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  1. AU="Van de Stadt, Jean"
  2. AU=Giannis Dimitrios

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  1. Artikel: Differentiated-Type Intraepithelial Neoplasia-Like Lesion Associated with Squamous Cell Carcinoma of the Anus: A Case Report with Molecular Profile.

    Koopmansch, Caroline / Maris, Calliope / Demetter, Pieter / Van de Stadt, Jean / Hendlisz, Alain / D'Haene, Nicky / Noël, Jean-Christophe

    Case reports in pathology

    2019  Band 2019, Seite(n) 2301640

    Abstract: Differentiated-type Intraepithelial Neoplasia (DIN) is defined as HPV-negative squamous intraepithelial proliferation with abnormal keratinocyte differentiation and basal cell atypia, originally described in the vulva, with following descriptions in the ... ...

    Abstract Differentiated-type Intraepithelial Neoplasia (DIN) is defined as HPV-negative squamous intraepithelial proliferation with abnormal keratinocyte differentiation and basal cell atypia, originally described in the vulva, with following descriptions in the oral cavity. DIN occurring in the anus is quite rare, and to the best of our knowledge, only one publication reported it. In this report, we describe the clinicopathological features of this entity on anal margin, associated with invasive squamous cell carcinoma. In addition, using the next generation sequencing (NGS) technique, we have demonstrated TP53 mutation in the invasive component but not in the associated DIN-like lesion, where p53 immunohistochemical expression was restricted to basal layers.
    Sprache Englisch
    Erscheinungsdatum 2019-01-27
    Erscheinungsland United States
    Dokumenttyp Case Reports
    ZDB-ID 2648758-5
    ISSN 2090-679X ; 2090-6781
    ISSN (online) 2090-679X
    ISSN 2090-6781
    DOI 10.1155/2019/2301640
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel: Professor Jean-Pierre Lambilliotte (1933-2011).

    Van de Stadt, Jean / Gelin, Michel

    Acta chirurgica Belgica

    2012  Band 112, Heft 1, Seite(n) 1–2

    Sprache Englisch
    Erscheinungsdatum 2012-01
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 210274-2
    ISSN 0001-5458
    ISSN 0001-5458
    DOI 10.1080/00015458.2012.11680786
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: The potential benefit of adjuvant chemotherapy in locally advanced rectal cancer treated with neoadjuvant chemoradiotherapy is not predicted by tumor regression grade.

    Bohlok, Ali / Hendlisz, Alain / Bouazza, Fikri / Galdon, Maria Gomez / Van de Stadt, Jean / Moretti, Luigi / El Nakadi, Issam / Liberale, Gabriel

    International journal of colorectal disease

    2018  Band 33, Heft 10, Seite(n) 1383–1391

    Abstract: Introduction: Recommended treatment for locally advanced rectal cancer (LARC) is neoadjuvant chemoradiotherapy (NACRT) followed by surgery and total mesorectal excision (TME). The role of adjuvant chemotherapy (ACT) in this regimen is still debated. ... ...

    Abstract Introduction: Recommended treatment for locally advanced rectal cancer (LARC) is neoadjuvant chemoradiotherapy (NACRT) followed by surgery and total mesorectal excision (TME). The role of adjuvant chemotherapy (ACT) in this regimen is still debated. Assessment of Dworak's tumor regression grade (TRG) after NACRT could potentially select patients who might benefit from ACT.
    Materials and methods: Data for patients who underwent NACRT and TME for LARC between 2007 and 2014 were retrieved from the Bordet Institute database. Overall survival (OS) and disease-free survival (DFS) were calculated for the whole population, according to whether or not they received ACT, and according to TRG.
    Results: We included 74 patients (38 males) with a median age of 62.7 years (33-84 years). AJCC stage cIIIb disease was the most frequent (73%). Pathologic complete response (pCR) was achieved in 13 patients (17.6%). ACT was administered to 42 patients (56.8%). Five-year OS and DFS of patients who received ACT or not were 92 and 84.5% (p = ns), and 79.9 and 84.8% (p = ns), respectively. OS was related to TRG (cut-off value of 3) (p = 0.001). ACT administration was not correlated with improved outcomes in any TRG groups.
    Conclusion: TRG is a prognostic factor for both OS and DFS but does not appear to have a significant benefit for the selection of patients with LARC treated with NACRT who might benefit from the administration of ACT. Prospective randomized trials with larger populations are needed to identify factors that predict which patients may benefit from the administration of ACT.
    Mesh-Begriff(e) Adult ; Aged ; Aged, 80 and over ; Chemoradiotherapy ; Chemoradiotherapy, Adjuvant ; Chemotherapy, Adjuvant ; Disease-Free Survival ; Female ; Humans ; Male ; Middle Aged ; Neoadjuvant Therapy ; Neoplasm Staging ; Prospective Studies ; Rectal Neoplasms/drug therapy ; Rectal Neoplasms/surgery ; Retrospective Studies ; Treatment Outcome
    Sprache Englisch
    Erscheinungsdatum 2018-07-08
    Erscheinungsland Germany
    Dokumenttyp Journal Article
    ZDB-ID 84975-3
    ISSN 1432-1262 ; 0179-1958
    ISSN (online) 1432-1262
    ISSN 0179-1958
    DOI 10.1007/s00384-018-3115-6
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel: Different surgical strategies in the treatment of familial adenomatous polyposis: what's the role of the ileorectal anastomosis?

    Wolthuis, Albert M / Leonard, Daniel / Kartheuser, Alex / Bruyninx, Luc / Van De Stadt, Jean / Van Cutsem, Eric / D'Hoore, André

    Acta gastro-enterologica Belgica

    2011  Band 74, Heft 3, Seite(n) 435–437

    Abstract: Prophylactic (procto-) colectomy is the treatment of choice to reduce the risk of colorectal cancer in FAP patients with multiple adenomas. Because patients present at young age, rectum-sparing surgery is sometimes advocated, so that there is no pelvic ... ...

    Abstract Prophylactic (procto-) colectomy is the treatment of choice to reduce the risk of colorectal cancer in FAP patients with multiple adenomas. Because patients present at young age, rectum-sparing surgery is sometimes advocated, so that there is no pelvic dissection with impact on quality of life, preserved pelvic innervation and sexual function and fertility. The main disadvantage of a total colectomy with an ileorectal anastomosis (IRA) is a rectal cancer risk of 50% at the age of 50 years and a cumulative risk of 25.8% after 25 years of follow-up. Therefore, this procedure should be reserved for patients with an unaffected rectum. There should be no discussion to perform a primary IPAA in patients with multiple rectal adenomas (> 20) or those with a severe dysplastic or large (> 3 cm) rectal adenoma or a cancer elsewhere in the colon. A patient with an IRA should undergo yearly follow-up by rectoscopy.
    Mesh-Begriff(e) Adenomatous Polyposis Coli/epidemiology ; Adenomatous Polyposis Coli/surgery ; Anastomosis, Surgical ; Colectomy/methods ; Humans ; Ileum/surgery ; Postoperative Complications/epidemiology ; Rectum/surgery ; Risk Factors
    Sprache Englisch
    Erscheinungsdatum 2011-09
    Erscheinungsland Belgium
    Dokumenttyp Journal Article ; Review
    ZDB-ID 127060-6
    ISSN 1784-3227 ; 0001-5644
    ISSN 1784-3227 ; 0001-5644
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel ; Online: Risk adjusted benchmarking of abdominoperineal excision for rectal adenocarcinoma in the context of the Belgian PROCARE improvement project.

    Penninckx, Freddy / Fieuws, Steffen / Beirens, Koen / Demetter, Pieter / Ceelen, Wim / Kartheuser, Alex / Molle, Gaetan / Van de Stadt, Jean / Vindevoghel, Koen / Van Eycken, Elizabeth

    Gut

    2013  Band 62, Heft 7, Seite(n) 1005–1011

    Abstract: Objective: The abdominoperineal excision (APE) rate, a quality of care indicator in rectal cancer surgery, has been criticised if not adjusted for confounding factors. This study evaluates variability in APE rate between centres participating in PROCARE, ...

    Abstract Objective: The abdominoperineal excision (APE) rate, a quality of care indicator in rectal cancer surgery, has been criticised if not adjusted for confounding factors. This study evaluates variability in APE rate between centres participating in PROCARE, a Belgian improvement initiative, before and after risk adjustment. It also explores the effect of merging the Hartmann resections (HR) rate with that of APE on benchmarking.
    Design: Data of 3197 patients who underwent elective radical resection for invasive rectal adenocarcinoma up to 15 cm were registered between January 2006 and March 2011 by 59 centres, each with at least 10 patients in the registry. Variability of APE or merged APE/HR rates between centres was analysed before and after adjustment for gender, age, ASA score (3 or more), tumour level (rectal third), depth of tumour invasion (cT4) and preoperative incontinence.
    Results: The overall APE rate was 21.1% (95% CI 19.7 to 22.5%). Significant variation of the APE rate was observed before and after risk adjustment (p<0.0001). For cancers in the lower rectal third, the overall APE rate increased to 45.8% (95% CI 43.1 to 48.5%). Also, variation between centres increased. Risk adjustment influenced the identification of outliers. HR was performed in only 2.6% of patients. However, merging of risk adjusted APE and HR rates identified other centres with outlying definitive colostomy rates than APE rate alone.
    Conclusion: Significant variation of the APE rate was observed. Adjustment for confounding factors as well as merging HR with APE rates were found to be important for the assessment of performances.
    Mesh-Begriff(e) Adenocarcinoma/pathology ; Adenocarcinoma/surgery ; Aged ; Aged, 80 and over ; Belgium ; Benchmarking ; Confounding Factors (Epidemiology) ; Female ; Humans ; Male ; Middle Aged ; Neoplasm Invasiveness ; Neoplasm Staging ; Quality Improvement ; Quality Indicators, Health Care/standards ; Rectal Neoplasms/pathology ; Rectal Neoplasms/surgery ; Risk Adjustment/methods
    Sprache Englisch
    Erscheinungsdatum 2013-07
    Erscheinungsland England
    Dokumenttyp Journal Article ; Multicenter Study ; Research Support, Non-U.S. Gov't
    ZDB-ID 80128-8
    ISSN 1468-3288 ; 0017-5749
    ISSN (online) 1468-3288
    ISSN 0017-5749
    DOI 10.1136/gutjnl-2011-301941
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 160: Hefte anzeigen Standort:
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