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  1. Book ; Online: The Acoustic Self in English Modernism and Beyond : Writing Musically

    Varga, Zoltan

    2022  

    Keywords Language: reference & general ; linguistics ; Aldous Huxley ; English modernist fiction ; E.M. Forster ; intermediality ; literary studies ; modernist studies ; multimodality ; musicalization ; musical semiotics ; narrative fiction ; semiotics ; subjectivity ; Virginia Woolf ; Zoltan Varga
    Size 1 electronic resource (146 pages)
    Publisher Taylor and Francis
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT021290711
    ISBN 9781032025858 ; 1032025859
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article ; Online: Centres of endemism of Noctuidae (Lepidoptera) in the Palaearctic arid mountains: biogeographical and phylogenetic implications

    Varga, Zoltan

    Contributions to Entomology. 2022 July 31, v. 72, no. 1 p.1-35

    2022  

    Abstract: The oreal fauna is connected with orographically limited non-arboreal habitats. Its chorological centres can be recognised by the high species-diversity of numerous typical genera, and by the accumulated occurrence of endemic species and/or subspecies of ...

    Abstract The oreal fauna is connected with orographically limited non-arboreal habitats. Its chorological centres can be recognised by the high species-diversity of numerous typical genera, and by the accumulated occurrence of endemic species and/or subspecies of disjunct species. The oreal fauna is partitioned to the alpine type, as the faunal type of humid high-mountains with strong connections to the tundral zonobiome, and the xeromontane type, as the faunal type of arid high-mountains with close connections to the eremic zonobiomes. As the results of revisions of several Noctuinae genera, species groups and/or sister species were recognised and their distributions were mapped. The restricted areas of allopatric sister species, often described by us as new for science, fulfil the criteria of the “areas of endemism”. Core areas of the Palaearctic xeromontane Noctuidae, outlined by the distribution of endemic species, have been proven by the occurrence of allopatric subspecies of polytypic species, and/or by the presence of allopatric sister species. In the revised genera of Noctuidae several types of allopatric speciation have been identified based on the analysis of the areas of endemism and of vicariance patterns. As a result of these analyses, it is proved that allopatric sister species, as elementary monophyletic supraspecific units, are suitable for phylogenetic biogeographical surveys. Although the major part of the xeromontane fauna appears to be range-restricted, a considerable fraction of the species could have expanded into the steppic zonobiome due to adaptive changes of their life cycles. High diversity of cold-adapted species originated from the Sino-Himalayan mountains by passing two main filtercorridors. One track of this bifurcation was directed across the “Rhododendron-corridor” to the Holarctic taiga zone while the other one, across the “Xeromontane filter-corridor” to the mountain systems of Central and Inner Asia. This bifurcation becomes apparent from the taxonomic division of the genera, composing both of these main faunal types. Supposedly, the faunal movements of the xeromontanean species in the West Palaearctic had been shaped by the Messinian salinity crisis and, additionally, significantly influenced by the Mid-Pleistocene climatic transition which deeply transformed the zonality of the vegetation by cooling and aridisation of vast areas.
    Keywords Noctuidae ; Palearctic region ; allopatric speciation ; allopatry ; entomology ; fauna ; geographical distribution ; indigenous species ; monophyly ; salinity ; species diversity ; taiga ; Asia
    Language English
    Dates of publication 2022-0731
    Size p. 1-35.
    Publishing place Senckenberg Gesellschaft für Naturforschung
    Document type Article ; Online
    ZDB-ID 2882838-0
    ISSN 2511-6428
    ISSN 2511-6428
    DOI 10.3897/contrib.entomol.72.e87196
    Database NAL-Catalogue (AGRICOLA)

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  3. Article ; Online: Endotheliitis bei COVID-19.

    Varga, Zsuzsanna

    Der Pathologe

    2020  Volume 41, Issue Suppl 2, Page(s) 99–102

    Abstract: COVID-19 disease is a systemic inflammatory viral reaction starting with the viral phase followed by the inflammatory phase. The first phase is rather mild and asymptomatic with only a small subset of infected patients turning into the inflammatory phase ...

    Title translation Endotheliitis in COVID-19.
    Abstract COVID-19 disease is a systemic inflammatory viral reaction starting with the viral phase followed by the inflammatory phase. The first phase is rather mild and asymptomatic with only a small subset of infected patients turning into the inflammatory phase with high mortality. Patients with pre-existing cardiovascular diseases and cardiovascular risk factors pose a considerably higher risk to develop severe or lethal COVID-19 disease course. COVID-19 affects not only the epithelial cells of the lung parenchyma via ACE2, but also endothelial cells across the whole body thus leading to generalized endothelial damage and inflammation, so-called endotheliitis. The histological morphology of endotheliitis comprises the accumulation of lymphocytes, plasma cells and macrophages beneath the endothelial cells and within the perivascular spaces. Endothelial cells play an important role in the regulation of vascular tone and the maintenance of vascular homeostasis. Endotheliitis thus can shift the vascular equilibrium towards more pronounced vasoconstriction with subsequent organ ischemia, inflammation with associated tissue edema and a procoagulant state. Patients with pre-existing endothelial dysfunction (male sex, smoking, hypertension, diabetes, obesity, and established cardiovascular disease) are particularly vulnerable and have adverse outcomes in COVID-19. This is a rationale for approaches to stabilize the endothelium. Most of these findings have been established from autopsies since the outbreak of the pandemic.
    MeSH term(s) COVID-19 ; Endothelial Cells ; Humans ; Inflammation ; Pandemics ; SARS-CoV-2
    Language German
    Publishing date 2020-12-11
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 135954-x
    ISSN 1432-1963 ; 0172-8113
    ISSN (online) 1432-1963
    ISSN 0172-8113
    DOI 10.1007/s00292-020-00875-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Impact of climatic fluctuations on the conditions of grapevine production on the base of long term meteorological data series of Mosoni-Plain

    Varga, Z.

    Acta Agronomica Ovariensis

    2019  Volume 60, Issue 2, Page(s) 4–29

    Abstract: Both forms of climate fluctuations affect the domestic and international situation of viticulture. While the impact assessment of climate change is deepening all over the world, the impact assessment of climatic variability is less pronounced today. At ... ...

    Title variant Az eghajlatingadozasok hatasai a szölötermesztes felteteleire a Mosoni-Sik hosszu adatsorai alapjan
    Institution Szechenyi Istvan University, Faculty of Agricultural and Food Sciences, Department of Water and Environmental Sciences, Mosonmagyarovar, Hungary
    Abstract Both forms of climate fluctuations affect the domestic and international situation of viticulture. While the impact assessment of climate change is deepening all over the world, the impact assessment of climatic variability is less pronounced today. At the same time, the complex and realistic interpretation of climate change coupled with climatic variability puts a great challenge on researchers in this field and on vine growers who need to gain this kind of knowledge in their tactical and strategic decisions. Based on a review of the relevant domestic and foreign literature, we quantify the climatic conditions, called as eco- or agroclimatic indicators that determine the vine cultivation and analyze their evolution in the last one and a half century in Northwestern Hungary. The results obtained which include possibilities, challenges and even hazards for viticulture, interpreted indirectly and cautiously, provide insight into the macroclimatic processes taking place in other regions of Hungary.
    Language Hungarian ; English
    Document type Article
    Database Viticulture and Oenology Abstracts

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  5. Article ; Online: Triple-negatives Mammakarzinom : Klassifikation, aktuelle Konzepte und therapierelevante Faktoren.

    Sinn, Hans-Peter / Varga, Zsuzsanna

    Pathologie (Heidelberg, Germany)

    2023  Volume 44, Issue 1, Page(s) 32–38

    Abstract: Triple-negative breast cancer (TNBC) accounts for about 10% of all breast cancer cases and is defined by the lack of expression of estrogen and progesterone receptors and the lack of overexpression or amplification of HER2. It differs with regard to the ... ...

    Title translation Triple-negative breast cancer : Classification, current concepts, and therapy-related factors.
    Abstract Triple-negative breast cancer (TNBC) accounts for about 10% of all breast cancer cases and is defined by the lack of expression of estrogen and progesterone receptors and the lack of overexpression or amplification of HER2. It differs with regard to the younger age of the patients, an increased association with a mutation of BRCA1 and a mostly low differentiation from hormone receptor-positive breast cancer. The spectrum of triple-negative breast cancer shows considerable heterogeneity both at the morphological and at the molecular level. It includes most commonly TNBC of no special type, with and without basal phenotype, triple-negative metaplastic breast carcinomas, triple-negative breast carcinomas with apocrine differentiation and rare triple-negative tumor types. At the gene-expression level, TNBC most commonly is associated with a basal phenotype, with rarer molecular variants of TNBC involving the Claudin-low, molecular apocrine types, and other rarer subtypes. Therefore, a critical use of the term TNBC, considering the histopathological tumor differentiation, is recommended.
    MeSH term(s) Humans ; Triple Negative Breast Neoplasms/genetics ; Receptor, ErbB-2/genetics ; Biomarkers, Tumor/genetics ; Mutation
    Chemical Substances Receptor, ErbB-2 (EC 2.7.10.1) ; Biomarkers, Tumor
    Language German
    Publishing date 2023-01-03
    Publishing country Germany
    Document type English Abstract ; Journal Article ; Review
    ISSN 2731-7196
    ISSN (online) 2731-7196
    DOI 10.1007/s00292-022-01177-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Molecular pathology in breast disease: diagnostic, prognostic, and therapeutic tools.

    Varga, Zsuzsanna / Maccio, Umberto

    Virchows Archiv : an international journal of pathology

    2023  Volume 484, Issue 2, Page(s) 247–261

    Abstract: Molecular testing in breast cancer gained increasing attention and importance as specific molecular results can tailor not only oncological decisions on systemic adjuvant or neoadjuvant or in metastatic setting, but increasingly serve in diagnostic ... ...

    Abstract Molecular testing in breast cancer gained increasing attention and importance as specific molecular results can tailor not only oncological decisions on systemic adjuvant or neoadjuvant or in metastatic setting, but increasingly serve in diagnostic routine histopathological services to differentiate between morphologically overlapping or ambiguous histological pictures. Diagnostic tools involve in most cases a broad spectrum of immunohistochemical panels, followed by entity-specific in situ hybridization probes and in given cases NGS-based sequencing. Workflow of which methodology is applied and in which order depends on the specific entity resp. on the given differential diagnosis in question. Regarding prognostic/predictive molecular testing, the choice of assay and the workflow are based on clinical algorithms and on the evidence of targeted therapies following the molecular alterations. In this review paper, we aim to address the use of molecular technics in [1] the histological diagnostic setting (such as subtyping of invasive carcinomas/malignant spindle cell tumors and sarcomas and some B3 lesions) and [2] in the context of adjuvant or neoadjuvant or other clinical settings with special focus of targeted therapies.
    MeSH term(s) Humans ; Female ; Prognosis ; Pathology, Molecular ; Breast Neoplasms/diagnosis ; Breast Neoplasms/genetics ; Breast Neoplasms/therapy ; Sarcoma ; Carcinoma
    Language English
    Publishing date 2023-11-28
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 1184867-4
    ISSN 1432-2307 ; 0945-6317
    ISSN (online) 1432-2307
    ISSN 0945-6317
    DOI 10.1007/s00428-023-03709-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Evolutionary significant units (ESUs) and functional conservation units (FCUs) in the Phengaris (Maculinea) nausithous populations of East-Central Europe.

    Pecsenye, Katalin / Bereczki, Judit / Hollós, Amáta / Varga, Zoltán

    Biologia futura

    2024  Volume 74, Issue 4, Page(s) 445–455

    Abstract: The aim of this study was to analyse the level and structure of genetic and morphometric variation in the East-Central European populations of Phengaris (Maculinea) nausithous. On the basis of the life cycle of the species, we expected a low level of ... ...

    Abstract The aim of this study was to analyse the level and structure of genetic and morphometric variation in the East-Central European populations of Phengaris (Maculinea) nausithous. On the basis of the life cycle of the species, we expected a low level of variation within the populations coupled with a relatively high level of differentiation among them. We also assumed that the differentiation among the populations has a regional pattern. In order to confirm these assumptions, we collected population samples from two regions within the Carpathian Basin (western Transdanubia and Transylvania) and from a region east of the Carpathian Mountains (Bukovina). The level of enzyme polymorphism and the amount of morphometric variation were investigated in the sampled populations. As the western (Transdanubia) and the eastern populations (Transylvania plus Bukovina) were suggested to belong to different subspecies (Rákosy et al. in Nota Lepidopterol 33:31-37, 2010), our working hypothesis was that these two groups of populations belong to different evolutionary significant units (ESUs). The results of all genetic analyses (PCA, Bayesian-clustering analysis and especially the UPGMA dendrogram) confirmed our assumption. The level of differentiation was higher between the western and eastern populations resulting in two monophyletic lineages of Phengaris (Maculinea) nausithous in East-Central Europe. This result suggests that these lineages can be considered as two different ESUs.
    MeSH term(s) Bayes Theorem ; Biological Evolution ; Europe
    Language English
    Publishing date 2024-03-11
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2987596-1
    ISSN 2676-8607 ; 2676-8615
    ISSN (online) 2676-8607
    ISSN 2676-8615
    DOI 10.1007/s42977-024-00211-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Somatische BRCA1/2 Genmutationen beim Mammakarzinom

    Varga, Z.

    Schweizer Krebs-Bulletin

    2017  Volume 37, Issue 1, Page(s) 32–33

    Language English ; French ; German
    Document type Article
    ZDB-ID 1340924-4
    Database Current Contents Medicine

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    Zs.A 4528: Show issues Location:
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  9. Article ; Online: Gene expression changes during the evolution of the tetrapod limb.

    Varga, Zsombor / Varga, Máté

    Biologia futura

    2022  

    Abstract: Major changes in the vertebrate anatomy have preceded the conquest of land by the members of this taxon, and continuous changes in limb shape and use have occurred during the later radiation of tetrapods. While the main, conserved mechanisms of limb ... ...

    Abstract Major changes in the vertebrate anatomy have preceded the conquest of land by the members of this taxon, and continuous changes in limb shape and use have occurred during the later radiation of tetrapods. While the main, conserved mechanisms of limb development have been discerned over the past century using a combination of classical embryological and molecular methods, only recent advances made it possible to identify and study the regulatory changes that have contributed to the evolution of the tetrapod appendage. These advances include the expansion of the model repertoire from traditional genetic model species to non-conventional ones, a proliferation of predictive mathematical models that describe gene interactions, an explosion in genomic data and the development of high-throughput methodologies. These revolutionary innovations make it possible to identify specific mutations that are behind specific transitions in limb evolution. Also, as we continue to apply them to more and more extant species, we can expect to gain a fine-grained view of this evolutionary transition that has been so consequential for our species as well.
    Language English
    Publishing date 2022-11-10
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2987596-1
    ISSN 2676-8607 ; 2676-8615
    ISSN (online) 2676-8607
    ISSN 2676-8615
    DOI 10.1007/s42977-022-00136-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Zukünftige Entwicklungen der personalisierten Therapie: Subtypisierung des Mammakarzinoms

    Varga, Z.

    Gyn-aktiv

    2016  Volume -, Issue 5, Page(s) 20

    Language German
    Document type Article
    ZDB-ID 2213296-X
    ISSN 1605-8828
    Database Current Contents Medicine

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    Zs.A 6202: Show issues Location:
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