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  1. Article ; Online: The Msp Protein of Treponema denticola Interrupts Activity of Phosphoinositide Processing in Neutrophils.

    Jones, Megan M / Vanyo, Stephen T / Visser, Michelle B

    Infection and immunity

    2019  Volume 87, Issue 11

    Abstract: Periodontal disease is a significant health burden, causing tooth loss and poor oral and overall systemic health. Dysbiosis of the oral biofilm and a dysfunctional immune response drive chronic inflammation, causing destruction of soft tissue and ... ...

    Abstract Periodontal disease is a significant health burden, causing tooth loss and poor oral and overall systemic health. Dysbiosis of the oral biofilm and a dysfunctional immune response drive chronic inflammation, causing destruction of soft tissue and alveolar bone supporting the teeth.
    MeSH term(s) Animals ; Bacterial Proteins/metabolism ; Bacterial Proteins/pharmacology ; Chemotaxis ; Gene Expression Regulation/drug effects ; Immunoprecipitation ; Male ; Mice ; Mice, Inbred C57BL ; Neutrophils/drug effects ; PTEN Phosphohydrolase/genetics ; PTEN Phosphohydrolase/metabolism ; Phosphatidylinositol 3-Kinase/metabolism ; Phosphatidylinositol-3,4,5-Trisphosphate 5-Phosphatases/genetics ; Phosphatidylinositol-3,4,5-Trisphosphate 5-Phosphatases/metabolism ; Phosphatidylinositols/metabolism ; Porins/metabolism ; Porins/pharmacology ; Treponema denticola/metabolism
    Chemical Substances Bacterial Proteins ; Phosphatidylinositols ; Porins ; major outer sheath protein, Treponema ; Phosphatidylinositol 3-Kinase (EC 2.7.1.137) ; PTEN Phosphohydrolase (EC 3.1.3.67) ; Pten protein, mouse (EC 3.1.3.67) ; Inpp5d protein, mouse (EC 3.1.3.86) ; Phosphatidylinositol-3,4,5-Trisphosphate 5-Phosphatases (EC 3.1.3.86)
    Language English
    Publishing date 2019-10-18
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 218698-6
    ISSN 1098-5522 ; 0019-9567
    ISSN (online) 1098-5522
    ISSN 0019-9567
    DOI 10.1128/IAI.00553-19
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 684: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Strontium-loaded hydrogel scaffolds to promote gingival fibroblast function.

    Alsharif, Shahad Bakheet / Wali, Rofida / Vanyo, Stephen T / Andreana, Sebastiano / Chen, Kaiwen / Sheth, Bhoomika / Swihart, Mark T / Dziak, Rosemary / Visser, Michelle B

    Journal of biomedical materials research. Part A

    2022  Volume 111, Issue 1, Page(s) 6–14

    Abstract: Dental implant clinical success is dependent on effective peri-implant tissue attachment to the trans-mucosal portion following placement. Modification of transmucosal implant surfaces can improve cellular adhesion and function leading to formation of an ...

    Abstract Dental implant clinical success is dependent on effective peri-implant tissue attachment to the trans-mucosal portion following placement. Modification of transmucosal implant surfaces can improve cellular adhesion and function leading to formation of an effective soft-tissue seal during healing, of which gingival fibroblasts are prominent cells to migrate to repair wounds and crucial for the development of a collagen rich connective tissue. Biocompatible loaded scaffold materials have been developed to allow local release of molecules with effective biological activity. Our previous studies indicate that strontium can promote gingival fibroblast metabolism, decrease apoptosis and support adhesion to titanium healing abutments. In this study, we developed a strontium-loaded alginate hydrogel scaffold which can be easily personalized to fit over any size and shape of implant transmucosal collar or healing abutment. Results indicate that biologically active strontium ions are effectively released from loaded alginate hydrogel material to promote fibroblast viability and migration to repair in vitro wounds similar to that of strontium citrate solution. Overall, this novel strontium-loaded alginate scaffold device displays good biocompatibility and functionality, demonstrating high potential as a system to provide local delivery of strontium to improve peri-implant mucosal healing following implant placement and clinical success.
    MeSH term(s) Strontium/pharmacology ; Hydrogels/pharmacology ; Gingiva ; Fibroblasts ; Titanium ; Alginates/pharmacology ; Dental Implants
    Chemical Substances Strontium (YZS2RPE8LE) ; Hydrogels ; Titanium (D1JT611TNE) ; Alginates ; Dental Implants
    Language English
    Publishing date 2022-08-29
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2099989-6
    ISSN 1552-4965 ; 1549-3296 ; 0021-9304
    ISSN (online) 1552-4965
    ISSN 1549-3296 ; 0021-9304
    DOI 10.1002/jbm.a.37439
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6195: Show issues Location:
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  3. Article ; Online: Treponema denticola stimulates Oncostatin M cytokine release and de novo synthesis in neutrophils and macrophages.

    Jones, Megan M / Vanyo, Stephen T / Ibraheem, Wael / Maddi, Abhiram / Visser, Michelle B

    Journal of leukocyte biology

    2020  Volume 108, Issue 5, Page(s) 1527–1541

    Abstract: Oncostatin M (OSM) is a pleiotropic cytokine elevated in a number of inflammatory conditions including periodontal disease. OSM is produced by a variety of immune cells and has diverse functionality such as regulation of metabolic processes, cell ... ...

    Abstract Oncostatin M (OSM) is a pleiotropic cytokine elevated in a number of inflammatory conditions including periodontal disease. OSM is produced by a variety of immune cells and has diverse functionality such as regulation of metabolic processes, cell differentiation, and the inflammatory response to bacterial pathogens. The oral cavity is under constant immune surveillance including complementary neutrophil and macrophage populations, due to a persistent symbiotic bacterial presence. Periodontal disease is characterized by a dysbiotic bacterial community, with an abundance of Treponema denticola. Despite strong associations with severe periodontal disease, the source and mechanism of the release of OSM have not been defined in the oral cavity. We show that OSM protein is elevated in the gingival epithelium and immune cell infiltrate during periodontal disease. Furthermore, salivary and oral neutrophil OSM is elevated in correlation with the presence of T. denticola. In an air pouch infection model, T. denticola stimulated higher levels of OSM than the oral pathogen Porphorymonas gingivalis, despite differential recruitment of innate immune cells suggesting T. denticola has distinct properties to elevate OSM levels. OSM release and transcription were increased in isolated human blood, oral neutrophils, or macrophages exposed to T. denticola in vitro as measured by ELISA, qPCR, and microscopy. Using transcription, translation, and actin polymerization inhibition, we found that T. denticola stimulates both OSM release through degranulation and de novo synthesis in neutrophils and also OSM release and synthesis in macrophages. Differential induction of OSM by T. denticola may promote clinical periodontal disease.
    MeSH term(s) Adult ; Aged ; Female ; Humans ; Macrophages/immunology ; Male ; Middle Aged ; Neutrophils/immunology ; Oncostatin M/immunology ; Treponema denticola/immunology ; Treponemal Infections/immunology
    Chemical Substances OSM protein, human ; Oncostatin M (106956-32-5)
    Language English
    Publishing date 2020-07-17
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 605722-6
    ISSN 1938-3673 ; 0741-5400
    ISSN (online) 1938-3673
    ISSN 0741-5400
    DOI 10.1002/JLB.4MA0620-072RR
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 603: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article: Synthesis and antibacterial activity of polymer–antibiotic conjugates incorporated into a resin-based dental adhesive

    Zhang, Ziwen / Jones, Megan M / Sabatini, Camila / Vanyo, Stephen T / Yang, Ming / Kumar, Abhishek / Jiang, Yancheng / Swihart, Mark T / Visser, Michelle B / Cheng, Chong

    Biomaterials science. 2021 Mar. 23, v. 9, no. 6

    2021  

    Abstract: This work reports on polymer–antibiotic conjugates (PACs) as additives to resin-based restorative dental materials as a new strategy to convey sustained antibacterial character to these materials. Such antibacterial performance is expected to improve ... ...

    Abstract This work reports on polymer–antibiotic conjugates (PACs) as additives to resin-based restorative dental materials as a new strategy to convey sustained antibacterial character to these materials. Such antibacterial performance is expected to improve their longevity in the oral cavity. Using the previously reported ciprofloxacin (Cip)-based PAC as a control, a penicillin V (PV)-based PAC was investigated. The monomer–antibiotic conjugate (MAC) containing a methacrylate monomer group and a PV moiety was prepared via nucleophilic substitution between 2-chloroethyl methacrylate (CEMA) and penicillin V potassium (PVK). The PV-based PAC was synthesized by reversible addition–fragmentation chain transfer (RAFT) polymerization of the MAC with hydroxyethyl methacrylate (HEMA), and further characterized by ¹H NMR and gel permeation chromatography (GPC) analysis. Antibiotic resistance was investigated by passaging bacteria in low concentrations of the antibiotic for 19 days, followed by a 48 h challenge at higher concentrations. Our results suggest that the development of antibiotic resistance is unlikely. Zone of inhibition (ZOI) assays revealed no clearing zones around PV-containing resins indicating minimal antibiotic leakage from the material. Similarly, MTT assay demonstrated that the antibiotic-containing specimens did not release cytotoxic byproducts that may inhibit human gingival fibroblast growth. Counting of colony-forming units in an S. mutans biofilm model was used to assess bacterial survival at baseline and after subjecting the antibiotic-containing resin specimens to an enzymatic challenge for 30 days. Significantly reduced bacterial counts were observed as the biofilm aged from 24 to 72 h, and salivary enzymatic exposure did not reduce the antibacterial efficacy of the discs, suggesting that PV-resin will be effective in reducing the re-incidence of dental caries.
    Keywords Lewis bases ; antibacterial properties ; antibiotic resistance ; biocompatible materials ; biofilm ; ciprofloxacin ; cytotoxicity ; dental caries ; fibroblasts ; gel chromatography ; humans ; longevity ; models ; moieties ; mouth ; penicillin V ; polymerization ; potassium ; toxicity testing
    Language English
    Dates of publication 2021-0323
    Size p. 2043-2052.
    Publishing place The Royal Society of Chemistry
    Document type Article
    Note NAL-AP-2-clean
    ZDB-ID 2693928-9
    ISSN 2047-4849 ; 2047-4830
    ISSN (online) 2047-4849
    ISSN 2047-4830
    DOI 10.1039/d0bm01910k
    Database NAL-Catalogue (AGRICOLA)

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  5. Article: Strontium Effects on Human Gingival Fibroblasts.

    Fernandes, Gabriela / Vanyo, Stephen T / Alsharif, Shahad Bakheet Atiano / Andreana, Sebastiano / Visser, Michelle B / Dziak, Rosemary

    The Journal of oral implantology

    2019  Volume 45, Issue 4, Page(s) 274–280

    Abstract: Strontium is a naturally occurring alkaline earth metal that has been shown to be useful not only in the treatment and prevention of osteoporosis but also in the treatment of dentinal hypersensitivity in the oral cavity; strontium is also an effective ... ...

    Abstract Strontium is a naturally occurring alkaline earth metal that has been shown to be useful not only in the treatment and prevention of osteoporosis but also in the treatment of dentinal hypersensitivity in the oral cavity; strontium is also an effective cariostatic, antiplaque, antigingivitis agent. Relatively little is known, however, about the effects of strontium on gingival fibroblasts. The purpose of the present investigation was to conduct in vitro studies on the potential for strontium to positively affect the activity of these cells such that it might be effective in the enhancement of gingival attachment to surfaces, such as healing abutments in implants in the oral cavity. The results indicate that strontium added as strontium citrate (0.5-1.0 mM), both in the absence and presence of a healing abutment, increases human gingival cell activity and decreases apoptosis in these cells. Scanning electron microscopy studies also reveal that the addition of strontium increases attachment of gingival fibroblasts to the surfaces of healing abutments. These studies provide the basis for further investigations on the use of strontium in the prevention and treatment of peri-implantitis by maximizing the formation of a peri-implant soft-tissue barrier.
    MeSH term(s) Dental Abutments ; Fibroblasts/drug effects ; Gingiva/drug effects ; Humans ; Strontium/pharmacology ; Surface Properties ; Titanium
    Chemical Substances Titanium (D1JT611TNE) ; Strontium (YZS2RPE8LE)
    Language English
    Publishing date 2019-06-19
    Publishing country United States
    Document type Journal Article
    ZDB-ID 448462-9
    ISSN 1548-1336 ; 0160-6972
    ISSN (online) 1548-1336
    ISSN 0160-6972
    DOI 10.1563/aaid-joi-D-18-00253
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1046: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: Synthesis and antibacterial activity of polymer-antibiotic conjugates incorporated into a resin-based dental adhesive.

    Zhang, Ziwen / Jones, Megan M / Sabatini, Camila / Vanyo, Stephen T / Yang, Ming / Kumar, Abhishek / Jiang, Yancheng / Swihart, Mark T / Visser, Michelle B / Cheng, Chong

    Biomaterials science

    2021  Volume 9, Issue 6, Page(s) 2043–2052

    Abstract: This work reports on polymer-antibiotic conjugates (PACs) as additives to resin-based restorative dental materials as a new strategy to convey sustained antibacterial character to these materials. Such antibacterial performance is expected to improve ... ...

    Abstract This work reports on polymer-antibiotic conjugates (PACs) as additives to resin-based restorative dental materials as a new strategy to convey sustained antibacterial character to these materials. Such antibacterial performance is expected to improve their longevity in the oral cavity. Using the previously reported ciprofloxacin (Cip)-based PAC as a control, a penicillin V (PV)-based PAC was investigated. The monomer-antibiotic conjugate (MAC) containing a methacrylate monomer group and a PV moiety was prepared via nucleophilic substitution between 2-chloroethyl methacrylate (CEMA) and penicillin V potassium (PVK). The PV-based PAC was synthesized by reversible addition-fragmentation chain transfer (RAFT) polymerization of the MAC with hydroxyethyl methacrylate (HEMA), and further characterized by
    MeSH term(s) Aged ; Anti-Bacterial Agents/pharmacology ; Biofilms ; Dental Caries ; Dental Cements ; Humans ; Materials Testing ; Methacrylates ; Polymers ; Streptococcus mutans
    Chemical Substances Anti-Bacterial Agents ; Dental Cements ; Methacrylates ; Polymers
    Language English
    Publishing date 2021-01-19
    Publishing country England
    Document type Journal Article
    ZDB-ID 2693928-9
    ISSN 2047-4849 ; 2047-4830
    ISSN (online) 2047-4849
    ISSN 2047-4830
    DOI 10.1039/d0bm01910k
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Copper@ZIF-8 Core-Shell Nanowires for Reusable Antimicrobial Face Masks.

    Kumar, Abhishek / Sharma, Anu / Chen, Yi / Jones, Megan M / Vanyo, Stephen T / Li, Changning / Visser, Michelle B / Mahajan, Supriya D / Sharma, Rakesh Kumar / Swihart, Mark T

    Advanced functional materials

    2020  Volume 31, Issue 10, Page(s) 2008054

    Abstract: SARS-CoV-2 and other respiratory viruses spread via aerosols generated by infected people. Face masks can limit transmission. However, widespread use of disposable masks consumes tremendous resources and generates waste. Here, a novel material for ... ...

    Abstract SARS-CoV-2 and other respiratory viruses spread via aerosols generated by infected people. Face masks can limit transmission. However, widespread use of disposable masks consumes tremendous resources and generates waste. Here, a novel material for treating blown polypropylene filtration media used in medical-grade masks to impart antimicrobial activity is reported. To produce thin copper@ZIF-8 core-shell nanowires (Cu@ZIF-8 NWs), Cu NWs are stabilized using a pluronic F-127 block copolymer, followed by growth of ZIF-8 to obtain uniform core-shell structures. The Cu@ZIF-8 NWs are applied to filtration media by dip coating. Aerosol filtration efficiency decreases upon exposure to ethanol (solvent for dip-coating), but increases with addition of Cu@ZIF-8 NWs. Cu@ZIF-8 NWs shows enhanced antibacterial activity, compared to Cu NWs or ZIF-8 alone, against
    Language English
    Publishing date 2020-12-13
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2039420-2
    ISSN 1616-3028 ; 1616-301X
    ISSN (online) 1616-3028
    ISSN 1616-301X
    DOI 10.1002/adfm.202008054
    Database MEDical Literature Analysis and Retrieval System OnLINE

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