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  1. Article ; Online: Five recommendations to increase the value of clinical practice.

    Varela, Jordi

    Medicina clinica

    2020  Volume 156, Issue 4, Page(s) 187–190

    Title translation Cinco recomendaciones para aumentar el valor de la práctica clínica.
    MeSH term(s) Evidence-Based Medicine ; Humans
    Language Spanish
    Publishing date 2020-06-13
    Publishing country Spain
    Document type Journal Article
    ZDB-ID 411607-0
    ISSN 1578-8989 ; 0025-7753
    ISSN (online) 1578-8989
    ISSN 0025-7753
    DOI 10.1016/j.medcli.2020.04.020
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  2. Article ; Online: The Ocean's Pharmacy: Health Discoveries in Marine Algae.

    Silva, Mélanie / Avni, Dorit / Varela, João / Barreira, Luísa

    Molecules (Basel, Switzerland)

    2024  Volume 29, Issue 8

    Abstract: Non-communicable diseases (NCDs) represent a global health challenge, constituting a major cause of mortality and disease burden in the 21st century. Addressing the prevention and management of NCDs is crucial for improving global public health, ... ...

    Abstract Non-communicable diseases (NCDs) represent a global health challenge, constituting a major cause of mortality and disease burden in the 21st century. Addressing the prevention and management of NCDs is crucial for improving global public health, emphasizing the need for comprehensive strategies, early interventions, and innovative therapeutic approaches to mitigate their far-reaching consequences. Marine organisms, mainly algae, produce diverse marine natural products with significant therapeutic potential. Harnessing the largely untapped potential of algae could revolutionize drug development and contribute to combating NCDs, marking a crucial step toward natural and targeted therapeutic approaches. This review examines bioactive extracts, compounds, and commercial products derived from macro- and microalgae, exploring their protective properties against oxidative stress, inflammation, cardiovascular, gastrointestinal, metabolic diseases, and cancer across in vitro, cell-based, in vivo, and clinical studies. Most research focuses on macroalgae, demonstrating antioxidant, anti-inflammatory, cardioprotective, gut health modulation, metabolic health promotion, and anti-cancer effects. Microalgae products also exhibit anti-inflammatory, cardioprotective, and anti-cancer properties. Although studies mainly investigated extracts and fractions, isolated compounds from algae have also been explored. Notably, polysaccharides, phlorotannins, carotenoids, and terpenes emerge as prominent compounds, collectively representing 42.4% of the investigated compounds.
    MeSH term(s) Humans ; Microalgae/chemistry ; Aquatic Organisms/chemistry ; Biological Products/pharmacology ; Biological Products/chemistry ; Biological Products/therapeutic use ; Animals ; Seaweed/chemistry ; Anti-Inflammatory Agents/pharmacology ; Anti-Inflammatory Agents/chemistry ; Anti-Inflammatory Agents/therapeutic use ; Antioxidants/pharmacology ; Antioxidants/therapeutic use ; Antioxidants/chemistry ; Oceans and Seas ; Oxidative Stress/drug effects ; Antineoplastic Agents/pharmacology ; Antineoplastic Agents/therapeutic use ; Antineoplastic Agents/chemistry
    Chemical Substances Biological Products ; Anti-Inflammatory Agents ; Antioxidants ; Antineoplastic Agents
    Language English
    Publishing date 2024-04-22
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules29081900
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.MO 81: Show issues

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  3. Article ; Online: Unidades de geriatría de agudos: la fuerza de la eficiencia y de la efectividad.

    Varela, Jordi

    Revista espanola de geriatria y gerontologia

    2018  Volume 54, Issue 2, Page(s) 63–64

    Title translation Acute geriatric units: The strength of efficiency and effectiveness.
    MeSH term(s) Aged ; Efficiency, Organizational ; Geriatrics ; Hospital Units/organization & administration ; Humans
    Language Spanish
    Publishing date 2018-12-05
    Publishing country Spain
    Document type Editorial
    ZDB-ID 605609-x
    ISSN 1578-1747 ; 0211-139X
    ISSN (online) 1578-1747
    ISSN 0211-139X
    DOI 10.1016/j.regg.2018.10.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.B 2677: Show issues Location:
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  4. Article ; Online: Overdiagnosis: Realities and perspectives.

    Varela, Jordi

    Medicina clinica

    2017  Volume 148, Issue 3, Page(s) 118–120

    Title translation Sobrediagnóstico: realidades y perspectivas.
    Language Spanish
    Publishing date 2017-02-09
    Publishing country Spain
    Document type Journal Article
    ZDB-ID 411607-0
    ISSN 1578-8989 ; 0025-7753
    ISSN (online) 1578-8989
    ISSN 0025-7753
    DOI 10.1016/j.medcli.2016.10.011
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ua VI Zs.279: Show issues Location:
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  5. Article ; Online: Las reformas necesarias en los hospitales: 10 recomendaciones para mejorar la eficiencia, la calidad y la efectividad.

    Varela, Jordi

    Medicina clinica

    2016  Volume 146, Issue 3, Page(s) 133–137

    Title translation Need for changes in hospitals: 10 recommendations to improve efficiency, quality and effectiveness.
    MeSH term(s) Access to Information ; Chronic Disease ; Clinical Competence ; Decision Making ; Efficiency ; Geriatrics ; Guidelines as Topic ; Health Care Reform ; Health Services Needs and Demand ; Hospital Administration/trends ; Hospital Volunteers ; Hospitals/trends ; Humans ; Intensive Care Units/organization & administration ; Interdisciplinary Communication ; Medicine ; Patient Participation ; Personnel, Hospital/education ; Precision Medicine ; Quality Improvement
    Language Spanish
    Publishing date 2016-02-05
    Publishing country Spain
    Document type Journal Article
    ZDB-ID 411607-0
    ISSN 1578-8989 ; 0025-7753
    ISSN (online) 1578-8989
    ISSN 0025-7753
    DOI 10.1016/j.medcli.2015.06.012
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Effects of endosperm type and storage length of whole-plant corn silage on nitrogen fraction, fermentation products, zein profile, and starch digestibility.

    Varela, José / Ferraretto, Luiz F / Kaeppler, Shawn M / de León, Natalia

    Journal of dairy science

    2023  Volume 106, Issue 12, Page(s) 8710–8722

    Abstract: Zeins are commercially important proteins found in corn endosperms. The objective of this study was to evaluate the effect of altering zein levels in corn inbred lines carrying endosperm mutations with differential allelic dosage and analyze the effects ... ...

    Abstract Zeins are commercially important proteins found in corn endosperms. The objective of this study was to evaluate the effect of altering zein levels in corn inbred lines carrying endosperm mutations with differential allelic dosage and analyze the effects on the composition, nutritive value, and starch digestibility of whole-plant corn silage (WPCS) at 5 storage lengths. Three inbred lines carrying 3 different endosperm modifiers (opaque-2 [o2], floury-2 [fl2], and soft endosperm-1 [h1]) were pollinated with 2 pollen sources to form pairs of near-isogenic lines with either 2 or 3 doses of the mutant allele for each endosperm modifier. The experiment was designed as a split-plot design with 3 replications. Pollinated genotype was the main plot factor, and storage length was the subplot-level factor. Agronomic precautions were taken to mimic hybrid WPCS to the extent possible. Samples were collected at approximately 30% dry matter (DM) using a forage harvester and ensiled in heat-sealed plastic bags for 0, 30, 60, 120, and 240 d. Thus, the experiment consisted of 30 treatments (6 genotypes × 5 storage lengths) and 90 ensiling units (3 replications per treatment). Measurements included nutrient analysis, including crude protein, soluble crude protein, amylase-treated neutral detergent fiber, acid detergent fiber, lignin, starch, fermentation end products, zein concentration, and in vitro starch digestibility (ivSD). The nutritional profile of the inbred-based silage samples was similar to hybrid values reported in literature. Significant differences were found in fresh (unfermented) sample kernels for endosperm vitreousness and zein profiles between and within isogenic pairs. The o2 homozygous (3 doses of mutant allele) had the highest reduction in vitreousness level (74.5 to 38%) and zein concentration (6.2 to 4.7% of DM) compared with the heterozygous counterpart (2 doses of mutant allele). All genotypes showed significant reduction of total zeins and α-zeins during progressive storage length. In vitro starch digestibility increased with storage length and had significant effects of genotype and storage length but not for genotype by storage length interaction, which suggests that the storage period did not attenuate the difference in ivSD between near-isogenic pairs caused by zeins in WPCS. Both total zeins and α-zeins showed a strong negative correlation with ivSD, which agrees with the general hypothesis that the degradation of zeins increases ruminal starch degradability. Homozygous o2 was the only mutant with significantly higher ivSD compared with the heterozygous version, which suggests that, if all other conditions remain constant in a WPCS systems, substantial reductions in endosperm α-zeins are required to significantly improve ivSD in the silo.
    MeSH term(s) Animals ; Silage/analysis ; Starch/metabolism ; Endosperm/metabolism ; Zea mays/metabolism ; Zein/metabolism ; Fermentation ; Nitrogen/metabolism ; Detergents/metabolism ; Rumen/metabolism ; Digestion
    Chemical Substances Starch (9005-25-8) ; Zein (9010-66-6) ; Nitrogen (N762921K75) ; Detergents
    Language English
    Publishing date 2023-08-23
    Publishing country United States
    Document type Journal Article
    ZDB-ID 242499-x
    ISSN 1525-3198 ; 0022-0302
    ISSN (online) 1525-3198
    ISSN 0022-0302
    DOI 10.3168/jds.2023-23382
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.B 810: Show issues Location:
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  7. Article: Microbiological strategies to produce beer and wine with reduced ethanol concentration

    Varela, J. / Varela, C.

    Current Opinion in Biotechnology

    2019  Volume 56, Page(s) 88–96

    Abstract: reduced alcohol content; wine; ethanol; yeast strains; low-ethanol yeasts; volatile composition; sensory profile. ...

    Institution School of Microbiology/Centre for Synthetic Biology and Biotechnology/Environmental Research Institute/APC Microbiome Institute, University College Cork, Cork T12 YN60, Irish Republic
    Abstract reduced alcohol content; wine; ethanol; yeast strains; low-ethanol yeasts; volatile composition; sensory profile.
    Language English
    Document type Article
    ZDB-ID 1052045-4
    ISSN 1879-0429 ; 0958-1669
    ISSN (online) 1879-0429
    ISSN 0958-1669
    DOI 10.1016/j.copbio.2018.10.003
    Database Viticulture and Oenology Abstracts

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  8. Article ; Online: Reducir actividades que no aportan valor: la reforma estructural pendiente.

    Varela, Jordi

    Revista de calidad asistencial : organo de la Sociedad Espanola de Calidad Asistencial

    2013  Volume 28, Issue 6, Page(s) 327–328

    Title translation Reducing activities that do not give value: the pending structural reform.
    MeSH term(s) Central Supply, Hospital/organization & administration ; Central Supply, Hospital/standards ; Drug Therapy/standards ; Hospitalization ; Humans ; Quality Improvement
    Language Spanish
    Publishing date 2013-11
    Publishing country Spain
    Document type Comment ; Editorial
    ISSN 1887-1364
    ISSN (online) 1887-1364
    DOI 10.1016/j.cali.2013.10.006
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  9. Article ; Online: Gratitude as a Protective Factor for Cyberbullying Victims: Conditional Effects on School and Life Satisfaction.

    Oriol, Xavier / Varela, Jorge / Miranda, Rafael

    International journal of environmental research and public health

    2021  Volume 18, Issue 5

    Abstract: Recently, studies linking the emotion of dispositional gratitude to cyberbullying have attracted attention. However, this is still a seminal research area that requires further scientific studies. Through longitudinal data, this study aims to analyze the ...

    Abstract Recently, studies linking the emotion of dispositional gratitude to cyberbullying have attracted attention. However, this is still a seminal research area that requires further scientific studies. Through longitudinal data, this study aims to analyze the mitigating effect of gratitude on cybervictimization and two indicators of adolescent subjective well-being, namely school and life satisfaction. To this end, 221 adolescents attending private schools in Peru (age: mean (M) = 12.09; standard deviation (SD) = 0.89) were selected to respond to a self-administered questionnaire in two waves that were six months apart. Descriptive data show that 27% of cybervictims also suffer other types of traditional bullying. The overlaps between forms of bullying contribute to higher probabilities of experiencing low school and life satisfaction compared to non-victims after six months. The results of the moderation analysis show that experience high gratitude help students to maintain stable levels of life satisfaction regardless of the prevalence of cyberbullying after six months The results are discussed in terms of the relevance of fostering gratitude from early ages.
    MeSH term(s) Adolescent ; Bullying ; Crime Victims ; Cyberbullying ; Humans ; Infant ; Internet ; Personal Satisfaction ; Peru ; Protective Factors ; Schools ; Surveys and Questionnaires
    Language English
    Publishing date 2021-03-09
    Publishing country Switzerland
    Document type Journal Article
    ISSN 1660-4601
    ISSN (online) 1660-4601
    DOI 10.3390/ijerph18052666
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Use of artificial intelligence in the detection of the critical view of safety during laparoscopic cholecystectomy.

    Petracchi, Enrique J / Olivieri, Sean E / Varela, Jose / Canullan, Carlos M / Zandalazini, Hugo / Ocampo, Carlos / Quesada, Bernabé M

    Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract

    2024  

    Abstract: Background: This study aimed to evaluate the use of artificial intelligence (AI) to detect the critical view of safety during elective laparoscopic cholecystectomy.: Methods: This was a prospective, observational study evaluating the detection of the ...

    Abstract Background: This study aimed to evaluate the use of artificial intelligence (AI) to detect the critical view of safety during elective laparoscopic cholecystectomy.
    Methods: This was a prospective, observational study evaluating the detection of the critical view of safety with an AI software in a consecutive series of elective laparoscopic cholecystectomies compared with the blinded evaluation of 3 surgeons. The program was created using the digital tools PyCharm (JetBrains), Google Colab Pro (https://colab.google/), and YOLOv8 (Ultralytics).
    Results: A total of 40 consecutive elective laparoscopic cholecystectomies were included in the study. The program was able to detect the critical view of safety in all cases following the experts' blinded opinion.
    Conclusion: In this preliminary experience, an AI software was able to detect the critical view of safety in elective laparoscopic cholecystectomies. Its application during nonelective cases, in which the critical view of safety is harder to achieve, might warrant further studies.
    Language English
    Publishing date 2024-03-18
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2012365-6
    ISSN 1873-4626 ; 1934-3213 ; 1091-255X
    ISSN (online) 1873-4626 ; 1934-3213
    ISSN 1091-255X
    DOI 10.1016/j.gassur.2024.03.018
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    Zs.MO 354: Show issues

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