Artikel ; Online: Identification of anaplastic lymphoma kinase fusion in clear cell renal carcinoma (ALK-tRCC): a precision oncology medicine case report.
2021 Band 112, Heft 1, Seite(n) 14e–15e
Abstract: Background: Translocation-associated renal cell carcinoma involving ALK (ALK-tRCC) is a rare subtype of adult renal cell carcinoma (RCC) reported in recent years.: Case presentation: A new Italian case of ALK-tRCC was reported. The patient was a ... ...
| Abstract | Background: Translocation-associated renal cell carcinoma involving ALK (ALK-tRCC) is a rare subtype of adult renal cell carcinoma (RCC) reported in recent years. Case presentation: A new Italian case of ALK-tRCC was reported. The patient was a female 44-year-old with a metastatic and pretreated RCC. The tumor showed a rearrangement of ALK gene in tumor cells detected by targeted next-generation sequencing panel. The patient received oral alectinib therapy and achieved a partial response. Conclusions: ALK-tRCC is a rare subtype of adult RCC. Its diagnosis is very difficult because the genomic alteration spectrum is very wide. We suggested that metastatic RCCs should be screened for uncommon genomic alterations expecially in good performance status pretreated resistant/refractory patients. |
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| Mesh-Begriff(e) | Adult ; Anaplastic Lymphoma Kinase/genetics ; Carcinoma, Renal Cell/diagnosis ; Carcinoma, Renal Cell/drug therapy ; Carcinoma, Renal Cell/genetics ; Female ; High-Throughput Nucleotide Sequencing ; Humans ; Kidney Neoplasms/diagnosis ; Kidney Neoplasms/drug therapy ; Kidney Neoplasms/genetics ; Precision Medicine | |||||
| Chemische Substanzen | Anaplastic Lymphoma Kinase (EC 2.7.10.1) | |||||
| Sprache | Englisch | |||||
| Erscheinungsdatum | 2021-01-29 | |||||
| Erscheinungsland | Italy | |||||
| Dokumenttyp | Case Reports ; Journal Article | |||||
| ZDB-ID | 138266-4 | |||||
| ISSN | 2038-1840 ; 0034-1193 | |||||
| ISSN (online) | 2038-1840 | |||||
| ISSN | 0034-1193 | |||||
| DOI | 10.1701/3525.35133 | |||||
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| Datenquelle | MEDical Literature Analysis and Retrieval System OnLINE |
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