Article ; Online: Novel clinical and immunological features associated with persistent post-acute sequelae of COVID-19 after six months of follow-up: a pilot study.
Infectious diseases (London, England)
2023 Volume 55, Issue 4, Page(s) 243–254
Abstract: Background: Currently, there is scant information regarding the features associated to the persistence of post-COVID-19 syndrome, which is the main aim of the present study.: Methods: A cohort study of 102 COVID-19 patients was conducted. The post- ... ...
Abstract | Background: Currently, there is scant information regarding the features associated to the persistence of post-COVID-19 syndrome, which is the main aim of the present study. Methods: A cohort study of 102 COVID-19 patients was conducted. The post-COVID-19 symptoms were assessed by a standardised questionnaire. Lymphocyte immunophenotyping was performed by flow cytometry and chemokines/cytokines, neutrophil extracellular traps, the tripartite motif 63, anti-cellular, and anti-SARS-CoV-2 IgG antibodies were addressed in serum. The primary outcome was the persistence of post-COVID-19 syndrome after six months follow-up. Results: Thirteen patients (12.7%) developed the primary outcome and had a more frequent history of post-COVID-19 syndrome 3 months after infection onset ( Conclusion: Our data suggest an important relationship between a pro-inflammatory state mediated through metabolic pathways related to obesity and increased cellular senescence as a key element in the persistence of post-COVID-19 syndrome at six months of follow-up. |
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MeSH term(s) | Humans ; COVID-19/complications ; Pilot Projects ; Post-Acute COVID-19 Syndrome ; CD8-Positive T-Lymphocytes ; Cohort Studies ; Chemokine CXCL10 ; Obesity |
Chemical Substances | Chemokine CXCL10 |
Language | English |
Publishing date | 2023-01-13 |
Publishing country | England |
Document type | Journal Article |
ZDB-ID | 2839775-7 |
ISSN | 2374-4243 ; 2374-4235 |
ISSN (online) | 2374-4243 |
ISSN | 2374-4235 |
DOI | 10.1080/23744235.2022.2158217 |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
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