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Article ; Online: Challenges in the treatment and prevention of monkeypox infection; A comprehensive review.

Nyame, Jennifer / Punniyakotti, Saranya / Khera, Kanav / Pal, Rashmi Saxena / Varadarajan, Nithya / Sharma, Prachi

Acta tropica

2023  Volume 245, Page(s) 106960

Abstract: Human monkeypox (HMPX) is a zoonotic disease, literally meaning that it can be passed on from animals (non-primate) to human (primate). All the reported and recorded cases have been traced back either to international travel or import of African animals. ...

Abstract Human monkeypox (HMPX) is a zoonotic disease, literally meaning that it can be passed on from animals (non-primate) to human (primate). All the reported and recorded cases have been traced back either to international travel or import of African animals. In the Unites states, sporadic monkeypox cases have been reported in specific over the past 50 years, starting its first identification in the Democratic Republic of the Congo (D.R.C.) in 1970. Due to its extreme versatility, this disease poses threat as a serious public health issue that needs to be monitored, researched and prevented. Data indicate that prior immunization with the smallpox vaccine is beneficial and may provide protection against the monkeypox virus. JYNNEOSTM is a live viral vaccine that has been approved to improve clinical manifestations of the infection. On the other hand, public ignorance about safety precaution towards monkeypox post-COVID is another challenge that needs to be overcome in tackling HMPX as a possible re-emergent infection. This review is a collation of the epidemiology, etiology, transmission, clinical features and treatment of human monkeypox (HMPX).
MeSH term(s) Animals ; Humans ; Mpox (monkeypox)/epidemiology ; Mpox (monkeypox)/prevention & control ; COVID-19 ; Monkeypox virus ; Smallpox Vaccine ; Zoonoses/epidemiology ; Zoonoses/prevention & control
Chemical Substances Smallpox Vaccine
Language English
Publishing date 2023-06-03
Publishing country Netherlands
Document type Journal Article ; Review
ZDB-ID 210415-5
ISSN 1873-6254 ; 0001-706X
ISSN (online) 1873-6254
ISSN 0001-706X
DOI 10.1016/j.actatropica.2023.106960
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