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Article ; Online: A 39 year-old man with acroparesthesia and uncommon renal arterial lesions. What is the diagnosis?

Creon, Antoine / Ferriere, Elsa / Rabant, Marion / Van Huyen, Jean-Paul Duong / Isnard, Pierre

2022 Volume 36, Issue 1, Page(s) 241–243

MeSH term(s)	Male ; Humans ; Adult ; Kidney/diagnostic imaging ; Kidney/pathology ; Fabry Disease/pathology ; alpha-Galactosidase
Chemical Substances	alpha-Galactosidase (EC 3.2.1.22)
Language	English
Publishing date	2022-02-23
Publishing country	Italy
Document type	Case Reports ; Journal Article
ZDB-ID	1093991-x
ISSN	1724-6059 ; 1120-3625 ; 1121-8428
ISSN (online)	1724-6059
ISSN	1120-3625 ; 1121-8428
DOI	10.1007/s40620-022-01277-1
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Article: Membranous nephropathy in primary antiphospholipid syndrome.

Stammler, Romain / Rapoport, Camille / Van Huyen, Jean Paul Duong / Zuily, Stéphane / Olivier, Moranne / Daugas, Eric / Esteve, Emmanuel / de Menthon, Mathilde / Perrochia, Helene / Mussini, Charlotte / Sannier, Aurélie / Rabant, Marion / Buob, David / Karras, Alexandre

Clinical kidney journal

2024 Volume 17, Issue 2, Page(s) sfae017

Language	English
Publishing date	2024-02-02
Publishing country	England
Document type	Journal Article
ZDB-ID	2655800-2
ISSN	2048-8513 ; 2048-8505
ISSN (online)	2048-8513
ISSN	2048-8505
DOI	10.1093/ckj/sfae017
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Zs.A 6587: Show issues

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Article ; Online: Emphysematous pyelonephritis in a diabetic patient.

Otiniano, Armelle / Tassin, Claire / Serris, Alexandra / Guennouni, Nadia / Lanternier, Fanny / Servais, Aude / Parize, Perrine / Guinebert, Sylvain / Van Huyen, Jean Paul Duong / Bodard, Sylvain / Boudhabhay, Idris

Journal of nephrology

2023 Volume 36, Issue 9, Page(s) 2621–2624

MeSH term(s)	Humans ; Pyelonephritis/complications ; Pyelonephritis/diagnosis ; Diabetes Mellitus ; Diabetes Complications
Language	English
Publishing date	2023-05-16
Publishing country	Italy
Document type	Journal Article
ZDB-ID	1093991-x
ISSN	1724-6059 ; 1120-3625 ; 1121-8428
ISSN (online)	1724-6059
ISSN	1120-3625 ; 1121-8428
DOI	10.1007/s40620-023-01639-3
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Article ; Online: Non-myeloma light chain cast nephropathy: a multicenter retrospective study on clinicopathological characteristics.

Martins, Ana Cristina / Gibier, Jean-Baptiste / Ronsin, Charles / Kandel-Aznar, Christine / Moreau, Anne / Chapal, Marion / Francisco, Diogo / Sakhi, Hamza / Oniszczuk, Julie / Gueguen, Lorraine / Grunenwald, Anne / Devaux, Mathilde / Karras, Alexandre / Royal, Virginie / Rabant, Marion / Gnemmi, Viviane / Olagne, Jérôme / Van Huyen, Jean-Paul Duong / Isnard, Pierre

Haematologica

2024

Abstract: Not available. ...

Abstract	Not available.
Language	English
Publishing date	2024-03-28
Publishing country	Italy
Document type	Journal Article
ZDB-ID	2333-4
ISSN	1592-8721 ; 0017-6567 ; 0390-6078
ISSN (online)	1592-8721
ISSN	0017-6567 ; 0390-6078
DOI	10.3324/haematol.2024.285031
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Article: Renal arcuate vein thrombosis-induced acute kidney injury: a rare multiple-Hit-mediated disease.

Pardinhas, Clara / Filipe, Rui / Vergnaud, Paul / Grapin, Mathilde / Ferrière, Elsa / Jamet, Anne / Fourgeaud, Jacques / Da Rocha, Nicolas / Pérot, Philippe / Boyer, Olivia / Rabant, Marion / Van Huyen, Jean-Paul Duong / Isnard, Pierre

Clinical kidney journal

2022 Volume 16, Issue 2, Page(s) 367–373

Abstract: Background: Renal arcuate vein thrombosis (RAVT) is a rare and recently recognized cause of acute kidney injury (AKI) in young adults. However, the precise incidence and underlying pathophysiologic mechanisms leading to AKI in these patients remain ... ...

Abstract	Background: Renal arcuate vein thrombosis (RAVT) is a rare and recently recognized cause of acute kidney injury (AKI) in young adults. However, the precise incidence and underlying pathophysiologic mechanisms leading to AKI in these patients remain elusive. Methods: This study included all patients who underwent a kidney biopsy over a 40-month period sent to the pathology department of Necker-Enfants Malades Hospital, with evidence of RAVT. We performed coagulation tests, genetic testing for thrombophilia, complete urine toxicologic screening and kidney metagenomic sequencing to identify an underlying cause of thrombosis. Results: We report five pediatric cases of RAVT discovered on kidney biopsy performed in the setting of unexplained AKI. Investigations did not reveal an underlying cause of thrombosis but only a significant nonsteroidal anti-inflammatory drugs (NSAIDs) use was reported in 4/5 patients, supporting a potential link between NSAIDs use and RAVT. By performing metagenomic sequencing on kidney biopsy samples, we detected severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA in the kidney of one patient. These results suggest that systemic SARS-CoV-2 infection may also be a key contributing factor of renal thrombosis, particularly by inducing potential endothelial disruption. Conclusions: In conclusion, RAVT-induced AKI appears to be a multiple hit-mediated disease in which NSAIDs consumption and viral infection such as SARS-CoV-2 may be crucial contributing factors. These findings may have significant public health implications given the prevalence of NSAIDs use in the general population. Increased awareness and additional study of future cases may lead to a better understanding of this rare cause of AKI in children and young adults.
Language	English
Publishing date	2022-11-11
Publishing country	England
Document type	Journal Article
ZDB-ID	2655800-2
ISSN	2048-8513 ; 2048-8505
ISSN (online)	2048-8513
ISSN	2048-8505
DOI	10.1093/ckj/sfac244
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Article ; Online: A Machine Learning-Driven Virtual Biopsy System For Kidney Transplant Patients.

Yoo, Daniel / Divard, Gillian / Raynaud, Marc / Cohen, Aaron / Mone, Tom D / Rosenthal, John Thomas / Bentall, Andrew J / Stegall, Mark D / Naesens, Maarten / Zhang, Huanxi / Wang, Changxi / Gueguen, Juliette / Kamar, Nassim / Bouquegneau, Antoine / Batal, Ibrahim / Coley, Shana M / Gill, John S / Oppenheimer, Federico / De Sousa-Amorim, Erika /

Nature communications

2024 Volume 15, Issue 1, Page(s) 554

Abstract: In kidney transplantation, day-zero biopsies are used to assess organ quality and discriminate between donor-inherited lesions and those acquired post-transplantation. However, many centers do not perform such biopsies since they are invasive, costly and ...

Abstract	In kidney transplantation, day-zero biopsies are used to assess organ quality and discriminate between donor-inherited lesions and those acquired post-transplantation. However, many centers do not perform such biopsies since they are invasive, costly and may delay the transplant procedure. We aim to generate a non-invasive virtual biopsy system using routinely collected donor parameters. Using 14,032 day-zero kidney biopsies from 17 international centers, we develop a virtual biopsy system. 11 basic donor parameters are used to predict four Banff kidney lesions: arteriosclerosis, arteriolar hyalinosis, interstitial fibrosis and tubular atrophy, and the percentage of renal sclerotic glomeruli. Six machine learning models are aggregated into an ensemble model. The virtual biopsy system shows good performance in the internal and external validation sets. We confirm the generalizability of the system in various scenarios. This system could assist physicians in assessing organ quality, optimizing allograft allocation together with discriminating between donor derived and acquired lesions post-transplantation.
MeSH term(s)	Humans ; Kidney Transplantation ; Kidney/pathology ; Transplantation, Homologous ; Kidney Diseases/pathology ; Biopsy
Language	English
Publishing date	2024-01-16
Publishing country	England
Document type	Journal Article
ZDB-ID	2553671-0
ISSN	2041-1723 ; 2041-1723
ISSN (online)	2041-1723
ISSN	2041-1723
DOI	10.1038/s41467-023-44595-z
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Article ; Online: Building a tissue-based molecular diagnostic system in heart transplant rejection: The heart Molecular Microscope Diagnostic (MMDx) System.

Halloran, Philip F / Potena, Luciano / Van Huyen, Jean-Paul Duong / Bruneval, Patrick / Leone, Ornella / Kim, Daniel H / Jouven, Xavier / Reeve, Jeff / Loupy, Alexandre

The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation

2017 Volume 36, Issue 11, Page(s) 1192–1200

Abstract: Background: The emergence of molecular systems offers opportunities for improving the assessment of rejection in heart transplant biopsy specimens. The present study developed a microarray-based system for assessing heart transplant endomyocardial ... ...

Abstract	Background: The emergence of molecular systems offers opportunities for improving the assessment of rejection in heart transplant biopsy specimens. The present study developed a microarray-based system for assessing heart transplant endomyocardial biopsy (EMB) specimens. Methods: We analyzed 331 protocol or for-cause EMB specimens from 221 subjects in 3 centers (Edmonton, Bologna, and Paris). Unsupervised principal component analysis (PCA) and archetype analysis used rejection-associated transcripts (RATs) shown in kidney transplants to be associated with antibody-mediated rejection (ABMR) or T cell-mediated rejection (TCMR), or both. To compare EMB specimens to kidney biopsy specimens, rejection status in both was simplified to TCMR, ABMR, or no rejection. Results: The pattern of RAT expression was similar in EMB and kidney specimens, permitting use of RATs to assign scores and group ("cluster") membership to each EMB, independent of histology. Three clusters emerged in EMB specimens, similar to kidney specimens: TCMR, ABMR, and no rejection. This permitted each EMB specimen to be given 3 scores and assigned to 1 cluster by its highest score. There was significant agreement between molecular phenotype-archetype scores or clusters-and both histologic diagnoses and donor-specific antibody. Area under curve estimates for predicting histologic TCMR, ABMR, and no rejection by molecular assessment were lower in EMB specimens than in kidney specimens, reflecting more uncertainty in EMB specimens, particularly in histologic diagnosis of TCMR. Conclusions: Rejection-associated transcripts can be used to estimate the probability of TCMR and ABMR in heart transplant specimens, providing a new dimension to improve the accuracy of diagnoses and an independent system for recalibrating the histology guidelines.
MeSH term(s)	Antibodies/immunology ; Biopsy ; Graft Rejection/diagnosis ; Graft Rejection/immunology ; Graft Rejection/metabolism ; Heart Transplantation ; Humans ; Molecular Diagnostic Techniques/instrumentation ; Myocardium/metabolism ; Myocardium/pathology ; Pathology, Molecular/methods ; Prognosis ; Prospective Studies ; T-Lymphocytes/immunology
Chemical Substances	Antibodies
Language	English
Publishing date	2017-05-29
Publishing country	United States
Document type	Journal Article ; Multicenter Study
ZDB-ID	1062522-7
ISSN	1557-3117 ; 1053-2498
ISSN (online)	1557-3117
ISSN	1053-2498
DOI	10.1016/j.healun.2017.05.029
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Article ; Online: Long-term Outcomes of Kidney Transplantation in Patients With High Levels of Preformed DSA: The Necker High-Risk Transplant Program.

Amrouche, Lucile / Aubert, Olivier / Suberbielle, Caroline / Rabant, Marion / Van Huyen, Jean-Paul Duong / Martinez, Frank / Sberro-Soussan, Rebecca / Scemla, Anne / Tinel, Claire / Snanoudj, Renaud / Zuber, Julien / Cavalcanti, Ruy / Timsit, Marc-Olivier / Lamhaut, Lionel / Anglicheau, Dany / Loupy, Alexandre / Legendre, Christophe

Transplantation

2017 Volume 101, Issue 10, Page(s) 2440–2448

Abstract: Background: There is an increasing number of anti-HLA sensitized and highly sensitized renal transplant candidates on waiting lists, and the presence of donor-specific alloantibodies (DSAs) at the time of transplantation leads to acute and chronic ... ...

Abstract	Background: There is an increasing number of anti-HLA sensitized and highly sensitized renal transplant candidates on waiting lists, and the presence of donor-specific alloantibodies (DSAs) at the time of transplantation leads to acute and chronic antibody-mediated rejection (AMR). Acceptable short-term outcomes have been described, notably because of desensitization protocols, but mid- and long-term data are still required. Methods: Our high immunologic risk program included 95 patients with high peak or day 0 DSA levels (mean fluorescence intensity [MFI] > 3000) with a complement-dependent cytotoxicity-negative crossmatch, who received a posttransplant desensitization protocol starting at day 0 with high-dose intravenous immunoglobulin, plasma exchanges, and eventually rituximab. Their characteristics were compared with a control group including 39 patients with a lower immunologic risk (MFI between 500 and 3000 at day 0) who received the same posttransplant desensitization. Results: The median MFI of the immunodominant class I or II DSA in the peak or day 0 serum was 9421 (interquartile range, 4959-12 610). An AMR occurred during the first posttransplant year in 31 patients (32.6%), and at one year, the rate of chronic AMR was 39.5%. The 1-, 3-, 5- and 7-year death-censored allograft survival rates were 98%, 91%, 86%, and 78%, respectively, with concomitant recipient survival rates of 97%, 93%, 85%, and 79%, respectively. Conclusions: These results suggest that DSA-sensitized patients with high MFI levels can receive transplantation across the HLA-barrier, with the use of an intensified posttransplant immunosuppressive therapy starting at day 0 combined with close clinical, immunologic, and histologic monitoring.
MeSH term(s)	Adult ; Allografts ; Biomarkers ; Donor Selection ; Female ; Graft Rejection/immunology ; Graft Rejection/prevention & control ; Graft Survival ; HLA Antigens/immunology ; Histocompatibility ; Humans ; Immunosuppressive Agents/therapeutic use ; Isoantibodies/blood ; Kaplan-Meier Estimate ; Kidney Transplantation/adverse effects ; Kidney Transplantation/mortality ; Male ; Middle Aged ; Paris ; Program Evaluation ; Risk Assessment ; Risk Factors ; Time Factors ; Treatment Outcome
Chemical Substances	Biomarkers ; HLA Antigens ; Immunosuppressive Agents ; Isoantibodies
Language	English
Publishing date	2017-10
Publishing country	United States
Document type	Journal Article ; Observational Study
ZDB-ID	208424-7
ISSN	1534-6080 ; 0041-1337
ISSN (online)	1534-6080
ISSN	0041-1337
DOI	10.1097/TP.0000000000001650
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Zs.A 488: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Focal segmental glomerulosclerosis plays a major role in the progression of IgA nephropathy. I. Immunohistochemical studies.

Hill, Gary S / Karoui, Khalil El / Karras, Alexandre / Mandet, Chantal / Van Huyen, Jean-Paul Duong / Nochy, Dominique / Bruneval, Patrick

Kidney international

2011 Volume 79, Issue 6, Page(s) 635–642

Abstract: IgA nephropathy (IgAN) often shows lesions morphologically identical with those of focal segmental glomerulosclerosis (FSGS). In order to determine the possible role of FSGS in IgAN lesions, we measured glomerular capsular adhesions, often the first step ...

Abstract	IgA nephropathy (IgAN) often shows lesions morphologically identical with those of focal segmental glomerulosclerosis (FSGS). In order to determine the possible role of FSGS in IgAN lesions, we measured glomerular capsular adhesions, often the first step toward FSGS, in biopsies from 127 patients with IgAN, 100 with lupus nephritis, and 26 with primary FSGS. Capsular adhesions with no lesions in the underlying tuft, consistent with podocyte abnormality or loss, were found regularly in FSGS and IgAN, but infrequently in lupus. Fifteen biopsies of patients with IgAN were studied immunohistochemically using markers for podocytes, Bowman's parietal epithelial cells, proliferating cells, and macrophages. Cytokeratins CK-8 and C2562 differentiated normal podocytes (negative) from parietal epithelial cells (variably positive). There was focal loss of the podocyte markers synaptopodin, glomerular epithelial protein 1 (GLEPP-1), nephrin, and vascular endothelial growth factor (VEGF), particularly at sites of capsular adhesions in otherwise histologically normal glomeruli. Cells displaying the parietal epithelial cell markers PAX2 (paired box gene 2) and the cytokeratins were also positive for the proliferating cell marker, proliferating cell nuclear antigen. These cells gathered at sites of adhesion, and in response to active lesions in the tuft, grew inward along the adhesion onto the tuft, forming a monolayer positive for parietal markers and the podocyte marker Wilms tumor protein-1 (WT-1). These cells deposited a layer of collagen over the sclerosing tuft. Thus, all biopsies of patients with IgAN had changes basically identical to those classically described in FSGS. Hence, our study strongly suggests that podocytopathy of a type similar to that in primary FSGS occurs frequently in IgAN.
MeSH term(s)	Antigens, CD/analysis ; Antigens, Differentiation, Myelomonocytic/analysis ; Biomarkers/analysis ; Biopsy ; Chi-Square Distribution ; Disease Progression ; Epithelial Cells/chemistry ; Glomerulonephritis, IGA/immunology ; Glomerulonephritis, IGA/metabolism ; Glomerulonephritis, IGA/pathology ; Glomerulosclerosis, Focal Segmental/immunology ; Glomerulosclerosis, Focal Segmental/metabolism ; Glomerulosclerosis, Focal Segmental/pathology ; Humans ; Immunohistochemistry ; Keratin-8/analysis ; Kidney Glomerulus/chemistry ; Kidney Glomerulus/immunology ; Kidney Glomerulus/pathology ; Lupus Nephritis/immunology ; Lupus Nephritis/metabolism ; Lupus Nephritis/pathology ; PAX2 Transcription Factor/analysis ; Paris ; Podocytes/chemistry ; Prognosis ; Proliferating Cell Nuclear Antigen/analysis ; WT1 Proteins/analysis
Chemical Substances	Antigens, CD ; Antigens, Differentiation, Myelomonocytic ; Biomarkers ; CD68 antigen, human ; KRT8 protein, human ; Keratin-8 ; PAX2 Transcription Factor ; PAX2 protein, human ; Proliferating Cell Nuclear Antigen ; WT1 Proteins
Language	English
Publishing date	2011-03
Publishing country	United States
Document type	Journal Article
ZDB-ID	120573-0
ISSN	1523-1755 ; 0085-2538
ISSN (online)	1523-1755
ISSN	0085-2538
DOI	10.1038/ki.2010.466
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Zs.A 797: Show issues

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Article: Antithrombin is not protective against renal ischaemia-reperfusion injury

Bourti, Yasmine / Saller, François / Bianchini, Elsa P. / Pautus, Stéphane / Van Huyen, Jean-Paul Duong / Marie, Anne-Lise / Tran, N. Thuy / Molina, Thierry Jo / Taverna, Myriam / Lerolle, Nicolas / Borgel, Delphine

Thrombosis and Haemostasis

2017 Volume 117, Issue 02, Page(s) 422–425

Language	English
Publishing date	2017-01-01
Publisher	Schattauer GmbH
Publishing place	Stuttgart ; New York
Document type	Article
ZDB-ID	518294-3
ISSN	2567-689X ; 0340-6245
ISSN (online)	2567-689X
ISSN	0340-6245
DOI	10.1160/TH16-06-0451
Database	Thieme publisher's database

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