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  1. Article: Audit of 30-day mortality following palliative radiotherapy: are we able to improve patient care at the end of life?

    Vargas, Andrés

    Reports of practical oncology and radiotherapy : journal of Greatpoland Cancer Center in Poznan and Polish Society of Radiation Oncology

    2024  Volume 28, Issue 6, Page(s) 720–727

    Abstract: Background: Several measurements defining the expected 30-day mortality (30-DM) to use in audit of radiation oncology departments have been proposed. However, its external validity is limited because of the lack of data from non-English speaking ... ...

    Abstract Background: Several measurements defining the expected 30-day mortality (30-DM) to use in audit of radiation oncology departments have been proposed. However, its external validity is limited because of the lack of data from non-English speaking countries. This study assessed 30-DM in patients treated with palliative radiotherapy (PRT) in a Chilean-reference radiotherapy centre and explored if there had been tailored treatment at the end of life.
    Materials and methods: Retrospective data collection was carried out for all patients treated at our institution between 1
    Results: 3,357 patients were included. The most common primary malignancies were breast (22%) and lung (16.1%). The most common treatment sites were bone (47.7%) and brain (12.2%). Overall, 30-DM was 14.7%, this rate was higher in patients treated for brain metastases (25.7%) and thoracic palliation (22.1%). 30-DM was associated with poor performance status (p < 0.01), lung and esophageal-gastric cancer (p = 0.04 and p = 0.02, respectively), metastases other than bone (p < 0.01), brain metastases (p < 0.01) and private health insurance (p <0.01).
    Conclusions: In patients treated for brain metastasis and thoracic palliation 30-DM was higher than suggested benchmarks. Moreover, in these groups long courses of PRT were often performed. Audit data should be useful for planning interventions that improve selection of patients and prompting review of policies for indication and fractionation schedules of PRT.
    Language English
    Publishing date 2024-02-16
    Publishing country Poland
    Document type Journal Article
    ZDB-ID 2188087-6
    ISSN 1507-1367
    ISSN 1507-1367
    DOI 10.5603/rpor.97734
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Is Performance Status Enough to Decide the Palliative Radiotherapy Schedule in Lung Cancer?

    Vargas, A

    Clinical oncology (Royal College of Radiologists (Great Britain))

    2021  Volume 33, Issue 10, Page(s) e463

    MeSH term(s) Carcinoma, Non-Small-Cell Lung ; Humans ; Lung Neoplasms/radiotherapy ; Palliative Care
    Language English
    Publishing date 2021-05-07
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 1036844-9
    ISSN 1433-2981 ; 0936-6555
    ISSN (online) 1433-2981
    ISSN 0936-6555
    DOI 10.1016/j.clon.2021.04.006
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Thirty-day expected mortality and hemostatic palliative radiotherapy: definitions, certainties and uncertainties.

    Vargas, Andrés

    Annals of palliative medicine

    2023  Volume 12, Issue 6, Page(s) 1485–1487

    Language English
    Publishing date 2023-10-20
    Publishing country China
    Document type Journal Article
    ZDB-ID 2828544-X
    ISSN 2224-5839 ; 2224-5839
    ISSN (online) 2224-5839
    ISSN 2224-5839
    DOI 10.21037/apm-23-485
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Expert opinion: regional nerve blocks in everyday pediatric urology: 2. Ultrasound-guided regional anesthetic caudal block.

    Vargas, A

    Journal of pediatric urology

    2018  Volume 14, Issue 5, Page(s) 462

    MeSH term(s) Anesthesia, Conduction ; Anesthetics, Local ; Child ; Humans ; Nerve Block ; Ultrasonography, Interventional ; Urology
    Chemical Substances Anesthetics, Local
    Language English
    Publishing date 2018-11-27
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 2237683-5
    ISSN 1873-4898 ; 1477-5131
    ISSN (online) 1873-4898
    ISSN 1477-5131
    DOI 10.1016/j.jpurol.2018.08.026
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Distinct and overlapping RNA determinants for binding and target-primed reverse transcription by Bombyx mori R2 retrotransposon protein.

    Rodríguez-Vargas, Anthony / Collins, Kathleen

    Nucleic acids research

    2024  

    Abstract: Eukaryotic retrotransposons encode a reverse transcriptase that binds RNA to template DNA synthesis. The ancestral non-long terminal repeat (non-LTR) retrotransposons encode a protein that performs target-primed reverse transcription (TPRT), in which the ...

    Abstract Eukaryotic retrotransposons encode a reverse transcriptase that binds RNA to template DNA synthesis. The ancestral non-long terminal repeat (non-LTR) retrotransposons encode a protein that performs target-primed reverse transcription (TPRT), in which the nicked genomic target site initiates complementary DNA (cDNA) synthesis directly into the genome. The best understood model system for biochemical studies of TPRT is the R2 protein from the silk moth Bombyx mori. The R2 protein selectively binds the 3' untranslated region of its encoding RNA as template for DNA insertion to its target site in 28S ribosomal DNA. Here, binding and TPRT assays define RNA contributions to RNA-protein interaction, template use for TPRT and the fidelity of template positioning for TPRT cDNA synthesis. We quantify both sequence and structure contributions to protein-RNA interaction. RNA determinants of binding affinity overlap but are not equivalent to RNA features required for TPRT and its fidelity of template positioning for full-length TPRT cDNA synthesis. Additionally, we show that a previously implicated RNA-binding protein surface of R2 protein makes RNA binding affinity dependent on the presence of two stem-loops. Our findings inform evolutionary relationships across R2 retrotransposon RNAs and are a step toward understanding the mechanism and template specificity of non-LTR retrotransposon mobility.
    Language English
    Publishing date 2024-03-18
    Publishing country England
    Document type Journal Article
    ZDB-ID 186809-3
    ISSN 1362-4962 ; 1362-4954 ; 0301-5610 ; 0305-1048
    ISSN (online) 1362-4962 ; 1362-4954
    ISSN 0301-5610 ; 0305-1048
    DOI 10.1093/nar/gkae194
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Radiotherapy in nonmelanoma skin cancer: Radiosensitivity, radioresistance and radiocurability. In regard to Gracia-Cazaña et al.

    Vargas, A

    Actas dermo-sifiliograficas

    2017  Volume 108, Issue 5, Page(s) 492–493

    Language Spanish
    Publishing date 2017-06
    Publishing country Spain
    Document type Letter
    ZDB-ID 390255-9
    ISSN 1578-2190 ; 0001-7310 ; 1138-8196
    ISSN (online) 1578-2190
    ISSN 0001-7310 ; 1138-8196
    DOI 10.1016/j.ad.2016.12.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Single dose radiotherapy in soft tissue tumoral masses: just enough palliation.

    Vargas, Andrés

    Reports of practical oncology and radiotherapy : journal of Greatpoland Cancer Center in Poznan and Polish Society of Radiation Oncology

    2019  Volume 25, Issue 1, Page(s) 64–67

    Abstract: Introduction: Single fraction radiotherapy (SFR) is effective in palliation of symptoms related to advanced cancer. Despite this, several studies have shown that the trend towards multiple fraction treatment (MFR) is largely maintained. Even in patients ...

    Abstract Introduction: Single fraction radiotherapy (SFR) is effective in palliation of symptoms related to advanced cancer. Despite this, several studies have shown that the trend towards multiple fraction treatment (MFR) is largely maintained. Even in patients with limited life expectancy, SFR is significantly underutilized in current practice.
    Cases description: Four patients diagnosed with advanced cancer who developed soft tissue lesions were treated with SFR due to frailty and/or a poor performance status.
    Conclusion: Despite the effectiveness of SFR is well-established in BM, its use in symptoms caused by soft tissue lesions have been underreported. SFR could be a good option for providing palliation in some patients, particularly in those who are frail or have a poor performance status.
    Language English
    Publishing date 2019-12-16
    Publishing country Poland
    Document type Case Reports
    ZDB-ID 2188087-6
    ISSN 1507-1367
    ISSN 1507-1367
    DOI 10.1016/j.rpor.2019.12.010
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Increasing diversity among Lens species for improving biological nitrogen fixation in lentil

    Vargas, Ana / Gorim, Linda Y. / Bett, Kirstin E.

    Crop Science. 2024 , v. 64, no. 1 p.164-178

    2024  

    Abstract: Exotic germplasm is a key resource for reintroducing genetic variability into cultivars. We evaluated 36 accessions from cultivated lentil (Lens culinaris Medik.) and six related wild species inoculated with a commercial strain of Rhizobium leguminosarum ...

    Abstract Exotic germplasm is a key resource for reintroducing genetic variability into cultivars. We evaluated 36 accessions from cultivated lentil (Lens culinaris Medik.) and six related wild species inoculated with a commercial strain of Rhizobium leguminosarum bv. viciae under greenhouse conditions. The objective was to explore Lens species and/or accessions that can contribute higher biological nitrogen fixation ability to the lentil crop. A split plot design was used with either Rhizobium inoculation, added nitrogen (+N), or neither as the main plots, and accessions in subplots randomized in blocks. Two repeats of the experiment were evaluated at flowering for N fixation and nodulation characters, and two subsequent experiments, with a subset of 14 accessions, were evaluated at maturity for seed production, seed quality, and harvest index. Differences in phenotypic expression corresponded to specific accessions but not to any particular Lens species. CDC Greenstar had the highest N fixation among lentil cultivars and also had superior yield results compared to the added N treatment. When inoculated, wild accessions, including IG 72643 (Lens orientalis), displayed unique and multiple desirable characteristics compared to cultivars, including indeterminate nodulation, higher N translocation, stable yield compared to added N treatment, and exceptionally high protein concentration in seeds.
    Keywords Lens culinaris subsp. orientalis ; Rhizobium leguminosarum ; cultivars ; experimental design ; genetic variation ; germplasm ; greenhouses ; harvest index ; lentils ; nitrogen ; nitrogen fixation ; nodulation ; phenotype ; seed quality
    Language English
    Dates of publication 2024-01
    Size p. 164-178.
    Publishing place John Wiley & Sons, Ltd
    Document type Article ; Online
    Note JOURNAL ARTICLE
    ZDB-ID 410209-5
    ISSN 0011-183X
    ISSN 0011-183X
    DOI 10.1002/csc2.21152
    Database NAL-Catalogue (AGRICOLA)

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  9. Article ; Online: Platelet Plugs Prevent Vascular Hemorrhage at Sites of Neutrophil Diapedesis.

    Vargas, Alex / Simon, Scott I

    The Journal of investigative dermatology

    2022  Volume 142, Issue 10, Page(s) 2558–2560

    MeSH term(s) Blood Platelets ; Hemorrhage/prevention & control ; Humans ; Neutrophils ; Transendothelial and Transepithelial Migration
    Language English
    Publishing date 2022-08-18
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Comment
    ZDB-ID 80136-7
    ISSN 1523-1747 ; 0022-202X
    ISSN (online) 1523-1747
    ISSN 0022-202X
    DOI 10.1016/j.jid.2022.06.009
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Assessing the Effect of the U.S. Vaccination Program on the Coronavirus Positivity Rate With a Multivariate Framework.

    Sanchez-Vargas, A / Mendez-Astudillo, J / López-Vidal, Y / López-Carr, D / Estrada, F

    GeoHealth

    2023  Volume 7, Issue 6, Page(s) e2022GH000771

    Abstract: The factors influencing the incidence of COVID-19, including the impact of the vaccination programs, have been studied in the literature. Most studies focus on one or two factors, without considering their interactions, which is not enough to assess a ... ...

    Abstract The factors influencing the incidence of COVID-19, including the impact of the vaccination programs, have been studied in the literature. Most studies focus on one or two factors, without considering their interactions, which is not enough to assess a vaccination program in a statistically robust manner. We examine the impact of the U.S. vaccination program on the SARS-CoV-2 positivity rate while simultaneously considering a large number of factors involved in the spread of the virus and the feedbacks among them. We consider the effects of the following sets of factors: socioeconomic factors, public policy factors, environmental factors, and non-observable factors. A time series Error Correction Model (ECM) was used to estimate the impact of the vaccination program at the national level on the positivity rate. Additionally, state-level ECMs with panel data were combined with machine learning techniques to assess the impact of the program and identify relevant factors to build the best-fitting models. We find that the vaccination program reduced the virus positivity rate. However, the program was partially undermined by a feedback loop in which increased vaccination led to increased mobility. Although some external factors reduced the positivity rate, the emergence of new variants increased the positivity rate. The positivity rate was associated with several forces acting simultaneously in opposite directions such as the number of vaccine doses administered and mobility. The existence of complex interactions, between the factors studied, implies that there is a need to combine different public policies to strengthen the impact of the vaccination program.
    Language English
    Publishing date 2023-06-06
    Publishing country United States
    Document type Journal Article
    ISSN 2471-1403
    ISSN (online) 2471-1403
    DOI 10.1029/2022GH000771
    Database MEDical Literature Analysis and Retrieval System OnLINE

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