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  1. Article ; Online: Lupin, a potential "hidden" food anaphylaxis allergen: An alert from the Allergy-Vigilance Network®.

    Pouessel, Guillaume / Sabouraud-Leclerc, Dominique / Beaumont, Pascale / Divaret-Chauveau, Amandine / Bradatan, Eléna / Dumond, Pascale / Karaca, Yasemin / Renaudin, Jean-Marie / Metz-Favre, Carine / Delalande, Delphine / Correard, Anne-Karine / Tscheiller, Sélina / Van der Brempt, Xavier

    Allergy

    2024  

    Language English
    Publishing date 2024-03-22
    Publishing country Denmark
    Document type Journal Article
    ZDB-ID 391933-x
    ISSN 1398-9995 ; 0105-4538
    ISSN (online) 1398-9995
    ISSN 0105-4538
    DOI 10.1111/all.16107
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Allergic reactions to COVID-19 vaccines: statement of the Belgian Society for Allergy and Clinical Immunology (BelSACI).

    Tuyls, Sebastiaan / Van Der Brempt, Xavier / Faber, Margaretha / Gadisseur, Romy / Dezfoulian, Bita / Schrijvers, Rik / Froidure, Antoine

    Acta clinica Belgica

    2021  Volume 77, Issue 3, Page(s) 552–557

    Abstract: Vaccination against COVID-19 constitutes a huge hope and a major challenge. For the first time in modern history, a global vaccination campaign has started worldwide in a short period of time and with products that were recently developed. Consequently, ... ...

    Abstract Vaccination against COVID-19 constitutes a huge hope and a major challenge. For the first time in modern history, a global vaccination campaign has started worldwide in a short period of time and with products that were recently developed. Consequently, legitimate concerns regarding the safety and tolerability of COVID-19 vaccines arise.In line with international allergy societies, the Belgian Society for Allergy and Clinical Immunology (BelSACI) provides this statement to guide health care providers (general practitioners, specialists including allergists) and stakeholders.In this statement, we first review current evidence on allergic reactions to vaccines and the potential risk factors that have been identified.Second, we provide a risk stratification method that may be used as a worksheet during the vaccination campaign.Finally, we discuss the management of suspected or confirmed allergic reactions following vaccination.
    MeSH term(s) Anaphylaxis ; Belgium ; COVID-19/prevention & control ; COVID-19 Vaccines/adverse effects ; General Practitioners ; Humans ; Hypersensitivity/etiology ; SARS-CoV-2 ; Vaccination/adverse effects
    Chemical Substances COVID-19 Vaccines
    Language English
    Publishing date 2021-04-01
    Publishing country England
    Document type Journal Article
    ZDB-ID 390201-8
    ISSN 2295-3337 ; 0001-5512 ; 1784-3286
    ISSN (online) 2295-3337
    ISSN 0001-5512 ; 1784-3286
    DOI 10.1080/17843286.2021.1909447
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Food anaphylaxis in the elderly: Analysis of allergy vigilance network data from 2002 to 2021.

    El Hanache, Hassan / Perennec, Tanguy / Beaumont, Pascale / Puillandre, Erick / Schwender, Denis / Louis Donguy, Frédérique / Froidefond, Claudine / Jarlot, Sophie / Petit, Nicolas / Nootens, Carine / Pirson, Françoise / Sullerot, Isabelle / Nicolie, Brigitte / Van der Brempt, Xavier / Morisset, Martine

    Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology

    2023  Volume 53, Issue 5, Page(s) 561–572

    Abstract: Background: Few studies have focused on food allergies in the elderly, even though it may persist or appear de novo.: Methods: We reviewed data for all cases of food-induced anaphylaxis in people age ≥ 60 reported to the French "Allergy Vigilance ... ...

    Abstract Background: Few studies have focused on food allergies in the elderly, even though it may persist or appear de novo.
    Methods: We reviewed data for all cases of food-induced anaphylaxis in people age ≥ 60 reported to the French "Allergy Vigilance Network" (RAV) between 2002 and 2021. RAV collates data reported by French-speaking allergists regarding cases of anaphylaxis graded II to IV according to the Ring and Messmer classification.
    Results: In total, 191 cases were reported, with an even sex distribution and mean age was 67.4 years (range 60 to 93). The most frequent allergens were mammalian meat and offal (31 cases, 16.2%), often associated with IgE to α-Gal. Legumes were reported in 26 cases (13.6%), fruits and vegetables in 25 cases (13.1%), shellfish 25 cases (13.1%), nuts 20 cases (10.5%), cereals 18 cases (9.4%), seeds 10 cases (5.2%), fish 8 cases (4.2%) and anisakis 8 cases (4.2%). Severity was grade II in 86 cases (45%), grade III in 98 cases (52%) and grade IV in 6 cases (3%) with one death. Most episodes occurred at home or in a restaurant and in most cases adrenaline was not used to treat the acute episode. Potentially relevant cofactors such as beta-blocker, alcohol or non-steroidal anti-inflammatory drug intake were present in 61% of cases. Chronic cardiomyopathy, present in 11.5% of the population, was associated with greater, grade III or IV reaction severity (OR 3.4; 1.24-10.95).
    Conclusion: Anaphylaxis in the elderly has different causes to younger people and requires detailed diagnostic testing and individualized care plans.
    MeSH term(s) Animals ; Anaphylaxis/epidemiology ; Anaphylaxis/etiology ; Anaphylaxis/diagnosis ; Food Hypersensitivity ; Epinephrine/therapeutic use ; Meat ; Seafood ; Allergens ; Vegetables ; Mammals
    Chemical Substances Epinephrine (YKH834O4BH) ; Allergens
    Language English
    Publishing date 2023-02-22
    Publishing country England
    Document type Review ; Journal Article
    ZDB-ID 645204-8
    ISSN 1365-2222 ; 0954-7894 ; 0960-2178
    ISSN (online) 1365-2222
    ISSN 0954-7894 ; 0960-2178
    DOI 10.1111/cea.14297
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Food-induced anaphylaxis in infancy compared to preschool age: A retrospective analysis.

    Pouessel, Guillaume / Jean-Bart, Charlotte / Deschildre, Antoine / Van der Brempt, Xavier / Tanno, Luciana Kase / Beaumont, Pascale / Dumond, Pascale / Sabouraud-Leclerc, Dominique / Beaudouin, Etienne / Ramdane, Nassima / Liabeuf, Valérie / Renaudin, Jean-Marie

    Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology

    2019  Volume 50, Issue 1, Page(s) 74–81

    Abstract: Objective: Little is known regarding food anaphylaxis in infancy. We aimed to describe specificities of food anaphylaxis in infants (≤12 months) as compared to preschool children (1-6 years).: Methods: We conducted a retrospective study of all food ... ...

    Abstract Objective: Little is known regarding food anaphylaxis in infancy. We aimed to describe specificities of food anaphylaxis in infants (≤12 months) as compared to preschool children (1-6 years).
    Methods: We conducted a retrospective study of all food anaphylaxis cases recorded by the Allergy Vigilance Network from 2002 to 2018, in preschool children focusing on infants.
    Results: Of 1951 food anaphylaxis reactions, 61 (3%) occurred in infants and 386 (20%) in preschool children. Two infants had two anaphylaxis reactions; thus, we analyzed data among 59 infants (male: 51%; mean age: 6 months [SD: 2.9]); 31% had a history of atopic dermatitis, 11% of previous food allergy. The main food allergens were cow's milk (59%), hen's egg (20%), wheat (7%) and peanut (3%) in infants as compared with peanut (27%) and cashew (23%) in preschool children. Anaphylaxis occurred in 28/61 (46%) cases at the first cow's milk intake after breastfeeding discontinuation. Clinical manifestations were mainly mucocutaneous (79%), gastrointestinal (49%), respiratory (48%) and cardiovascular (21%); 25% of infants received adrenaline. Hives, hypotension and neurologic symptoms were more likely to be reported in infants than in preschool children (P = .02; P = .004; P = .002, respectively). Antihistamines and corticosteroids were more often prescribed in preschool children than in infants (P = .005; P = .025, respectively).
    Conclusion: Our study found that in infants presenting with their first food allergy, in a setting with a high rate of infant formula use, the most predominant trigger was cow's milk. As compared to older preschool children, hives, hypotonia and hypotension were more likely to be reported in infants. We believe that this represents a distinct food anaphylaxis phenotype that can further support developing the clinical anaphylaxis criteria in infants.
    MeSH term(s) Age Distribution ; Anacardium ; Anaphylaxis/epidemiology ; Anaphylaxis/etiology ; Anaphylaxis/physiopathology ; Angioedema/physiopathology ; Child, Preschool ; Cough/physiopathology ; Crying ; Dyspnea/physiopathology ; Egg Hypersensitivity/complications ; Egg Hypersensitivity/epidemiology ; Egg Hypersensitivity/physiopathology ; Female ; Food Hypersensitivity/complications ; Food Hypersensitivity/epidemiology ; Food Hypersensitivity/physiopathology ; Humans ; Hypotension/physiopathology ; Infant ; Laryngeal Edema/physiopathology ; Male ; Milk Hypersensitivity/complications ; Milk Hypersensitivity/epidemiology ; Milk Hypersensitivity/physiopathology ; Muscle Hypotonia/physiopathology ; Nut Hypersensitivity/complications ; Nut Hypersensitivity/epidemiology ; Nut Hypersensitivity/physiopathology ; Peanut Hypersensitivity/complications ; Peanut Hypersensitivity/epidemiology ; Peanut Hypersensitivity/physiopathology ; Pruritus/physiopathology ; Psychomotor Agitation/physiopathology ; Respiratory Sounds/physiopathology ; Retrospective Studies ; Seizures/physiopathology ; Urticaria/physiopathology ; Vomiting/physiopathology ; Wheat Hypersensitivity/complications ; Wheat Hypersensitivity/epidemiology ; Wheat Hypersensitivity/physiopathology
    Language English
    Publishing date 2019-11-21
    Publishing country England
    Document type Journal Article
    ZDB-ID 645204-8
    ISSN 1365-2222 ; 0954-7894 ; 0960-2178
    ISSN (online) 1365-2222
    ISSN 0954-7894 ; 0960-2178
    DOI 10.1111/cea.13519
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Gaps in the management of food-induced anaphylaxis reactions at school.

    Pouessel, Guillaume / Dumond, Pascale / Liabeuf, Valérie / Kase Tanno, Luciana / Deschildre, Antoine / Beaumont, Pascale / Van der Brempt, Xavier / Beaudouin, Etienne / Labreuche, Julien / Renaudin, Jean-Marie / Sabouraud-Leclerc, Dominique

    Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology

    2019  Volume 30, Issue 7, Page(s) 767–770

    MeSH term(s) Adolescent ; Allergens/immunology ; Anaphylaxis/diagnosis ; Anaphylaxis/drug therapy ; Anaphylaxis/epidemiology ; Child ; Child, Preschool ; Epinephrine/therapeutic use ; Female ; Food ; Food Hypersensitivity/diagnosis ; Food Hypersensitivity/drug therapy ; Food Hypersensitivity/epidemiology ; France/epidemiology ; Humans ; Male ; Population ; Schools ; Surveys and Questionnaires
    Chemical Substances Allergens ; Epinephrine (YKH834O4BH)
    Language English
    Publishing date 2019-07-18
    Publishing country England
    Document type Letter ; Research Support, Non-U.S. Gov't
    ZDB-ID 1057059-7
    ISSN 1399-3038 ; 0905-6157 ; 0906-5784
    ISSN (online) 1399-3038
    ISSN 0905-6157 ; 0906-5784
    DOI 10.1111/pai.13091
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Phenotype and risk factors of venom-induced anaphylaxis: A case-control study of the European Anaphylaxis Registry.

    Francuzik, Wojciech / Ruëff, Franziska / Bauer, Andrea / Bilò, Maria Beatrice / Cardona, Victoria / Christoff, George / Dölle-Bierke, Sabine / Ensina, Luis / Fernández Rivas, Montserrat / Hawranek, Thomas / O'B Hourihane, Jonathan / Jakob, Thilo / Papadopoulos, Nicos G / Pföhler, Claudia / Poziomkowska-Gęsicka, Iwona / Van der Brempt, Xavier / Scherer Hofmeier, Kathrin / Treudler, Regina / Wagner, Nicola /
    Wedi, Bettina / Worm, Margitta

    The Journal of allergy and clinical immunology

    2020  Volume 147, Issue 2, Page(s) 653–662.e9

    Abstract: Background: Venom-induced anaphylaxis (VIA) is a common, potentially life-threatening hypersensitivity reaction associated with (1) a specific symptom profile, 2) specific cofactors, and 3) specific management. Identifying the differences in phenotypes ... ...

    Abstract Background: Venom-induced anaphylaxis (VIA) is a common, potentially life-threatening hypersensitivity reaction associated with (1) a specific symptom profile, 2) specific cofactors, and 3) specific management. Identifying the differences in phenotypes of anaphylaxis is crucial for future management guidelines and development of a personalized medicine approach.
    Objective: This study aimed to evaluate the phenotype and risk factors of VIA.
    Methods: Using data from the European Anaphylaxis Registry (12,874 cases), we identified 3,612 patients with VIA and analyzed their cases in comparison with sex- and age-matched anaphylaxis cases triggered by other elicitors (non-VIA cases [n = 3,605]).
    Results: VIA more frequently involved more than 3 organ systems and was associated with cardiovascular symptoms. The absence of skin symptoms during anaphylaxis was correlated with baseline serum tryptase level and was associated with an increased risk of a severe reaction. Intramuscular or intravenous epinephrine was administered significantly less often in VIA, in particular, in patients without a history of anaphylaxis. A baseline serum tryptase level within the upper normal range (8-11.5 ng/mL) was more frequently associated with severe anaphylaxis.
    Conclusion: Using a large cohort of VIA cases, we have validated that patients with intermediate baseline serum tryptase levels (8-11 ng/mL) and without skin involvement have a higher risk of severe VIA. Patients receiving β-blockers or angiotensin-converting enzyme inhibitors had a higher risk of developing severe cardiovascular symptoms (including cardiac arrest) in VIA and non-VIA cases. Patients experiencing VIA received epinephrine less frequently than did cases with non-VIA.
    MeSH term(s) Adult ; Anaphylaxis/etiology ; Anaphylaxis/physiopathology ; Anaphylaxis/therapy ; Arthropod Venoms/adverse effects ; Case-Control Studies ; Child ; Cohort Studies ; Europe ; Female ; Humans ; Insect Bites and Stings/complications ; Male ; Phenotype ; Registries ; Risk Factors
    Chemical Substances Arthropod Venoms
    Language English
    Publishing date 2020-06-22
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 121011-7
    ISSN 1097-6825 ; 1085-8725 ; 0091-6749
    ISSN (online) 1097-6825 ; 1085-8725
    ISSN 0091-6749
    DOI 10.1016/j.jaci.2020.06.008
    Database MEDical Literature Analysis and Retrieval System OnLINE

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