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  1. Article ; Online: Prostatic Artery Embolization in Patients with Refractory Lower Urinary Tract Symptoms after a Prior Minimally Invasive Surgical Treatment.

    Goyal, Piyush / Varadhan, Ajay K / Jenkins, Kimberly / Hohlastos, Elias / Salem, Riad / Mouli, Samdeep K

    Journal of vascular and interventional radiology : JVIR

    2024  Volume 35, Issue 5, Page(s) 744–750

    Abstract: The purpose of this study was to report on prostatic artery embolization (PAE) outcomes in patients with refractory or recurrent lower urinary tract symptoms (LUTSs) due to benign prostatic hyperplasia (BPH) who had previously undergone a minimally ... ...

    Abstract The purpose of this study was to report on prostatic artery embolization (PAE) outcomes in patients with refractory or recurrent lower urinary tract symptoms (LUTSs) due to benign prostatic hyperplasia (BPH) who had previously undergone a minimally invasive surgical technique (MIST). A single-center retrospective study identified 16 eligible patients. Baseline prostate volume at the time of PAE was 112.9 mL (SD ± 52.7). There were no adverse events throughout the follow-up period. There was significant improvement in International Prostate Symptom Score and quality of life from baseline of 23.5 (SD ± 5.1) and 4.9 (SD ± 0.9), respectively, to the last follow-up of 11.6 (SD ± 7.2) and 2 (SD ± 1.6), respectively. There was nonsignificant improvement in sexual function after PAE compared with baseline after MIST. PAE can be a safe and effective treatment in patients who have undergone prior MIST without negatively impacting erectile or ejaculatory function.
    MeSH term(s) Humans ; Male ; Embolization, Therapeutic/adverse effects ; Prostatic Hyperplasia/therapy ; Prostatic Hyperplasia/surgery ; Prostatic Hyperplasia/physiopathology ; Prostatic Hyperplasia/diagnostic imaging ; Prostatic Hyperplasia/complications ; Lower Urinary Tract Symptoms/etiology ; Lower Urinary Tract Symptoms/therapy ; Lower Urinary Tract Symptoms/physiopathology ; Retrospective Studies ; Aged ; Treatment Outcome ; Prostate/blood supply ; Middle Aged ; Quality of Life ; Minimally Invasive Surgical Procedures ; Time Factors ; Recurrence ; Recovery of Function ; Aged, 80 and over
    Language English
    Publishing date 2024-02-02
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1137756-2
    ISSN 1535-7732 ; 1051-0443
    ISSN (online) 1535-7732
    ISSN 1051-0443
    DOI 10.1016/j.jvir.2024.01.026
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3720: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  2. Article ; Online: Tabletized Supramolecular Assemblies for Sublingual Peptide Immunization.

    Kelly, Sean H / Opolot, Emmanuel E / Wu, Yaoying / Cossette, Benjamin / Varadhan, Ajay K / Collier, Joel H

    Advanced healthcare materials

    2021  Volume 10, Issue 6, Page(s) e2001614

    Abstract: Widespread vaccination is essential to global health. Significant barriers exist to improving vaccine coverage in lower- and middle-income countries, including the costly requirements for cold-chain distribution and trained medical personnel to ... ...

    Abstract Widespread vaccination is essential to global health. Significant barriers exist to improving vaccine coverage in lower- and middle-income countries, including the costly requirements for cold-chain distribution and trained medical personnel to administer the vaccines. A heat-stable and highly porous tablet vaccine that can be administered sublingually via simple dissolution under the tongue is described. SIMPL tablet vaccines (Supramolecular IMmunization with Peptides subLingually) are produced by freeze-drying a mixture of self-assembling peptide-polymer nanofibers, sugars, and adjuvant. Sublingual immunization with SIMPL tablets raises antibody responses against both a model epitope from ovalbumin and a clinically relevant epitope from Mycobacterium tuberculosis. Further, sublingual antibody responses are not diminished after heating the tablets for 1 week at 45 °C, in contrast to a more conventional carrier vaccine (KLH). This approach directly addresses the need for a heat-stable and easily deliverable vaccine to improve equity in global vaccine coverage.
    MeSH term(s) Administration, Sublingual ; Epitopes ; Immunization ; Ovalbumin ; Peptides
    Chemical Substances Epitopes ; Peptides ; Ovalbumin (9006-59-1)
    Language English
    Publishing date 2021-02-26
    Publishing country Germany
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 2649576-4
    ISSN 2192-2659 ; 2192-2640
    ISSN (online) 2192-2659
    ISSN 2192-2640
    DOI 10.1002/adhm.202001614
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6966: Show issues Location:
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  3. Article ; Online: Titrating Polyarginine into Nanofibers Enhances Cyclic-Dinucleotide Adjuvanticity

    Kelly, Sean H / Cossette, Benjamin J / Varadhan, Ajay K / Wu, Yaoying / Collier, Joel H

    ACS biomaterials science & engineering

    2021  Volume 7, Issue 5, Page(s) 1876–1888

    Abstract: Effective sublingual peptide immunization requires overcoming challenges of both delivery and immunogenicity. Mucosal adjuvants, such as cyclic-dinucleotides (CDN), can promote sublingual immune responses but must be codelivered with the antigen to the ... ...

    Abstract Effective sublingual peptide immunization requires overcoming challenges of both delivery and immunogenicity. Mucosal adjuvants, such as cyclic-dinucleotides (CDN), can promote sublingual immune responses but must be codelivered with the antigen to the epithelium for maximum effect. We designed peptide-polymer nanofibers (PEG-Q11) displaying nona-arginine (R9) at a high density to promote complexation with CDNs
    MeSH term(s) Administration, Sublingual ; Immunization ; Nanofibers ; Peptides
    Chemical Substances Peptides ; polyarginine (25212-18-4)
    Language English
    Publishing date 2021-03-27
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ISSN 2373-9878
    ISSN (online) 2373-9878
    DOI 10.1021/acsbiomaterials.0c01429
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  4. Article ; Online: Growing role of SGLT2i in heart failure: evidence from clinical trials.

    Varadhan, Ajay / Stephan, Katarina / Gupta, Rahul / Vyas, Apurva V / Ranchal, Purva / Aronow, Wilbert S / Hawwa, Nael / Lanier, Gregg M

    Expert review of clinical pharmacology

    2022  Volume 15, Issue 2, Page(s) 147–159

    Abstract: Introduction: : There is an unmet need for therapies that improve overall mortality and morbidity for patients with preserved ejection fraction, who comprise roughly half of all heart failure (HF) cases. The growing role of sodium-glucose cotransporter- ... ...

    Abstract Introduction: : There is an unmet need for therapies that improve overall mortality and morbidity for patients with preserved ejection fraction, who comprise roughly half of all heart failure (HF) cases. The growing role of sodium-glucose cotransporter-2 inhibitors (SGLT2is) in cardiovascular outcomes provides a paradigm shift in the treatment of HF.
    Areas covered: : This review article provides a general overview of the growing role of SGLT2is and summarizes the mechanism of action, side effects, and contraindications for the treatment of HF. We also discuss recent clinical trials measuring the effects of different SGLT2is as possible treatment options for HF with reduced ejection fraction and HF with mid-range and preserved EF. We conducted a review of all the randomized, controlled studies with SGLT2is in patients with known heart failure with and without type-2 diabetes (T2DM). We performed a literature search in PubMed, Google Scholar, the Web of Science, and the Cochrane Library while screening results by the use of titles and abstracts.
    Expert opinion: : The promising pathophysiological profile of SGLT2i and their role in cardioprotective effects demonstrate an invaluable discovery in the management of patients with HF irrespective of their diabetes status.
    MeSH term(s) Diabetes Mellitus, Type 2/drug therapy ; Heart Failure/drug therapy ; Humans ; Research Design ; Sodium-Glucose Transporter 2 Inhibitors/pharmacology ; Sodium-Glucose Transporter 2 Inhibitors/therapeutic use ; Stroke Volume
    Chemical Substances Sodium-Glucose Transporter 2 Inhibitors
    Language English
    Publishing date 2022-03-21
    Publishing country England
    Document type Journal Article ; Review
    ISSN 1751-2441
    ISSN (online) 1751-2441
    DOI 10.1080/17512433.2022.2051480
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  5. Article: Enabling sublingual peptide immunization with molecular self-assemblies

    Kelly, Sean H / Wu, Yaoying / Varadhan, Ajay K / Curvino, Elizabeth J / Chong, Anita S / Collier, Joel H

    Biomaterials. 2020 May, v. 241

    2020  

    Abstract: Short peptides are poorly immunogenic when delivered sublingually – under the tongue. Nanomaterial delivery of peptides could be utilized to improve immunogenicity towards designed sublingual vaccines, but nanomaterials have not been widely successful in ...

    Abstract Short peptides are poorly immunogenic when delivered sublingually – under the tongue. Nanomaterial delivery of peptides could be utilized to improve immunogenicity towards designed sublingual vaccines, but nanomaterials have not been widely successful in sublingual vaccines owing to the challenges of transport through the sublingual mucosa. Here, we report that the sublingual immunogenicity of peptides is negligible, even in the presence of sublingual adjuvants or when PEGylated, but can be dramatically enhanced by assembly into supramolecular polymer-peptide nanofibers bearing low-molecular weight PEG, optimally between 2000 and 3000 Da. Neither PEGylation nor a sublingual adjuvant were capable of rendering peptides immunogenic without assembly into nanofibers. We found that PEG decreased nanofiber interactions with mucin and promoted longer residence time at the sublingual immunization site. Parallel investigations with shortened nanofibers indicated that the size of the assemblies had a surprisingly negligible influence over sublingual immunogenicity. In mice, optimized formulations were capable of raising strong and highly durable systemic antibody responses, antibodies in the upper respiratory and reproductive tracts, and systemic antigen-specific T-cell responses. These nanofiber-based sublingual vaccines were effective with both protein and nucleotide adjuvants and raised responses against both a model peptide epitope and a peptide epitope from M. tuberculosis. Further, PASylation (modification of nanofibers with peptide sequences rich in Pro, Ala, and Ser) could be substituted for PEGylation to also achieve sublingual immunogenicity. These findings indicated that surface properties supersede nanomaterial size in modulating sublingual nanomaterial immunogenicity, having important implications for the design of synthetic sublingual vaccines.
    Keywords Mycobacterium tuberculosis ; T-lymphocytes ; adjuvants ; antibodies ; biocompatible materials ; chemical bonding ; epitopes ; immunization ; immunogenicity ; mucins ; mucosa ; nanofibers ; peptides ; tongue
    Language English
    Dates of publication 2020-05
    Publishing place Elsevier Ltd
    Document type Article
    Note NAL-AP-2-clean
    ZDB-ID 603079-8
    ISSN 0142-9612
    ISSN 0142-9612
    DOI 10.1016/j.biomaterials.2020.119903
    Database NAL-Catalogue (AGRICOLA)

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    Zs.B 2371: Show issues Location:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
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  6. Article ; Online: Enabling sublingual peptide immunization with molecular self-assemblies.

    Kelly, Sean H / Wu, Yaoying / Varadhan, Ajay K / Curvino, Elizabeth J / Chong, Anita S / Collier, Joel H

    Biomaterials

    2020  Volume 241, Page(s) 119903

    Abstract: Short peptides are poorly immunogenic when delivered sublingually - under the tongue. Nanomaterial delivery of peptides could be utilized to improve immunogenicity towards designed sublingual vaccines, but nanomaterials have not been widely successful in ...

    Abstract Short peptides are poorly immunogenic when delivered sublingually - under the tongue. Nanomaterial delivery of peptides could be utilized to improve immunogenicity towards designed sublingual vaccines, but nanomaterials have not been widely successful in sublingual vaccines owing to the challenges of transport through the sublingual mucosa. Here, we report that the sublingual immunogenicity of peptides is negligible, even in the presence of sublingual adjuvants or when PEGylated, but can be dramatically enhanced by assembly into supramolecular polymer-peptide nanofibers bearing low-molecular weight PEG, optimally between 2000 and 3000 Da. Neither PEGylation nor a sublingual adjuvant were capable of rendering peptides immunogenic without assembly into nanofibers. We found that PEG decreased nanofiber interactions with mucin and promoted longer residence time at the sublingual immunization site. Parallel investigations with shortened nanofibers indicated that the size of the assemblies had a surprisingly negligible influence over sublingual immunogenicity. In mice, optimized formulations were capable of raising strong and highly durable systemic antibody responses, antibodies in the upper respiratory and reproductive tracts, and systemic antigen-specific T-cell responses. These nanofiber-based sublingual vaccines were effective with both protein and nucleotide adjuvants and raised responses against both a model peptide epitope and a peptide epitope from M. tuberculosis. Further, PASylation (modification of nanofibers with peptide sequences rich in Pro, Ala, and Ser) could be substituted for PEGylation to also achieve sublingual immunogenicity. These findings indicated that surface properties supersede nanomaterial size in modulating sublingual nanomaterial immunogenicity, having important implications for the design of synthetic sublingual vaccines.
    MeSH term(s) Adjuvants, Immunologic ; Administration, Sublingual ; Animals ; Immunization ; Mice ; Peptides ; Vaccines, Subunit
    Chemical Substances Adjuvants, Immunologic ; Peptides ; Vaccines, Subunit
    Language English
    Publishing date 2020-02-24
    Publishing country Netherlands
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 603079-8
    ISSN 1878-5905 ; 0142-9612
    ISSN (online) 1878-5905
    ISSN 0142-9612
    DOI 10.1016/j.biomaterials.2020.119903
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  7. Article ; Online: Effects of preoperative pulmonary function on perioperative outcomes after robotic-assisted pulmonary lobectomy.

    Chase, Collin B / Mhaskar, Rahul / Fiedler, Cole / West, William J / Varadhan, Ajay / Cobb, Jessica / Cool, Sarah / Fishberger, Gregory / Dolorit, Maykel / Weeden, Emily E / Strang, Harrison E / Nguyen, Diep / Garrett, Joseph R / Moodie, Carla C / Fontaine, Jacques P / Tew, Jenna R / Baldonado, Jobelle J A R / Toloza, Eric M

    American journal of surgery

    2023  Volume 226, Issue 1, Page(s) 128–132

    Abstract: Introduction: Effects of pulmonary function test (PFT) results on perioperative outcomes were investigated after robotic-assisted video-thoracoscopic (RAVT) pulmonary lobectomy.: Methods: We retrospectively analyzed 706 consecutive patients who ... ...

    Abstract Introduction: Effects of pulmonary function test (PFT) results on perioperative outcomes were investigated after robotic-assisted video-thoracoscopic (RAVT) pulmonary lobectomy.
    Methods: We retrospectively analyzed 706 consecutive patients who underwent RAVT lobectomy by one surgeon over 10.8 years. Preoperative (preop) forced expiratory volume in 1 s as a percent of predicted (FEV1%) was used to group patients as having normal FEV1% (≥80%) versus reduced FEV1% (<80%). Demographics, preop comorbidities, intraoperative (intraop) and postoperative (postop) complications, perioperative outcomes, and median survival time (MST) were compared across patients with normal vs. reduced FEV1% using Chi-Square (X
    Results: There were 470 patients with normal FEV1% and 236 patients with reduced FEV1%. The two FEV1% groups did not differ in intraop or postop complication rates, except for higher postop other arrhythmia requiring intervention (p = 0.004), prolonged air leak >5 days (p = 0.002), mucous plug formation (p = 0.009), hypoxia (p < 0.001), and pneumonia (p = 0.002), and total postop complications (p < 0.001) in reduced-FEV1% patients. Reduced FEV1% correlated with increased intraop estimated blood loss (p < 0.0001) and skin-to-skin operative time (p < 0.0001). Median overall survival in patients with normal FEV1% was 93.20 months (95% CI: 76.5-126.0) versus 58.9 months (95% CI: 50.4-68.4) in patients with reduced FEV1% (p = 0.0004).
    Conclusion: Patients should have PFTs conducted before surgery to determine at-risk patients. However, RAVT pulmonary lobectomy is feasible and safe even in patients with reduced FEV1%.
    MeSH term(s) Humans ; Lung ; Lung Diseases/surgery ; Lung Neoplasms/surgery ; Pneumonectomy/methods ; Retrospective Studies ; Robotic Surgical Procedures ; Thoracic Surgery, Video-Assisted
    Language English
    Publishing date 2023-03-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2953-1
    ISSN 1879-1883 ; 0002-9610
    ISSN (online) 1879-1883
    ISSN 0002-9610
    DOI 10.1016/j.amjsurg.2023.02.016
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