our study calls for increased awareness among clinicians regarding the unique pharmacokinetic/pharmacodynamic challenges in IVDUs and advocates for tailored antibiotic dosing strategies to enhance treatment outcomes in this marginalized population.
MeSH term(s)	Humans ; Drug Users ; Methicillin-Resistant Staphylococcus aureus ; Substance Abuse, Intravenous/drug therapy ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/therapeutic use ; Vancomycin
Chemical Substances	Anti-Bacterial Agents ; Vancomycin (6Q205EH1VU)
Language	English
Publishing date	2024-02-08
Publishing country	France
Document type	Review ; Journal Article
ZDB-ID	196729-0
ISSN	2107-0180 ; 0398-7639 ; 0378-7966
ISSN (online)	2107-0180
ISSN	0398-7639 ; 0378-7966
DOI	10.1007/s13318-024-00882-8
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Article ; Online: The possible role of serum bactericidal titres in long-term suppressive antibiotic treatment for infective endocarditis: report of three cases.

Valsecchi, Pietro / Calia, Matteo / Marvulli, Lea Nadia / Bono, Enrica / Monzillo, Vincenzina / Bruno, Raffaele / Seminari, Elena

Infectious diseases (London, England)

2023 Volume 55, Issue 7, Page(s) 514–518

Abstract: Introduction: long term suppressive antibiotic treatment may be the only feasible option for patients with infective endocarditis (IE) not suitable for surgery.: Case reports: we present three cases of prosthetic valve endocarditis (PVE) caused by !## ...

Abstract	Introduction: long term suppressive antibiotic treatment may be the only feasible option for patients with infective endocarditis (IE) not suitable for surgery. Case reports: we present three cases of prosthetic valve endocarditis (PVE) caused by Conclusions: long term oral amoxicillin was effective and well-tolerated. SBTs after switch to oral therapy were quite heterogeneous, in some cases not reaching the conventionally established titre to assess bactericidal effect (1:8).Key pointsendovascular infection in non-suitable-for-surgery patients can be managed with long-term oral suppressive therapy.serum bactericidal assay confirmed high effectiveness of parenteral antibiotic therapy.serum bactericidal assay showed highly variable titres during oral therapy.
MeSH term(s)	Humans ; Endocarditis, Bacterial/drug therapy ; Anti-Bacterial Agents/therapeutic use ; Heart Valve Prosthesis ; Tomography, X-Ray Computed ; Endocarditis/drug therapy ; Anti-Infective Agents ; Amoxicillin/therapeutic use
Chemical Substances	Anti-Bacterial Agents ; Anti-Infective Agents ; Amoxicillin (804826J2HU)
Language	English
Publishing date	2023-06-02
Publishing country	England
Document type	Case Reports ; Journal Article
ZDB-ID	2839775-7
ISSN	2374-4243 ; 2374-4235
ISSN (online)	2374-4243
ISSN	2374-4235
DOI	10.1080/23744235.2023.2216271
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Article ; Online: Mortality due to COVID-19 during the pandemic: A comparison of first, second and third SMAtteo COvid19 REgistry (SMACORE)

Zuccaro, Valentina / Colaneri, Marta / Asperges, Erika / Valsecchi, Pietro / Sambo, Margherita / Maiocchi, Laura / Sacchi, Paolo / Muzzi, Alba / Musella, Valeria / Cutti, Sara / Rettani, Marco / Mojoli, Francesco / Perlini, Stefano / Corsico, Angelo Guido / Di Sabatino, Antonio / Brunetti, Enrico / Bruno, Raffaele / Klersy, Catherine

Heliyon. 2022 Feb., v. 8, no. 2 p.e08895-

2022

Abstract: COVID-19 tide had shattered on European countries with three distinct and tough waves, from March and April, 2020; October and November, 2020 and March and April, 2021 respectively. We observed a 50% reduction in the hazard of death during both wave II ... ...

Abstract	COVID-19 tide had shattered on European countries with three distinct and tough waves, from March and April, 2020; October and November, 2020 and March and April, 2021 respectively. We observed a 50% reduction in the hazard of death during both wave II and III compared with wave I (HR 0.54, 95%CI 0.39–0.74 and HR 0.57, 95%CI 0.41–0.80, respectively). Sex and age were independent predictors of death. We compare in-hospital mortality of COVID-19 patients admitted at our Referral Hospital of Northern Italy during the different waves, discuss the reasons of the observed differences and suggest approaches to the challenges ahead.
Keywords	COVID-19 infection ; death ; hospitals ; mortality ; pandemic ; Italy ; Covid-19 ; In-hospital mortality
Language	English
Dates of publication	2022-02
Publishing place	Elsevier Ltd
Document type	Article ; Online
Note	Use and reproduction
ZDB-ID	2835763-2
ISSN	2405-8440
ISSN	2405-8440
DOI	10.1016/j.heliyon.2022.e08895
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Article ; Online: Running out of bullets: The challenging management of acute hepatitis and SARS-COV-2 from the SMatteo COvid19 Registry (SMACORE).

Colaneri, Marta / Valsecchi, Pietro / Perotti, Luciano / Ludovisi, Serena / Seminari, Elena / Pieri, Teresa Chiara / Sacchi, Paolo / Bruno, Raffaele

Liver international : official journal of the International Association for the Study of the Liver

2020 Volume 40, Issue 11, Page(s) 2655–2659

Abstract: Liver impairment is frequent in patients with novel coronavirus disease (COVID-19) and direct viral tropism for the liver has been proven. Since several of the currently administered drugs against severe acute respiratory syndrome coronavirus 2 (SARS-CoV- ...

Abstract	Liver impairment is frequent in patients with novel coronavirus disease (COVID-19) and direct viral tropism for the liver has been proven. Since several of the currently administered drugs against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are possibly hepatotoxic, the management of patients with COVID-19 and liver failure is still an almost unexplored field. Taking this challenging case of acute HBV with persistent hyperbilirubinemia and SARS-COV-2 infection with respiratory distress as a starting point, we here loop through this condition. Where the available therapeutic options are scarce, we here propose hemoperfusion (HP) as an attractive alternative to both delay any late-stage progression of hyper inflammation process in COVID-19 and remove the toxins involved in acute liver failure.
MeSH term(s)	COVID-19/blood ; COVID-19/complications ; COVID-19/therapy ; Hepatitis B/blood ; Hepatitis B/complications ; Hepatitis B/therapy ; Humans ; Male ; Middle Aged ; Registries ; SARS-CoV-2/isolation & purification
Keywords	covid19
Language	English
Publishing date	2020-08-06
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	2102783-3
ISSN	1478-3231 ; 1478-3223
ISSN (online)	1478-3231
ISSN	1478-3223
DOI	10.1111/liv.14609
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Article: The obesity paradox: Analysis from the SMAtteo COvid-19 REgistry (SMACORE) cohort

Biscarini, Simona / Colaneri, Marta / Ludovisi, Serena / Seminari, Elena / Pieri, Teresa C / Valsecchi, Pietro / Gallazzi, Ilaria / Giusti, Emanuele / Cammà, Calogero / Zuccaro, Valentina / Mondelli, Mario U

The Italian Diabetes Society, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition and the Department of Clinical Medicine and Surgery, Federico II University Nutrition, metabolism, and cardiovascular diseases. 2020 Oct. 30, v. 30, no. 11

2020

Abstract: Obesity has been suggested as a possible risk factor for a more severe course of COVID-19; however, conclusive evidence is lacking and few studies have investigated the role of BMI as a risk factor for admission to intensive care unit (ICU) and mortality. ...

Abstract	Obesity has been suggested as a possible risk factor for a more severe course of COVID-19; however, conclusive evidence is lacking and few studies have investigated the role of BMI as a risk factor for admission to intensive care unit (ICU) and mortality.We retrospectively analyzed a COVID-19 cohort recruited during the first 40 days of the epidemic in Italy. We examined the association between obesity and 30-day mortality, admission to ICU, mortality and length of hospital stay in patients with COVID-19.Demographic, clinical and outcome data were retrospectively analyzed in 331 patients with COVID-19 admitted to hospital between 21 February and 31 March 2020. The predictive effect of obesity on mortality was assessed using a Cox proportional-hazard regression model, its effect on ICU admission and mortality in the ICU using logistic regressions, and its effect on length of hospital stay using a linear regression.Seventy-four of 331 patients had a BMI ≥30 kg/m². Among obese patients, 21 (28.4%) required admission in ICU and 25 died (33.8%). After controlling for sex, age, comorbidities and clinical data, obesity was not significantly associated with mortality, mortality in ICU and length of hospital stay. The effect of obesity on ICU admission remained significant after controlling for sex, age, interstitial lung disease, heart disease and serum C-reactive protein.Obese patients with COVID-19 were more likely to be admitted to ICU than non-obese patients. However, there were no significant differences in mortality between the two groups.
Keywords	Coronavirus infections ; age ; blood serum ; comorbidity ; heart diseases ; hospitals ; length ; metabolism ; mortality ; nutrition ; obesity ; patients ; regression analysis ; respiratory tract diseases ; risk factors ; Italy
Language	English
Dates of publication	2020-1030
Size	p. 1920-1925.
Publishing place	Elsevier B.V.
Document type	Article
Note	NAL-light
ZDB-ID	1067704-5
ISSN	0939-4753
ISSN	0939-4753
DOI	10.1016/j.numecd.2020.07.047
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Article: Mortality due to COVID-19 during the pandemic: A comparison of first, secondo and third SMAtteo COvid19 REgistry (SMACORE).

Heliyon

2022 Volume 8, Issue 2, Page(s) e08895

Abstract	COVID-19 tide had shattered on European countries with three distinct and tough waves, from March and April, 2020; October and November, 2020 and March and April, 2021 respectively. We observed a 50% reduction in the hazard of death during both wave II and III compared with wave I (HR 0.54, 95%CI 0.39-0.74 and HR 0.57, 95%CI 0.41-0.80, respectively). Sex and age were independent predictors of death. We compare in-hospital mortality of COVID-19 patients admitted at our Referral Hospital of Northern Italy during the different waves, discuss the reasons of the observed differences and suggest approaches to the challenges ahead.
Language	English
Publishing date	2022-02-03
Publishing country	England
Document type	Journal Article
ZDB-ID	2835763-2
ISSN	2405-8440
ISSN	2405-8440
DOI	10.1016/j.heliyon.2022.e08895
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Article: Is a radiological score needed to define the severity of Nontuberculous mycobacteria lung disease?

Colaneri, Marta / Valsecchi, Pietro / Vancheri, Sergio G / Valentini, Adele / Marchetti, Francesca / Tarantino, Francesco / Sambo, Margherita / Fabbiani, Massimiliano / Calliada, Fabrizio / Monzillo, Vincenzina / Di Matteo, Angela / Maiocchi, Laura / Lombardi, Andrea / Klersy, Catherine / Preda, Lorenzo / Bruno, Raffaele

The new microbiologica

2022 Volume 45, Issue 4

Abstract: High-resolution CT-scan (HRCT) plays a major role in the diagnosis of Nontuberculous mycobacteria lung disease (NTM-LD), but its role in follow-up is controversial. Our aim was first to conceive a radiological score able to quantify the severity of ... ...

Abstract	High-resolution CT-scan (HRCT) plays a major role in the diagnosis of Nontuberculous mycobacteria lung disease (NTM-LD), but its role in follow-up is controversial. Our aim was first to conceive a radiological score able to quantify the severity of pulmonary involvement by NTM infection and, second, to check its association with the NTM-LD clinical burden. We also intended, if possible, to verify the potential influence of NTM specific treatment on the radiological score. We retrospectively collected the clinical, microbiological and radiological data of all patients who were admitted to our hospital from 1 January 2012 to 1 January 2020 with a confirmed diagnosis of NTM-LD. A radiological score was applied to evaluate lung involvement on HRCT at diagnosis and at 6-18 months follow-up. Twenty-eight patients with NTM-LD performed follow-up HRCT. No association was found between radiological and clinical score (Spearman R -0.05, 95%CI -0.41 to 0.33). Repeated measures analysis showed a significant increase in radiological score over time (change 1.11, 95%CI 0.10 to 2.11; p-value 0.032), while Mann-Whitney test did not show any difference between treated and untreated patients (p value 0.922). Further studies are needed to assess the usefulness of routine radiological follow-up in patients with NTM-LD.
Language	English
Publishing date	2022-02-04
Publishing country	Italy
Document type	Journal Article
ZDB-ID	756168-4
ISSN	1121-7138 ; 0391-5352
ISSN	1121-7138 ; 0391-5352
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Article: Impact of Pneumococcal Urinary Antigen Testing in COVID-19 Patients: Outcomes from the San Matteo COVID-19 Registry (SMACORE).

Valsecchi, Pietro / Colaneri, Marta / Zuccaro, Valentina / Asperges, Erika / Costanzo, Filippo / Mariani, Bianca / Roda, Silvia / Minucci, Rita / Bertuccio, Francesco / Fraolini, Elia / Bosio, Matteo / Tirelli, Claudio / Oggionni, Tiberio / Corsico, Angelo / Bruno, Raffaele

Journal of personalized medicine

2021 Volume 11, Issue 8

Abstract: Despite low rates of bacterial co-infections, most COVID-19 patients receive antibiotic therapy. We hypothesized that patients with positive pneumococcal urinary antigens (PUAs) would benefit from antibiotic therapy in terms of clinical outcomes (death, ... ...

Abstract	Despite low rates of bacterial co-infections, most COVID-19 patients receive antibiotic therapy. We hypothesized that patients with positive pneumococcal urinary antigens (PUAs) would benefit from antibiotic therapy in terms of clinical outcomes (death, ICU admission, and length of stay). The San Matteo COVID-19 Registry (SMACORE) prospectively enrolls patients admitted for COVID-19 pneumonia at IRCCS Policlinico San Matteo, Pavia. We retrospectively extracted the data of patients tested for PUA from October to December 2020. Demographic, clinical, and laboratory data were recorded. Of 469 patients, 42 tested positive for PUA (8.95%), while 427 (91.05%) tested negative. A positive PUA result had no significant impact on death (HR 0.53 CI [0.22-1.28]
Language	English
Publishing date	2021-07-31
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662248-8
ISSN	2075-4426
ISSN	2075-4426
DOI	10.3390/jpm11080762
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Article ; Online: What prompts clinicians to start antibiotic treatment in COVID-19 patients? An Italian web survey helps us to understand where the doubts lie.

Colaneri, Marta / Valsecchi, Pietro / Vecchia, Marco / Di Filippo, Alessandro / Zuccaro, Valentina / Seminari, Elena / Sacchi, Paolo / Maiocchi, Laura / Fabbiani, Massimiliano / Ricciardi, Alessandra / Muzzi, Alba / Bruno, Raffaele

Journal of global antimicrobial resistance

2021 Volume 26, Page(s) 74–76

MeSH term(s)	Anti-Bacterial Agents/therapeutic use ; Antimicrobial Stewardship ; COVID-19 ; Humans ; Italy ; SARS-CoV-2
Chemical Substances	Anti-Bacterial Agents
Language	English
Publishing date	2021-06-09
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2710046-7
ISSN	2213-7173 ; 2213-7165
ISSN (online)	2213-7173
ISSN	2213-7165
DOI	10.1016/j.jgar.2021.05.014
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Article ; Online: The obesity paradox: Analysis from the SMAtteo COvid-19 REgistry (SMACORE) cohort.

Nutrition, metabolism, and cardiovascular diseases : NMCD

2020 Volume 30, Issue 11, Page(s) 1920–1925

Abstract: Background and aims: Obesity has been suggested as a possible risk factor for a more severe course of COVID-19; however, conclusive evidence is lacking and few studies have investigated the role of BMI as a risk factor for admission to intensive care ... ...

Abstract	Background and aims: Obesity has been suggested as a possible risk factor for a more severe course of COVID-19; however, conclusive evidence is lacking and few studies have investigated the role of BMI as a risk factor for admission to intensive care unit (ICU) and mortality. We retrospectively analyzed a COVID-19 cohort recruited during the first 40 days of the epidemic in Italy. We examined the association between obesity and 30-day mortality, admission to ICU, mortality and length of hospital stay in patients with COVID-19. Methods and results: Demographic, clinical and outcome data were retrospectively analyzed in 331 patients with COVID-19 admitted to hospital between 21 February and 31 March 2020. The predictive effect of obesity on mortality was assessed using a Cox proportional-hazard regression model, its effect on ICU admission and mortality in the ICU using logistic regressions, and its effect on length of hospital stay using a linear regression. Seventy-four of 331 patients had a BMI ≥30 kg/m Conclusions: Obese patients with COVID-19 were more likely to be admitted to ICU than non-obese patients. However, there were no significant differences in mortality between the two groups.
MeSH term(s)	Aged ; Aged, 80 and over ; Betacoronavirus ; C-Reactive Protein/analysis ; COVID-19 ; Coronavirus Infections/complications ; Coronavirus Infections/mortality ; Female ; Humans ; Intensive Care Units ; Length of Stay ; Male ; Middle Aged ; Obesity/complications ; Pandemics ; Pneumonia, Viral/complications ; Pneumonia, Viral/mortality ; Proportional Hazards Models ; Registries ; Retrospective Studies ; SARS-CoV-2
Chemical Substances	C-Reactive Protein (9007-41-4)
Keywords	covid19
Language	English
Publishing date	2020-08-11
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1067704-5
ISSN	1590-3729 ; 0939-4753
ISSN (online)	1590-3729
ISSN	0939-4753
DOI	10.1016/j.numecd.2020.07.047
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