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  1. Article: Intubation Time, Lung Mechanics and Outcome in COVID-19 Patients Suffering Acute Respiratory Distress Syndrome: A Single-Center Study.

    Aretha, Diamanto / Kefala, Sotiria / Nikolopoulou, Alexandra / Karamouzos, Vasilios / Valta, Maria / Mplani, Virginia / Georgakopoulou, Alexandra / Papamichail, Chrysavgi / Sklavou, Christina / Fligou, Fotini

    Journal of clinical medicine research

    2024  Volume 16, Issue 1, Page(s) 15–23

    Abstract: Background: We examined the effect of intubation time and the lung mechanics on clinical outcomes in coronavirus disease 2019 (COVID-19) patients.: Methods: Based on the patient's hospital admission, intubation time was defined as early (≤ 2 days) or ...

    Abstract Background: We examined the effect of intubation time and the lung mechanics on clinical outcomes in coronavirus disease 2019 (COVID-19) patients.
    Methods: Based on the patient's hospital admission, intubation time was defined as early (≤ 2 days) or late (> 2 days). Patients were further divided into three groups; early (≤ 3 days), late (4 - 6 days), and very late (> 6 days) intubated.
    Results: A total of 194 patients were included; 66.5% male, median age 65 years. Fifty-eight patients (29.9%) were intubated early and 136 (70.1%) late. Early intubated patients revealed lower mortality (44.8% vs. 72%, P < 0.001), were younger (60 vs. 67, P = 0.002), had lower sequential organ failure assessment (SOFA) scores (6 vs. 8, P = 0.002) and higher lung compliance on admission days 1, 6 and 12 (42 vs. 36, P = 0.006; 40 vs. 33, P < 0.001; and 37.5 vs. 32, P < 0.001, respectively). Older age (adjusted odds ratio (aOR) = 1.15, P < 0.001), intubation time (aOR = 1.15, P = 0.004), high SOFA scores (aOR = 1.81, P < 0.001), low partial pressure of oxygen (PaO
    Conclusions: Among COVID-19 intubated patients, age, late intubation, high SOFA scores, low PaO
    Language English
    Publishing date 2024-01-31
    Publishing country Canada
    Document type Journal Article
    ZDB-ID 2548987-2
    ISSN 1918-3011 ; 1918-3003
    ISSN (online) 1918-3011
    ISSN 1918-3003
    DOI 10.14740/jocmr4984
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Role of source control in critically ill candidemic patients: a multicenter retrospective study.

    Marangos, Markos / Ioannou, Petros / Senn, Laurence / Spiliopoulou, Anastasia / Tzalis, Sotiris / Kolonitsiou, Fevronia / Valta, Maria / Kokkini, Sofia / Pagani, Jean-Luc / Stafylaki, Dimitra / Paliogianni, Fotini / Fligou, Fotini / Kofteridis, Diamantis P / Lamoth, Frédéric / Papadimitriou-Olivgeris, Matthaios

    Infection

    2024  

    Abstract: Purpose: Candidemia is associated with high mortality especially in critically ill patients. Our aim was to identify predictors of mortality among critically ill patients with candidemia with a focus on early interventions that can improve prognosis.: ...

    Abstract Purpose: Candidemia is associated with high mortality especially in critically ill patients. Our aim was to identify predictors of mortality among critically ill patients with candidemia with a focus on early interventions that can improve prognosis.
    Methods: Multicenter retrospective study.
    Setting: This retrospective study was conducted in Intensive Care Units from three European university hospitals from 2015 to 2021. Adult patients with at least one positive blood culture for Candida spp. were included. Patients who did not require source control were excluded. Primary outcome was 14-day mortality.
    Results: A total of 409 episodes of candidemia were included. Most candidemias were catheter related (173; 41%), followed by unknown origin (170; 40%). Septic shock developed in 43% episodes. Overall, 14-day mortality rate was 29%. In Cox proportional hazards regression model, septic shock (P 0.001; HR 2.20, CI 1.38-3.50), SOFA score ≥ 10 points (P 0.008; HR 1.83, CI 1.18-2.86), and prior SARS-CoV-2 infection (P 0.003; HR 1.87, CI 1.23-2.85) were associated with 14-day mortality, while combined early appropriate antifungal treatment and source control (P < 0.001; HR 0.15, CI 0.08-0.28), and early source control without appropriate antifungal treatment (P < 0.001; HR 0.23, CI 0.12-0.47) were associated with better survival compared to those without neither early appropriate antifungal treatment nor source control.
    Conclusion: Early source control was associated with better outcome among candidemic critically ill patients.
    Language English
    Publishing date 2024-03-12
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 185104-4
    ISSN 1439-0973 ; 0300-8126 ; 0173-2129
    ISSN (online) 1439-0973
    ISSN 0300-8126 ; 0173-2129
    DOI 10.1007/s15010-024-02222-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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