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  1. Article ; Online: Hypoimmunogenic Human Pluripotent Stem Cells as a Powerful Tool for Liver Regenerative Medicine.

    Trionfini, Piera / Romano, Elena / Varinelli, Marco / Longaretti, Lorena / Rizzo, Paola / Giampietro, Roberta / Caroli, Annalina / Aiello, Sistiana / Todeschini, Marta / Casiraghi, Federica / Remuzzi, Giuseppe / Benigni, Ariela / Tomasoni, Susanna

    International journal of molecular sciences

    2023  Volume 24, Issue 14

    Abstract: Induced pluripotent stem cells (iPSC) have huge potential as cell therapy for various diseases, given their potential for unlimited self-renewal and capability to differentiate into a wide range of cell types. Although autologous iPSCs represents the ... ...

    Abstract Induced pluripotent stem cells (iPSC) have huge potential as cell therapy for various diseases, given their potential for unlimited self-renewal and capability to differentiate into a wide range of cell types. Although autologous iPSCs represents the ideal source for patient-tailored regenerative medicine, the high costs of the extensive and time-consuming production process and the impracticability for treating acute conditions hinder their use for broad applications. An allogeneic iPSC-based strategy may overcome these issues, but it carries the risk of triggering an immune response. So far, several approaches based on genome-editing techniques to silence human leukocyte antigen class I (HLA-I) or II (HLA-II) expression have been explored to overcome the immune rejection of allogeneic iPSCs. In this study, we employed the CRISPR/Cas9 (clustered regularly interspaced short palindromic repeats/CRISPR associated protein 9) system to delete the β2-Microglobulin (
    MeSH term(s) Humans ; Regenerative Medicine ; Pluripotent Stem Cells ; Gene Editing/methods ; Induced Pluripotent Stem Cells ; Histocompatibility Antigens Class I/genetics ; Histocompatibility Antigens Class I/metabolism ; Liver
    Chemical Substances Histocompatibility Antigens Class I
    Language English
    Publishing date 2023-07-22
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms241411810
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Deficiency of AP1 Complex

    Mignani, Luca / Facchinello, Nicola / Varinelli, Marco / Massardi, Elena / Tiso, Natascia / Ravelli, Cosetta / Mitola, Stefania / Schu, Peter / Monti, Eugenio / Finazzi, Dario / Borsani, Giuseppe / Zizioli, Daniela

    International journal of molecular sciences

    2023  Volume 24, Issue 8

    Abstract: In vertebrates, two homologous heterotetrameric AP1 complexes regulate the intracellular protein sorting via vesicles. AP-1 complexes are ubiquitously expressed and are composed of four different subunits: γ, β1, μ1 and σ1. Two different complexes are ... ...

    Abstract In vertebrates, two homologous heterotetrameric AP1 complexes regulate the intracellular protein sorting via vesicles. AP-1 complexes are ubiquitously expressed and are composed of four different subunits: γ, β1, μ1 and σ1. Two different complexes are present in eukaryotic cells, AP1G1 (contains γ1 subunit) and AP1G2 (contains γ2 subunit); both are indispensable for development. One additional tissue-specific isoform exists for μ1A, the polarized epithelial cells specific to μ1B; two additional tissue-specific isoforms exist for σ1A: σ1B and σ1C. Both AP1 complexes fulfil specific functions at the
    MeSH term(s) Animals ; Female ; Humans ; Male ; Mice ; Endosomes/metabolism ; Epithelial Cells/metabolism ; Protein Isoforms/metabolism ; trans-Golgi Network/metabolism ; Zebrafish/genetics ; Zebrafish/metabolism ; Neurodevelopmental Disorders/genetics ; Transcription Factor AP-1/metabolism ; Zebrafish Proteins/metabolism
    Chemical Substances Protein Isoforms ; Transcription Factor AP-1 ; Zebrafish Proteins
    Language English
    Publishing date 2023-04-12
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms24087108
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Development of BCR-ABL1 Transgenic Zebrafish Model Reproducing Chronic Myeloid Leukemia (CML) Like-Disease and Providing a New Insight into CML Mechanisms.

    Zizioli, Daniela / Bernardi, Simona / Varinelli, Marco / Farina, Mirko / Mignani, Luca / Bosio, Katia / Finazzi, Dario / Monti, Eugenio / Polverelli, Nicola / Malagola, Michele / Borsani, Elisa / Borsani, Giuseppe / Russo, Domenico

    Cells

    2021  Volume 10, Issue 2

    Abstract: Zebrafish has proven to be a versatile and reliable experimental in vivo tool to study human hematopoiesis and model hematological malignancies. Transgenic technologies enable the generation of specific leukemia types by the expression of human oncogenes ...

    Abstract Zebrafish has proven to be a versatile and reliable experimental in vivo tool to study human hematopoiesis and model hematological malignancies. Transgenic technologies enable the generation of specific leukemia types by the expression of human oncogenes under specific promoters. Using this technology, a variety of myeloid and lymphoid malignancies zebrafish models have been described. Chronic myeloid leukemia (CML) is a clonal myeloproliferative neoplasia characterized by the
    MeSH term(s) Animals ; Animals, Genetically Modified ; Disease Models, Animal ; Humans ; Leukemia, Myelogenous, Chronic, BCR-ABL Positive/genetics ; Zebrafish
    Language English
    Publishing date 2021-02-19
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2661518-6
    ISSN 2073-4409 ; 2073-4409
    ISSN (online) 2073-4409
    ISSN 2073-4409
    DOI 10.3390/cells10020445
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Zebrafish disease models in hematology: Highlights on biological and translational impact.

    Zizioli, Daniela / Mione, Marina / Varinelli, Marco / Malagola, Michele / Bernardi, Simona / Alghisi, Elisa / Borsani, Giuseppe / Finazzi, Dario / Monti, Eugenio / Presta, Marco / Russo, Domenico

    Biochimica et biophysica acta. Molecular basis of disease

    2018  Volume 1865, Issue 3, Page(s) 620–633

    Abstract: Zebrafish (Danio rerio) has proven to be a versatile and reliable in vivo experimental model to study human hematopoiesis and hematological malignancies. As vertebrates, zebrafish has significant anatomical and biological similarities to humans, ... ...

    Abstract Zebrafish (Danio rerio) has proven to be a versatile and reliable in vivo experimental model to study human hematopoiesis and hematological malignancies. As vertebrates, zebrafish has significant anatomical and biological similarities to humans, including the hematopoietic system. The powerful genome editing and genome-wide forward genetic screening tools have generated models that recapitulate human malignant hematopoietic pathologies in zebrafish and unravel cellular mechanisms involved in these diseases. Moreover, the use of zebrafish models in large-scale chemical screens has allowed the identification of new molecular targets and the design of alternative therapies. In this review we summarize the recent achievements in hematological research that highlight the power of the zebrafish model for discovery of new therapeutic molecules. We believe that the model is ready to give an immediate translational impact into the clinic.
    MeSH term(s) Animals ; Disease Models, Animal ; Drug Discovery/methods ; Drug Screening Assays, Antitumor ; Hematologic Neoplasms/pathology ; Hematology/methods ; Hematology/trends ; Hematopoiesis ; Humans ; Translational Medical Research/methods ; Translational Medical Research/trends ; Zebrafish/physiology
    Language English
    Publishing date 2018-12-26
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 60-7
    ISSN 1879-260X ; 1879-2596 ; 1872-8006 ; 1879-2642 ; 1879-2618 ; 1879-2650 ; 0006-3002 ; 0005-2728 ; 0005-2736 ; 0304-4165 ; 0167-4838 ; 1388-1981 ; 0167-4889 ; 0167-4781 ; 0304-419X ; 1570-9639 ; 0925-4439 ; 1874-9399
    ISSN (online) 1879-260X ; 1879-2596 ; 1872-8006 ; 1879-2642 ; 1879-2618 ; 1879-2650
    ISSN 0006-3002 ; 0005-2728 ; 0005-2736 ; 0304-4165 ; 0167-4838 ; 1388-1981 ; 0167-4889 ; 0167-4781 ; 0304-419X ; 1570-9639 ; 0925-4439 ; 1874-9399
    DOI 10.1016/j.bbadis.2018.12.015
    Database MEDical Literature Analysis and Retrieval System OnLINE

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