LIVIVO - Search results -

Search results

Result 1 - 10 of total 18

Search options

Article ; Online: Comparative Analysis between Reid’s Colposcopic Index and Swede’s Score for Detection of Premalignant Lesions of Cervix

Smriti Pandey / Vandana Saini / Keya Kalra

Journal of Clinical and Diagnostic Research, Vol 17, Iss 4, Pp QC10-QC

A Prospective Study

2023 Volume 14

Abstract: Introduction: Colposcopy is an effective tool to detect premalignant lesions of the cervix. It is an observer-dependent technique; hence, various colposcopic-based scoring systems have been employed to minimise interobserver variations. Aim: To compare ... ...

Abstract	Introduction: Colposcopy is an effective tool to detect premalignant lesions of the cervix. It is an observer-dependent technique; hence, various colposcopic-based scoring systems have been employed to minimise interobserver variations. Aim: To compare Reid’s Colposcopic Index (RCI) and Swede’s score for the detection of premalignant lesions of the cervix and compare it with colposcopic directed biopsy and histopathology. Materials and Methods: In this prospective observational study conducted at a tertiary care hospital in Delhi, India, between August 2019 to April 2020, 100 women of the reproductive age group were recruited. Pap (Papanicolaou) smear and colposcopy were done for all the patients. Scoring of colposcopic lesions was done according to Reid’s and Swede’s scoring system. In women with RCI or Swedes score ≥3, biopsy of the cervix for histopathology was carried out. Data was recorded and statistically analysed using Statistical Package for the Social Sciences (SPSS) software. Pearson and spearmen correlation coefficient was used for correlation of RCI and Swede’s score. Results: Mean age of women was 43.89±8.2 years. A positive correlation was found between RCI and Swedes score as the correlation coefficient was 0.995 and p-value<0.001. Sensitivity was better with Swede’s scoring system as compared to RCI for predicting Cervical Intraepithelial Neoplasia (CIN)-I lesions. However, for predicting CIN-II and CIN-III lesions sensitivity with both the scoring system was comparable. The sensitivity, specificity, Positive Predictive Value (PPV) and Negative Predictive Value (NPV) of RCI at a cut-off score of 5 was 54.54%, 87.17%, 54.54%, and 87.1% for CIN-I, for CIN-II was 100%, 86.67%, 45.45%, and 100%. CIN-III was 100%, 82.1%, 22.7%, and 100%. Similarly, the sensitivity, specificity, PPV, and NPV of Swedes score at a cut-off score of 5 was 59%, 84.6%, 52%, and 88% for CIN-I, for CIN-II was 100%, 83.33%, 40%, and 100%. And that for CIN-III was 100%, 78.94%, 20% and 100%. Conclusion: Both scoring systems ...
Keywords	cervical biopsy ; colposcopy ; premalignant cervical lesion ; reid’s colposcopic index ; swede’s score ; Medicine ; R
Subject code	616
Language	English
Publishing date	2023-04-01T00:00:00Z
Publisher	JCDR Research and Publications Private Limited
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Caesarean Section

Mamta Gupta / Vandana Saini

Journal of Clinical and Diagnostic Research, Vol 12, Iss 9, Pp QE01-QE

Mortality and Morbidity

2018 Volume 06

Abstract: Caesarean Section (CS) is the most common obstetric surgery performed today. With advancement of anaesthesia and technique resulting in improved outcome and safety, its rate has been rising. Nevertheless, it carries risk of complications resulting in ... ...

Abstract	Caesarean Section (CS) is the most common obstetric surgery performed today. With advancement of anaesthesia and technique resulting in improved outcome and safety, its rate has been rising. Nevertheless, it carries risk of complications resulting in morbidity and sometimes mortality. Therefore, CSs done without medial indications, remains questionable. Maternal mortality and morbidity after caesarean birth is nearly five times than vaginal births, especially the risks of haemorrhage, sepsis, thromboembolism and amniotic fluid embolism. In a subsequent pregnancy, CS increases the risks of placenta previa and adherent placenta which may further result in higher risk of haemorrhage and peripartum hysterectomy. Technical difficulties due to adhesions increase the risk of injury to bladder and bowel. Though CS can be life saving for a foetus in jeopardy, yet in countries with high caesarean rate increased neonatal mortality and morbidity is seen i.e., iatrogenic pre-term births and respiratory morbidity. Risk of rupture uterus and stillbirths in women with previous CS also increase perinatal mortality. Neonatal adaptations is delayed in caesarean babies i.e., maintenance of body temperature, glycaemia and pulmonary respiration. Development of neonatal immune system is also affected in babies born by CS. Hence, CS should be done only if medically indicated.
Keywords	complications ; maternal outcome ; neonatal outcome ; Medicine ; R
Subject code	610
Language	English
Publishing date	2018-09-01T00:00:00Z
Publisher	JCDR Research and Publications Private Limited
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Can microRNA become next-generation tools in molecular diagnostics and therapeutics? A systematic review

Vandana Saini / Rajni Dawar / Shilpa Suneja / Sukanya Gangopadhyay / Charanjeet Kaur

Egyptian Journal of Medical Human Genetics, Vol 22, Iss 1, Pp 1-

2021 Volume 9

Abstract: Abstract Background MicroRNAs (miRNAs) represent a novel class of single-stranded RNA molecules of 18–22 nucleotides that serve as powerful tools in the regulation of gene expression. They are important regulatory molecules in several biological ... ...

Abstract	Abstract Background MicroRNAs (miRNAs) represent a novel class of single-stranded RNA molecules of 18–22 nucleotides that serve as powerful tools in the regulation of gene expression. They are important regulatory molecules in several biological processes. Main body Alteration in the expression profiles of miRNAs have been found in several diseases. It is anticipated that miRNA expression profiling can become a novel diagnostic tool in the future. Hence, this review evaluates the implications of miRNAs in various diseases and the recent advances in miRNA expression level detection and their target identification. A systematic approach to review existing literature available on databases such as Medline, PubMed, and EMBASE was conducted to have a better understanding of mechanisms mediating miRNA-dependent gene regulation and their role as diagnostic markers and therapeutic agents. Conclusion A clear understanding of the complex multilevel regulation of miRNA expression is a prerequisite to explicate the origin of a wide variety of diseases. It is understandable that miRNAs offer potential targets both in diagnostics and therapeutics of a multitude of diseases. The inclusion of specific miRNA expression profiles as biomarkers may lead to crucial advancements in facilitating disease diagnosis and classification, monitoring its prognosis, and treatment. However, standardization of methods has a pivotal role in the success of extensive use of miRNA expression profiling in routine clinical settings.
Keywords	Gene regulation ; miRNA gene silencing ; miRNA expression profiling ; miRNA antagonists ; miRNA mimics ; Medicine (General) ; R5-920 ; Genetics ; QH426-470
Subject code	610
Language	English
Publishing date	2021-01-01T00:00:00Z
Publisher	SpringerOpen
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Emerging Diabetic Novel Biomarkers of the 21st Century

Shilpa Suneja / Sukanya Gangopadhyay / Vandana Saini / Rajni Dawar / Charanjeet Kaur

Annals of the National Academy of Medical Sciences (India), Vol 57, Iss 03, Pp 69-

2021 Volume 81

Abstract: Diabetes is a growing epidemic with estimated prevalence of infected to reach ~592 million by the year 2035. An effective way to approach is to detect the disease at a very early stage to reduce the complications and improve lifestyle management. ... ...

Abstract	Diabetes is a growing epidemic with estimated prevalence of infected to reach ~592 million by the year 2035. An effective way to approach is to detect the disease at a very early stage to reduce the complications and improve lifestyle management. Although several traditional biomarkers including glucated hemoglobin, glucated albumin, fructosamine, and 1,5-anhydroglucitol have helped in ease of diagnosis, there is lack of sensitivity and specificity and are inaccurate in certain clinical settings. Thus, search for new and effective biomarkers is a continuous process with an aim of accurate and timely diagnosis. Several novel biomarkers have surged in the present century that are helpful in timely detection of the disease condition. Although it is accepted that a single biomarker will have its inherent limitations, combining several markers will help to identify individuals at high risk of developing prediabetes and eventually its progression to frank diabetes. This review describes the novel biomarkers of the 21st century, both in type 1 and type 2 diabetes mellitus, and their present potential for assessing risk stratification due to insulin resistance that will pave the way for improved clinical outcome.
Keywords	21st century ; biomarkers ; review ; type 1 diabetes mellitus ; type 2 diabetes mellitus ; General works ; R5-130.5 ; Science ; Q
Language	English
Publishing date	2021-05-01T00:00:00Z
Publisher	Thieme Medical and Scientific Publishers Pvt. Ltd.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Molecular mechanisms of insulin resistance in type 2 diabetes mellitus

Vandana Saini

World Journal of Diabetes, Vol 1, Iss 3, Pp 68-

2010 Volume 75

Abstract: Free fatty acids are known to play a key role in promoting loss of insulin sensitivity in type 2 diabetes mellitus but the underlying mechanism is still unclear. It has been postulated that an increase in the intracellular concentration of fatty acid ... ...

Abstract	Free fatty acids are known to play a key role in promoting loss of insulin sensitivity in type 2 diabetes mellitus but the underlying mechanism is still unclear. It has been postulated that an increase in the intracellular concentration of fatty acid metabolites activates a serine kinase cascade, which leads to defects in insulin signaling downstream to the insulin receptor. In addition, the complex network of adipokines released from adipose tissue modulates the response of tissues to insulin. Among the many molecules involved in the intracellular processing of the signal provided by insulin, the insulin receptor substrate-2, the protein kinase B and the forkhead transcription factor Foxo 1a are of particular interest, as recent data has provided strong evidence that dysfunction of these proteins results in insulin resistance in vivo. Recently, studies have revealed that phosphoinositidedependent kinase 1-independent phosphorylation of protein kinase Cε causes a reduction in insulin receptor gene expression. Additionally, it has been suggested that mitochondrial dysfunction triggers activation of several serine kinases, and weakens insulin signal transduction. Thus, in this review, the current developments in understanding the pathophysiological processes of insulin resistance in type 2 diabetes have been summarized. In addition, this study provides potential new targets for the treatment and prevention of type 2 diabetes.
Keywords	Adipokines ; Forkhead box protein O ; Insulin receptor ; Insulin resistance ; Insulin signaling ; Insulin receptor substrate proteins ; Type 2 diabetes mellitus ; Phosphatidylinositol 3-kinase ; Protein kinase B ; Diseases of the endocrine glands. Clinical endocrinology ; RC648-665 ; Specialties of internal medicine ; RC581-951 ; Internal medicine ; RC31-1245 ; Medicine ; R ; DOAJ:Internal medicine ; DOAJ:Medicine (General) ; DOAJ:Health Sciences
Subject code	571
Language	English
Publishing date	2010-07-01T00:00:00Z
Publisher	Baishideng Publishing
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Association between PON1 rs662 gene polymorphism and serum paraoxonase1 level in coronary artery disease patients in Northern India

Rohit Kumar / Vandana Saini / Charanjeet Kaur / H. S. Isser / Nitin Tyagi / Subhra Sahoo

Egyptian Journal of Medical Human Genetics, Vol 22, Iss 1, Pp 1-

2021 Volume 8

Abstract: Abstract Background Coronary artery disease (CAD) is a leading cause of morbidity and mortality, with a shifting trend towards the younger population. Paraoxonase1 (PON1) is a glycoprotein enzyme associated with high-density lipoprotein (HDL) particles ... ...

Abstract	Abstract Background Coronary artery disease (CAD) is a leading cause of morbidity and mortality, with a shifting trend towards the younger population. Paraoxonase1 (PON1) is a glycoprotein enzyme associated with high-density lipoprotein (HDL) particles in the blood. It has the ability to protect against lipid oxidation, thereby reducing the risk of atherogenesis. PON1 rs662 gene polymorphism may affect serum PON1 levels as well as its activity and may have a significant role in the pathogenesis of CAD. The present study was conducted to identify the association of PON1 rs662 gene polymorphism with serum PON1 levels in CAD patients in the North Indian population. This case–control study included 71 angiography-proven CAD patients (with > 50% luminal stenosis in one or more coronary arteries) and 71 controls (with < 50% luminal obstruction in angiography). PON1 rs662 gene polymorphism was studied using PCR and RFLP under the standardized protocol. Serum PON1 levels were estimated by ELISA. Results The serum PON1 level was significantly lower in the CAD group than in the controls (7.79 ± 3.16 vs. 10.79 ± 3.19 ng/mL; p < 0.0001). Logistic regression analysis showed that homozygous GG genotype of PON1 rs662 SNP has ninefold increased risk of developing CAD in an Indian population (OR = 9.0, 95%CI 2.79–29.06, p = 0.0002). A significantly higher frequency of G allele was also observed in CAD patients than in controls (OR 2.64, 95%CI 1.61–4.33, p = 0.001). Conclusions The reduced serum PON1 level is associated with CAD. PON1 rs662 gene polymorphism is significantly associated with CAD susceptibility in the North Indian population.
Keywords	Paraoxonase1 ; Coronary artery disease ; rs662 gene polymorphism ; Oxidized LDL ; Medicine (General) ; R5-920 ; Genetics ; QH426-470
Subject code	610
Language	English
Publishing date	2021-09-01T00:00:00Z
Publisher	SpringerOpen
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: An Incidental Finding of Bilateral Dysgerminoma During Cesarean Section

Mamta Gupta / Rita Jindal / Vandana Saini

Journal of Clinical and Diagnostic Research, Vol 10, Iss 8, Pp QD04-QD

Dilemmas in Management

2016 Volume 05

Abstract: Dysgerminoma is an uncommon malignant tumour arising from germ cells of ovary. It occurs mostly in the reproductive age group. Its association with pregnancy is rare. Its management remains a challenge especially in an unsuspected case. We present a case ...

Abstract	Dysgerminoma is an uncommon malignant tumour arising from germ cells of ovary. It occurs mostly in the reproductive age group. Its association with pregnancy is rare. Its management remains a challenge especially in an unsuspected case. We present a case of a woman, aged 28-year-old gravida2 para1 who reported to us at 36 weeks’ pregnancy with severe preeclampsia and previous caesarean section. On ultrasound she was reported as having subserosal fibroids with single live fetus of 35 weeks and 3 days gestation. She delivered a live baby by caesarean section done for failed induction. Intraoperatively bilateral ovarian masses were found and removed which were later confirmed to be dysgerminoma on histopathological examination. As she was not diagnosed dysgerminoma preoperatively, complete work up i.e., tumour markers and MRI was not done, leading to dilemmas in management. Though standard protocols for management of dysgerminoma with pregnancy exist, yet management of these incidentally diagnosed dysgerminomas remains a dilemma.
Keywords	fertility sparing surgery ; germ cells of ovary ; incompletely staged dysgerminomas ; Medicine ; R
Language	English
Publishing date	2016-08-01T00:00:00Z
Publisher	JCDR Research and Publications Private Limited
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Prediction of Delivery in Women with Threatening Preterm Labour using Phosphorylated Insulin-Like Growth Factor Binding Protein-1 and Cervical Length using Transvaginal Ultrasound

Amrita Kumari / Vandana Saini / P.K. Jain / Mamta Gupta

Journal of Clinical and Diagnostic Research, Vol 11, Iss 9, Pp QC01-QC

2017 Volume 04

Abstract: Introduction: Preterm delivery remains a challenge in Obstetrics as it is responsible for significant cause of perinatal morbidity and mortality. At present there is no standard test for prediction of preterm labour for timely referral to a center with ... ...

Abstract	Introduction: Preterm delivery remains a challenge in Obstetrics as it is responsible for significant cause of perinatal morbidity and mortality. At present there is no standard test for prediction of preterm labour for timely referral to a center with NICU facilities. Aim: To evaluate the effectiveness of the cervical phosphorylated insulin like growth factor binding protein-1(phIGFBP-1), cervical length measurement and combination of phIGFBP-1 with cervical length for Predicting Preterm Labour (PTL). Materials and Methods: It was a observational prospective study done from January 2014 to April 2015 in Department of Obstetrics and Gynaecology, NDMC Medical College and Hindu Rao Hospital, Delhi, India. A total of 100 women with singleton pregnancy, between 24 and 36 weeks of gestation with complaint of uterine contractions were randomly selected. These women were subjected to detect phIGFBP-1 in cervical secretions and cervical length measurement by Transvaginal Sonography (TVS). Result of the test, cervical length and time lapse between test and delivery was noted and the results were analysed. The cervical length less than 25 mm was used as a cut off point for predicting pre-term delivery. Data was analysed using SPSS software version 20.0. Results: The Negative Predictive Value (NPV) of phIGFBP-1 and cervical length was similar (95.2% vs 94.05%) respectively for prediction of preterm labour within one week of admission and 93.92% vs 94.80% at 37 weeks of gestational age. Combined test had higher NPV of 96.38% at 34 weeks of gestation and 94% within two days of admission. Positive Predictive Value (PPV) was low for both the test and combining the two-test did not have any advantage as far as PPV was concerned. Receiver Operating Characteristic (ROC) curve showed that the combined test had a superior result in predicting PTL compared to either phIGFBP-1 or cervical length. The combined test had steepest ROC curve at < 34 weeks of gestation (AUC-0.83 with 95% CI). Conclusion: The phIGFBP-1 test and cervical ...
Keywords	fetal fibronectin ; preterm delivery ; risk of preterm labor ; shortened cervical length ; Medicine ; R
Subject code	610
Language	English
Publishing date	2017-09-01T00:00:00Z
Publisher	JCDR Research and Publications Private Limited
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: NT-proBNP

Supriya Kumari / Mamta Gupta / Harsh Vardhan / Vandana Saini / SK Gupta

Journal of Clinical and Diagnostic Research, Vol 11, Iss 11, Pp QC12-QC

A Biochemical Marker of Maternal Complications in Pre-eclampsia

2017 Volume 16

Abstract: Introduction: Elevated serum levels of NT-proBNP (N terminal pro-Brain Natriuretic Peptide) are associated with Pre-Eclampsia (PE) and its complications. Aim: To evaluate NT-proBNP in women with PE and correlate its levels with maternal outcome. ... ...

Abstract	Introduction: Elevated serum levels of NT-proBNP (N terminal pro-Brain Natriuretic Peptide) are associated with Pre-Eclampsia (PE) and its complications. Aim: To evaluate NT-proBNP in women with PE and correlate its levels with maternal outcome. Materials and Methods: A total 90 out of which 45 women with PE (Group A) and 45 normotensive healthy pregnant women with singleton pregnancy (Group B) were enrolled. NT-proBNP was estimated at term or just before induction of labour or in early labour. These women were followed till 48 hours postpartum. Maternal outcome was recorded and analysed using statistical tests like Student t-test, Mann-whitney, ANOVA, Kruskal Wallis, Pearson and Spearman correlation. Results: Significant elevated serum levels of NT-proBNP were seen in PE women than controls (mean 439.47±431.99 and 99.40±37.89 respectively) (p-value <0.001). Severity and early onset of PE was associated with further increased serum NTproBNP levels. In Group B none of the women developed any complication whereas, in Group A 19/45 (42.22%) women had a total of 31 complications. Forty percent of these PE women had maternal complications and elevated NT-proBNP levels above 500 pg/mL. Cardiovascular complications were observed in 4/45 women with NT-proBNP levels of 770 pg/mL and above. The positive predictive value for NT-proBNP for detecting complications was 83.33% at a cut-off level of 500 pg/mL. The negative predictive value was 92.85% at a cut-off level of 100 pg/mL. Women in Group A with early onset PE, who did not develop maternal complications, had low serum NT-proBNP. Women without severe features of PE (n=12) in Group A who developed complications, had elevated NT-proBNP (mean 434±307.219 pg/mL) than those who had no complication (mean NT-proBNP 80.66±37.54 pg/mL). Conclusion: NT-proBNP is a useful marker for predicting maternal complications and risk stratification for optimum maternal outcome in a PE women.
Keywords	hypertensive disorders ; maternal complications ; n terminal pro-brain natriuretic peptide ; Medicine ; R
Subject code	610
Language	English
Publishing date	2017-11-01T00:00:00Z
Publisher	JCDR Research and Publications Private Limited
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Role of leptin and adiponectin in gestational diabetes mellitus

Vandana Saini / Megha Kataria / Amita Yadav / Anju Jain

Internet Journal of Medical Update, Vol 10, Iss

a study in a North Indian tertiary care hospital

2015 Volume 1

Keywords	Medicine ; R ; Medicine (General) ; R5-920
Language	English
Publishing date	2015-01-01T00:00:00Z
Publisher	AKS Publication
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

To top

Full text online

More links

Kategorien

Inter-library loan at ZB MED

Full text online

More links

Kategorien

Inter-library loan at ZB MED

Full text online

More links

Kategorien

Inter-library loan at ZB MED

Full text online

More links

Kategorien

Inter-library loan at ZB MED

Full text online

More links

Kategorien

Inter-library loan at ZB MED

Full text online

More links

Kategorien

Inter-library loan at ZB MED

Full text online

More links

Kategorien

Inter-library loan at ZB MED

Full text online

More links

Kategorien

Inter-library loan at ZB MED

Full text online

More links

Kategorien

Inter-library loan at ZB MED

Full text online

More links

Kategorien

Inter-library loan at ZB MED