LIVIVO - Search results -

Search results

Result 1 - 10 of total 345

Search options

Article ; Online: Classification of the primary progressive aphasias: principles and review of progress since 2011.

Vandenberghe, Rik

2016 Volume 8, Issue 1, Page(s) 16

Abstract: Highly influential recommendations published in 2011 for the classification of the primary progressive aphasias (PPA) distinguished three subtypes: the semantic variant, the nonfluent/agrammatic variant, and the logopenic variant. We review empirical ... ...

Abstract	Highly influential recommendations published in 2011 for the classification of the primary progressive aphasias (PPA) distinguished three subtypes: the semantic variant, the nonfluent/agrammatic variant, and the logopenic variant. We review empirical evidence published after 2011 that bears relevance to the validity of the recommended classification scheme. The studies that we review principally rely on monocentric, memory clinic-based consecutive series of PPA patients. We review whether a data-driven analysis of neurolinguistic test scores confirms the subtyping that was based on expert consensus, whether the 2011 subtyping covers the diversity of PPA in a comprehensive manner, and whether the proposed subgroups differ along dimensions that are not explicitly part of the defining criteria, such as diffusion tractography. Data-driven mathematical analyses of neurolinguistic data in PPA broadly confirm the presence of separate clusters corresponding to the subtypes but also leave 15-30% unclassified. A comprehensive description of PPA requires the addition of the mixed variant as a fourth subtype and needs to leave room for cases fulfilling the criteria for a root diagnosis of PPA but not those of any of the three subtypes. Finally, given the limited predictive value of the clinical phenotype for the underlying neuropathology, biomarkers of the underlying pathology are likely of clinical utility in PPA.
MeSH term(s)	Aphasia, Primary Progressive/classification ; Aphasia, Primary Progressive/diagnosis ; Aphasia, Primary Progressive/metabolism ; Brain/metabolism ; Humans
Language	English
Publishing date	2016-04-21
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	2506521-X
ISSN	1758-9193 ; 1758-9193
ISSN (online)	1758-9193
ISSN	1758-9193
DOI	10.1186/s13195-016-0185-y
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Full text

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Details ▾
- Full text online
- Order with fees

Article ; Online: In vivo PET of synaptic density as potential diagnostic marker for cognitive disorders: prospective comparison with current imaging markers for neuronal dysfunction and relation to symptomatology - study protocol.

Vanderlinden, Greet / Carron, Charles / Vandenberghe, Rik / Vandenbulcke, Mathieu / Van Laere, Koen

BMC medical imaging

2024 Volume 24, Issue 1, Page(s) 41

Abstract: Background: 18: Methods: In this prospective, multimodal imaging study, 110 patients with uncertain diagnosis of cognitive impairment who are referred for : Discussion: The main endpoint of the study will be the comparison of the diagnostic ... ...

Abstract	Background: 18 Methods: In this prospective, multimodal imaging study, 110 patients with uncertain diagnosis of cognitive impairment who are referred for Discussion: The main endpoint of the study will be the comparison of the diagnostic accuracy between
MeSH term(s)	Humans ; Fluorodeoxyglucose F18 ; Prospective Studies ; Fluorine Radioisotopes ; Cognitive Dysfunction/diagnostic imaging ; Positron-Emission Tomography/methods ; Magnetic Resonance Imaging/methods ; Pyridines ; Pyrrolidines
Chemical Substances	SynVesT-1 (9HJJ2N3UU8) ; Fluorodeoxyglucose F18 (0Z5B2CJX4D) ; Fluorine Radioisotopes ; Pyridines ; Pyrrolidines
Language	English
Publishing date	2024-02-12
Publishing country	England
Document type	Journal Article
ZDB-ID	2061975-3
ISSN	1471-2342 ; 1471-2342
ISSN (online)	1471-2342
ISSN	1471-2342
DOI	10.1186/s12880-024-01224-5
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Semantic representations in inferior frontal and lateral temporal cortex during picture naming, reading, and repetition.

Liuzzi, Antonietta Gabriella / Meersmans, Karen / Peeters, Ronald / De Deyne, Simon / Dupont, Patrick / Vandenberghe, Rik

Human brain mapping

2024 Volume 45, Issue 2, Page(s) e26603

Abstract: Reading, naming, and repetition are classical neuropsychological tasks widely used in the clinic and psycholinguistic research. While reading and repetition can be accomplished by following a direct or an indirect route, pictures can be named only by ... ...

Abstract	Reading, naming, and repetition are classical neuropsychological tasks widely used in the clinic and psycholinguistic research. While reading and repetition can be accomplished by following a direct or an indirect route, pictures can be named only by means of semantic mediation. By means of fMRI multivariate pattern analysis, we evaluated whether this well-established fundamental difference at the cognitive level is associated at the brain level with a difference in the degree to which semantic representations are activated during these tasks. Semantic similarity between words was estimated based on a word association model. Twenty subjects participated in an event-related fMRI study where the three tasks were presented in pseudo-random order. Linear discriminant analysis of fMRI patterns identified a set of regions that allow to discriminate between words at a high level of word-specificity across tasks. Representational similarity analysis was used to determine whether semantic similarity was represented in these regions and whether this depended on the task performed. The similarity between neural patterns of the left Brodmann area 45 (BA45) and of the superior portion of the left supramarginal gyrus correlated with the similarity in meaning between entities during picture naming. In both regions, no significant effects were seen for repetition or reading. The semantic similarity effect during picture naming was significantly larger than the similarity effect during the two other tasks. In contrast, several regions including left anterior superior temporal gyrus and left ventral BA44/frontal operculum, among others, coded for semantic similarity in a task-independent manner. These findings provide new evidence for the dynamic, task-dependent nature of semantic representations in the left BA45 and a more task-independent nature of the representational activation in the lateral temporal cortex and ventral BA44/frontal operculum.
MeSH term(s)	Humans ; Semantics ; Reading ; Brain Mapping ; Temporal Lobe/diagnostic imaging ; Temporal Lobe/physiology ; Brain ; Magnetic Resonance Imaging
Language	English
Publishing date	2024-02-09
Publishing country	United States
Document type	Journal Article
ZDB-ID	1197207-5
ISSN	1097-0193 ; 1065-9471
ISSN (online)	1097-0193
ISSN	1065-9471
DOI	10.1002/hbm.26603
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 4028: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: The relationship between amyloid deposition, neurodegeneration, and cognitive decline in dementia.

Vandenberghe, Rik

Current neurology and neuroscience reports

2014 Volume 14, Issue 11, Page(s) 498

Abstract: Amyloid imaging has been clinically approved for measuring β amyloid plaque load in patients being evaluated for Alzheimer's disease or other causes of cognitive decline. Here we explore a multidimensional approach to cognitive decline, where we situate ... ...

Abstract	Amyloid imaging has been clinically approved for measuring β amyloid plaque load in patients being evaluated for Alzheimer's disease or other causes of cognitive decline. Here we explore a multidimensional approach to cognitive decline, where we situate amyloid plaque burden among a number of other relevant dimensions, such as aging, volume loss, other proteinopathies such as TDP43 and Lewy bodies, and functional reorganisation of cognitive brain systems. The multidimensional model incorporates a 'pure AD' trajectory, corresponding to e.g. monogenic Alzheimer's disease, but leaves room for other combinations of biomarker abnormalities (e.g. volume loss without amyloid positivity) and other trajectories. More tools will become available in the future that allow one to carve out a causal-mechanistic space for explaing cognitive decline in a personalized manner, enhancing progress towards more efficacious interventions.
MeSH term(s)	Amyloid/metabolism ; Cognition Disorders/etiology ; Cognition Disorders/metabolism ; Dementia/complications ; Humans ; Neurodegenerative Diseases/metabolism
Chemical Substances	Amyloid
Language	English
Publishing date	2014-09-17
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2057363-7
ISSN	1534-6293 ; 1528-4042
ISSN (online)	1534-6293
ISSN	1528-4042
DOI	10.1007/s11910-014-0498-9
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 5549: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Book ; Online: Cross-Lingual Transfer Learning for Alzheimer's Detection From Spontaneous Speech

Tamm, Bastiaan / Vandenberghe, Rik / Van hamme, Hugo

2023

Abstract: Alzheimer's disease (AD) is a progressive neurodegenerative disease most often associated with memory deficits and cognitive decline. With the aging population, there has been much interest in automated methods for cognitive impairment detection. One ... ...

Abstract	Alzheimer's disease (AD) is a progressive neurodegenerative disease most often associated with memory deficits and cognitive decline. With the aging population, there has been much interest in automated methods for cognitive impairment detection. One approach that has attracted attention in recent years is AD detection through spontaneous speech. While the results are promising, it is not certain whether the learned speech features can be generalized across languages. To fill this gap, the ADReSS-M challenge was organized. This paper presents our submission to this ICASSP-2023 Signal Processing Grand Challenge (SPGC). The model was trained on 228 English samples of a picture description task and was transferred to Greek using only 8 samples. We obtained an accuracy of 82.6% for AD detection, a root-mean-square error of 4.345 for cognitive score prediction, and ranked 2nd place in the competition out of 24 competitors. Comment: 2 pages, submitted to ICASSP 2023
Keywords	Electrical Engineering and Systems Science - Audio and Speech Processing ; Computer Science - Sound
Publishing date	2023-03-06
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Prognostic value of amyloid/tau/neurodegeneration (ATN) classification based on diagnostic cerebrospinal fluid samples for Alzheimer's disease.

Delmotte, Koen / Schaeverbeke, Jolien / Poesen, Koen / Vandenberghe, Rik

Alzheimer's research & therapy

2021 Volume 13, Issue 1, Page(s) 84

Abstract: Objective: The primary study objective of this retrospective academic memory clinic-based observational longitudinal study was to investigate the prognostic value of a cerebrospinal fluid (CSF)-based ATN classification for subsequent cognitive decline ... ...

Abstract	Objective: The primary study objective of this retrospective academic memory clinic-based observational longitudinal study was to investigate the prognostic value of a cerebrospinal fluid (CSF)-based ATN classification for subsequent cognitive decline during the 3 years following lumbar puncture in a clinical, real-life setting. The secondary objective was to investigate the prognostic value of CSF biomarkers as continuous variables. Methods: Data from 228 patients (median age 67 (47-85) years), who presented at the Neurology Memory Clinic UZ/KU Leuven between September 2011 and December 2016, were included with a follow-up period of up to 36 months. Patients underwent a CSF AD biomarker test for amyloid-beta 1-42 (Aβ Results: The distribution in the current clinical sample was as follows: A-/T-/N- 32.02%, A+/T-/N- 33.33%, A+/T+/N+ 17.11%, A+/T-/N+ 11.84%, A-/T-/N+ 4.39%, A-/T+/N+ 1.32% (3 cases), with no cases in the A-/T+/N- and A+/T+/N- class. Hence, the latter 3 classes were excluded from further analyses. The change of MMSE relative to A-/T-/N- over a 36-month period was significant in all four ATN classes: A+/T+/N+ = - 4.78 points on the MMSE; A-/T-/N+ = - 4.76; A+/T-/N+ = - 2.83; A+/T-/N- = - 1.96. The earliest significant difference was seen in the A+/T+/N+ class at 12 months after baseline. The effect of ATN class on future cognitive decline was confirmed for a different set of CSF thresholds. All individual baseline CSF biomarkers including the Aβ Conclusion: ATN classification based on CSF biomarkers has a statistically significant and clinically relevant prognostic value for the course of cognitive decline in a 3-year period in a clinical practice setting.
MeSH term(s)	Alzheimer Disease/diagnosis ; Amyloid beta-Peptides ; Biomarkers ; Child, Preschool ; Cognitive Dysfunction/diagnosis ; Disease Progression ; Humans ; Longitudinal Studies ; Peptide Fragments ; Prognosis ; Retrospective Studies ; tau Proteins
Chemical Substances	Amyloid beta-Peptides ; Biomarkers ; Peptide Fragments ; tau Proteins
Language	English
Publishing date	2021-04-20
Publishing country	England
Document type	Journal Article ; Observational Study
ZDB-ID	2506521-X
ISSN	1758-9193 ; 1758-9193
ISSN (online)	1758-9193
ISSN	1758-9193
DOI	10.1186/s13195-021-00817-4
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article: Cognitive and Behavioral Manifestations in ALS: Beyond Motor System Involvement.

Rusina, Robert / Vandenberghe, Rik / Bruffaerts, Rose

Diagnostics (Basel, Switzerland)

2021 Volume 11, Issue 4

Abstract: Amyotrophic lateral sclerosis (ALS) has long been considered to be a purely motor disorder. However, it has become apparent that many ALS patients develop cognitive and behavioral manifestations similar to frontotemporal dementia and the term amyotrophic ...

Abstract	Amyotrophic lateral sclerosis (ALS) has long been considered to be a purely motor disorder. However, it has become apparent that many ALS patients develop cognitive and behavioral manifestations similar to frontotemporal dementia and the term amyotrophic lateral sclerosis-frontotemporal spectrum disorder (ALS-FTSD) is now used in these circumstances. This review is intended to be an overview of the cognitive and behavioral manifestations commonly encountered in ALS patients with the goal of improving case-oriented management in clinical practice. We introduce the principal ALS-FTSD subtypes and comment on their principal clinical manifestations, neuroimaging findings, neuropathological and genetic background, and summarize available therapeutic options. Diagnostic criteria for ALS-FTSD create distinct categories based on the type of neuropsychological manifestations, i.e., changes in behavior, impaired social cognition, executive dysfunction, and language or memory impairment. Cognitive impairment is found in up to 65%, while frank dementia affects about 15% of ALS patients. ALS motor and cognitive manifestations can worsen in parallel, becoming more pronounced when bulbar functions (affecting speech, swallowing, and salivation) are involved. Dementia can precede or develop after the appearance of motor symptoms. ALS-FTSD patients have a worse prognosis and shorter survival rates than patients with ALS or frontotemporal dementia alone. Important negative prognostic factors are behavioral and personality changes. From the clinician's perspective, there are five major distinguishable ALS-FTSD subtypes: ALS with cognitive impairment, ALS with behavioral impairment, ALS with combined cognitive and behavioral impairment, fully developed frontotemporal dementia in combination with ALS, and comorbid ALS and Alzheimer's disease. Although the most consistent ALS and ALS-FTSD pathology is a disturbance in transactive response DNA binding protein 43 kDa (TDP-43) metabolism, alterations in microtubule-associated tau protein metabolism have also been observed in ALS-FTSD. Early detection and careful monitoring of cognitive deficits in ALS are crucial for patient and caregiver support and enable personalized management of individual patient needs.
Language	English
Publishing date	2021-03-30
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2662336-5
ISSN	2075-4418
ISSN	2075-4418
DOI	10.3390/diagnostics11040624
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Independency of Coding for Affective Similarities and for Word Co-occurrences in Temporal Perisylvian Neocortex.

Liuzzi, Antonietta Gabriella / Meersmans, Karen / Storms, Gerrit / De Deyne, Simon / Dupont, Patrick / Vandenberghe, Rik

Neurobiology of language (Cambridge, Mass.)

2023 Volume 4, Issue 2, Page(s) 257–279

Abstract: Word valence is one of the principal dimensions in the organization of word meaning. Co-occurrence-based similarities calculated by predictive natural language processing models are relatively poor at representing affective content, but very powerful in ... ...

Abstract	Word valence is one of the principal dimensions in the organization of word meaning. Co-occurrence-based similarities calculated by predictive natural language processing models are relatively poor at representing affective content, but very powerful in their own way. Here, we determined how these two canonical but distinct ways of representing word meaning relate to each other in the human brain both functionally and neuroanatomically. We re-analysed an fMRI study of word valence. A co-occurrence-based model was used and the correlation with the similarity of brain activity patterns was compared to that of affective similarities. The correlation between affective and co-occurrence-based similarities was low (
Language	English
Publishing date	2023-04-11
Publishing country	United States
Document type	Journal Article
ISSN	2641-4368
ISSN (online)	2641-4368
DOI	10.1162/nol_a_00095
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Sense and sensitivity of novel criteria for frontotemporal dementia.

Vandenberghe, Rik

Brain : a journal of neurology

2011 Volume 134, Issue Pt 9, Page(s) 2450–2453

MeSH term(s)	Age of Onset ; Behavior/physiology ; Dementia/diagnosis ; Dementia/pathology ; Female ; Frontotemporal Dementia/diagnosis ; Frontotemporal Dementia/physiopathology ; Frontotemporal Lobar Degeneration/pathology ; Frontotemporal Lobar Degeneration/physiopathology ; Guidelines as Topic ; Humans ; Male
Language	English
Publishing date	2011-09
Publishing country	England
Document type	Comment ; Journal Article
ZDB-ID	80072-7
ISSN	1460-2156 ; 0006-8950
ISSN (online)	1460-2156
ISSN	0006-8950
DOI	10.1093/brain/awr208
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Ui II Zs.26: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Orienting to different dimensions of word meaning alters the representation of word meaning in early processing regions.

Meersmans, Karen / Storms, Gerrit / De Deyne, Simon / Bruffaerts, Rose / Dupont, Patrick / Vandenberghe, Rik

Cerebral cortex (New York, N.Y. : 1991)

2022 Volume 32, Issue 15, Page(s) 3302–3317

Abstract: Conscious processing of word meaning can be guided by attention. In this event-related functional magnetic resonance imaging study in 22 healthy young volunteers, we examined in which regions orienting attention to two fundamental and generic dimensions ... ...

Abstract	Conscious processing of word meaning can be guided by attention. In this event-related functional magnetic resonance imaging study in 22 healthy young volunteers, we examined in which regions orienting attention to two fundamental and generic dimensions of word meaning, concreteness versus valence, alters the semantic representations coded in activity patterns. The stimuli consisted of 120 nouns in written or spoken modality which varied factorially along the concreteness and valence axis. Participants performed a forced-choice judgement of either concreteness or valence. Rostral and subgenual anterior cingulate were strongly activated during valence judgement, and precuneus and the dorsal attention network during concreteness judgement. Task and stimulus type interacted in right posterior fusiform gyrus, left lingual gyrus, precuneus, and insula. In the right posterior fusiform gyrus and the left lingual gyrus, the correlation between the pairwise similarity in activity patterns evoked by words and the pairwise distance in valence and concreteness was modulated by the direction of attention, word valence or concreteness. The data indicate that orienting attention to basic dimensions of word meaning exerts effects on the representation of word meaning in more peripheral nodes, such as the ventral occipital cortex, rather than the core perisylvian language regions.
MeSH term(s)	Brain Mapping ; Humans ; Language ; Magnetic Resonance Imaging ; Semantics ; Temporal Lobe
Language	English
Publishing date	2022-02-04
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1077450-6
ISSN	1460-2199 ; 1047-3211
ISSN (online)	1460-2199
ISSN	1047-3211
DOI	10.1093/cercor/bhab416
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 3235: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

To top

Full text online

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

Inter-library loan at ZB MED

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito