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  1. Article ; Online: Controversies in Pediatric Angle Surgery and Secondary Surgical Treatment.

    Young, Alexander K / Vanderveen, Deborah K

    Seminars in ophthalmology

    2022  Volume 38, Issue 3, Page(s) 248–254

    Abstract: Pediatric glaucoma is a constellation of challenging ophthalmic conditions that, left untreated, can result in irreversible vision loss. The mainstay of treatment for primary congenital glaucoma and select secondary glaucoma subtypes is angle surgery, ... ...

    Abstract Pediatric glaucoma is a constellation of challenging ophthalmic conditions that, left untreated, can result in irreversible vision loss. The mainstay of treatment for primary congenital glaucoma and select secondary glaucoma subtypes is angle surgery, either trabeculotomy or goniotomy. More recently, MIGS devices have been utilized to enhance the efficacy of these procedures. Despite the high success rates of these primary surgical options, refractory cases are challenging to manage. There is no consensus on the next step of treatment following primary angle surgery. Glaucoma drainage devices and trabeculectomies have been the traditional options, with laser treatment reserved for more severe cases. The benefits and disadvantages of each of these options are discussed.
    MeSH term(s) Child ; Humans ; Glaucoma/surgery ; Glaucoma/congenital ; Trabeculectomy/methods ; Glaucoma Drainage Implants ; Eye ; Vision Disorders ; Intraocular Pressure ; Treatment Outcome
    Language English
    Publishing date 2022-12-06
    Publishing country England
    Document type Journal Article
    ZDB-ID 632820-9
    ISSN 1744-5205 ; 0882-0538
    ISSN (online) 1744-5205
    ISSN 0882-0538
    DOI 10.1080/08820538.2022.2152711
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  2. Article ; Online: Association of Neighborhood Opportunity With Severity of Retinoblastoma at Presentation.

    Altamirano-Lamarque, Francisco / Lim, Caleb / Shah, Ankoor S / Vanderveen, Deborah K / Gonzalez, Efren / Oke, Isdin

    American journal of ophthalmology

    2024  Volume 261, Page(s) 1–6

    Abstract: Purpose: To examine the relationship between the Child Opportunity Index (COI) and severity of retinoblastoma at presentation.: Design: Cross-sectional study.: Methods: Children (age <18 years) treated for retinoblastoma at a tertiary care center ... ...

    Abstract Purpose: To examine the relationship between the Child Opportunity Index (COI) and severity of retinoblastoma at presentation.
    Design: Cross-sectional study.
    Methods: Children (age <18 years) treated for retinoblastoma at a tertiary care center between January 2000 and May 2023 were included. Residential census tract was used to determine the overall and domain-specific COI score for each child. Collected variables included age, sex, race/ethnicity, insurance type, and the International Classification of Retinoblastoma (ICRB) Group at initial examination. The primary outcome was Group D or E retinoblastoma at presentation. Mixed effects regression models were used to estimate the association of COI scores with disease severity at presentation.
    Results: This study included 125 children (51.2% male). Median age at diagnosis was 13 months (IQR, 5-24 months). One hundred nine (87.2%) children presented with Group D or E retinoblastoma and 33 (26.4%) resided in low or very low opportunity neighborhoods. Children residing in neighborhoods with low overall COI scores (OR, 1.62; 95% CI, 1.01-2.58; P = .044) and low education COI scores (OR, 1.77; 95% CI, 1.13-2.79; P = .013) were at increased odds of presenting with ICRB Group D or E retinoblastoma after adjusting for individual-level socioeconomic factors.
    Conclusion: Children residing in low opportunity neighborhoods-particularly low education opportunity-more often presented with advanced stage retinoblastoma than children residing in neighborhoods with higher opportunity scores. Efforts to improve preventative vision care and access to eye specialty care for children residing in low-resource areas are needed to reduce existing disparities in retinoblastoma.
    MeSH term(s) Child ; Humans ; Male ; Infant ; Child, Preschool ; Adolescent ; Female ; Retinoblastoma/diagnosis ; Retinoblastoma/therapy ; Cross-Sectional Studies ; Retrospective Studies ; Socioeconomic Factors ; Retinal Neoplasms/diagnosis ; Retinal Neoplasms/therapy
    Language English
    Publishing date 2024-01-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80030-2
    ISSN 1879-1891 ; 0002-9394
    ISSN (online) 1879-1891
    ISSN 0002-9394
    DOI 10.1016/j.ajo.2024.01.013
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  3. Article ; Online: Reply.

    Lambert, Scott R / Vanderveen, Deborah K / Kim, Stephen J

    Ophthalmology

    2019  Volume 127, Issue 1, Page(s) e6–e7

    MeSH term(s) Academies and Institutes ; Lens Implantation, Intraocular ; Ophthalmology ; United States
    Language English
    Publishing date 2019-10-11
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 392083-5
    ISSN 1549-4713 ; 0161-6420
    ISSN (online) 1549-4713
    ISSN 0161-6420
    DOI 10.1016/j.ophtha.2019.09.017
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  4. Article ; Online: Long-term strabismus outcomes after unilateral infantile cataract surgery in the Infant Aphakia Treatment Study.

    Bothun, Erick D / Shainberg, Marla J / Christiansen, Stephen P / Vanderveen, Deborah K / Neely, Dan E / Kruger, Stacey J / Cotsonis, George / Lambert, Scott R

    Journal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus

    2022  Volume 26, Issue 4, Page(s) 174.e1–174.e4

    Abstract: Purpose: To characterize long-term strabismus outcomes in children in the Infant Aphakia Treatment Study (IATS).: Methods: This study was a secondary data analysis of long-term ocular alignment characteristics of children aged 10.5 years who had ... ...

    Abstract Purpose: To characterize long-term strabismus outcomes in children in the Infant Aphakia Treatment Study (IATS).
    Methods: This study was a secondary data analysis of long-term ocular alignment characteristics of children aged 10.5 years who had previously been enrolled in a randomized clinical trial evaluating aphakic management after unilateral cataract surgery between 1 and 6 months of age.
    Results: In the IATS study, 96 of 109 children (88%) developed strabismus through age 10.5 years. Half of the 20 children who were orthophoric at distance through age 5 years maintained orthophoria at distance fixation at 10.5 years. Esotropia was the most common type of strabismus prior to age 5 years (56/109 [51%]), whereas exotropia (49/109 [45%]) was the most common type of strabismus at 10.5 years (esotropia, 21%; isolated hypertropia, 17%). Strabismus surgery had been performed on 52 children (48%), with 18 of these (35%) achieving microtropia <10
    Conclusions: Strabismus-in particular, exotropia-is common irrespective of aphakia management 10 years following infant monocular cataract surgery. The delayed emergence of exotropia with longer follow-up indicates a need for caution in managing early esotropia in these children. Children with better visual acuity at 10 years of age are more likely to have better ocular alignment.
    MeSH term(s) Aphakia, Postcataract/surgery ; Cataract/complications ; Cataract Extraction ; Child ; Esotropia/surgery ; Exotropia/surgery ; Follow-Up Studies ; Humans ; Infant ; Lens Implantation, Intraocular ; Pseudophakia ; Strabismus/etiology ; Strabismus/surgery
    Language English
    Publishing date 2022-07-14
    Publishing country United States
    Document type Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 1412476-2
    ISSN 1528-3933 ; 1091-8531
    ISSN (online) 1528-3933
    ISSN 1091-8531
    DOI 10.1016/j.jaapos.2022.05.003
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  5. Article ; Online: Reply.

    Lambert, Scott R / Vanderveen, Deborah K / Aakalu, Vinay K / Kim, Stephen J

    Ophthalmology

    2019  Volume 127, Issue 1, Page(s) e8–e9

    MeSH term(s) Academies and Institutes ; Lens Implantation, Intraocular ; Ophthalmology ; United States
    Language English
    Publishing date 2019-10-11
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 392083-5
    ISSN 1549-4713 ; 0161-6420
    ISSN (online) 1549-4713
    ISSN 0161-6420
    DOI 10.1016/j.ophtha.2019.09.040
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  6. Article ; Online: Electroretinographic Responses in Retinopathy of Prematurity Treated Using Intravitreal Bevacizumab or Laser.

    Curran, Amber-Lee K / Stukin, Justyna / Ambrosio, Lucia / Mantagos, Iason S / Wu, Carolyn / Vanderveen, Deborah K / Hansen, Ronald M / Akula, James D / Fulton, Anne B

    American journal of ophthalmology

    2023  Volume 252, Page(s) 275–285

    Abstract: Purpose: Intravitreal injection of bevacizumab (IVB) offers advantages over laser photoablation for treatment of type 1 retinopathy of prematurity (ROP). However, retinal function has not, to date, been quantitatively compared following these ... ...

    Abstract Purpose: Intravitreal injection of bevacizumab (IVB) offers advantages over laser photoablation for treatment of type 1 retinopathy of prematurity (ROP). However, retinal function has not, to date, been quantitatively compared following these interventions. Therefore, electroretinography (ERG) was used compare retinal function among eyes treated using IVB or laser, and control eyes. In addition, among the IVB-treated eyes, ERG was used to compare function in individuals in whom subsequent laser was and was not required.
    Design: Prospective clinical cohort study.
    Methods: ERG was used to record dark- and light-adapted stimulus/response functions in 21 children treated using IVB (12 of whom required subsequent laser in at least 1 eye for persistent avascular retina [PAR]). Sensitivity and amplitude parameters were derived from the a-wave, b-wave, and oscillatory potentials (OPs), representing activity in photoreceptor, postreceptor, and inner retinal cells, respectively. These parameters were then referenced to those of 76 healthy, term-born controls and compared to those of 10 children treated using laser only.
    Results: In children with treated ROP, every ERG parameter was significantly below the mean in controls. However, these significant ERG deficits did not differ between IVB- and laser-treated eyes. Among children treated using IVB, no ERG parameter was significantly associated with dose or need for subsequent laser.
    Conclusion: Retinal function was significantly impaired in treated ROP eyes. Function in IVB-treated eyes did not differ from that in laser-treated eyes. Functional differences also did not distinguish those IVB-treated eyes that would subsequently need laser for PAR.
    MeSH term(s) Infant, Newborn ; Child ; Humans ; Infant ; Bevacizumab/therapeutic use ; Retinopathy of Prematurity/diagnosis ; Retinopathy of Prematurity/drug therapy ; Retinopathy of Prematurity/surgery ; Angiogenesis Inhibitors/therapeutic use ; Electroretinography ; Cohort Studies ; Prospective Studies ; Intravitreal Injections ; Lasers ; Laser Coagulation ; Gestational Age ; Retrospective Studies
    Chemical Substances Bevacizumab (2S9ZZM9Q9V) ; Angiogenesis Inhibitors
    Language English
    Publishing date 2023-05-03
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 80030-2
    ISSN 1879-1891 ; 0002-9394
    ISSN (online) 1879-1891
    ISSN 0002-9394
    DOI 10.1016/j.ajo.2023.04.014
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  7. Article ; Online: Complications of pediatric cataract surgery.

    Whitman, Mary C / Vanderveen, Deborah K

    Seminars in ophthalmology

    2014  Volume 29, Issue 5-6, Page(s) 414–420

    Abstract: Purpose: Cataract surgery in young children poses different challenges and potential complications compared to those encountered in adult populations. We performed a literature review of the complications of pediatric cataract surgery.: Methods: ... ...

    Abstract Purpose: Cataract surgery in young children poses different challenges and potential complications compared to those encountered in adult populations. We performed a literature review of the complications of pediatric cataract surgery.
    Methods: Literature review of complications of pediatric cataract surgery.
    Results: Complications in children vary based on the age of the patient at surgery and the cause of the cataract. Common events discussed include increased inflammatory response, opacification of the posterior capsule, lens reproliferation, pupillary membrane, and amblyopia; less common events include infections, significant bleeding, and retinal detachment.
    Conclusion: Complications after cataract surgery in children are often associated with a robust inflammatory reaction or secondary opacity and, in infants, glaucoma. Late complications can occur decades later, so that long-term follow-up is required. Though surgery carries significant risks, the consequences of no surgery and irreversible deprivation amblyopia in very young children should be considered.
    MeSH term(s) Adolescent ; Aphakia, Postcataract/etiology ; Cataract/congenital ; Cataract Extraction/adverse effects ; Child ; Child, Preschool ; Corneal Diseases/etiology ; Endophthalmitis/etiology ; Glaucoma/etiology ; Humans ; Infant ; Infant, Newborn ; Lens Implantation, Intraocular ; Retinal Diseases/etiology
    Language English
    Publishing date 2014-09
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 632820-9
    ISSN 1744-5205 ; 0882-0538
    ISSN (online) 1744-5205
    ISSN 0882-0538
    DOI 10.3109/08820538.2014.959192
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  8. Article: Cataract update 2008: all you need to know about your pediatric cataract patients.

    Vanderveen, Deborah K

    Binocular vision & strabismus quarterly

    2008  Volume 23, Issue 3, Page(s) 145–158

    MeSH term(s) Cataract/diagnosis ; Cataract/etiology ; Cataract/genetics ; Child, Preschool ; Humans ; Infant
    Language English
    Publishing date 2008
    Publishing country United States
    Document type Lectures
    ZDB-ID 1477386-7
    ISSN 1088-6281
    ISSN 1088-6281
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    Zs.A 5317: Show issues Location:
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  9. Article ; Online: Retinopathy of prematurity screening and risk mitigation during the COVID-19 pandemic.

    Mantagos, Iason S / Wu, Carolyn / Griffith, Joseph F / Jastrzembski, Benjamin G / Gonzalez, Efren / Goldstein, Samantha / Pearlo, Lori / Vanderveen, Deborah K

    Journal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus

    2021  Volume 25, Issue 2, Page(s) 91.e1–91.e5

    Abstract: Background: The coronavirus disease 2019 (COVID-19) pandemic has significantly disrupted the delivery of healthcare. Although most nonurgent ophthalmology visits at Boston Children's Hospital were canceled, premature infants at risk for retinopathy of ... ...

    Abstract Background: The coronavirus disease 2019 (COVID-19) pandemic has significantly disrupted the delivery of healthcare. Although most nonurgent ophthalmology visits at Boston Children's Hospital were canceled, premature infants at risk for retinopathy of prematurity (ROP) still required timely, in-person care during the initial 3-month period of the infection surge in Massachusetts. The purpose of the current study was to report our protocols for mitigating risk of exposure to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) between infants and eye care providers and to compare examination rates and results with the same 3-month period in 2019.
    Methods: During the infection surge, we added new infection control measures and strengthened existing ones. Additional personal protective equipment was used, and the number of ophthalmologists rotating in the three high-capacity NICUs we service was limited.
    Results: More infants required ROP examinations during the study period in 2020 than in the same period in 2019, but fewer examinations were performed. There were no cases of missed progression to severe ROP during this time and no known transmission of SARS-CoV-2 between ROP patients and ophthalmology staff.
    Conclusions: Overall, effective ROP care was safely provided during the COVID-19 pandemic, and contact with this vulnerable population was minimized.
    MeSH term(s) COVID-19 ; Humans ; Infant ; Infant, Newborn ; Massachusetts ; Pandemics ; Retinopathy of Prematurity/epidemiology ; Risk Factors
    Language English
    Publishing date 2021-04-18
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1412476-2
    ISSN 1528-3933 ; 1091-8531
    ISSN (online) 1528-3933
    ISSN 1091-8531
    DOI 10.1016/j.jaapos.2020.11.015
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  10. Article ; Online: Accuracy of intraocular lens power calculation formulae in children less than two years.

    Nihalani, Bharti R / Vanderveen, Deborah K

    American journal of ophthalmology

    2012  Volume 154, Issue 4, Page(s) 759–60; author reply 760

    MeSH term(s) Cataract/congenital ; Female ; Humans ; Lens Implantation, Intraocular ; Lenses, Intraocular ; Male ; Optics and Photonics ; Vision Disorders/rehabilitation
    Language English
    Publishing date 2012-10
    Publishing country United States
    Document type Comment ; Letter
    ZDB-ID 80030-2
    ISSN 1879-1891 ; 0002-9394
    ISSN (online) 1879-1891
    ISSN 0002-9394
    DOI 10.1016/j.ajo.2012.06.017
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