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  1. Article ; Online: Is overall survival not influenced by partial vs radical nephrectomy?

    Van Poppel, Hein / Sylvester, Richard

    BJU international

    2018  Volume 121, Issue 3, Page(s) 319

    MeSH term(s) Carcinoma, Renal Cell ; Humans ; Kidney Neoplasms ; Nephrectomy ; Retrospective Studies
    Language English
    Publishing date 2018
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 1462191-5
    ISSN 1464-410X ; 1464-4096 ; 1358-8672
    ISSN (online) 1464-410X
    ISSN 1464-4096 ; 1358-8672
    DOI 10.1111/bju.14113
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    Ui VI Zs.107: Show issues Location:
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  2. Article ; Online: Improving Patient Information and Enhanced Consent in Urology: The Impact of Simulation and Multimedia Tools. A Systematic Literature Review from the European Association of Urology Patient Office.

    Nedbal, Carlotta / Juliebø-Jones, Patrick / Rogers, Eamonn / N'Dow, James / Ribal, Maria / Rassweiler, Jens / Liatsikos, Evangelos / Van Poppel, Hein / Somani, Bhaskar Kumar

    European urology

    2024  

    Abstract: Background and objective: Discussions surrounding urological diagnoses and planned procedures can be challenging, and patients might experience difficulty in understanding the medical language, even when shown radiological imaging or drawings. With the ... ...

    Abstract Background and objective: Discussions surrounding urological diagnoses and planned procedures can be challenging, and patients might experience difficulty in understanding the medical language, even when shown radiological imaging or drawings. With the introduction of virtual reality and simulation, informed consent could be enhanced by audiovisual content and interactive platforms. Our aim was to assess the role of enhanced consent in the field of urology.
    Methods: A systematic review of the literature was performed in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines, using informed consent, simulation, and virtual reality in urology as the search terms. All original articles were screened.
    Key findings and limitations: Thirteen original studies were included in the review. The overall quality of these studies was deemed good according to the Newcastle-Ottawa Scale. The studies analysed the application of different modalities for enhanced consent: 3D printed or digital models, audio visual multimedia contents, virtual simulation of procedures and interactive navigable apps. Published studies agreed upon a significantly improved effect on patient understanding of the diagnosis, including basic anatomical details, and surgery-related issues such as the aim, steps and the risks connected to the planned intervention. Patient satisfaction was unanimously reported as improved as a result of enhanced consent.
    Conclusions and clinical implications: Simulation and multimedia tools are extremely valuable for improving patients' understanding of and satisfaction with urological procedures. Widespread application of enhanced consent would represent a milestone for patient-urologist communication.
    Patient summary: Several multimedia tools can be used to improve patients' understanding of urological conditions and procedures, such as simulation and models. Use of these tools for preoperative discussion enhances knowledge and patient satisfaction, resulting in more realistic patient expectations and better informed consent.
    Language English
    Publishing date 2024-04-24
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 193790-x
    ISSN 1873-7560 ; 1421-993X ; 0302-2838
    ISSN (online) 1873-7560 ; 1421-993X
    ISSN 0302-2838
    DOI 10.1016/j.eururo.2024.04.009
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    Zs.MO 294: Show issues

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  3. Article ; Online: Lymph node dissection is not obsolete in clinically node-negative renal cell carcinoma patients.

    Van Poppel, Hein

    European urology

    2011  Volume 59, Issue 1, Page(s) 24–25

    MeSH term(s) Blood Coagulation ; Carcinoma, Renal Cell/blood ; Carcinoma, Renal Cell/secondary ; Carcinoma, Renal Cell/surgery ; Humans ; Kidney Neoplasms/blood ; Kidney Neoplasms/pathology ; Kidney Neoplasms/surgery ; Lymph Node Excision ; Lymphatic Metastasis ; Necrosis ; Neoplasm Staging ; Nephrectomy ; Patient Selection ; Risk Assessment ; Risk Factors ; Treatment Outcome
    Language English
    Publishing date 2011-01
    Publishing country Switzerland
    Document type Comment ; Editorial
    ZDB-ID 193790-x
    ISSN 1873-7560 ; 1421-993X ; 0302-2838
    ISSN (online) 1873-7560 ; 1421-993X
    ISSN 0302-2838
    DOI 10.1016/j.eururo.2010.09.033
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  4. Article ; Online: Efficacy and safety of nephron-sparing surgery.

    Van Poppel, Hein

    International journal of urology : official journal of the Japanese Urological Association

    2010  Volume 17, Issue 4, Page(s) 314–326

    Abstract: To analyse the current evidence of efficacy and safety of nephron-sparing surgery (NSS) that encompasses open partial nephrectomy (OPN), laparoscopic partial nephrectomy (LPN) and robotic partial nephrectomy in the management of localized renal cell ... ...

    Abstract To analyse the current evidence of efficacy and safety of nephron-sparing surgery (NSS) that encompasses open partial nephrectomy (OPN), laparoscopic partial nephrectomy (LPN) and robotic partial nephrectomy in the management of localized renal cell carcinoma (RCC). Oncological data, complications and postoperative renal function were reviewed for the most important series of partial nephrectomy. Partial nephrectomy (PN) provides similar oncological control as radical nephrectomy (RN) and is superior to RN with respect to preserving renal function and preventing chronic kidney disease. OPN remains the first treatment option for T1 renal tumors in centers without advanced laparoscopic expertise. Indications for LPN have expanded as such that LPN is suited for most renal tumors provided that the procedure is carried out in selected patients by an experienced laparoscopic surgeon. Warm ischemia time should be kept within 20 min, which is currently recommended regardless of surgical approach. In experienced hands, LPN yields intermediate oncological efficacy and renal function outcome comparable to open surgery in the treatment of pT1 renal tumors. Positive surgical margin rates are comparable after LPN and OPN. In contemporary series, the morbidity of LPN is decreasing to become similar to that of OPN. Preliminary results with robotic PN are comparable to results obtained with LPN. Additional studies are required to validate these results and compare with other current methods, such as thermal ablation. NSS is effective and safe for the management of localized RCC and is the gold standard to which new ablative techniques need to be compared.
    MeSH term(s) Carcinoma, Renal Cell/surgery ; Humans ; Kidney Neoplasms/surgery ; Laparoscopy ; Nephrectomy/adverse effects ; Nephrectomy/methods ; Robotics
    Language English
    Publishing date 2010-04
    Publishing country Australia
    Document type Comparative Study ; Journal Article ; Review
    ZDB-ID 1328401-0
    ISSN 1442-2042 ; 0919-8172
    ISSN (online) 1442-2042
    ISSN 0919-8172
    DOI 10.1111/j.1442-2042.2010.02482.x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.MO 278: Show issues

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  5. Article: Oligometastatic prostate cancer: Metastases-directed therapy?

    Van Poppel, Hein / De Meerleer, Gert / Joniau, Steven

    Arab journal of urology

    2016  Volume 14, Issue 3, Page(s) 179–182

    Abstract: Since the introduction of anatomical and functional imaging with multiparametric magnetic resonance imaging and choline or prostate-specific membrane antigen positron emission tomography-computed tomography, we are able to diagnose a previously unknown ... ...

    Abstract Since the introduction of anatomical and functional imaging with multiparametric magnetic resonance imaging and choline or prostate-specific membrane antigen positron emission tomography-computed tomography, we are able to diagnose a previously unknown disease, the oligometastatic prostate cancer after local therapy. Reports on surgical and radiation treatment for low-volume metastatic recurrence have shown promising results, with definitive cure in few but a relevant delay of androgen-deprivation therapy with both treatment methods. Obviously, these results need to be validated with prospective randomised data.
    Language English
    Publishing date 2016-07-20
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2631788-6
    ISSN 2090-598X
    ISSN 2090-598X
    DOI 10.1016/j.aju.2016.06.004
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  6. Article ; Online: Is radiotherapy useful in node-positive prostate cancer patients after radical prostatectomy?

    Van Poppel, Hein

    European urology

    2009  Volume 55, Issue 5, Page(s) 1012–1013

    MeSH term(s) Aged ; Aged, 80 and over ; Disease-Free Survival ; Follow-Up Studies ; Humans ; Lymph Node Excision/methods ; Lymph Nodes/pathology ; Lymphatic Metastasis ; Male ; Middle Aged ; Neoplasm Invasiveness/pathology ; Neoplasm Staging ; Postoperative Care ; Prostate-Specific Antigen/blood ; Prostatectomy ; Prostatic Neoplasms/mortality ; Prostatic Neoplasms/pathology ; Prostatic Neoplasms/radiotherapy ; Prostatic Neoplasms/surgery ; Risk Assessment ; Sensitivity and Specificity ; Survival Analysis ; Treatment Outcome
    Chemical Substances Prostate-Specific Antigen (EC 3.4.21.77)
    Language English
    Publishing date 2009-05
    Publishing country Switzerland
    Document type Comment ; Editorial
    ZDB-ID 193790-x
    ISSN 1873-7560 ; 1421-993X ; 0302-2838
    ISSN (online) 1873-7560 ; 1421-993X
    ISSN 0302-2838
    DOI 10.1016/j.eururo.2009.02.015
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    Zs.MO 294: Show issues

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  7. Article ; Online: Update on the management of invasive bladder cancer 2012.

    Goethuys, Hans / Van Poppel, Hein

    Cancer management and research

    2012  Volume 4, Page(s) 177–182

    Abstract: Muscle-invasive bladder cancer is a deadly disease for which a number of new approaches have become available to improve prognosis. A recent review emphasized the importance of timely indication of surgery and highlighted current views regarding the ... ...

    Abstract Muscle-invasive bladder cancer is a deadly disease for which a number of new approaches have become available to improve prognosis. A recent review emphasized the importance of timely indication of surgery and highlighted current views regarding the adequate extent of the surgery and the importance of lymph node dissection. Furthermore, treatment using neoadjuvant and adjuvant systemic chemotherapy has become more prominent, while cystectomy and diversion should be conducted only in experienced centers. Optimal methods of urinary diversion and the use of robot-assisted laparoscopic cystectomy require further study.
    Language English
    Publishing date 2012-07-18
    Publishing country New Zealand
    Document type Journal Article
    ZDB-ID 2508013-1
    ISSN 1179-1322 ; 1179-1322
    ISSN (online) 1179-1322
    ISSN 1179-1322
    DOI 10.2147/CMAR.S30850
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  8. Article ; Online: Gonadotropin-releasing hormone: an update review of the antagonists versus agonists.

    Van Poppel, Hein / Klotz, Laurence

    International journal of urology : official journal of the Japanese Urological Association

    2012  Volume 19, Issue 7, Page(s) 594–601

    Abstract: Gonadotropin-releasing hormone agonists and antagonists provide androgen-deprivation therapy for prostate cancer. Unlike agonists, gonadotropin-releasing hormone antagonists have a direct mode of action to block pituitary gonadotropin-releasing hormone ... ...

    Abstract Gonadotropin-releasing hormone agonists and antagonists provide androgen-deprivation therapy for prostate cancer. Unlike agonists, gonadotropin-releasing hormone antagonists have a direct mode of action to block pituitary gonadotropin-releasing hormone receptors. There are two licensed gonadotropin-releasing hormone antagonists, degarelix and abarelix. Of these, degarelix is the more extensively studied and has been documented to be more effective than the well-established, first-line agonist, leuprolide, in terms of substantially faster onset of castration, faster suppression of prostate-specific antigen, no risk for testosterone surge or clinical flare, and improved prostate-specific antigen progression-free survival, suggesting a delay in castration resistance. Other than minor injection-site reactions, degarelix is generally well tolerated, without systemic allergic reactions and with most adverse events consistent with androgen suppression or the underlying condition. In conclusion, degarelix provides a rational, first-line androgen-deprivation therapy suitable for the treatment of prostate cancer, with faster onset of castration than with agonists, and no testosterone surge. Furthermore, data suggest that degarelix improves disease control compared with leuprolide, and might delay the onset of castration-resistant disease. In view of these clinical benefits and the lack of need for concomitant anti-androgen treatment, gonadotropin-releasing hormone antagonists might replace gonadotropin-releasing hormone agonists as first-line androgen-deprivation therapy in the future.
    MeSH term(s) Antineoplastic Agents, Hormonal/adverse effects ; Antineoplastic Agents, Hormonal/therapeutic use ; Gonadotropin-Releasing Hormone/agonists ; Gonadotropin-Releasing Hormone/antagonists & inhibitors ; Humans ; Leuprolide/adverse effects ; Leuprolide/therapeutic use ; Male ; Oligopeptides/adverse effects ; Oligopeptides/therapeutic use ; Prostate-Specific Antigen/blood ; Prostatic Neoplasms/blood ; Prostatic Neoplasms/drug therapy ; Testosterone/blood
    Chemical Substances Antineoplastic Agents, Hormonal ; Oligopeptides ; acetyl-2-naphthylalanyl-3-chlorophenylalanyl-1-oxohexadecyl-seryl-4-aminophenylalanyl(hydroorotyl)-4-aminophenylalanyl(carbamoyl)-leucyl-ILys-prolyl-alaninamide ; Gonadotropin-Releasing Hormone (33515-09-2) ; Testosterone (3XMK78S47O) ; Prostate-Specific Antigen (EC 3.4.21.77) ; Leuprolide (EFY6W0M8TG) ; abarelix (W486SJ5824)
    Language English
    Publishing date 2012-07
    Publishing country Australia
    Document type Comparative Study ; Journal Article ; Review
    ZDB-ID 1328401-0
    ISSN 1442-2042 ; 0919-8172
    ISSN (online) 1442-2042
    ISSN 0919-8172
    DOI 10.1111/j.1442-2042.2012.02997.x
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  9. Article ; Online: Is nephron-sparing surgery as safe and effective as radical nephrectomy in patients with locally advanced RCC?

    Van Poppel, Hein

    Nature clinical practice. Urology

    2008  Volume 5, Issue 6, Page(s) 296–297

    Language English
    Publishing date 2008-06
    Publishing country United States
    Document type Comment ; Journal Article
    ZDB-ID 2177665-9
    ISSN 1743-4289 ; 1743-4270
    ISSN (online) 1743-4289
    ISSN 1743-4270
    DOI 10.1038/ncpuro1110
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  10. Article: Words of wisdom. Re: long-term outcome following three-dimensional conformal/intensity-modulated external- beam radiotherapy for clinical stage T3 prostate cancer.

    Van Poppel, Hein

    European urology

    2008  Volume 54, Issue 6, Page(s) 1440–1441

    Language English
    Publishing date 2008-12-11
    Publishing country Switzerland
    Document type Comment ; Journal Article
    ZDB-ID 193790-x
    ISSN 1421-993X ; 0302-2838
    ISSN (online) 1421-993X
    ISSN 0302-2838
    DOI 10.1016/j.eururo.2008.08.045
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